Genomes and Genes
Affiliation: Sapporo Medical University
- Degradation of vitamin B12 in dietary supplementsKeiko Yamada
Department of Liberal Arts and Sciences, School of Health Sciences, Sapporo Medical University, Sapporo, Japan
Int J Vitam Nutr Res 78:195-203. 2008....
- Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cellsKeiko Yamada
Department of Liberal Arts and Sciences, School of Health Sciences, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
Biochem Biophys Res Commun 305:101-7. 2003..The results suggest that DGKgamma negatively regulates macrophage differentiation through its catalytic action operating on the cytoskeleton...
- The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domainShin ichi Imai
Department of Biochemistry, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
Biochem J 382:957-66. 2004..Our results provide evidence of the phosphorylation of the DGKdelta1 PH domain by cPKC, and suggest that the phosphorylation is involved in the control of subcellular localization of DGKdelta1...
- Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formationShuichi Tsushima
Department of Biochemistry, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
J Biol Chem 279:28603-13. 2004..Taken together, these results strongly suggest that DGKgamma functions through its catalytic action as an upstream suppressor of Rac1 and, consequently, lamellipodium/ruffle formation...
- Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activationKenji Yanagisawa
Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan
Biochim Biophys Acta 1771:462-74. 2007..Together, these results strongly suggest that DGKalpha is a novel positive regulator of NF-kappaB, which suppresses TNF-alpha-induced melanoma cell apoptosis...
- Analyses of non-leucine-rich repeat (non-LRR) regions intervening between LRRs in proteinsNorio Matsushima
Sapporo Medical University Center for Medical Education, Sapporo, Hokkaido 060 8556, Japan
Biochim Biophys Acta 1790:1217-37. 2009..Many proteins have LRR (leucine-rich repeat) units interrupted by non-LRRs which we call IR (non-LRR island region)...
- Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functionsFumio Sakane
Department of Biochemistry, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
J Biol Chem 277:43519-26. 2002..Taken together, alternative splicing of the human DGKdelta gene generates at least two isoforms, differing in their expressions and regulatory functions...
- Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptorsNorio Matsushima
School of Health Sciences, Sapporo Medical University, Hokkaido, Japan
BMC Genomics 8:124. 2007..The repeat numbers of LRRs and their "phasing" in TLRs differ with isoforms and species; they are aligned differently in various databases. We identified and aligned LRRs in TLRs by a new method described here...
- Diacylglycerol kinases: emerging downstream regulators in cell signaling systemsHideo Kanoh
Department of Biochemistry, School of Medicine, Sapporo Medical University, South West 17, Sapporo 060 8556, Japan
J Biochem 131:629-33. 2002....
- Copper binding to plant ozone-inducible proteins (OI2-2 and OI14-3)Masakatsu Kamiya
Division of Biological Sciences, Graduate School of Science, Hokkaido University, 060 0810, Sapporo, Japan
Biochem Biophys Res Commun 314:908-15. 2004..Thus, the ozone-inducible proteins are capable of binding at least four or five copper ions per protein. These copper-binding proteins would function as active oxygen scavengers...