Fumio Sakane

Summary

Affiliation: Sapporo Medical University
Country: Japan

Publications

  1. ncbi request reprint Diacylglycerol kinases as emerging potential drug targets for a variety of diseases
    Fumio Sakane
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Curr Drug Targets 9:626-40. 2008
  2. ncbi request reprint Diacylglycerol kinases: why so many of them?
    Fumio Sakane
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Biochim Biophys Acta 1771:793-806. 2007
  3. ncbi request reprint Identification and characterization of a novel human type II diacylglycerol kinase, DGK kappa
    Shin ichi Imai
    Department of Biochemistry, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo 060 8556, Japan
    J Biol Chem 280:39870-81. 2005
  4. ncbi request reprint Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation
    Shuichi Tsushima
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    J Biol Chem 279:28603-13. 2004
  5. ncbi request reprint Phorbol ester and hydrogen peroxide synergistically induce the interaction of diacylglycerol kinase gamma with the Src homology 2 and C1 domains of beta2-chimaerin
    Satoshi Yasuda
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Biochem J 409:95-106. 2008
  6. pmc The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain
    Shin ichi Imai
    Department of Biochemistry, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Biochem J 382:957-66. 2004
  7. ncbi request reprint Tyrosine phosphorylation of beta2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activity
    Masahiro Kai
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Biochim Biophys Acta 1773:1407-15. 2007
  8. pmc Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization
    Satoshi Yasuda
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556
    J Biol Chem 284:29559-70. 2009
  9. ncbi request reprint Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor
    Satoshi Yasuda
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    FEBS Lett 581:551-7. 2007
  10. ncbi request reprint Identification and characterization of two splice variants of human diacylglycerol kinase eta
    Tomohiro Murakami
    Department of Biochemistry, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    J Biol Chem 278:34364-72. 2003

Collaborators

  • Hideo Kanoh
  • Satoshi Yasuda
  • Keiko Yamada
  • Minoru Toyota
  • Toshiharu Yamashita
  • Ikuo Wada
  • Koaru Goto
  • MATTHEW TOPHAM
  • Yasuhito Shirai
  • Ushio Kikkawa
  • Takehiko Ueyama
  • Shinji Kamada
  • Francesco Beguinot
  • Naoaki Saito
  • Shin ichi Imai
  • Masahiro Kai
  • Tsukasa Ito
  • Hisatake Kondo
  • Yasukazu Hozumi
  • Yan Jun Jia
  • Alexander V Chibalin
  • Akinori Kawakami
  • Bryan T Harada
  • Kowichi Jimbow
  • Kenji Yanagisawa
  • Claudia Miele
  • Takehiro Matsubara
  • Tracy Crotty
  • Stephen M Prescott
  • Mayumi Toya
  • Debra S Regier
  • Yuji Katagiri
  • Sachiko Saino-Saito
  • Shuichi Tsushima
  • Kiyohiro Houkin
  • Tomohiro Murakami
  • David E Fisher
  • Hai Ying Jin
  • James U Bowie
  • Olga Kotova
  • Elaine Vieira
  • Mary Jane Knight
  • Marie Björnholm
  • Ying Leng
  • Yun Chau Long
  • Markku Laakso
  • Harriet Wallberg-Henriksson
  • Jianjun Wang
  • Anna Krook
  • Zhihui Zhong
  • Tatiana Steiler
  • Feng Qiao
  • Ranjini Ramachander
  • Kuninori Hirosaki
  • Carolina Nylén
  • Juleen R Zierath
  • Mari Gingery
  • Marc Gilbert
  • Michael R Sawaya
  • Raffaele Teperino
  • Paola Ungaro
  • Francesco Oriente
  • Francesca Fiory
  • Pietro Formisano
  • Rossella Valentino
  • Flora Paturzo
  • Kei Miyasaka
  • Takuya Murakami
  • Akinobu Taketomi
  • Jinjin Cai
  • Yasuto Yamaguchi
  • Toshiaki Hashimoto
  • Masahiko Hiroi
  • Makoto Sata
  • Kazuhisa Otake
  • Akira Suwabe
  • Isao Kubota
  • Hidekazu Saito
  • Katrina M Lund
  • Morihiko Takeda
  • Jared Higbee
  • Hirohisa Kurachi
  • Masaru Aoyagi

Detail Information

Publications29

  1. ncbi request reprint Diacylglycerol kinases as emerging potential drug targets for a variety of diseases
    Fumio Sakane
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Curr Drug Targets 9:626-40. 2008
    ..Unfortunately, there are no DGK isozyme-specific inhibitors/activators at present. Development of these compounds is eagerly awaited for the development of novel drugs targeting DGKs...
  2. ncbi request reprint Diacylglycerol kinases: why so many of them?
    Fumio Sakane
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Biochim Biophys Acta 1771:793-806. 2007
    ....
  3. ncbi request reprint Identification and characterization of a novel human type II diacylglycerol kinase, DGK kappa
    Shin ichi Imai
    Department of Biochemistry, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo 060 8556, Japan
    J Biol Chem 280:39870-81. 2005
    ..The expression patterns, subcellular distribution, and regulatory mechanisms of DGK kappa are distinct from those of DGKdelta and DGKeta despite high structural similarity, suggesting unique functions of the individual type II isozymes...
  4. ncbi request reprint Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation
    Shuichi Tsushima
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    J Biol Chem 279:28603-13. 2004
    ..Taken together, these results strongly suggest that DGKgamma functions through its catalytic action as an upstream suppressor of Rac1 and, consequently, lamellipodium/ruffle formation...
  5. ncbi request reprint Phorbol ester and hydrogen peroxide synergistically induce the interaction of diacylglycerol kinase gamma with the Src homology 2 and C1 domains of beta2-chimaerin
    Satoshi Yasuda
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Biochem J 409:95-106. 2008
    ..Our work offers a novel mechanism of protein-protein interaction, that is, the phosphotyrosine-independent interaction of the SH2 domain acting in co-operation with the C1 domain...
  6. pmc The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain
    Shin ichi Imai
    Department of Biochemistry, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Biochem J 382:957-66. 2004
    ..Our results provide evidence of the phosphorylation of the DGKdelta1 PH domain by cPKC, and suggest that the phosphorylation is involved in the control of subcellular localization of DGKdelta1...
  7. ncbi request reprint Tyrosine phosphorylation of beta2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activity
    Masahiro Kai
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Biochim Biophys Acta 1773:1407-15. 2007
    ..These results suggest Tyr-21 phosphorylation as a novel, SFK-dependent mechanism that negatively regulates beta2-chimaerin Rac-GAP activity...
  8. pmc Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization
    Satoshi Yasuda
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556
    J Biol Chem 284:29559-70. 2009
    ..Taken together, the results obtained strongly support that DGKeta acts as a novel critical regulatory component of the Ras/B-Raf/C-Raf/MEK/ERK signaling cascade via a previously unidentified mechanism...
  9. ncbi request reprint Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor
    Satoshi Yasuda
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    FEBS Lett 581:551-7. 2007
    ..These results indicate that DGKgamma is a novel regulator of beta2-chimaerin, and thus suggest that beta2-chimaerin is an effector molecule, linking DGKgamma functionally with Rac1...
  10. ncbi request reprint Identification and characterization of two splice variants of human diacylglycerol kinase eta
    Tomohiro Murakami
    Department of Biochemistry, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    J Biol Chem 278:34364-72. 2003
    ..Taken together, alternative splicing of the human DGK eta gene generates at least two isoforms with distinct biochemical and cell biological properties responding to different cellular metabolic requirements...
  11. doi request reprint Diacylglycerol kinase delta associates with receptor for activated C kinase 1, RACK1
    Shin ichi Imai
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Biochim Biophys Acta 1791:246-53. 2009
    ..These results suggest that DGKdelta serves as an adaptor protein to regulate the localization of the versatile scaffold protein, RACK1...
  12. ncbi request reprint Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation
    Kenji Yanagisawa
    Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Biochim Biophys Acta 1771:462-74. 2007
    ..Together, these results strongly suggest that DGKalpha is a novel positive regulator of NF-kappaB, which suppresses TNF-alpha-induced melanoma cell apoptosis...
  13. ncbi request reprint Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts
    Masahiro Kai
    Department of Biochemistry, Sapporo Medical University School of Medicine, West 17, South 1, Sapporo 060 8556
    J Biochem 140:677-86. 2006
    ..These results indicate that LPP1 and LPP3 are distributed in distinct lipid rafts that may provide unique microenvironments defining their non-redundant physiological functions...
  14. doi request reprint Diacylglycerol kinase alpha enhances protein kinase Czeta-dependent phosphorylation at Ser311 of p65/RelA subunit of nuclear factor-kappaB
    Masahiro Kai
    Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo, Japan
    FEBS Lett 583:3265-8. 2009
    ..These results strongly suggest that DGKalpha positively regulates TNF-alpha-dependent NF-kappaB activation via the PKCzeta-mediated Ser311 phosphorylation of p65/RelA...
  15. ncbi request reprint Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions
    Fumio Sakane
    Department of Biochemistry, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    J Biol Chem 277:43519-26. 2002
    ..Taken together, alternative splicing of the human DGKdelta gene generates at least two isoforms, differing in their expressions and regulatory functions...
  16. ncbi request reprint Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells
    Keiko Yamada
    Department of Liberal Arts and Sciences, School of Health Sciences, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Biochem Biophys Res Commun 305:101-7. 2003
    ..The results suggest that DGKgamma negatively regulates macrophage differentiation through its catalytic action operating on the cytoskeleton...
  17. ncbi request reprint Rab7 regulates maturation of melanosomal matrix protein gp100/Pmel17/Silv
    Akinori Kawakami
    Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Invest Dermatol 128:143-50. 2008
    ..Moreover, siRNA-mediated Rab7 knockdown considerably inhibited gp100 maturation. These results collectively suggest that the GTP-bound form of Rab7 promotes melanogenesis through the regulation of gp100 maturation in melanoma cells...
  18. ncbi request reprint Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells
    Yan Jun Jia
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, 060 8556 Sapporo, Japan
    FEBS Lett 552:240-6. 2003
    ..Our work shows that LPP1 and LPP3 are equipped with distinct sorting signals that cause them to differentially localize to the apical vs. the basolateral subdomain, respectively...
  19. ncbi request reprint Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocation
    Shin ichi Imai
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    J Biol Chem 277:35323-32. 2002
    ..The present studies demonstrated that the formation and dissociation of oligomers serve as the regulatory mechanisms of DGKdelta and that DGKdelta is a novel downstream effector of phorbol ester/protein kinase C signaling pathway...
  20. ncbi request reprint Diacylglycerol kinases: emerging downstream regulators in cell signaling systems
    Hideo Kanoh
    Department of Biochemistry, School of Medicine, Sapporo Medical University, South West 17, Sapporo 060 8556, Japan
    J Biochem 131:629-33. 2002
    ....
  21. doi request reprint Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance
    Alexander V Chibalin
    Department of Molecular Medicine and Surgery, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Cell 132:375-86. 2008
    ..DGKdelta deficiency causes peripheral insulin resistance and metabolic inflexibility. These defects in glucose and energy homeostasis contribute to mild obesity later in life...
  22. ncbi request reprint Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization
    Claudia Miele
    Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Federico II University of Naples, Via Pansini 5, Naples 80131, Italy
    J Biol Chem 282:31835-43. 2007
    ..The latter may mediate, at least in part, glucose induction of its own metabolism...
  23. ncbi request reprint Cloning and characterization of diacylglycerol kinase iota splice variants in rat brain
    Tsukasa Ito
    Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Japan
    J Biol Chem 279:23317-26. 2004
    ....
  24. pmc Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling
    Tracy Crotty
    Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 103:15485-90. 2006
    ....
  25. ncbi request reprint Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleus
    Takehiro Matsubara
    Laboratory of Molecular Pharmacology and Laboratory of Biochemistry, Biosignal Research Center, Rokkodai cho 1 1, Nada Ku, Kobe 657 8501
    J Biol Chem 281:6152-64. 2006
    ..The cells expressing the kinase-negative mutant of DGKgamma were larger in size and showed slower growth rate, and the S phase of the cells was extended. These findings implicate that nuclear DGKgamma regulates cell cycle...
  26. ncbi request reprint Expression and localization of diacylglycerol kinase isozymes and enzymatic features in rat lung
    Yuji Katagiri
    Dept of Anatomy and Cell Biology, Yamagata Univ School of Medicine, Iida nishi 2 2 2, Yamagata 990 9585, Japan
    Am J Physiol Lung Cell Mol Physiol 288:L1171-8. 2005
    ..These unique changes in the expression pattern during the perinatal period suggest that each isozyme may play a distinct role in the adaptation of the lung to air or oxygen breathing at birth...
  27. doi request reprint Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta1
    Bryan T Harada
    Molecular Biology Institute, University of California, Los Angeles, Boyer Hall, Los Angeles, CA 90095 1570, USA
    Structure 16:380-7. 2008
    ..Thus, polymerization of DGK delta regulates the activity of the enzyme by sequestering DGK delta in an inactive cellular location. Regulation by dynamic polymerization is an emerging theme in signal transduction...
  28. ncbi request reprint Gene expression, cellular localization, and enzymatic activity of diacylglycerol kinase isozymes in rat ovary and placenta
    Mayumi Toya
    Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Iida nishi 2 2 2, Yamagata, 990 9585, Japan
    Cell Tissue Res 320:525-33. 2005
    ..The present study reveals distinct patterns of mRNA localization for DGK isozymes in the rat ovary and placenta, suggesting that each isozyme plays a unique role in distinct cell types in these organs...
  29. pmc Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling
    Debra S Regier
    The Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 102:7595-600. 2005
    ..Thus, type IV DGKs regulate RasGRPs, but the downstream effects differ depending on the DGK...