Tsuneyuki Oikawa

Summary

Affiliation: Sasaki Institute
Country: Japan

Publications

  1. pmc Extinction of expression of the genes encoding haematopoietic cell-restricted transcription factors in T-lymphoma x fibroblast cell hybrids
    T Oikawa
    Department of Cell Genetics, Sasaki Institute, Kanda Surugadai, Tokyo, Japan
    Immunology 104:162-7. 2001
  2. ncbi ETS transcription factors: possible targets for cancer therapy
    Tsuneyuki Oikawa
    Department of Cell Genetics, Sasaki Institute, Chiyoda ku, Tokyo 101 0062, Japan
    Cancer Sci 95:626-33. 2004
  3. ncbi Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells
    Toshiyuki Yamada
    Department of Cell Genetics, Sasaki Institute, Tokyo 101 0062, Japan
    Exp Cell Res 294:39-50. 2004
  4. ncbi Molecular biology of the Ets family of transcription factors
    Tsuneyuki Oikawa
    Department of Cell Genetics, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Gene 303:11-34. 2003
  5. ncbi Impaired repressor activity and biological functions of PU.1 in MEL cells induced by mutations in the acetylation motifs within the ETS domain
    Fumiko Kihara-Negishi
    Department of Cell Genetics, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Biochem Biophys Res Commun 335:477-84. 2005
  6. ncbi Prevention of PU.1-induced growth inhibition and apoptosis but not differentiation block in murine erythroleukemia cells by overexpression of CBP
    Noriyoshi Manabe
    Department of Cell Genetics, Sasaki Institute, Tokyo 101 0062, Japan
    Int J Oncol 22:1345-50. 2003
  7. ncbi Classification of neural differentiation-associated genes in P19 embryonal carcinoma cells by their expression patterns induced after cell aggregation and/or retinoic acid treatment
    Sayaka Teramoto
    Department of Cell Genetics, Sasaki Institute, Tokyo 101 0062, Japan
    Oncol Rep 14:1231-8. 2005
  8. ncbi Effects of overexpression of the Ets family transcription factor TEL on cell growth and differentiation of K562 cells
    Takuya Sakurai
    Department of Cell Genetics, Sasaki Institute, Tokyo 101 0062, Japan
    Int J Oncol 22:1327-33. 2003
  9. ncbi Direct association between PU.1 and MeCP2 that recruits mSin3A-HDAC complex for PU.1-mediated transcriptional repression
    Mitsuhiro Suzuki
    Department of Cell Genetics, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Oncogene 22:8688-98. 2003
  10. ncbi Functional roles of Fli-1, a member of the Ets family of transcription factors, in human breast malignancy
    Takuya Sakurai
    Department of Cell Genetics, Sasaki Institute, Kanda Surugadai, Tokoyo 101 0062, Japan
    Cancer Sci 98:1775-84. 2007

Collaborators

Detail Information

Publications14

  1. pmc Extinction of expression of the genes encoding haematopoietic cell-restricted transcription factors in T-lymphoma x fibroblast cell hybrids
    T Oikawa
    Department of Cell Genetics, Sasaki Institute, Kanda Surugadai, Tokyo, Japan
    Immunology 104:162-7. 2001
    ....
  2. ncbi ETS transcription factors: possible targets for cancer therapy
    Tsuneyuki Oikawa
    Department of Cell Genetics, Sasaki Institute, Chiyoda ku, Tokyo 101 0062, Japan
    Cancer Sci 95:626-33. 2004
    ....
  3. ncbi Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells
    Toshiyuki Yamada
    Department of Cell Genetics, Sasaki Institute, Tokyo 101 0062, Japan
    Exp Cell Res 294:39-50. 2004
    ..1, were not provoked in the cells overexpressing mCKLiK. These results suggest that mCKLiK is up-regulated by PU.1 in MEL cells and involved in apoptosis of the cells...
  4. ncbi Molecular biology of the Ets family of transcription factors
    Tsuneyuki Oikawa
    Department of Cell Genetics, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Gene 303:11-34. 2003
    ..Several Ets family proteins also participate in malignancy of tumor cells including invasion and metastasis by activating the transcription of several protease genes and angiogenesis-related genes...
  5. ncbi Impaired repressor activity and biological functions of PU.1 in MEL cells induced by mutations in the acetylation motifs within the ETS domain
    Fumiko Kihara-Negishi
    Department of Cell Genetics, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Biochem Biophys Res Commun 335:477-84. 2005
    ..1 did not. Taken together, our data suggest that acetylation might regulate the biological functions of PU.1 in erythroid cells...
  6. ncbi Prevention of PU.1-induced growth inhibition and apoptosis but not differentiation block in murine erythroleukemia cells by overexpression of CBP
    Noriyoshi Manabe
    Department of Cell Genetics, Sasaki Institute, Tokyo 101 0062, Japan
    Int J Oncol 22:1345-50. 2003
    ..These results also suggest that the molecular mechanisms on PU.1-induced growth inhibition and apoptosis are different from the mechanism on PU.1-induced differentiation block in MEL cells...
  7. ncbi Classification of neural differentiation-associated genes in P19 embryonal carcinoma cells by their expression patterns induced after cell aggregation and/or retinoic acid treatment
    Sayaka Teramoto
    Department of Cell Genetics, Sasaki Institute, Tokyo 101 0062, Japan
    Oncol Rep 14:1231-8. 2005
    ..Our results suggest that although both treatments are required for complete neural differentiation of P19 cells, cell aggregation or RA treatment alone drive differentiation to a certain extent at the gene expression level...
  8. ncbi Effects of overexpression of the Ets family transcription factor TEL on cell growth and differentiation of K562 cells
    Takuya Sakurai
    Department of Cell Genetics, Sasaki Institute, Tokyo 101 0062, Japan
    Int J Oncol 22:1327-33. 2003
    ....
  9. ncbi Direct association between PU.1 and MeCP2 that recruits mSin3A-HDAC complex for PU.1-mediated transcriptional repression
    Mitsuhiro Suzuki
    Department of Cell Genetics, Sasaki Institute, 2 2 Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Oncogene 22:8688-98. 2003
    ..The complex disappeared from the region during the course of erythroid differentiation of MEL cells. Our results suggest that MeCP2 acts as a corepressor of PU.1 probably due to facilitating complex formation with mSin3A and HDACs...
  10. ncbi Functional roles of Fli-1, a member of the Ets family of transcription factors, in human breast malignancy
    Takuya Sakurai
    Department of Cell Genetics, Sasaki Institute, Kanda Surugadai, Tokoyo 101 0062, Japan
    Cancer Sci 98:1775-84. 2007
    ..In addition, human bcl-2 promoter activity was transactivated by Fli-1. These results suggest that Fli-1 contributes to the malignancy of human breast cancer by inhibiting apoptosis through upregulated expression of the bcl-2 gene...
  11. ncbi Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb
    Hitomi Yamamoto
    Department of Cell Genetics, Sasaki Institute, Tokyo 101 0062, Japan
    Cell Growth Differ 13:69-75. 2002
    ..Our results suggest that CBP acts as a transcriptional coactivator of Spi-B and mediates synergistic or antagonistic interactions between other transcription factors...
  12. ncbi Involvement of mutation-based inhibition of beta-catenin phosphorylation at Ser33 in the malignant progression of lung (pre)neoplastic lesions induced by N-nitrosobis(2-hydroxypropyl)amine in male Fischer 344 rats
    Maki Igarashi
    Laboratory of Protection of Body Function, Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya, Tokyo, 156 0054, Japan
    Lung 185:271-8. 2007
    ..These phenomena might contribute to the malignant progression of the lung (pre)neoplastic lesions, which start from the relatively early stage in lung carcinogenesis...
  13. ncbi Interaction between the homeodomain protein HOXC13 and ETS family transcription factor PU.1 and its implication in the differentiation of murine erythroleukemia cells
    Toshiyuki Yamada
    Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Exp Cell Res 314:847-58. 2008
    ..It was, thus, suggested that although HOXC13 negatively regulates the differentiation of MEL cells into erythroid cells, it antagonizes PU.1 possibly by down-regulation of PU.1 protein in the presence of a differentiation stimulus...
  14. ncbi Activation of anchorage-independent growth of HT1080 human fibrosarcoma cells by dexamethasone
    Nobuo Kondoh
    Department of Biochemistry II, National Defense Medical College, Tokorozawa, Saitama, Japan
    In Vitro Cell Dev Biol Anim 38:111-7. 2002
    ..e., one that leads to the suppression of P27Kip1 protein without requiring cytoskeletal integrity, and another that requires cytoskeletal integrity, leading to stimulation of cyclin A and hyperphosphorylation of Rb protein...