Research Topics
Genomes and Genes | Fumio SakaneSummaryAffiliation: Sapporo Medical University Country: Japan Publications
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Detail Information
Publications
Diacylglycerol kinases as emerging potential drug targets for a variety of diseasesFumio Sakane
Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
Curr Drug Targets 9:626-40. 2008..Unfortunately, there are no DGK isozyme-specific inhibitors/activators at present. Development of these compounds is eagerly awaited for the development of novel drugs targeting DGKs...- Diacylglycerol kinases: why so many of them?Fumio Sakane
Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
Biochim Biophys Acta 1771:793-806. 2007.... - Identification and characterization of a novel human type II diacylglycerol kinase, DGK kappaShin ichi Imai
Department of Biochemistry, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo 060 8556, Japan
J Biol Chem 280:39870-81. 2005..The expression patterns, subcellular distribution, and regulatory mechanisms of DGK kappa are distinct from those of DGKdelta and DGKeta despite high structural similarity, suggesting unique functions of the individual type II isozymes... - Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formationShuichi Tsushima
Department of Biochemistry, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
J Biol Chem 279:28603-13. 2004..Taken together, these results strongly suggest that DGKgamma functions through its catalytic action as an upstream suppressor of Rac1 and, consequently, lamellipodium/ruffle formation... - Phorbol ester and hydrogen peroxide synergistically induce the interaction of diacylglycerol kinase gamma with the Src homology 2 and C1 domains of beta2-chimaerinSatoshi Yasuda
Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
Biochem J 409:95-106. 2008..Our work offers a novel mechanism of protein-protein interaction, that is, the phosphotyrosine-independent interaction of the SH2 domain acting in co-operation with the C1 domain... 
The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domainShin ichi Imai
Department of Biochemistry, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
Biochem J 382:957-66. 2004..Our results provide evidence of the phosphorylation of the DGKdelta1 PH domain by cPKC, and suggest that the phosphorylation is involved in the control of subcellular localization of DGKdelta1...- Tyrosine phosphorylation of beta2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activityMasahiro Kai
Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
Biochim Biophys Acta 1773:1407-15. 2007..These results suggest Tyr-21 phosphorylation as a novel, SFK-dependent mechanism that negatively regulates beta2-chimaerin Rac-GAP activity... - Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerizationSatoshi Yasuda
Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556
J Biol Chem 284:29559-70. 2009..Taken together, the results obtained strongly support that DGKeta acts as a novel critical regulatory component of the Ras/B-Raf/C-Raf/MEK/ERK signaling cascade via a previously unidentified mechanism... - Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factorSatoshi Yasuda
Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
FEBS Lett 581:551-7. 2007..These results indicate that DGKgamma is a novel regulator of beta2-chimaerin, and thus suggest that beta2-chimaerin is an effector molecule, linking DGKgamma functionally with Rac1... - Identification and characterization of two splice variants of human diacylglycerol kinase etaTomohiro Murakami
Department of Biochemistry, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
J Biol Chem 278:34364-72. 2003..Taken together, alternative splicing of the human DGK eta gene generates at least two isoforms with distinct biochemical and cell biological properties responding to different cellular metabolic requirements... 
Diacylglycerol kinase delta associates with receptor for activated C kinase 1, RACK1Shin ichi Imai
Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
Biochim Biophys Acta 1791:246-53. 2009..These results suggest that DGKdelta serves as an adaptor protein to regulate the localization of the versatile scaffold protein, RACK1...- Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activationKenji Yanagisawa
Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan
Biochim Biophys Acta 1771:462-74. 2007..Together, these results strongly suggest that DGKalpha is a novel positive regulator of NF-kappaB, which suppresses TNF-alpha-induced melanoma cell apoptosis... - Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid raftsMasahiro Kai
Department of Biochemistry, Sapporo Medical University School of Medicine, West 17, South 1, Sapporo 060 8556
J Biochem 140:677-86. 2006..These results indicate that LPP1 and LPP3 are distributed in distinct lipid rafts that may provide unique microenvironments defining their non-redundant physiological functions... - Diacylglycerol kinase alpha enhances protein kinase Czeta-dependent phosphorylation at Ser311 of p65/RelA subunit of nuclear factor-kappaBMasahiro Kai
Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo, Japan
FEBS Lett 583:3265-8. 2009..These results strongly suggest that DGKalpha positively regulates TNF-alpha-dependent NF-kappaB activation via the PKCzeta-mediated Ser311 phosphorylation of p65/RelA... - Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functionsFumio Sakane
Department of Biochemistry, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
J Biol Chem 277:43519-26. 2002..Taken together, alternative splicing of the human DGKdelta gene generates at least two isoforms, differing in their expressions and regulatory functions... - Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cellsKeiko Yamada
Department of Liberal Arts and Sciences, School of Health Sciences, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
Biochem Biophys Res Commun 305:101-7. 2003..The results suggest that DGKgamma negatively regulates macrophage differentiation through its catalytic action operating on the cytoskeleton... - Rab7 regulates maturation of melanosomal matrix protein gp100/Pmel17/SilvAkinori Kawakami
Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan
J Invest Dermatol 128:143-50. 2008..Moreover, siRNA-mediated Rab7 knockdown considerably inhibited gp100 maturation. These results collectively suggest that the GTP-bound form of Rab7 promotes melanogenesis through the regulation of gp100 maturation in melanoma cells... - Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocationShin ichi Imai
Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
J Biol Chem 277:35323-32. 2002..The present studies demonstrated that the formation and dissociation of oligomers serve as the regulatory mechanisms of DGKdelta and that DGKdelta is a novel downstream effector of phorbol ester/protein kinase C signaling pathway... - Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cellsYan-Jun Jia
Department of Biochemistry, Sapporo Medical University School of Medicine, South-1, West-17, 060-8556 Sapporo, Japan
FEBS Lett 552:240-6. 2003..Our work shows that LPP1 and LPP3 are equipped with distinct sorting signals that cause them to differentially localize to the apical vs. the basolateral subdomain, respectively... - Diacylglycerol kinases: emerging downstream regulators in cell signaling systemsHideo Kanoh
Department of Biochemistry, School of Medicine, Sapporo Medical University, South West 17, Sapporo 060 8556, Japan
J Biochem 131:629-33. 2002.... - Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistanceAlexander V Chibalin
Department of Molecular Medicine and Surgery, Karolinska Institutet, S 171 77, Stockholm, Sweden
Cell 132:375-86. 2008..DGKdelta deficiency causes peripheral insulin resistance and metabolic inflexibility. These defects in glucose and energy homeostasis contribute to mild obesity later in life... - Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localizationClaudia Miele
Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Federico II University of Naples, Via Pansini 5, Naples 80131, Italy
J Biol Chem 282:31835-43. 2007..The latter may mediate, at least in part, glucose induction of its own metabolism... - Cloning and characterization of diacylglycerol kinase iota splice variants in rat brainTsukasa Ito
Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Japan
J Biol Chem 279:23317-26. 2004.... - Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signalingTracy Crotty
Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
Proc Natl Acad Sci U S A 103:15485-90. 2006.... - Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleusTakehiro Matsubara
Laboratory of Molecular Pharmacology and Laboratory of Biochemistry, Biosignal Research Center, Rokkodai cho 1 1, Nada Ku, Kobe 657 8501
J Biol Chem 281:6152-64. 2006..The cells expressing the kinase-negative mutant of DGKgamma were larger in size and showed slower growth rate, and the S phase of the cells was extended. These findings implicate that nuclear DGKgamma regulates cell cycle... - Expression and localization of diacylglycerol kinase isozymes and enzymatic features in rat lungYuji Katagiri
Dept. of Anatomy and Cell Biology, Yamagata Univ. School of Medicine, Iida-Nishi 2-2-2, Yamagata 990-9585, Japan
Am J Physiol Lung Cell Mol Physiol 288:L1171-8. 2005..These unique changes in the expression pattern during the perinatal period suggest that each isozyme may play a distinct role in the adaptation of the lung to air or oxygen breathing at birth... - Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta1Bryan T Harada
Molecular Biology Institute, University of California, Los Angeles, Boyer Hall, Los Angeles, CA 90095 1570, USA
Structure 16:380-7. 2008..Thus, polymerization of DGK delta regulates the activity of the enzyme by sequestering DGK delta in an inactive cellular location. Regulation by dynamic polymerization is an emerging theme in signal transduction... - Gene expression, cellular localization, and enzymatic activity of diacylglycerol kinase isozymes in rat ovary and placentaMayumi Toya
Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Iida-Nishi 2-2-2, Yamagata, 990-9585, Japan
Cell Tissue Res 320:525-33. 2005..The present study reveals distinct patterns of mRNA localization for DGK isozymes in the rat ovary and placenta, suggesting that each isozyme plays a unique role in distinct cell types in these organs... - Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signalingDebra S Regier
The Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
Proc Natl Acad Sci U S A 102:7595-600. 2005..Thus, type IV DGKs regulate RasGRPs, but the downstream effects differ depending on the DGK...