Takao Saruta

Summary

Country: Japan

Publications

  1. ncbi request reprint Effects of the angiotensin II type 1 receptor antagonist candesartan, compared with angiotensin-converting enzyme inhibitors, on the urinary excretion of albumin and type IV collagen in patients with diabetic nephropathy
    Atsuhisa Sato
    Department of Internal Medicine, Mito Red Cross Hospital, 3 12 48 San nomaru, Mito, Ibaraki 310 0011, Japan
    Clin Exp Nephrol 7:215-20. 2003
  2. ncbi request reprint Role of nitric oxide and prostaglandin E2 in acute renal hypoperfusion
    Hirobumi Tokuyama
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nephrology (Carlton) 8:65-71. 2003
  3. ncbi request reprint An overview of blood pressure regulation associated with the kidney
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School, Moroyama machi, Iruma gun, Saitama, Japan
    Contrib Nephrol 143:1-15. 2004
  4. ncbi request reprint Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats--studies in the isolated perfused hydronephrotic kidney
    Koichi Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 54:102-8. 2005
  5. ncbi request reprint Dimethylarginine dimethylaminohydrolase 2 increases vascular endothelial growth factor expression through Sp1 transcription factor in endothelial cells
    Kazuhiro Hasegawa
    Department of Internal Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 26:1488-94. 2006
  6. ncbi request reprint Effectiveness of aldosterone blockade in patients with diabetic nephropathy
    Atsuhisa Sato
    Department of Internal Medicine, Mito Red Cross Hospital, Mito City, Ibaraki, Japan
    Hypertension 41:64-8. 2003
  7. ncbi request reprint Combination therapy with aldosterone blockade and renin-angiotensin inhibitors confers organ protection
    Atsuhisa Sato
    Department of Internal Medicine, International University of Health and Welfare Mita Hospital, Tokyo, Japan
    Hypertens Res 29:211-6. 2006
  8. ncbi request reprint Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease
    Atsuhisa Sato
    Department of Internal Medicine, Mito Red Cross Hospital, Ibaraki, Japan
    Am J Hypertens 18:44-9. 2005
  9. ncbi request reprint Aldosterone breakthrough during angiotensin-converting enzyme inhibitor therapy
    Atsuhisa Sato
    Department of Internal Medicine, Mito Red Cross Hospital, 3 12 48 San nomaru, Mito City, Ibaraki 310 0011, Japan
    Am J Hypertens 16:781-8. 2003
  10. ncbi request reprint Relative long-term effects of spironolactone in conjunction with an angiotensin-converting enzyme inhibitor on left ventricular mass and diastolic function in patients with essential hypertension
    Atsuhisa Sato
    Department of Internal Medicine, Mito Red Cross Hospital, Mito, Japan
    Hypertens Res 25:837-42. 2002

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Effects of the angiotensin II type 1 receptor antagonist candesartan, compared with angiotensin-converting enzyme inhibitors, on the urinary excretion of albumin and type IV collagen in patients with diabetic nephropathy
    Atsuhisa Sato
    Department of Internal Medicine, Mito Red Cross Hospital, 3 12 48 San nomaru, Mito, Ibaraki 310 0011, Japan
    Clin Exp Nephrol 7:215-20. 2003
    ....
  2. ncbi request reprint Role of nitric oxide and prostaglandin E2 in acute renal hypoperfusion
    Hirobumi Tokuyama
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nephrology (Carlton) 8:65-71. 2003
    ..In contrast, sustained increases in renal PGE2 in both clipped and non-clipped kidneys indicate that the COX-2-mediated PGE2 contributes importantly to the failure of the sodium reabsorption in response to acute renal hypoperfusion...
  3. ncbi request reprint An overview of blood pressure regulation associated with the kidney
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School, Moroyama machi, Iruma gun, Saitama, Japan
    Contrib Nephrol 143:1-15. 2004
  4. ncbi request reprint Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats--studies in the isolated perfused hydronephrotic kidney
    Koichi Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 54:102-8. 2005
    ..Furthermore, the enhancement in nifedipine-induced afferent arteriolar dilation by staurosporine in SHR suggests that L-type Ca channel activity is augmented in hypertensive animals...
  5. ncbi request reprint Dimethylarginine dimethylaminohydrolase 2 increases vascular endothelial growth factor expression through Sp1 transcription factor in endothelial cells
    Kazuhiro Hasegawa
    Department of Internal Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 26:1488-94. 2006
    ..The molecular mechanism for DDAH-induced vascular endothelial growth factor (VEGF) expression was examined...
  6. ncbi request reprint Effectiveness of aldosterone blockade in patients with diabetic nephropathy
    Atsuhisa Sato
    Department of Internal Medicine, Mito Red Cross Hospital, Mito City, Ibaraki, Japan
    Hypertension 41:64-8. 2003
    ..Additional, larger, prospectively randomized, double-blind studies will be needed before adaptation of this strategy...
  7. ncbi request reprint Combination therapy with aldosterone blockade and renin-angiotensin inhibitors confers organ protection
    Atsuhisa Sato
    Department of Internal Medicine, International University of Health and Welfare Mita Hospital, Tokyo, Japan
    Hypertens Res 29:211-6. 2006
    ..Adverse effects will occur only if the usage recommendations based on previous researches are not followed...
  8. ncbi request reprint Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease
    Atsuhisa Sato
    Department of Internal Medicine, Mito Red Cross Hospital, Ibaraki, Japan
    Am J Hypertens 18:44-9. 2005
    ..Additional, larger, prospective, randomized double-blind studies will be needed for general acceptance of this strategy...
  9. ncbi request reprint Aldosterone breakthrough during angiotensin-converting enzyme inhibitor therapy
    Atsuhisa Sato
    Department of Internal Medicine, Mito Red Cross Hospital, 3 12 48 San nomaru, Mito City, Ibaraki 310 0011, Japan
    Am J Hypertens 16:781-8. 2003
    ..At present, the mechanisms of aldosterone breakthrough remain obscure, requiring further studies, including those on regional nonepithelial effects of aldosterone...
  10. ncbi request reprint Relative long-term effects of spironolactone in conjunction with an angiotensin-converting enzyme inhibitor on left ventricular mass and diastolic function in patients with essential hypertension
    Atsuhisa Sato
    Department of Internal Medicine, Mito Red Cross Hospital, Mito, Japan
    Hypertens Res 25:837-42. 2002
    ....
  11. ncbi request reprint Aldosterone-induced organ damage: plasma aldosterone level and inappropriate salt status
    Atsuhisa Sato
    Department of Internal Medicine, Mito Red Cross Hospital, San no maru, Mito, Japan
    Hypertens Res 27:303-10. 2004
    ..This means that the new aldosterone blocker eplerenone may also have significance as a drug inhibiting inflammation, possibly serving as a trigger of organ damage...
  12. ncbi request reprint Ca2+ channel subtypes and pharmacology in the kidney
    Koichi Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Circ Res 100:342-53. 2007
    ..Furthermore, multifaceted activity of CCBs on T- and N-type Ca(2+) channels may offer additive benefits through nonhemodynamic mechanisms in the progression of chronic kidney disease...
  13. doi request reprint Candesartan and insulin reduce renal sympathetic nerve activity in hypertensive type 1 diabetic rats
    Chie Takimoto
    Divison of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 31:1941-51. 2008
    ....
  14. ncbi request reprint COUP-TF and transcriptional co-regulators in adrenal steroidogenesis
    Hirotaka Shibata
    Health Center, Keio University, Tokyo, Japan
    Endocr Res 30:795-801. 2004
    ..These findings indicate that Ubc9 and PIAS1 can function as transcriptional co-regulators of COUP-TFI to modulate adrenal cortical steroidogenesis in a SUMOylation-independent manner...
  15. ncbi request reprint Role of nitric oxide-producing and -degrading pathways in coronary endothelial dysfunction in chronic kidney disease
    Satoru Tatematsu
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 18:741-9. 2007
    ..The dysfunction is attributed to the downregulation of eNOS and/or DDAH-II in coronary arteries. Furthermore, the manipulation of NO pathways may constitute a therapeutic strategy for the prevention of coronary dysfunction in CKD...
  16. ncbi request reprint Altered renal microvascular response in Zucker obese rats
    Koichi Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Metabolism 51:1553-61. 2002
    ..The blunted myogenic afferent arteriolar constriction would allow glomerular hypertension, and in concert with the impaired endothelium-dependent vasodilation, could be responsible for the development of glomerular injury in obesity...
  17. ncbi request reprint Developmental activity of the renin-angiotensin system during the "critical period" modulates later L-NAME-induced hypertension and renal injury
    Kimiko Ishiguro
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Hypertens Res 30:63-75. 2007
    ..Conversely, developmental exposure to Ang II during this "critical" period had the opposite effect, predisposing rats to higher blood pressure, renal injury, and oxidative stress after L-NAME administration...
  18. ncbi request reprint GAD-reactive T cells were mainly detected in autoimmune-related type 1 diabetic patients with HLA DR9
    Arata Itoh
    Department of Internal Medicine, Keio Univ School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1037:33-40. 2004
    ..There was an association between T cell reactivity against GAD and HLA DR9 in Japanese type 1 diabetes...
  19. ncbi request reprint Pioglitazone lowers systemic asymmetric dimethylarginine by inducing dimethylarginine dimethylaminohydrolase in rats
    Shu Wakino
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hypertens Res 28:255-62. 2005
    ..Since ADMA is one of the risk factors for cardiovascular events, this study provides compelling evidence that PPARgamma ligands have the potential for reducing cardiovascular risks...
  20. ncbi request reprint Electrophysiological properties of rostral ventrolateral medulla neurons in angiotensin II 1a receptor knockout mice
    Tomokazu Matsuura
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    Hypertension 46:349-54. 2005
    ..These results suggest that the angiotensin II type 2 receptor in rostral ventrolateral medulla plays an antagonistic role against the angiotensin II type 1a receptor in controlling the neuronal activity of rostral ventrolateral medulla...
  21. ncbi request reprint Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population
    Takeo Ogawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Metabolism 53:879-85. 2004
    ....
  22. ncbi request reprint Free radical activity depends on underlying vasoconstrictors in renal microcirculation
    Yuri Ozawa
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Clin Exp Hypertens 26:219-29. 2004
    ..The heterogeneity in the responsiveness to free radical scavengers is attributed to both magnitude of free radicals produced and sensitivity of the underlying vasoconstrictors to nitric oxide...
  23. doi request reprint Renal cytochrome P450 as a determinant of impaired natriuresis by PPAR-gamma ligands in ovariectomized obese rats
    Kyoko Yoshioka
    Department of Internal Medicine, Keio University, Tokyo, Japan
    Obesity (Silver Spring) 16:965-71. 2008
    ..The aim of this study was to elucidate the mechanism for PIO-induced sodium retention and to discover the therapeutic strategy for the PIO-induced changes in renal sodium handling...
  24. doi request reprint Relation of blood pressure quantitative trait locus on rat chromosome 1 to hyperactivity of rostral ventrolateral medulla
    Kamon Iigaya
    Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo
    Hypertension 53:42-8. 2009
    ..The QTL on rat chromosome 1 was primarily related to the postsynaptic response of RVLM bulbospinal neurons to brain angiotensin II, whereas both the QTL and other genomic regions influenced the basal activity of RVLM neurons...
  25. ncbi request reprint Rho-kinase as a molecular target for insulin resistance and hypertension
    Takeshi Kanda
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    FASEB J 20:169-71. 2006
    ..Collectively, Rho-kinase is responsible for the impairment of insulin signaling and may constitute a critical mediator linking between metabolic and hemodynamic abnormalities in insulin resistance...
  26. ncbi request reprint Spironolactone in combination with cilazapril ameliorates proteinuria and renal interstitial fibrosis in rats with anti-Thy-1 irreversible nephritis
    Masaki Asai
    Department of Internal Medicine, Keio University School of Medicine, Shinanomachi, Tokyo, Japan
    Hypertens Res 27:971-8. 2004
    ..These data suggest that concomitant treatment with spironolactone and an ACE inhibitor has beneficial effects on immune-initiated progressive kidney disease...
  27. doi request reprint Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design
    Takashi Eguchi
    Department of Internal Medicine, School of Medicine, Keio University, Saitama Prefecture, Japan
    Hypertens Res 32:775-9. 2009
    ..These results suggest that the TNFR2 gene locus has a potential effect on developing severe hypertension through the augmented TNF pathway and insulin resistance...
  28. ncbi request reprint Impaired nitric oxide- and endothelium-derived hyperpolarizing factor-dependent dilation of renal afferent arteriole in Dahl salt-sensitive rats
    Yuri Ozawa
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nephrology (Carlton) 9:272-7. 2004
    ..The present study examined whether free radicals interacted with nitric oxide-dependent and EDHF-dependent vasodilator mechanisms in renal microvessels of salt-sensitive hypertension, using the isolated perfused hydronephrotic kidney...
  29. ncbi request reprint Congenic substitution mapping for intracellular Ca2+ in spontaneously hypertensive rats
    Yoichi Ohno
    Department of Internal Medicine, Saitama Municipal Hospital, Saitama, Japan
    Am J Hypertens 20:172-6. 2007
    ....
  30. ncbi request reprint Distinct modulation of superficial and juxtamedullary arterioles by prostaglandin in vivo
    Hiroto Matsuda
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Hypertens Res 25:901-10. 2002
    ....
  31. ncbi request reprint Role of asymmetrical dimethylarginine in renal microvascular endothelial dysfunction in chronic renal failure with hypertension
    Ken Okubo
    Department of Internal Medicine, School of Medicine, Keio University Tokyo, Japan Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hypertens Res 28:181-9. 2005
    ..The deranged NO metabolic pathway including ADMA and DDAH is a novel mechanism for the aggravation of renal function...
  32. ncbi request reprint FHL2, UBC9, and PIAS1 are novel estrogen receptor alpha-interacting proteins
    Sakiko Kobayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Endocr Res 30:617-21. 2004
    ..The present studies indicate that ERalpha exhibit tissue-specific functions utilizing multiple tissue-restricted receptor-interacting proteins...
  33. ncbi request reprint Role of Rho-kinase and p27 in angiotensin II-induced vascular injury
    Takeshi Kanda
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku Tokyo 160 8582, Japan
    Hypertension 45:724-9. 2005
    ..Inhibition of Rho-kinase activity improves angiotensin II-induced vascular injury through p27-dependent and p27-independent mechanisms...
  34. ncbi request reprint Peroxisome proliferator-activated receptor gamma ligands inhibit Rho/Rho kinase pathway by inducing protein tyrosine phosphatase SHP-2
    Shu Wakino
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Circ Res 95:e45-55. 2004
    ..The full text of this article is available online at http://circres.ahajournals.org...
  35. ncbi request reprint Molecular mechanisms and therapeutic strategies of chronic renal injury: role of rho-kinase in the development of renal injury
    Koichi Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Pharmacol Sci 100:29-33. 2006
    ..Collectively, the Rho-kinase pathway is involved in the pathogenesis of renal injury. Clinical application of this type of therapy however awaits further investigations...
  36. ncbi request reprint Low doses of losartan and trandolapril improve arterial stiffness in hemodialysis patients
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Kidney Dis 45:866-74. 2005
    ....
  37. ncbi request reprint Relation between development of nephropathy and the p22phox C242T and receptor for advanced glycation end product G1704T gene polymorphisms in type 2 diabetic patients
    Seiko Matsunaga-Irie
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Diabetes Care 27:303-7. 2004
    ..We studied the relation between the genotypes of the NADPH p22phox C242T and RAGE G1704T polymorphisms and the development of diabetic nephropathy in type 2 diabetic patients...
  38. ncbi request reprint NF-kappaB-dependent increase in intrarenal angiotensin II induced by proteinuria
    Osamu Takase
    Department of Internal Medicine, and Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan
    Kidney Int 68:464-73. 2005
    ..We investigated the roles of nuclear factor kappaB (NF-kappaB) activation in the intrarenal renin-angiotensin system changes induced by proteinuria...
  39. ncbi request reprint Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats
    Takeshi Kanda
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Kidney Int 64:2009-19. 2003
    ..Although Rho-kinase is reported to play an important role in vascular injury, the contribution of Rho-kinase to the progression of renal injury remains unestablished...
  40. ncbi request reprint Novel axonal projection from the caudal end of the ventrolateral medulla to the intermediolateral cell column
    Kamon Iigaya
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Physiol Regul Integr Comp Physiol 292:R927-36. 2007
    ..The increase in EPSPs of the IML neurons in response to glutamate application suggests that the CeVLM participates in the regulation of sympathetic nerve activity and blood pressure and may correspond to the caudal pressor area...
  41. ncbi request reprint Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population
    Yukihiro Yamamoto
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 89:87-90. 2004
    ..162 and r = -0.140, respectively). These findings suggest that the serum adiponectin concentration predicts subsequent changes in insulin resistance, but not in lipid profile or body weight...
  42. ncbi request reprint Distinct role of intrarenal cyclooxygenase-1/2 in chronic unilateral renal ischemia
    Hirobumi Tokuyama
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nephron 92:183-91. 2002
    ..The role of cyclooxygenase (COX)-1/2-induced prostaglandins (PG) in unilateral chronic renal ischemia of anesthetized dogs was examined...
  43. ncbi request reprint Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9
    Kenichi Yokota
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Biol Chem 282:1998-2010. 2007
    ..These findings support a physiological role of Ubc9 as a transcriptional MR coactivator, beyond the known SUMO E2-conjugating enzyme...
  44. ncbi request reprint Extracellular matrix glycoprotein biglycan enhances vascular smooth muscle cell proliferation and migration
    Ryoko Shimizu-Hirota
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Circ Res 94:1067-74. 2004
    ..Furthermore, changes in biglycan expression could be a factor influencing the susceptibility of arteries to vascular injury, and may play a direct role in the pathogenesis of vascular lesions...
  45. ncbi request reprint CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice
    Toshikatsu Shigihara
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Immunol 175:8401-8. 2005
    ..Therefore, CXCL10 neutralization is suggested to be useful for maintaining beta cell mass at any stage of autoimmune diabetes...
  46. ncbi request reprint Proteasome-mediated mineralocorticoid receptor degradation attenuates transcriptional response to aldosterone
    Kenichi Yokota
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Endocr Res 30:611-6. 2004
    ..These findings demonstrate a coupling between MR up-regulation and transcriptional hyperactivity...
  47. ncbi request reprint Vessel- and vasoconstrictor-dependent role of rho/rho-kinase in renal microvascular tone
    Akira Nakamura
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Vasc Res 40:244-51. 2003
    ....
  48. ncbi request reprint Combination therapy with PPARgamma and PPARalpha agonists increases glucose-stimulated insulin secretion in db/db mice
    Ken Yajima
    Department of Internal Medicine, Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Physiol Endocrinol Metab 284:E966-71. 2003
    ..GSIS was further increased by PPARgamma and -alpha agonists. We conclude that combination therapy with PPARgamma and PPARalpha agonists may be more useful with respect to body weight and pancreatic GSIS in type 2 diabetes with obesity...
  49. pmc NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor
    Ayano Murai-Takeda
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 285:8084-93. 2010
    ..These findings indicate that NF-YC functions as a new corepressor of agonist-bound MR via alteration of aldosterone-induced MR conformation...
  50. ncbi request reprint Differential regulation of elevated renal angiotensin II in chronic renal ischemia
    Hirobumi Tokuyama
    Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Hypertension 40:34-40. 2002
    ..Furthermore, the mechanisms for intrarenal Ang II generation differ, and chymase activity is enhanced in clipped kidneys, whereas ACE-mediated Ang II generation is possibly responsible for elevated Ang II contents in nonclipped kidneys...
  51. ncbi request reprint Angiotensin II type 2 receptor inhibits prorenin processing in juxtaglomerular cells
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 26:915-21. 2003
    ..Long-term treatment with an ARB may decrease PRA in part by diminishing the storage of active renin in JG cells...
  52. ncbi request reprint Effects of the angiotensin receptor blocker candesartan on arterial stiffness and markers of extracellular matrix metabolism in patients with essential hypertension
    Hiroyuki Sasamura
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Clin Exp Hypertens 28:511-20. 2006
    ..These effects on ECM metabolism could have a beneficial effect in decreasing vascular pathology in patients with essential hypertension...
  53. doi request reprint Monosynaptic excitatory connection from the rostral ventrolateral medulla to sympathetic preganglionic neurons revealed by simultaneous recordings
    Naoki Oshima
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hypertens Res 31:1445-54. 2008
    ..The results explain the mechanism by which Ang II in the RVLM area increases peripheral sympathetic activity and blood pressure...
  54. doi request reprint Effects of candesartan and amlodipine on cardiovascular events in hypertensive patients with chronic kidney disease: subanalysis of the CASE-J Study
    Takao Saruta
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 32:505-12. 2009
    ..Furthermore, candesartan prevented a new onset of diabetes in CKD, which would be favorable for the long-term management of CKD...
  55. ncbi request reprint Ovariectomy enhances renal cortical expression and function of cyclooxygenase-2
    Yuko Tada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Kidney Int 66:1966-76. 2004
    ..This study was performed to determine the renal expression of COX-2 and on COX-2-dependent regulation of renal blood flow (RBF) in ovariectomized rats...
  56. pmc Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 114:1128-35. 2004
    ..The mechanism and substances causing nonproteolytic activation of prorenin may serve as important therapeutic targets for the prevention of diabetic organ damage...
  57. ncbi request reprint Role of actions of calcium antagonists on efferent arterioles--with special references to glomerular hypertension
    Koichi Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Am J Nephrol 23:229-44. 2003
    ..These divergent actions of these agents on the efferent arteriole may alter differently the glomerular hemodynamics, and could affect the final outcome of underlying renal diseases...
  58. ncbi request reprint Cellular mechanism for mibefradil-induced vasodilation of renal microcirculation: studies in the isolated perfused hydronephrotic kidney
    Koichi Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Shinanomachi, Tokyo, Japan
    J Cardiovasc Pharmacol 42:697-702. 2003
    ....
  59. ncbi request reprint Hepatocyte growth factor regulates proteoglycan synthesis in interstitial fibroblasts
    Emi Kobayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Kidney Int 64:1179-88. 2003
    ..In this study, we examined the effects of HGF on proteoglycan synthesis in interstitial fibroblasts, and the mechanisms of these effects...
  60. ncbi request reprint Pathophysiological significance of T-type Ca2+ channels: role of T-type Ca2+ channels in renal microcirculation
    Koichi Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Pharmacol Sci 99:221-7. 2005
    ..Collectively, T-type Ca(2+) channel blockade provides beneficial action in renal injury. Various mechanisms serve to protect against renal injury, including systemic/glomerular hemodynamic action and non-hemodynamic mechanisms...
  61. ncbi request reprint Detection of GAD-reactive CD4+ cells in so-called "type 1B" diabetes
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1005:378-86. 2003
    ..In this study, we tried to demonstrate the existence of islet-associated antigen-specific T cells in type 1 diabetes without islet-associated autoantibody...
  62. ncbi request reprint Involvement of renal sympathetic nerve in pathogenesis of hypertension
    Hiroo Kumagai
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Contrib Nephrol 143:32-45. 2004
  63. ncbi request reprint GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men
    Takeo Ogawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Metabolism 54:296-9. 2005
    ..These results suggest that the Arg211His polymorphism in the GPR40 gene may contribute to the variation of insulin secretory capacity in Japanese men...
  64. ncbi request reprint Transmural pressure control of prorenin processing and secretion in diabetic rat juxtaglomerular cells
    Nobuhisa Hirota
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 26:493-501. 2003
    ..Pressure-induced inhibition of prorenin processing in JG cells via phospholipase D-dependent pathways is enhanced in late diabetes...
  65. ncbi request reprint Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population
    Yukihiro Yamamoto
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Clin Sci (Lond) 103:137-42. 2002
    ..377). These findings suggest that the serum adiponectin level is negatively correlated with HOMA-IR and positively correlated with HDL-cholesterol, independent of age, sex and BMI, in the Japanese population...
  66. ncbi request reprint Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription
    Isao Kurihara
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 280:6721-30. 2005
    ..Our data support a physiological role of Ubc9 and PIAS1 as transcriptional coactivators in COUP-TFI-mediated CYP11B2 transcription...
  67. ncbi request reprint Potentiated sympathetic nervous and renin-angiotensin systems reduce nonlinear correlation between sympathetic activity and blood pressure in conscious spontaneously hypertensive rats
    Katsufumi Sakata
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Circulation 106:620-5. 2002
    ..Patients with a reduced nonlinear component of heart rate regulation have a poorer outcome...
  68. ncbi request reprint A ring-finger protein CIP-2 is a novel regulator of COUP-TF action in the adrenal cortex
    Isao Kurihara
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Endocr Res 28:581. 2002
  69. ncbi request reprint Rostral ventrolateral medulla neurons of neonatal Wistar-Kyoto and spontaneously hypertensive rats
    Tomokazu Matsuura
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Hypertension 40:560-5. 2002
    ..These differences in RVLM neurons suggest a mechanism that possibly leads to elevation in blood pressure...
  70. ncbi request reprint Fluvastatin prevents development of arterial stiffness in haemodialysis patients with type 2 diabetes mellitus
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 17:1513-7. 2002
    ..We studied the preventive effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, fluvastatin, on arterial PWV values in this population...
  71. ncbi request reprint Anti-insulin-like growth factor-1 autoantibodies in type 1 diabetes
    Taro Maruyama
    Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, 336 0002, Japan
    Ann N Y Acad Sci 958:267-70. 2002
    ..Further study is necessary to clarify whether anti-IGF-1 autoantibodies are existent in human type 1 diabetes and to determine the significance of IGF-1 in the pathogensesis of type 1 diabetes...
  72. ncbi request reprint Expression of the Na+/H+ exchanger regulatory protein family in genetically hypertensive rats
    Kazuo Kobayashi
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Hypertens 22:1723-30. 2004
    ....
  73. ncbi request reprint Regulation of differential COUP-TF-coregulator interactions in adrenal cortical steroidogenesis
    Hirotaka Shibata
    Health Center, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Steroid Biochem Mol Biol 85:449-56. 2003
    ..The bifunctional activities of COUP-TFI may be derived from the promoter context and our newly identified COUP-TFI coregulator...
  74. ncbi request reprint Nuclear receptors and co-regulators in adrenal tumors
    Hirotaka Shibata
    Health Center, School of Medicine, Keio University, Tokyo, Japan
    Horm Res 59:85-93. 2003
    ..CIP-1 expression profiles parallel those of COUP-TFI in steroidogenic tissues, strongly suggesting that, together, COUP-TFI and CIP-1 play an important role in steroidogenesis...
  75. ncbi request reprint Quantitative trait loci mapping for intracellular calcium in spontaneously hypertensive rats
    Yoichi Ohno
    Department of Internal Medicine, Green Town Clinic Center, Saitama, Japan
    Am J Hypertens 18:666-71. 2005
    ..Increased [Ca2+]i in platelets is hypothesized to contribute to atherothrombotic events. Platelet hyperactivity is frequently associated with cardiovascular disease...
  76. ncbi request reprint Antihypertensive efficacy and safety of fixed-dose combination therapy with losartan plus hydrochlorothiazide in Japanese patients with essential hypertension
    Takao Saruta
    Department of Internal Medicine, Keio University, Tokyo, Japan
    Hypertens Res 30:729-39. 2007
    ..5 mg is well tolerated and more efficacious in lowering DBP and SBP than monotherapy in Japanese hypertensive patients...
  77. doi request reprint Differential effects of transient treatment of spontaneously hypertensive rats with various antihypertensive agents on the subsequent development of diabetic nephropathy
    Kimiko Ishiguro
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nephron Exp Nephrol 109:e20-8. 2008
    ....
  78. ncbi request reprint Efficacy and safety of the selective aldosterone blocker eplerenone in Japanese patients with hypertension: a randomized, double-blind, placebo-controlled, dose-ranging study
    Takao Saruta
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Clin Hypertens (Greenwich) 6:175-83; quiz 184-5. 2004
    ..8 to -10.6 mm Hg vs. -2.1 mm Hg; p< or =0.0022 vs. placebo). Eplerenone offers significant blood pressure reduction with good tolerability in Japanese patients with hypertension, including those with low-renin hypertension...
  79. ncbi request reprint Prepubertal treatment with angiotensin receptor blocker causes partial attenuation of hypertension and renal damage in adult Dahl salt-sensitive rats
    Hideaki Nakaya
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nephron 91:710-8. 2002
    ....
  80. ncbi request reprint Long-term effects of intensive blood-pressure lowering on arterial wall stiffness in hypertensive patients
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Hypertens 16:959-65. 2003
    ..To determine the long-term effects of intensive blood pressure (BP) lowering by antihypertensive drug therapy on aortic stiffness assessed by PWV, a single-blind randomized prospective study was performed...
  81. ncbi request reprint Comparison of health costs associated with treatment of hypertension with a calcium channel blocker and angiotensin-converting enzyme inhibitor in the United States and Japan
    Yusuke Sakamaki
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Hypertens Res 29:333-8. 2006
    ..It is predicted that future treatment of hypertension will be increasingly tailored to the epidemiologic profiles and medical costs of individual communities...
  82. ncbi request reprint Effect of efonidipine and ACE inhibitors on proteinuria in human hypertension with renal impairment
    Koichi Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Am J Hypertens 16:116-22. 2003
    ..The antiproteinuric effect was apparent in patients with greater proteinuria. The beneficial action of efonidipine, along with fewer side effects, may favor the use of this agent in the treatment of hypertension with renal impairment...
  83. ncbi request reprint Insulin-like growth factor-1 (IGF-1)-derived peptide protects against diabetes in NOD mice
    Keiichi Kodama
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Autoimmunity 37:481-7. 2004
    ..It was suggested that IGF-1 peptide 50-70 immunization can be used as a tool for prevention of type 1 diabetes...
  84. ncbi request reprint CIP-1 is a novel corepressor for nuclear receptor COUP-TF: a potential negative regulator in adrenal steroidogenesis
    Sakiko Kobayashi
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Endocr Res 28:579. 2002
  85. ncbi request reprint Status of home blood pressure measured in morning and evening: evaluation in normotensives and hypertensives in Japanese urban population
    Hiroshi Kawabe
    Health Center, School of Medicine, Keio University, Tokyo, Japan
    Hypertens Res 28:491-8. 2005
    ..Furthermore, morning home blood pressure control in the treated hypertensive group classified as under control by casual blood pressure was insufficient, especially in patients who were taking medication only in the morning...
  86. ncbi request reprint Insulin resistance and hypertension: seven-year follow-up study in middle-aged Japanese men (the KEIO study)
    Hiroshi Hirose
    Health Center, School of Medicine, Keio University, Tokyo, Japan
    Hypertens Res 26:795-800. 2003
    ..These findings suggest an important role of insulin resistance in predicting the future incidence of hypertension in middle-aged Japanese men...
  87. ncbi request reprint High frequency of valpha24(+) vbeta11(+) T-cells observed in type 1 diabetes
    Yoichi Oikawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Diabetes Care 25:1818-23. 2002
    ..In this study, we measured the frequency of peripheral Valpha24(+) Vbeta11(+) T-cells, which include human NKT cells, in Japanese diabetic patients...
  88. ncbi request reprint Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 56:83-92. 2002
    ..These results suggest that insulin secretion from the rat insulinoma cell line, INS-1, is modulated by troglitazone, acting somewhere in the ATP-sensitive K(+) channel pathway, possibly through PPAR gamma...
  89. ncbi request reprint Intrarenal injection of bone marrow-derived angiogenic cells reduces endothelial injury and mesangial cell activation in experimental glomerulonephritis
    Hideki Uchimura
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 16:997-1004. 2005
    ..1 glomerulonephritis. Incorporation into the glomerular endothelial lining and production of angiogenic factor(s) are likely to contribute to the protective effects of culture-modified mononuclear cells against glomerular injury...
  90. doi request reprint Effects of candesartan compared with amlodipine in hypertensive patients with high cardiovascular risks: candesartan antihypertensive survival evaluation in Japan trial
    Toshio Ogihara
    Osaka University Graduate School of Medicine, Osaka, Japan
    Hypertension 51:393-8. 2008
    ..We disclosed that candesartan-based and amlodipine-based regimens produced no statistical differences in terms of the primary cardiovascular end point, whereas candesartan prevented new-onset diabetes more effectively than amlodipine...
  91. doi request reprint Clinical efficacy of a new angiotensin II type 1 receptor blocker, pratosartan, in hypertensive patients
    Toshio Ogihara
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 31:281-7. 2008
    ..In conclusion, pratosartan is an effective and well tolerated antihypertensive drug, and may have beneficial effects on hypertensive patients with some metabolic disorders...
  92. doi request reprint Cost-utility analysis of antihypertensive combination therapy in Japan by a Monte Carlo simulation model
    Ikuo Saito
    Health Center, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 0016, Japan
    Hypertens Res 31:1373-83. 2008
    ..In conclusion, ARB plus CCB combination therapy may be a more cost-effective lifetime antihypertensive strategy than monotherapy with either agent alone...
  93. ncbi request reprint Controlled release nifedipine and valsartan combination therapy in patients with essential hypertension: the adalat CR and valsartan cost-effectiveness combination (ADVANCE-combi) study
    Ikuo Saito
    Health Center, Keio University, Yokohama, Japan
    Hypertens Res 29:789-96. 2006
    ..These results indicate that the nifedipine CR-based combination therapy was superior to the amlodipine-based therapy for decreasing blood pressure and achieving the target blood pressure in patients with essential hypertension...
  94. ncbi request reprint [Future aspects of the Japanese guidelines for the management of hypertension]
    Takao Saruta
    Department of Internal Medicine, School of Medicine, Keio University
    Nihon Rinsho 62:639-43. 2004
  95. ncbi request reprint [Organ protection by angiotensin II receptor blockers]
    Hiroo Kumagai
    Department of Internal Medicine, Keio University School of Medicine
    Nihon Rinsho 62:569-73. 2004
  96. ncbi request reprint valsartan in elderly isolated systolic hypertension (VALISH) study: rationale and design
    Toshio Ogihara
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Hypertens Res 27:657-61. 2004
    ..The VALISH study, a large-scale investigator-initiated trial in Japan, will determine whether age should be considered in setting target blood pressure in treatment of isolated systolic hypertension in elderly patients...
  97. ncbi request reprint Comparison of nifedipine retard with angiotensin converting enzyme inhibitors in Japanese hypertensive patients with coronary artery disease: the Japan Multicenter Investigation for Cardiovascular Diseases-B (JMIC-B) randomized trial
    Yoshiki Yui
    Department of Cardiovascular Medicine, Kyoto University Hospital, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Hypertens Res 27:181-91. 2004
    ..Nifedipine retard seems to be as effective as angiotensin converting enzyme inhibitors in reducing the incidence of cardiac events and mortality...
  98. ncbi request reprint [Hypertension in acromegaly]
    Hiroo Kumagai
    Department of Internal Medicine, Keio University School of Medicine
    Nihon Rinsho 62:508-11. 2004
  99. ncbi request reprint [The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2004)]
    Takao Saruta
    Department of Internal Medicine, Keio University School of Medicine
    Nihon Rinsho 63:952-8. 2005
    ..In the management of aged hypertensive patients over 65, target blood pressure is generally below 140/90mmHg, but in those over 75, transient target blood pressure is below 150/90 mmHg, if hypertension is moderate or severe...
  100. ncbi request reprint Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial of cardiovascular events in high-risk hypertensive patients: rationale, design, and methods
    Tsuguya Fukui
    Department of General Medicine and Clinical Epidemiology, School of Public Health, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hypertens Res 26:979-90. 2003
    ..In addition, the use of the ABCD system is expected to contribute to the development of more efficient data management systems for large-scale clinical trials...
  101. ncbi request reprint Differing anti-proteinuric action of candesartan and losartan in chronic renal disease
    Hiroto Matsuda
    Ashikaga Red Cross Hospital, Ashikaga, Japan
    Hypertens Res 26:875-80. 2003
    ..Furthermore, renal nitric oxide may contribute to the renal protective action of these agents when administered to patients with chronic renal disease...