Research Topics
Genomes and Genes | Katsuko YamashitaSummaryAffiliation: Sasaki Institute Country: Japan Publications
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Detail Information
Publications
Structural basis for recognition of high mannose type glycoproteins by mammalian transport lectin VIP36Tadashi Satoh
Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK, Tsukuba, Ibaraki 305 0801, Japan
J Biol Chem 282:28246-55. 2007..The complex structures reveal the structural basis for high mannose type glycoprotein recognition by VIP36 in a Ca(2+)-dependent and D1 arm-specific manner...
Intracellular lectins associated with N-linked glycoprotein trafficK Yamashita
Department of Biochemistry, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, and CREST Core Research for Evolutional Science and Technology of the Japan Science and Technology Corporation JST, Tokyo, Japan
Biochim Biophys Acta 1473:147-60. 1999....
The carbohydrate recognition by cytokines modulates their physiological activitiesKatsuko Yamashita
Department of Biochemistry, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
Glycoconj J 21:31-4. 2004....
Carbohydrate recognition of vesicular integral protein of 36 kDa (ViP36) in intracellular transport of newly synthesized glycoproteinsSayuri Hara-Kuge
Sasaki Institute, 2-2 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
Methods Enzymol 363:525-32. 2003
Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cellsHiroko Ideo
Department of Biochemistry, Sasaki Institute, 2 2, Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
J Biol Chem 280:4730-7. 2005..These findings suggest that SB1a and CEA in the patches on the cell surface of human colon adenocarcinoma cells could be biologically important ligands for galectin-4...
Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinomaAkira Seko
Department of Biochemistry, Sasaki Institute, 2 2, Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
Glycobiology 12:379-88. 2002..From these results, it was indicated that GlcNAc6ST-2 corresponds to mucinous adenocarcinoma-specific SulT-b and that expression of GlcNAc6ST-3 is down-regulated in colonic adenocarcinomas...
beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycansAkira Seko
Department of Biochemistry, Sasaki Institute, 2 2, Kanda Surugadai, Chiyoda ku, 101 0062, Tokyo, Japan
FEBS Lett 556:216-20. 2004..These results indicate that beta3Gn-T7 is the one that most efficiently elongates L2L2 and may be involved in the biosynthesis of keratan sulfate...
The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinityHiroko Ideo
Department of Biochemistry, Sasaki Institute, 2 2, Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
Glycobiology 13:713-23. 2003..The binding ability of galectin-8 to membrane-associated GM3 was confirmed using CHO cells, which predominantly express GM3. Binding of CHO cells to the mutein was significantly lower than to the N-domain...
Occurrence of secretory glycoprotein-specific GalNAc beta 1-->4GlcNAc sequence in N-glycans in MDCK cellsTakashi Ohkura
Department of Biochemistry, Sasaki Institute and Core Research for Evolutional Science and Technology of the Japan Science and Technology Corporation, Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
J Biochem (Tokyo) 132:891-901. 2002..These results suggest that the secretory glycoprotein-specific (sialyl)LacdiNAc sequence and the corresponding beta 4GalNAc-T are involved in transport of secretory glycoproteins...
Porcine, mouse and human galactose 3-O-sulphotransferase-2 enzymes have different substrate specificities; the porcine enzyme requires basic compounds for its catalytic activityAkira Seko
Department of Biochemistry, Sasaki Institute, 2 2, Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
Biochem J 391:77-85. 2005..These results suggest that porcine Gal3ST-2 requires basic compounds for catalytic activity and that human, mouse and porcine Gal3ST-2 orthologues have diverse substrate specificities...
A beta-N-acetylglucosaminyl phosphate diester residue is attached to the glycosylphosphatidylinositol anchor of human placental alkaline phosphatase: a target of the channel-forming toxin aerolysinKeiko Fukushima
Department of Biochemistry, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
J Biol Chem 278:36296-303. 2003..Furthermore, we found that the beta-N-acetylglucosaminyl phosphate diester residue is important for GPI anchor recognition of aerolysin, a channel-forming toxin derived from Aeromonas hydrophila...
Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma productionKeiko Fukushima
Department of Biochemistry, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
J Biol Chem 280:18056-62. 2005..IL-18Ralpha. CD48 via both the peptide portion and GPI glycan triggers the binding to IL-18Rbeta, and the IL-18.IL-18Ralpha.CD48.IL-18Rbeta complex induces cellular signaling...
High-affinity binding of recombinant human galectin-4 to SO(3)(-)-->3Galbeta1-->3GalNAc pyranosideHiroko Ideo
CREST Core Research for Evolutional Science and Technology of the Japan Science and Technology Corporation, 2 3, Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
Glycobiology 12:199-208. 2002..These results suggest that galectin-4 has a unique carbohydrate binding specificity and interacts with O-linked sulfoglycans...
Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis XAkira Seko
Department of Biochemistry, Sasaki Institute, Kanda-Surugadai 2-2, Tokyo 101-0062, Japan
J Biol Chem 278:9150-8. 2003..These results suggested that beta4GalT-IV is a 6SGN-specific beta4GalT and may be involved in the biosynthesis of various glycoproteins carrying a 6-O-sulfated N-acetyllactosamine moiety...
Carbohydrate recognition of interleukin-2 in cell proliferationKeiko Fukushima
Sasaki Institute, 2-2 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
Methods Enzymol 363:518-25. 2003
Recognition by TNF-alpha of the GPI-anchor glycan induces apoptosis of U937 cellsKeiko Fukushima
Department of Biochemistry, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
Arch Biochem Biophys 426:298-305. 2004..These data suggest that TNF-alpha stimulates U937 cell apoptosis by forming a high-affinity nanomeric (TNF-alpha)(3)-(TNFR)(3)-(GPI-anchored glycan)(3) complex. The GPI-anchored glycoprotein involved remains to be identified...
Involvement of VIP36 in intracellular transport and secretion of glycoproteins in polarized Madin-Darby canine kidney (MDCK) cellsSayuri Hara-Kuge
Department of Biochemistry, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
J Biol Chem 277:16332-9. 2002..These results indicated that VIP36 was involved in the transport and sorting of glycoproteins carrying high mannose-type glycan(s)...
Characterization of a novel galactose beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8): the complex formation of beta3Gn-T2 and beta3Gn-T8 enhances enzymatic activityAkira Seko
Department of Biochemistry, Sasaki Institute, 2-2, Kanda-Surugadai, Tokyo 101-0062, Japan
Glycobiology 15:943-51. 2005..These results suggested that beta3Gn-T8 and beta3Gn-T2 are cooperatively involved in the elongation of specific branch structures of multiantennary N-glycans...
The binding of VIP36 and alpha-amylase in the secretory vesicles via high-mannose type glycansSayuri Hara-Kuge
Department of Biochemistry, Sasaki Institute, 2-2 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
Glycobiology 14:739-44. 2004..In addition, VIP36 coprecipitated with alpha-amylase in an endo H treatment-sensitive manner. These results suggest that VIP36 is involved in the secretion of alpha-amylase in the rat parotid gland...
Down-regulation of Gal 3-O-sulfotransferase-2 (Gal3ST-2) expression in human colonic non-mucinous adenocarcinomaAkira Seko
Department of Biochemistry, Sasaki Institute, Chiyoda ku, Tokyo 101 0062
Jpn J Cancer Res 93:507-15. 2002..These results suggest that Gal3ST-2 is one of the enzymes responsible for biosynthesis of sulfomucin, and that expression levels of Gal3ST-2 are down-regulated in non-mucinous adenocarcinoma...
Effects of antisecretory agents on angiogenesis during healing of gastric ulcersMasumi Akimoto
Institute of Geriatrics, Tokyo Women's Medical University, 2-15-1 Shibuya, Shibuya-ku, Tokyo, 150-0002, Japan
J Gastroenterol 40:685-9. 2005..These results suggest that PPIs increase the expression of CXCR4 mRNA and thus promote vessel regeneration and maturation, facilitating ulcer healing...
Structures of the carbohydrate recognition domain of Ca2+-independent cargo receptors Emp46p and Emp47pTadashi Satoh
Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK, Tsukuba, Ibaraki 305 0801, Japan
J Biol Chem 281:10410-9. 2006....
[Carbohydrate recognition modulates cell proliferation]Keiko Fukushima
Tanpakushitsu Kakusan Koso 48:1120-5. 2003
Examination of changes in TGF-beta1 and KL-6 expression over time in patients with chronic hepatitis C by AT-II receptor blocker therapyTakeshi Kurihara
J Gastroenterol 40:855-6. 2005
Recognition mechanism of galectin-4 for cholesterol 3-sulfateHiroko Ideo
Innovative Research Initiatives, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8503, Japan
J Biol Chem 282:21081-9. 2007..These results suggested that not only sulfated glycosphingolipids but also cholesterol 3-sulfate are endogenous ligands for galectin-4 in vivo...
Efficacy of bezafibrate in a patient with primary sclerosing cholangitisTakeshi Kurihara
J Gastroenterol 38:300-1. 2003
