Research Topics
Species | Tomohide TsukaharaSummaryAffiliation: Sapporo Medical University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothoraxTomohide Tsukahara
Department of Pathology, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
Diagn Pathol 7:114. 2012..We finally diagnosed this case as extranodal NK/T-cell lymphoma (nasal type). Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8050621197741854...
Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcomaTomohide Tsukahara
Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
Cancer Sci 100:47-53. 2009....- HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factorTomohide Tsukahara
Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
J Transl Med 7:44. 2009..However, clinical application of PBF-based immunotherapy requires identification of naturally presented CTL epitopes in osteosarcoma cells in the context of more common HLA molecules such as HLA-A2... - Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcomaTomohide Tsukahara
Department of Orthopaedic Surgery, Sapporo Medical Unviersity School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Japan
Cancer Sci 99:368-75. 2008..These findings suggested prognostic significance and immunodominancy of PBF in patients with osteosarcoma. PBF is the candidate target for immunotherapy in patients with osteosarcoma... 
Clonal T-cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A*0206Shigeharu Kimura
Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, 060 8543, Japan
J Orthop Res 26:271-8. 2008..These findings suggest that CTL2004-c6 and CTL2004-c17 recognize autologous tumor-rejection antigens presented by HLA-A*0206, which may have been expressed by tumor cells that had been eradicated by the host's immunosurveillance system...- Prognostic significance of HLA class I expression in osteosarcoma defined by anti-pan HLA class I monoclonal antibody, EMR8-5Tomohide Tsukahara
Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo 060-8543, Japan
Cancer Sci 97:1374-80. 2006..These findings suggest that the class I-restricted cytotoxic T lymphocyte pathway plays a major role in immune surveillance of patients with osteosarcoma... - SYT-SSX breakpoint peptide vaccines in patients with synovial sarcoma: a study from the Japanese Musculoskeletal Oncology GroupSatoshi Kawaguchi
Departments of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Japan
Cancer Sci 103:1625-30. 2012..Of note, one patient showed transient shrinkage of a metastatic lesion. The response of the patients to the B protocols is encouraging and warrants further investigation... - Recognition by cellular and humoral autologous immunity in a human osteosarcoma cell lineYuki Nabeta
Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, S. 1, W. 16, Chuo-ku, 060-8543, Sapporo, Japan
J Orthop Sci 8:554-9. 2003..In conclusion, our results demonstrated the presence of host cellular and humoral immune responses to autologous osteosarcoma cells. This offered the opportunity to identify osteosarcoma antigens recognized by autologous immunity... - Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family, Livin/ML-IAP in lung cancerHiroyuki Hariu
Department of Pathology, Sapporo Medical University School of Medicine, South-1 West-17 Chuo-ku, Sapporo 060-8556, Japan
Clin Cancer Res 11:1000-9. 2005..Our data suggest that Livin/ML-IAP may be an excellent target antigen in immunotherapy for lung cancer and Livin7 peptide may serve as a potent peptide vaccine for HLA-A*2402(+)/Livin(+) lung cancer patients... - Crisscross CTL induction by SYT-SSX junction peptide and its HLA-A*2402 anchor substituteKazunori Ida
Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
J Immunol 173:1436-43. 2004.... - Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factorTomohide Tsukahara
Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
Cancer Res 64:5442-8. 2004..These findings suggest that PBF is a shared tumor-associated antigen, which may serve as a source of peptides applicable to peptide-based immunotherapy for osteosarcoma and other malignant tumors... - HLA-restricted specific tumor cytolysis by autologous T-lymphocytes infiltrating metastatic bone malignant fibrous histiocytoma of lymph nodeTomohide Tsukahara
Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, 060-8543 Japan
J Orthop Res 24:94-101. 2006..The present autologous cell lines provide the basis for identification of novel tumor-associated antigens and may be helpful in the establishment of immunotherapy for patients with MFH of the bone... - Molecular pathological approaches to human tumor immunologyNoriyuki Sato
Department of Pathology, Sapporo Medical University School of Medicine, Sapporo Japan
Pathol Int 59:205-17. 2009..Finally, the type of basic and clinical tumor immunology research highly required currently, and in the very near future, are described... - Improved generation of HLA class I/peptide tetramersYuriko Sato
Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo-ku, Japan
J Immunol Methods 271:177-84. 2002..Consequently, by using mutant HLA-A*2402/peptide tetramers, CTL precursors (CTLp) that specifically recognize antigenic peptide derived from the X;18 chromosomal translocations of synovial sarcoma were detected in patients' PBL... - Autologous CTL response against cancer stem-like cells/cancer-initiating cells of bone malignant fibrous histiocytomaMasanobu Kano
Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
Cancer Sci 102:1443-7. 2011..Thus, CTL-based immunotherapy could target CSC of bone sarcoma to help prevent tumor recurrence... - Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytesAkari Takahashi
Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo, Japan
Cell Stress Chaperones 17:757-63. 2012..These results suggest that heat shock enhances effector phase of the adaptive immune system and promotes eradication of microbe and tumor cells... - Immunotherapeutic benefit of α-interferon (IFNα) in survivin2B-derived peptide vaccination for advanced pancreatic cancer patientsHidekazu Kameshima
Department of Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
Cancer Sci 104:124-9. 2013..This trial was registered with the UMIN Clinical Trials Registry, no. UMIN000000905... - ECRG4 is a negative regulator of caspase-8-mediated apoptosis in human T-leukemia cellsJunichi Matsuzaki
Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
Carcinogenesis 33:996-1003. 2012..Since ECRG4 expression is downregulated in activated T cells, our results suggest that ECRG4 is a novel antiapoptotic gene which is involved in the negative regulation of caspase-8-mediated apoptosis in T cells... - Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patientsHidekazu Kameshima
Departments of Surgery Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
Cancer Sci 102:1181-7. 2011.... - Overexpression of papillomavirus binding factor in Ewing's sarcoma family of tumors conferring poor prognosisHiroki Yabe
Department of Orthopaedic Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
Oncol Rep 19:129-34. 2008..PBF may also serve as a putative target antigen in immunotherapy for patients with ESFT that have a poor prognosis and PBF overexpression... - Detection and induction of CTLs specific for SYT-SSX-derived peptides in HLA-A24(+) patients with synovial sarcomaYuriko Sato
Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Japan
J Immunol 169:1611-8. 2002..The identification of SYT-SSX peptides may offer an opportunity to design peptide-based immunotherapeutic approaches for HLA-A24(+) patients with synovial sarcoma... - Simultaneous radial closing wedge and ulnar shortening osteotomies for distal radius malunionTakuro Wada
Department of Orthopaedic Surgery, Sapporo Medical University, School of Medicine, South 1 West 16, Sapporo 060-8543, Japan
J Hand Surg [Am] 29:264-72. 2004..Our procedure is indicated for patients with osteopenia for whom opening wedge osteotomy of the radius is inadequate...