Tomohide Tsukahara

Summary

Affiliation: Sapporo Medical University
Country: Japan

Publications

  1. pmc NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
    Tomohide Tsukahara
    Department of Pathology, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Diagn Pathol 7:114. 2012
  2. doi request reprint Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma
    Tomohide Tsukahara
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Cancer Sci 100:47-53. 2009
  3. pmc HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Transl Med 7:44. 2009
  4. doi request reprint Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical Unviersity School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Japan
    Cancer Sci 99:368-75. 2008
  5. ncbi request reprint Clonal T-cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A*0206
    Shigeharu Kimura
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, 060 8543, Japan
    J Orthop Res 26:271-8. 2008
  6. ncbi request reprint Prognostic significance of HLA class I expression in osteosarcoma defined by anti-pan HLA class I monoclonal antibody, EMR8-5
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Sci 97:1374-80. 2006
  7. ncbi request reprint Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor
    Tomohide Tsukahara
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Res 64:5442-8. 2004
  8. ncbi request reprint Recognition by cellular and humoral autologous immunity in a human osteosarcoma cell line
    Yuki Nabeta
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, 060 8543, Sapporo, Japan
    J Orthop Sci 8:554-9. 2003
  9. ncbi request reprint Improved generation of HLA class I/peptide tetramers
    Yuriko Sato
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Japan
    J Immunol Methods 271:177-84. 2002
  10. doi request reprint SYT-SSX breakpoint peptide vaccines in patients with synovial sarcoma: a study from the Japanese Musculoskeletal Oncology Group
    Satoshi Kawaguchi
    Departments of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Japan
    Cancer Sci 103:1625-30. 2012

Collaborators

Detail Information

Publications25

  1. pmc NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
    Tomohide Tsukahara
    Department of Pathology, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Diagn Pathol 7:114. 2012
    ..We finally diagnosed this case as extranodal NK/T-cell lymphoma (nasal type). Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8050621197741854...
  2. doi request reprint Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma
    Tomohide Tsukahara
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Cancer Sci 100:47-53. 2009
    ....
  3. pmc HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Transl Med 7:44. 2009
    ..However, clinical application of PBF-based immunotherapy requires identification of naturally presented CTL epitopes in osteosarcoma cells in the context of more common HLA molecules such as HLA-A2...
  4. doi request reprint Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical Unviersity School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Japan
    Cancer Sci 99:368-75. 2008
    ..These findings suggested prognostic significance and immunodominancy of PBF in patients with osteosarcoma. PBF is the candidate target for immunotherapy in patients with osteosarcoma...
  5. ncbi request reprint Clonal T-cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A*0206
    Shigeharu Kimura
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, 060 8543, Japan
    J Orthop Res 26:271-8. 2008
    ..These findings suggest that CTL2004-c6 and CTL2004-c17 recognize autologous tumor-rejection antigens presented by HLA-A*0206, which may have been expressed by tumor cells that had been eradicated by the host's immunosurveillance system...
  6. ncbi request reprint Prognostic significance of HLA class I expression in osteosarcoma defined by anti-pan HLA class I monoclonal antibody, EMR8-5
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Sci 97:1374-80. 2006
    ..These findings suggest that the class I-restricted cytotoxic T lymphocyte pathway plays a major role in immune surveillance of patients with osteosarcoma...
  7. ncbi request reprint Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor
    Tomohide Tsukahara
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Res 64:5442-8. 2004
    ..These findings suggest that PBF is a shared tumor-associated antigen, which may serve as a source of peptides applicable to peptide-based immunotherapy for osteosarcoma and other malignant tumors...
  8. ncbi request reprint Recognition by cellular and humoral autologous immunity in a human osteosarcoma cell line
    Yuki Nabeta
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, 060 8543, Sapporo, Japan
    J Orthop Sci 8:554-9. 2003
    ..In conclusion, our results demonstrated the presence of host cellular and humoral immune responses to autologous osteosarcoma cells. This offered the opportunity to identify osteosarcoma antigens recognized by autologous immunity...
  9. ncbi request reprint Improved generation of HLA class I/peptide tetramers
    Yuriko Sato
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Japan
    J Immunol Methods 271:177-84. 2002
    ..Consequently, by using mutant HLA-A*2402/peptide tetramers, CTL precursors (CTLp) that specifically recognize antigenic peptide derived from the X;18 chromosomal translocations of synovial sarcoma were detected in patients' PBL...
  10. doi request reprint SYT-SSX breakpoint peptide vaccines in patients with synovial sarcoma: a study from the Japanese Musculoskeletal Oncology Group
    Satoshi Kawaguchi
    Departments of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Japan
    Cancer Sci 103:1625-30. 2012
    ..Of note, one patient showed transient shrinkage of a metastatic lesion. The response of the patients to the B protocols is encouraging and warrants further investigation...
  11. ncbi request reprint Crisscross CTL induction by SYT-SSX junction peptide and its HLA-A*2402 anchor substitute
    Kazunori Ida
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Immunol 173:1436-43. 2004
    ....
  12. doi request reprint Molecular pathological approaches to human tumor immunology
    Noriyuki Sato
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo Japan
    Pathol Int 59:205-17. 2009
    ..Finally, the type of basic and clinical tumor immunology research highly required currently, and in the very near future, are described...
  13. ncbi request reprint Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family, Livin/ML-IAP in lung cancer
    Hiroyuki Hariu
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17 Chuo ku, Sapporo 060 8556, Japan
    Clin Cancer Res 11:1000-9. 2005
    ..Our data suggest that Livin/ML-IAP may be an excellent target antigen in immunotherapy for lung cancer and Livin7 peptide may serve as a potent peptide vaccine for HLA-A*2402(+)/Livin(+) lung cancer patients...
  14. ncbi request reprint HLA-restricted specific tumor cytolysis by autologous T-lymphocytes infiltrating metastatic bone malignant fibrous histiocytoma of lymph node
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543 Japan
    J Orthop Res 24:94-101. 2006
    ..The present autologous cell lines provide the basis for identification of novel tumor-associated antigens and may be helpful in the establishment of immunotherapy for patients with MFH of the bone...
  15. doi request reprint Autologous CTL response against cancer stem-like cells/cancer-initiating cells of bone malignant fibrous histiocytoma
    Masanobu Kano
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Sci 102:1443-7. 2011
    ..Thus, CTL-based immunotherapy could target CSC of bone sarcoma to help prevent tumor recurrence...
  16. doi request reprint ECRG4 is a negative regulator of caspase-8-mediated apoptosis in human T-leukemia cells
    Junichi Matsuzaki
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Carcinogenesis 33:996-1003. 2012
    ..Since ECRG4 expression is downregulated in activated T cells, our results suggest that ECRG4 is a novel antiapoptotic gene which is involved in the negative regulation of caspase-8-mediated apoptosis in T cells...
  17. pmc High Expression of CD109 Antigen Regulates the Phenotype of Cancer Stem-Like Cells/Cancer-Initiating Cells in the Novel Epithelioid Sarcoma Cell Line ESX and Is Related to Poor Prognosis of Soft Tissue Sarcoma
    Makoto Emori
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    PLoS ONE 8:e84187. 2013
    ..009). In conclusion, CD109 might be a CSC/CIC marker in epithelioid sarcoma. Moreover, CD109 is a promising prognostic biomarker and a molecular target of cancer therapy for sarcomas including ES. ..
  18. pmc Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes
    Akari Takahashi
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo, Japan
    Cell Stress Chaperones 17:757-63. 2012
    ..These results suggest that heat shock enhances effector phase of the adaptive immune system and promotes eradication of microbe and tumor cells...
  19. doi request reprint Immunotherapeutic benefit of α-interferon (IFNα) in survivin2B-derived peptide vaccination for advanced pancreatic cancer patients
    Hidekazu Kameshima
    Department of Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Sci 104:124-9. 2013
    ..This trial was registered with the UMIN Clinical Trials Registry, no. UMIN000000905...
  20. doi request reprint Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients
    Hidekazu Kameshima
    Departments of Surgery Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Sci 102:1181-7. 2011
    ....
  21. doi request reprint Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal
    Yoshitaka Michifuri
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan Department of Oral Surgery, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Biochem Biophys Res Commun 439:96-102. 2013
    ..Taken together, the results indicate that the expression of SPRR1B is upregulated in oral CSCs/CICs and that SPRR1B has a role in cell growth by suppression of RASSF4...
  22. pmc Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells
    Akari Takahashi
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan Cancer Diagnosis Laboratory, Japan Science and Technology Agency Innovation Plaza Hokkaido, Japan Science and Technology Agency, Kita ku, Sapporo, Japan
    PLoS ONE 8:e69095. 2013
    ....
  23. ncbi request reprint Overexpression of papillomavirus binding factor in Ewing's sarcoma family of tumors conferring poor prognosis
    Hiroki Yabe
    Department of Orthopaedic Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
    Oncol Rep 19:129-34. 2008
    ..PBF may also serve as a putative target antigen in immunotherapy for patients with ESFT that have a poor prognosis and PBF overexpression...
  24. ncbi request reprint Detection and induction of CTLs specific for SYT-SSX-derived peptides in HLA-A24(+) patients with synovial sarcoma
    Yuriko Sato
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Japan
    J Immunol 169:1611-8. 2002
    ..The identification of SYT-SSX peptides may offer an opportunity to design peptide-based immunotherapeutic approaches for HLA-A24(+) patients with synovial sarcoma...
  25. ncbi request reprint Simultaneous radial closing wedge and ulnar shortening osteotomies for distal radius malunion
    Takuro Wada
    Department of Orthopaedic Surgery, Sapporo Medical University, School of Medicine, South 1 West 16, Sapporo 060 8543, Japan
    J Hand Surg Am 29:264-72. 2004
    ..We report the functional and radiographic outcomes of 5 patients treated for symptomatic distal radius malunion with simultaneous radial closing wedge and ulnar shortening osteotomies...