K Omote

Summary

Affiliation: Sapporo Medical University
Country: Japan

Publications

  1. ncbi request reprint Effects of a novel selective agonist for prostaglandin receptor subtype EP4 on hyperalgesia and inflammation in monoarthritic model
    Keiichi Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Chuoku, Sapporo, Japan
    Anesthesiology 97:170-6. 2002
  2. ncbi request reprint Peripheral nitric oxide in carrageenan-induced inflammation
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuoku, 060 8543, Sapporo, Japan
    Brain Res 912:171-5. 2001
  3. ncbi request reprint The effects of intrathecal administration of an antagonist for prostaglandin E receptor subtype EP(1) on mechanical and thermal hyperalgesia in a rat model of postoperative pain
    Keiichi Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan
    Anesth Analg 95:1708-12, table of contents. 2002
  4. ncbi request reprint The effects of peripheral administration of a novel selective antagonist for prostaglandin E receptor subtype EP(1), ONO-8711, in a rat model of postoperative pain
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Anesth Analg 92:233-8. 2001
  5. ncbi request reprint Activation of peripheral NMDA-nitric oxide cascade in formalin test
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan
    Anesthesiology 93:173-8. 2000
  6. ncbi request reprint Formalin-induced nociception activates a monoaminergic descending inhibitory system
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuoku, Sapporo 060, Japan
    Brain Res 814:194-8. 1998
  7. ncbi request reprint Formalin-induced release of excitatory amino acids in the skin of the rat hindpaw
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuoku, Sapporo 060, Japan
    Brain Res 787:161-4. 1998
  8. doi request reprint Down-regulation of mu opioid receptor expression within distinct subpopulations of dorsal root ganglion neurons in a murine model of bone cancer pain
    J Yamamoto
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Neuroscience 151:843-53. 2008
  9. ncbi request reprint Analgesic mechanisms of ketamine in the presence and absence of peripheral inflammation
    T Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan
    Anesthesiology 93:520-8. 2000
  10. ncbi request reprint Antinociceptive interaction of intrathecal alpha2-adrenergic agonists, tizanidine and clonidine, with lidocaine in rats
    T Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Hokkaido, Japan
    Anesthesiology 87:436-48. 1997

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Effects of a novel selective agonist for prostaglandin receptor subtype EP4 on hyperalgesia and inflammation in monoarthritic model
    Keiichi Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Chuoku, Sapporo, Japan
    Anesthesiology 97:170-6. 2002
    ..The purpose of this study was to evaluate whether a novel EP(4) agonist would be able to suppress thermal and mechanical hyperalgesia and paw swelling in acute and chronic phases in rat monoarthritic model...
  2. ncbi request reprint Peripheral nitric oxide in carrageenan-induced inflammation
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuoku, 060 8543, Sapporo, Japan
    Brain Res 912:171-5. 2001
    ..The results of the current study show that carrageenan induces peripheral release of NO, the production of which is mediated by nNOS in the early phase and by both nNOS and iNOS in the late phase of carrageenan-induced inflammation...
  3. ncbi request reprint The effects of intrathecal administration of an antagonist for prostaglandin E receptor subtype EP(1) on mechanical and thermal hyperalgesia in a rat model of postoperative pain
    Keiichi Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan
    Anesth Analg 95:1708-12, table of contents. 2002
    ....
  4. ncbi request reprint The effects of peripheral administration of a novel selective antagonist for prostaglandin E receptor subtype EP(1), ONO-8711, in a rat model of postoperative pain
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Anesth Analg 92:233-8. 2001
    ..Implications: The peripheral administration of an antagonist for EP(1) receptor that is a subtype of prostaglandin E receptors can inhibit the mechanical hyperalgesia induced by a surgical incision...
  5. ncbi request reprint Activation of peripheral NMDA-nitric oxide cascade in formalin test
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan
    Anesthesiology 93:173-8. 2000
    ..This study was conducted to determine whether NO was released in the periphery after subcutaneous injection of formalin and whether the peripheral N-methyl-d-aspartate (NMDA)-NO cascade was activated...
  6. ncbi request reprint Formalin-induced nociception activates a monoaminergic descending inhibitory system
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuoku, Sapporo 060, Japan
    Brain Res 814:194-8. 1998
    ..These results suggest that the pain state produced by formalin-induced chemical and/or inflammatory nociception is under the modulation of the monoaminergic (noradrenergic and serotonergic) descending inhibitory system...
  7. ncbi request reprint Formalin-induced release of excitatory amino acids in the skin of the rat hindpaw
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuoku, Sapporo 060, Japan
    Brain Res 787:161-4. 1998
    ..This shows that nociception and inflammation caused by formalin injection induces the release of peripheral glutamate and aspartate, which would contribute to nociception and inflammatory pain...
  8. doi request reprint Down-regulation of mu opioid receptor expression within distinct subpopulations of dorsal root ganglion neurons in a murine model of bone cancer pain
    J Yamamoto
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Neuroscience 151:843-53. 2008
    ....
  9. ncbi request reprint Analgesic mechanisms of ketamine in the presence and absence of peripheral inflammation
    T Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan
    Anesthesiology 93:520-8. 2000
    ..In this study, the authors investigated the contribution of supraspinal monoaminergic descending inhibitory system to ketamine analgesia for acute nociception and inflammation-induced hyperalgesia...
  10. ncbi request reprint Antinociceptive interaction of intrathecal alpha2-adrenergic agonists, tizanidine and clonidine, with lidocaine in rats
    T Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Hokkaido, Japan
    Anesthesiology 87:436-48. 1997
    ..This study was designed to evaluate the antinociceptive and hemodynamic interactions of tizanidine and clonidine with lidocaine...
  11. ncbi request reprint Bone cancer increases transient receptor potential vanilloid subfamily 1 expression within distinct subpopulations of dorsal root ganglion neurons
    Y Niiyama
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1 West 16, Sapporo, Hokkaido 060 8543, Japan
    Neuroscience 148:560-72. 2007
    ..These findings may lead to novel strategies for the treatment of bone cancer pain...
  12. ncbi request reprint Activation of spinal N-methyl-D-aspartate receptors stimulates a nitric oxide/cyclic guanosine 3,5-monophosphate/glutamate release cascade in nociceptive signaling
    T Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan
    Anesthesiology 91:1415-24. 1999
    ..The authors hypothesized that the activation of NMDA receptors stimulates an NO/cGMP pathway, and this pathway evokes glutamate release within the spinal cord, modulating spinal nociceptive transmission...
  13. ncbi request reprint Involvement of capsaicin-sensitive fibers in spinal NMDA-induced glutamate release
    T Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
    Neuroreport 12:3447-50. 2001
    ..Our results showed that glutamate release from capsaicin-sensitive primary afferent terminals is involved in spinal NMDA-induced pain...
  14. ncbi request reprint Direct evidence for the role of nitric oxide on the glutamate-induced neuronal death in cultured cortical neurons
    M Yamauchi
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan
    Brain Res 780:253-9. 1998
    ..In conclusion, an increase in NO concentration does induce neuronal death, and the inhibition of the production of NO prevents glutamate-induced neuronal death...
  15. ncbi request reprint Immunohistochemical analysis of acid-sensing ion channel 2 expression in rat dorsal root ganglion and effects of axotomy
    T Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Neuroscience 143:175-87. 2006
    ..These results show that ASIC2 is expressed in the distinct neurochemical population of sensory neurons as well as satellite cells, and that peripheral axotomy induced marked reductions in ASIC2 in neurons...
  16. ncbi request reprint [The effect of continuous intra-articular and intra-bursal infusion of lidocaine on postoperative pain following shoulder arthroscopic surgery]
    Y Niiyama
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo 060-8543
    Masui 50:251-5. 2001
    ..No adverse effects were observed during this study. We conclude that continuous intra-articular and intra-bursal infusion of lidocaine provides effective postoperative pain relief for shoulder arthroscopic surgery...
  17. ncbi request reprint Recovery characteristics and post-operative delirium after long-duration laparoscope-assisted surgery in elderly patients: propofol-based vs. sevoflurane-based anesthesia
    K Nishikawa
    Department of Anesthesia, Muroran City General Hospital, Yamate chou 3 8 1, Muroran, Hokkaido 051 8512, Japan
    Acta Anaesthesiol Scand 48:162-8. 2004
    ..This study was designed to compare the effects of propofol and sevoflurane anesthesia on recovery characteristics and the incidence of post-operative delirium (POD) in long-duration laparoscopic surgery for elderly patients...
  18. ncbi request reprint Endothelin-1 enhances capsaicin-evoked intracellular Ca2+ response via activation of endothelin a receptor in a protein kinase Cepsilon-dependent manner in dorsal root ganglion neurons
    H Yamamoto
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Neuroscience 137:949-60. 2006
    ..Our results indicate that endothelin-1 enhances the response of dorsal root ganglion neurons to capsaicin in a protein kinase Cepsilon-dependent manner. Our findings may lead to a new strategy to treat pain associated with endothelin-1...
  19. ncbi request reprint Acute respiratory and metabolic acidosis induced by excessive muscle contraction during spinal evoked stimulation
    Y Tohdoh
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Hokkaido, Japan
    Br J Anaesth 86:589-93. 2001
    ..To prevent SSEP-induced respiratory and metabolic acidosis, we recommend that SSEPs should be measured only when profound neuromuscular blockade has been obtained...
  20. ncbi request reprint Pneumocephalus following an epidural blood patch
    T Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Acta Anaesthesiol Scand 47:907-9. 2003
    ..Pneumocephalus may occur during an epidural blood patch procedure, even if the epidural needle tip is within the epidural space...
  21. ncbi request reprint Effects of thiopental on bispectral index and heart rate variability
    S Tsuchiya
    Department of Anesthesiology, School of Medicine, Sapporo Medical University, Sapporo, Japan
    Eur J Anaesthesiol 23:454-9. 2006
    ..The purpose of the present study was to evaluate changes in heart rate variability at different depths of hypnosis during induction of anaesthesia with thiopental...
  22. ncbi request reprint A selective beta2-adrenergic agonist, terbutaline, improves sepsis-induced diaphragmatic dysfunction in the rat
    Tetsuo Ito
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Life Sci 79:905-12. 2006
    ....
  23. ncbi request reprint Pain management after lumbar spinal fusion surgery using continuous subcutaneous infusion of buprenorphine
    Tomoyuki Kawamata
    Department of Anaesthesiology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Anesth 19:199-203. 2005
    ..The continuous subcutaneous infusion (CSI) technique is a simple, inexpensive method for managing postoperative pain. We examined the analgesic effects of CSI of buprenorphine in patients undergoing lumbar spinal fusion surgery...
  24. ncbi request reprint The addition of epidural morphine to ropivacaine improves epidural analgesia after lower abdominal surgery
    Yukitoshi Niiyama
    Department of Anesthesiology, Sapporo Medical University, School of Medicine, S1 W16 Chuou ku, Sapporo, Hokkaido 060 8556, Japan
    Can J Anaesth 52:181-5. 2005
    ..To assess the analgesic and side effects of the continuous epidural infusion of 0.2% ropivacaine combined with morphine compared to both drugs alone...
  25. ncbi request reprint Role of prostaglandin receptor subtype EP1 in prostaglandin E2-induced nociceptive transmission in the rat spinal dorsal horn
    Yoshito Nakayama
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuoku, Sapporo 060 8543, Japan
    Brain Res 1010:62-8. 2004
    ....
  26. ncbi request reprint Endoscopic thoracic sympathectomy suppresses baroreflex control of heart rate in patients with essential hyperhidrosis
    Yurie T Kawamata
    Department of Anesthesiology, Nippon Telegraph and Telephone East Japan Sapporo Hospital, Sapporo, Japan
    Anesth Analg 98:37-9, table of contents. 2004
    ..Baroreflex was completely suppressed in 1 of 19 patients in the pressor test and in 9 of 21 patients in the depressor test. We conclude that baroreflex responses are suppressed in patients who receive ETS...
  27. ncbi request reprint A comparison of hyperbaric 1% and 3% solutions of small-dose lidocaine in spinal anesthesia
    Yurie Tohdoh Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan
    Anesth Analg 96:881-4, table of contents. 2003
    ..Levels of sensory block were similar. Therefore, the more dilute lidocaine for spinal anesthesia may be suitable for day-care surgery and short duration surgery...
  28. ncbi request reprint Intracerebroventricular morphine produces antinociception by evoking gamma-aminobutyric acid release through activation of 5-hydroxytryptamine 3 receptors in the spinal cord
    Tomoyuki Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Anesthesiology 96:1175-82. 2002
    ..In this study, the authors investigated the contribution of spinal 5-HT3 receptor and the GABAergic system in the intracerebroventricular morphine-induced antinociception...
  29. ncbi request reprint Prophylactic IM small-dose phenylephrine blunts spinal anesthesia-induced hypotensive response during surgical repair of hip fracture in the elderly
    Kohki Nishikawa
    Department of Anesthesiology, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Anesth Analg 95:751-6, table of contents. 2002
    ..Phenylephrine 1.5 mg IM was effective for reducing the incidence of hypotension and avoided adverse effects...
  30. ncbi request reprint Different mechanisms of development and maintenance of experimental incision-induced hyperalgesia in human skin
    Mikito Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan
    Anesthesiology 97:550-9. 2002
    ....
  31. ncbi request reprint Role of prostaglandin receptor EP1 in the spinal dorsal horn in carrageenan-induced inflammatory pain
    Yoshito Nakayama
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan
    Anesthesiology 97:1254-62. 2002
    ....
  32. ncbi request reprint Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain
    Tomoyuki Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Hokkaido, Japan
    Anesthesiology 98:1480-3. 2003
    ..This study was designed to evaluate the antihyperalgesic effects and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain...
  33. ncbi request reprint The activation of 5-HT(3) receptors evokes GABA release in the spinal cord
    Tomoyuki Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 978:250-5. 2003
    ..The concentration of aspartate was increased only by 3.0 mM of 1-phenylbiguanide. Our results have provided direct evidence that activation of 5-HT(3) receptors evokes GABA release in the spinal dorsal horn, possibly producing analgesia...
  34. ncbi request reprint [Anesthetic management in a patient with Goldenhar's syndrome using a perilaryngeal airway and a videolaryngoscope]
    Shigekazu Sugino
    Department of Anesthesiology, Sapporo Medical University School of Medicine
    Masui 54:1367-70. 2005
    ..In conclusion, a PLA and a videolaryngoscope are useful for airway management of patients with Goldenhar's syndrome for whom difficulty in intubation is anticipated...
  35. ncbi request reprint [Inhibitory action of sensory transmission by inhalational anesthetics in the spinal cord]
    Masanori Yamauchi
    Department of Anesthesiology, Yale University School of Medicine, 06520 8051, USA
    Masui 52:240-50. 2003
    ....
  36. ncbi request reprint [Anesthetic management of endovascular repair for aortic abdominal aneurysm in a patient with severe chronic obstructive pulmonary disease]
    Shigekazu Sugino
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo
    Masui 55:1480-3. 2006
    ....
  37. ncbi request reprint Hazard with a triple-lumen catheter
    Hiroki Yamamoto
    Anesth Analg 94:234. 2002
  38. ncbi request reprint [Pneumothorax during laparoscopic adrenal surgery: a case report]
    Masayuki Nawa
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo 060 8543
    Masui 52:857-9. 2003
    ..Attention should be paid to the possibility of pneumothorax occurring during laparoscopic adrenal surgery even if there is no apparent surgical injury...