Research Topics
Species | Midori YoshidaSummaryAffiliation: Sasaki Institute Country: Japan Publications
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Detail Information
Publications
Uterine adenocarcinoma in N-ethyl-N'-nitro-N-nitrosoguanidine-treated rats with high-dose exposure to p-tert-octylphenol during adulthoodShin-ichi Katsuda
Department of Pathology, Sasaki Institute, Chiyoda-ku, Tokyo 101-0062, Japan
Jpn J Cancer Res 93:117-24. 2002..The results provide clues to the mechanisms of influence of hormonal disrupters on uterine carcinogenesis...- Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolismMidori Yoshida
Department of Pathology, Sasaki Institute, Tokyo, Japan
Carcinogenesis 25:2257-64. 2004.... - Maternal exposure to low doses of bisphenol a has no effects on development of female reproductive tract and uterine carcinogenesis in Donryu ratsMidori Yoshida
Department of Pathology, Sasaki Institute, Tokyo, Japan
J Reprod Dev 50:349-60. 2004..The present study showed that the experimental animals were also exposed to environmental BPA in the animal room... - Lack of toxicity or carcinogenicity of S-170, a sucrose fatty acid ester, in F344 ratsMidori Yoshida
Department of Pathology, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
Food Chem Toxicol 42:667-76. 2004..37 g/kg/day in males and 2.80 g/kg/day in females, and 2.12 g/kg/day in males and 2.42 g/kg/day in females, respectively... - Reduction of primordial follicles caused by maternal treatment with busulfan promotes endometrial adenocarcinoma development in donryu ratsMidori Yoshida
Department of Pathology, Sasaki Institute, Tokyo, Japan
J Reprod Dev 51:707-14. 2005..These results provide evidence that the reduction of primordial follicles promotes uterine adenocarcinoma development in rats in association with an earlier occurrence of the persistent estrus status... - Thesaurus for histopathological findings in publically available reports of repeated-dose oral toxicity studies in rats for 156 chemicalsSatoshi Nishikawa
Chemical Management Center, National Institute of Technology and Evaluation, Nishihara, Shibuya ku, Tokyo, Japan
J Toxicol Sci 35:295-8. 2010..The RTS database with this thesaurus will be made publically available in 2012... - Effects of estrogens and metabolites on endometrial carcinogenesis in young adult mice initiated with N-ethyl-N'-nitro-N-nitrosoguanidineMasakazu Takahashi
Department of Pathology, Sasaki Institute, Sasaki Foundation, 2-2 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan
Cancer Lett 211:1-9. 2004.... - Induction of different types of uterine adenocarcinomas in Donryu rats due to neonatal exposure to high-dose p-t-octylphenol for different periodsMidori Yoshida
Department of Pathology, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
Carcinogenesis 23:1745-50. 2002.... 
Life stage-related differences in susceptibility to acrylamide-induced neural and testicular toxicityMiwa Takahashi
Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, 158 8501, Japan
Arch Toxicol 85:1109-20. 2011..Regarding testicular toxicity, young animals around puberty proved more susceptible than adult animals, possibly due to their lower level of testicular GST activity than that in adult animals...- Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassayKaoru Inoue
Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
Cancer Sci 100:2261-7. 2009..Rubiadin may also target the liver and large intestine, suggesting a major role in madder color-induced carcinogenicity... - Delayed adverse effects of neonatal exposure to diethylstilbestrol and their dose dependency in female ratsMidori Yoshida
Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, Japan
Toxicol Pathol 39:823-34. 2011..Early onset of persistent estrus appears to be the most sensitive parameter... - Promotion, but not progression, effects of tamoxifen on uterine carcinogenesis in mice initiated with N-ethyl-N'-nitro-N-nitrosoguanidineMasakazu Takahashi
Department of Pathology, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
Carcinogenesis 23:1549-55. 2002..These results indicate that TAM may itself exert promotion effects, while exhibiting an anti-progression influence on uterine carcinogenesis in adult mice initiated by ENNG and receiving E(2)... - Long-term treatment with bromocriptine inhibits endometrial adenocarcinoma development in ratsMidori Yoshida
Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
J Reprod Dev 55:105-9. 2009..While the precise pathway to the inhibitory effect could not be determined; the pathway by which ovarian hormonal imbalance decreases the serum E: P ratio most likely plays a crucial role... - Methylation of neutral endopeptidase 24.11 promoter in rat hepatocellular carcinomaFumiyuki Uematsu
Department of Pathology, Sasaki Institute, Sasaki Foundation, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062
Cancer Sci 97:611-7. 2006.... - Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non-cancerous, cirrhotic liver tissues in rats fed a choline-deficient, L-amino acid-defined dietFumiyuki Uematsu
Department of Pathology, Sasaki Institute, Sasaki Foundation, Chiyoda ku, Tokyo, Japan
Cancer Sci 96:414-24. 2005.... - Neonatal exposure to p-tert-octylphenol causes abnormal expression of estrogen receptor alpha and subsequent alteration of cell proliferating activity in the developing Donryu rat uterusMidori Yoshida
Department of Pathology, Sasaki Institute, Tokyo, Japan
Toxicol Pathol 30:357-64. 2002.... - Inhibition of the development of hepatocellular carcinomas by phenyl N-tert-butyl nitrone in rats fed with a choline-deficient, L-amino acid-defined dietDai Nakae
Department of Pathology, Sasaki Institute, Sasaki Foundation, 2 2 Kanda Surugadai, Chiyoda, Tokyo 101 0062, Japan
Cancer Lett 206:1-13. 2004..If such findings can be generalized, PBN may be able to serve as a good tool to investigate molecular mechanisms underlying carcinogenic processes... - Possible contribution of rubiadin, a metabolite of madder color, to renal carcinogenesis in ratsKaoru Inoue
Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
Food Chem Toxicol 47:752-9. 2009..These results indicate that Rub may be a potent carcinogenic metabolite of MC, targeting proximal tubule cells in the outer medulla, although oxidative stress increased by Alz or LuP might also be involved in renal carcinogenesis by MC... - Age-related susceptibility to induction of osteochondral and vascular lesions by semicarbazide hydrochloride in ratsMiwa Takahashi
Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
Toxicol Pathol 38:598-605. 2010..These results suggest that growing animals are more susceptible to toxicity of SEM-HCl than adults are. Effects and the induced lesions link to the developing stage of the target organs... - A case report of a choroid plexus carcinoma spontaneously occurring in the right lateral ventricle of a 14-week-old, female Donryu ratTakasumi Shimomoto
Department of Pathology, Sasaki Institute, Sasaki Foundation, 2 2, Kanda Surugadai, Chiyoda, Tokyo 101 0062, Japan
Toxicol Pathol 32:264-8. 2004..In conclusion, the present tumor was diagnosed as a rat choroid plexus carcinoma, only the third such case to be reported in the world literature, with particular features... - Hormonally active doses of isoflavone aglycones promote mammary and endometrial carcinogenesis and alter the molecular tumor environment in Donryu ratsAnna Kakehashi
Department of Pathology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
Toxicol Sci 126:39-51. 2012.... - Involvement of mutation-based inhibition of beta-catenin phosphorylation at Ser33 in the malignant progression of lung (pre)neoplastic lesions induced by N-nitrosobis(2-hydroxypropyl)amine in male Fischer 344 ratsMaki Igarashi
Laboratory of Protection of Body Function, Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya, Tokyo, 156 0054, Japan
Lung 185:271-8. 2007..These phenomena might contribute to the malignant progression of the lung (pre)neoplastic lesions, which start from the relatively early stage in lung carcinogenesis... - Morphological characterization of the ovary under normal cycling in rats and its viewpoints of ovarian toxicity detectionMidori Yoshida
Division of Pathology, Biology Safety Research Center, National Institute of Health Sciences, Tokyo, Japan
J Toxicol Sci 34:SP189-97. 2009..Morphological deviation from any synchronized combination provides a first pointer of ovarian toxicity. PCNA immunohistochemical staining is also useful to detect small follicles... - Erratum : Thesaurus for histopathological findings in publically available reports of repeated-dose oral toxicity studies in rats for 156 chemicalsSatoshi Nishikawa
Chemical Management Center, National Institute of Technology and Evaluation, Nishihara, Shibuya ku, Tokyo, Japan
J Toxicol Sci 35:E1-8. 2010..The RTS database with this thesaurus will be made publically available in 2010... - Development of an early induction model of medulloblastoma in Ptch1 heterozygous mice initiated with N-ethyl-N-nitrosoureaMiwa Takahashi
Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
Cancer Sci 103:2051-5. 2012..In summary, neonatal treatment with ENU is available for the induction of medulloblastoma in ptch1 mice, and 10 mg of ENU administered on d1 appeared to be an appropriate dose to induce medulloblastoma... - Proposal of new uncertainty factor application to derive tolerable daily intakeRyuichi Hasegawa
National Institute of Health Sciences, Tokyo, Japan
Regul Toxicol Pharmacol 58:237-42. 2010..These default UFs, which come from actual experimental data, may be more appropriate than previous default UFs to derive tolerable daily intake values... - Limited lactational transfer of acrylamide to rat offspring on maternal oral administration during the gestation and lactation periodsMiwa Takahashi
Division of Pathology, National Institute of Health Sciences, Setagaya, Tokyo, Japan
Arch Toxicol 83:785-93. 2009.... - Possible carcinogenic risks of copper gluconate and their prevention by co-administered green tea catechins evaluated by a rat medium-term multi-organ carcinogenicity bioassay protocolMasayoshi Abe
Toxicology and Environmental Science Department, Biological Research Laboratories, Nissan Chemical Industries, Limited, Minamisaitama, Saitama, Japan
Food Chem Toxicol 46:1760-70. 2008..The present results indicate that copper gluconate may possess carcinogenic risks for the liver and forestomach at its high dose level, and that co-administered green tea catechins may exert preventive effects... - Chemopreventive effects of hydroxymatairesinol on uterine carcinogenesis in Donryu ratsShin Ichi Katsuda
Department of Biological Safety Research, Japan Food Research Laboratories, Tama shi, Tokyo 206 0025, Japan
Exp Biol Med (Maywood) 229:417-24. 2004..From urinalysis, HMR was metabolized mainly to enterolactone and hydroxyenterolactone. These findings suggest that HMR or its metabolites exert chemo-preventive effects in the rat ENNG-uterine carcinogenesis model... - Inhibin B regulating follicle-stimulating hormone secretion during testicular recrudescence in the male golden hamsterWanzhu Jin
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu University, Japan
J Androl 23:845-53. 2002.... - Molecular characterization of sucrose:sucrose 1-fructosyltransferase and sucrose:fructan 6-fructosyltransferase associated with fructan accumulation in winter wheat during cold hardeningAkira Kawakami
National Agricultural Research Center for Hokkaido Region, Hitsujigaoka, Sapporo 062 8555, Japan
Biosci Biotechnol Biochem 66:2297-305. 2002..Our results showed that Wft1 and Wft2 were important in fructan accumulation during cold hardening of winter wheat... - Exercise training enhances tumor necrosis factor-alpha-induced expressions of anti-apoptotic genes without alterations in caspase-3 activity in rat epididymal adipocytesTakuya Sakurai
Department of Kinesiology, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan
Jpn J Physiol 55:181-9. 2005..Thus, exercise training enhanced TNF-alpha signaling directed toward the expressions of survival signals and the suppression of FAS gene expression... - Neonatal death of mice treated with perfluorooctane sulfonateDoha Yahia
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
J Toxicol Sci 33:219-26. 2008..The cause of neonatal death in mice exposed to PFOS may be attributed either to the intracranial blood vessel dilatation or to respiratory dysfunction. The former might be a cause of the latter... - Purification, cloning and functional differences of a third fructan 1-exohydrolase (1-FEHw3) from wheat (Triticum aestivum)Liesbet Van Riet
Laboratory of Molecular Plant Physiology, Department of Biology, Botanical Institute, K U Leuven, Kasteelpark Arenberg 31, B 3001 Leuven, Belgium
Physiol Plant 133:242-53. 2008..The relative abundance of 1-FEH transcripts in different tissues was investigated by using quantitative RT-PCR... - Ectopic expression of N-acetylglucosamine 6-O-sulfotransferase 2 in chemotherapy-resistant ovarian adenocarcinomasAkira Kanoh
Hanno Discovery Center, TAIHCO Pharmaceutical Co Ltd, Saitama, Japan
Glycoconj J 23:453-60. 2006..These results indicate that GlcNAc6ST-2 would be a novel tumor antigen that is specifically expressed in ovarian mucinous, clear cell and papillary serous adenocarcinomas...