Tetsuji Miura

Summary

Affiliation: Sapporo Medical University
Country: Japan

Publications

  1. ncbi request reprint The mPTP and its regulatory proteins: final common targets of signalling pathways for protection against necrosis
    Tetsuji Miura
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cardiovasc Res 94:181-9. 2012
  2. ncbi request reprint Does glycemic control reverse dispersion of ventricular repolarization in type 2 diabetes?
    Takayuki Miki
    Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Sapporo 060 8543, Chuo Ku, Japan
    Cardiovasc Diabetol 13:125. 2014
  3. ncbi request reprint Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population
    Takahiro Fuseya
    Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S 1, W 16 Chuo ku, Sapporo 060 8543, Japan
    Cardiovasc Diabetol 13:126. 2014
  4. pmc Role of ER stress in ventricular contractile dysfunction in type 2 diabetes
    Akifumi Takada
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 7:e39893. 2012
  5. pmc Glucagon-like peptide-1 secretory function as an independent determinant of blood pressure: analysis in the Tanno-Sobetsu study
    Mayumi Yoshihara
    Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 8:e67578. 2013
  6. pmc Diabetic cardiomyopathy: pathophysiology and clinical features
    Takayuki Miki
    Division of Cardiology, Second Department of Internal Medicine, School of Medicine, Sapporo Medical University, South 1 West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Heart Fail Rev 18:149-66. 2013
  7. pmc Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning
    Takayuki Miki
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Sapporo 060 8543, Japan
    Cardiovasc Diabetol 11:67. 2012
  8. ncbi request reprint ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart
    Tetsuji Miura
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan
    Curr Vasc Pharmacol 1:251-8. 2003
  9. ncbi request reprint Role of the gap junction in ischemic preconditioning in the heart
    Tetsuji Miura
    Second Dept of Internal Medicine, Sapporo Medical Univ, Japan
    Am J Physiol Heart Circ Physiol 298:H1115-25. 2010
  10. ncbi request reprint GSK-3beta, a therapeutic target for cardiomyocyte protection
    Tetsuji Miura
    Division of Cardiology, Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Circ J 73:1184-92. 2009

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint The mPTP and its regulatory proteins: final common targets of signalling pathways for protection against necrosis
    Tetsuji Miura
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cardiovasc Res 94:181-9. 2012
    ....
  2. ncbi request reprint Does glycemic control reverse dispersion of ventricular repolarization in type 2 diabetes?
    Takayuki Miki
    Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Sapporo 060 8543, Chuo Ku, Japan
    Cardiovasc Diabetol 13:125. 2014
    ..Abnormal ventricular repolarization is a predictor of cardiovascular mortality. In this study, we tested the hypothesis that glycemic control reverses abnormal ventricular repolarization in patients with type 2 diabetes...
  3. ncbi request reprint Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population
    Takahiro Fuseya
    Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S 1, W 16 Chuo ku, Sapporo 060 8543, Japan
    Cardiovasc Diabetol 13:126. 2014
    ..However, little is known about role of FABP4 in cardiac function...
  4. pmc Role of ER stress in ventricular contractile dysfunction in type 2 diabetes
    Akifumi Takada
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 7:e39893. 2012
    ..Here we assessed the role of endoplasmic reticulum (ER) stress in ventricular dysfunction and outcomes after MI in type 2 DM (T2DM)...
  5. pmc Glucagon-like peptide-1 secretory function as an independent determinant of blood pressure: analysis in the Tanno-Sobetsu study
    Mayumi Yoshihara
    Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 8:e67578. 2013
    ..Roles of glucagon-like peptide-1 (GLP-1) in extra-pancreatic tissues remain unclear. The aim of this study was to examine determinants of GLP-1 secretory function and possible contribution of GLP-1 to blood pressure (BP) regulation...
  6. pmc Diabetic cardiomyopathy: pathophysiology and clinical features
    Takayuki Miki
    Division of Cardiology, Second Department of Internal Medicine, School of Medicine, Sapporo Medical University, South 1 West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Heart Fail Rev 18:149-66. 2013
    ..Here, we review both basic and clinical studies on diabetic cardiomyopathy and summarize problems remaining to be solved for improving management of this type of cardiomyopathy...
  7. pmc Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning
    Takayuki Miki
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Sapporo 060 8543, Japan
    Cardiovasc Diabetol 11:67. 2012
    ..Here we summarize observations of the effects of DM on myocardial infarct size and ischemic PC and PostC and discuss perspectives for protection of DM hearts...
  8. ncbi request reprint ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart
    Tetsuji Miura
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan
    Curr Vasc Pharmacol 1:251-8. 2003
    ....
  9. ncbi request reprint Role of the gap junction in ischemic preconditioning in the heart
    Tetsuji Miura
    Second Dept of Internal Medicine, Sapporo Medical Univ, Japan
    Am J Physiol Heart Circ Physiol 298:H1115-25. 2010
    ....
  10. ncbi request reprint GSK-3beta, a therapeutic target for cardiomyocyte protection
    Tetsuji Miura
    Division of Cardiology, Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Circ J 73:1184-92. 2009
    ..Considering predominant roles of GSK-3beta in cardiomyocyte death, manipulation of this protein kinase is a promising strategy for myocardial protection in coronary artery disease and heart failure...
  11. ncbi request reprint Mitochondria and GSK-3beta in cardioprotection against ischemia/reperfusion injury
    Tetsuji Miura
    Division of Cardiology, Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Cardiovasc Drugs Ther 24:255-63. 2010
    ..Regulatory mechanisms of mPTP, and their alterations by morbidities frequently associated with ischemic heart disease need to be further characterized for translation of mitochondrial and mPTP biology to the clinical arena...
  12. ncbi request reprint Mitochondrial kinase signalling pathways in myocardial protection from ischaemia/reperfusion-induced necrosis
    Tetsuji Miura
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Cardiovasc Res 88:7-15. 2010
    ..In this review, recent findings supporting roles of mitochondrial protein kinases in protection from myocardial necrosis after ischaemia/reperfusion are summarized and discussed...
  13. ncbi request reprint Protective role of gap junctions in preconditioning against myocardial infarction
    Tetsuji Miura
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo 060 8543, Japan
    Am J Physiol Heart Circ Physiol 286:H214-21. 2004
    ..These results suggest that PC-induced reduction of GJ permeability during ischemia, presumably by PKC-mediated Cx43 phosphorylation, contributes to infarct size limitation...
  14. ncbi request reprint Roles of mitochondrial ATP-sensitive K channels and PKC in anti-infarct tolerance afforded by adenosine A1 receptor activation
    T Miura
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    J Am Coll Cardiol 35:238-45. 2000
    ..This study intended to assess the role of mitochondrial ATP-sensitive potassium (mitoK ATP) channels and the sequence of signal transduction with protein kinase C (PKC) and adenosine A1 receptors in rabbits...
  15. ncbi request reprint Delta-opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-epsilon-mediated phosphorylation of connexin 43
    Tetsuji Miura
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo 060 8543, Japan
    Am J Physiol Heart Circ Physiol 293:H1425-31. 2007
    ....
  16. ncbi request reprint Limitation of myocardial infarct size in the clinical setting: current status and challenges in translating animal experiments into clinical therapy
    Tetsuji Miura
    Division of Cardiology, 2nd Dept of Internal Medicine, School of Medicine, Sapporo Medical University, South 1 West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Basic Res Cardiol 103:501-13. 2008
    ..Few agents have been thoroughly tested in clinically relevant animal models prior to their testing in man...
  17. ncbi request reprint Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in myocardial protection against ischemia/reperfusion injury
    Tetsuji Miura
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan
    J Pharmacol Sci 109:162-7. 2009
    ..Thus, GSK-3beta appears to be a target of novel therapy for cardioprotection upon reperfusion...
  18. ncbi request reprint Infarct size limitation by a new Na(+)-H+ exchange inhibitor, Hoe 642: difference from preconditioning in the role of protein kinase C
    T Miura
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    J Am Coll Cardiol 29:693-701. 1997
    ..In addition, we assessed the possible alteration of Hoe 642-induced cardioprotection by commonly used animal anesthetic drugs...
  19. ncbi request reprint Adenosine and preconditioning revisited
    T Miura
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Clin Exp Pharmacol Physiol 26:92-9. 1999
    ..The PKC isoform and location of KATP channels (i.e. sarcolemmal vs mitochondrial KATP) that induce anti-infarct tolerance in myocytes remain to be identified...
  20. ncbi request reprint Mitochondrial ATP-sensitive K+ channels play a role in cardioprotection by Na+-H+ exchange inhibition against ischemia/reperfusion injury
    T Miura
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    J Am Coll Cardiol 37:957-63. 2001
    ..The possible role of the ATP-sensitive potassium (KATP) channel in cardioprotection by Na+-H+ exchange (NHE) inhibition was examined...
  21. pmc Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition
    Takayuki Miki
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Diabetes 58:2863-72. 2009
    ....
  22. ncbi request reprint MitoKATP channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK-dependent mechanism
    Kazuyuki Naitoh
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo 060 8543, Japan
    Cardiovasc Res 70:374-83. 2006
    ..We hypothesized that the mitochondrial ATP-sensitive K+ (mitoKATP) channel is one of the mechanisms regulating GJ permeability through the mitogen-activated protein kinase ERK, leading to cardioprotection...
  23. ncbi request reprint Roles of phospho-GSK-3β in myocardial protection afforded by activation of the mitochondrial K ATP channel
    Yoshiaki Terashima
    Division of Cardiology, Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo 060 8543, Japan
    J Mol Cell Cardiol 49:762-70. 2010
    ..Inhibition of CypD-ANT interaction may contribute to mK(ATP)-induced myocardial protection, though it is not the sole mechanism of phospho-GSK-3β-mediated cytoprotection...
  24. ncbi request reprint Roles of Cx43-associated protein kinases in suppression of gap junction-mediated chemical coupling by ischemic preconditioning
    Kazuyuki Naitoh
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Am J Physiol Heart Circ Physiol 296:H396-403. 2009
    ..Suppression of GJ permeability during ischemia by PC is primarily achieved by enhanced interaction of Cx43 with PKCepsilon, which overwhelms the counterbalancing effect of reduced Cx43-p38MAPKalpha interaction...
  25. ncbi request reprint Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3 beta
    Masahiro Nishihara
    Second Dept of Internal Medicine, Sapporo Medical Univ School of Medicine, Sapporo 060 8543, Japan
    Am J Physiol Heart Circ Physiol 291:H748-55. 2006
    ..0 +/- 2.0% by 1.2 mg/kg SB). These results suggest that EPO and PC afford additive infarct size-limiting effects by additive phosphorylation of GSK-3beta at the time of reperfusion by Akt-dependent and -independent mechanisms...
  26. ncbi request reprint Interruption of signal transduction between G protein and PKC-epsilon underlies the impaired myocardial response to ischemic preconditioning in postinfarct remodeled hearts
    Takayuki Miki
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Mol Cell Biochem 247:185-93. 2003
    ..The present results suggest that persistent activation of AT1 receptors during remodeling disturbed the PC signaling between G proteins and PKC-epsilon, which underlies the refractoriness of the remodeled myocardium to PC...
  27. ncbi request reprint Angiotensin II type 1 receptor-mediated upregulation of calcineurin activity underlies impairment of cardioprotective signaling in diabetic hearts
    Hiroyuki Hotta
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Circ Res 106:129-32. 2010
    ..The diabetic heart is resistant to ischemic preconditioning because of diabetes-associated impairment of phosphatidylinositol 3-kinase (PI3K)-Akt signaling. The mechanism by which PI3K-Akt signaling is impaired by diabetes remains unclear...
  28. ncbi request reprint Impact of abnormal glucose tolerance, hypertension and other risk factors on coronary artery disease
    Yosuke Nakamura
    Second Department of Internal Medicine, Sapporo Medical University, Japan
    Circ J 71:20-5. 2007
    ....
  29. ncbi request reprint Ser9 phosphorylation of mitochondrial GSK-3beta is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis
    Katsuhiko Ohori
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Sapporo 060 8543, Japan
    Am J Physiol Heart Circ Physiol 295:H2079-86. 2008
    ....
  30. ncbi request reprint Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning
    Yoshito Ohnuma
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Am J Physiol Heart Circ Physiol 283:H440-7. 2002
    ..Together with the results of earlier studies showing mitochondrial K(ATP) opening by PKC, the present results suggest that mitochondrial K(ATP)-mediated cardioprotection occurs subsequent to PKC-epsilon activation by PC...
  31. ncbi request reprint Infarct size limitation by nicorandil: roles of mitochondrial K(ATP) channels, sarcolemmal K(ATP) channels, and protein kinase C
    Akihito Tsuchida
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Am Coll Cardiol 40:1523-30. 2002
    ....
  32. ncbi request reprint Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection
    Masahiro Nishihara
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1 W 16, Chuo Ku, Sapporo 060 8543, Japan
    J Mol Cell Cardiol 43:564-70. 2007
    ..These results suggest that reduction in affinity of ANT to cyclophilin D by increased phospho-GSK-3beta binding to ANT may be responsible for suppression of mPTP opening and myocardial protection afforded by IPC+EPO...
  33. ncbi request reprint Cytoprotective regulation of the mitochondrial permeability transition pore is impaired in type 2 diabetic Goto-Kakizaki rat hearts
    Takahito Itoh
    Division of Cardiology, Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, Japan
    J Mol Cell Cardiol 53:870-9. 2012
    ..These results suggest that cytoprotective regulation of the mPTP is impaired in GK by enhanced CypD-PiC interaction in which UPRs are involved...
  34. ncbi request reprint K(ATP) channel opening is an endogenous mechanism of protection against the no-reflow phenomenon but its function is compromised by hypercholesterolemia
    Satoshi Genda
    Second Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    J Am Coll Cardiol 40:1339-46. 2002
    ..This study aimed to clarify the role of adenosine triphosphate-sensitive K(+) (K(ATP)) channels in the no-reflow phenomenon and in its extension by hypercholesterolemia...
  35. ncbi request reprint Mitochondrial KATP channel-dependent and -independent phases of ischemic preconditioning against myocardial infarction in the rat
    Yukinaga Nozawa
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, South 1 West 16, Chuo Ku, Japan
    Basic Res Cardiol 98:50-8. 2003
    ....
  36. ncbi request reprint Does enhanced expression of the Na+-Ca2+ exchanger increase myocardial vulnerability to ischemia/reperfusion injury in rabbit hearts?
    Tomoaki Matsumoto
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Mol Cell Biochem 248:141-7. 2003
    ..e. 45% reduction of infarct size). These results suggest that enhanced NCX expression does not necessarily increase myocardial vulnerability to myocardial stunning and infarction...
  37. ncbi request reprint Role of microtubules in ischemic preconditioning against myocardial infarction
    Yuichi Nakamura
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, South 1 West 16, Chuo Ku, Sapporo 060 8543, Japan
    Cardiovasc Res 64:322-30. 2004
    ..The role of microtubules in ischemic preconditioning (PC) was investigated in isolated perfused rabbit hearts...
  38. ncbi request reprint Hypertensive hypertrophied myocardium is vulnerable to infarction and refractory to erythropoietin-induced protection
    Toshiyuki Yano
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Hypertension 57:110-5. 2011
    ....
  39. ncbi request reprint Role of connexin-43 in protective PI3K-Akt-GSK-3β signaling in cardiomyocytes
    Satoko Ishikawa
    Division of Cardiology, Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Am J Physiol Heart Circ Physiol 302:H2536-44. 2012
    ..These results suggest that Cx43 contributes to activation of class I(B) PI3K in PI3K-Akt-GSK-3β signaling possibly as a cofactor of Gβ in cardiomyocytes...
  40. ncbi request reprint Insulin resistance functionally limits endothelium-dependent coronary vasodilation in nondiabetic patients
    Noriyuki Fujii
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 0061, Japan
    Heart Vessels 23:9-15. 2008
    ..58, P = 0.038; [%VFI Ach 1 microg] = 176.8 - 0.47.[120' IRI], r = -0.57, P = 0.035). Insulin resistance limits endothelium-dependent coronary vasodilation in association with the severity of IR in non-diabetic patients...
  41. ncbi request reprint Activation of ERK and suppression of calcineurin are interacting mechanisms of cardioprotection afforded by delta-opioid receptor activation
    Yoshihiro Ikeda
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Basic Res Cardiol 101:418-26. 2006
    ..These results suggest that suppression of calcineurin and activation of ERK1/2 are interacting mechanisms involved in cardioprotection by delta-opioid receptor activation...
  42. ncbi request reprint Alteration in erythropoietin-induced cardioprotective signaling by postinfarct ventricular remodeling
    Takayuki Miki
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Chuo Ku, Japan
    J Pharmacol Exp Ther 317:68-75. 2006
    ..However, in the remodeled myocardium, lack of PI3K/Akt activation by the EPO receptor seems to be compensated by a mechanism upstream of the guanylyl cyclase-mitoK(ATP) channel pathway to achieve EPO-induced protection...
  43. ncbi request reprint The role of ADAM protease in the tyrosine kinase-mediated trigger mechanism of ischemic preconditioning
    Yoshihiko Ichikawa
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Cardiovasc Res 62:167-75. 2004
    ..The aim of this study was to determine the role of an a disintegrin and metalloprotease (ADAM) in tyrosine kinase-mediated mechanisms of ischemic preconditioning (PC)...
  44. ncbi request reprint Impairment of cardioprotective PI3K-Akt signaling by post-infarct ventricular remodeling is compensated by an ERK-mediated pathway
    Takayuki Miki
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Basic Res Cardiol 102:163-70. 2007
    ..These results suggest that PI3K-independent activation of ERK compensates the lack of signal input from the PI3K-Akt pathway to achieve EPO-induced protection in the remodeled myocardium...
  45. ncbi request reprint Cardiac mortality assessment improved by evaluation of cardiac sympathetic nerve activity in combination with hemoglobin and kidney function in chronic heart failure patients
    Takahiro Doi
    Second Department of Internal Medicine Cardiology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Nucl Med 53:731-40. 2012
    ....
  46. ncbi request reprint Angiotensin II receptor activation in youth triggers persistent insulin resistance and hypertension--a legacy effect?
    Nobuhiko Togashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Hypertens Res 35:334-40. 2012
    ..These findings suggest that Ang II receptor activation in youth triggers the upregulation of inflammatory cytokines and the production of reactive oxygen species, thereby inducing later insulin resistance and hypertension...
  47. ncbi request reprint Blockade of the Na+-Ca2+ exchanger is more efficient than blockade of the Na+-H+ exchanger for protection of the myocardium from lethal reperfusion injury
    Tomoaki Matsumoto
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Cardiovasc Drugs Ther 16:295-301. 2002
    ..3 microM KBR upon reperfusion. These results suggest that lethal reperfusion injury is more efficiently suppressed by blockade of the NCX than by blockade of the NHE...
  48. ncbi request reprint Erythropoietin (EPO) affords more potent cardioprotection by activation of distinct signaling to mitochondrial kinases compared with carbamylated EPO
    Takahiro Sato
    Division of Cardiology, Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Cardiovasc Drugs Ther 24:401-8. 2010
    ..The aim of this study was to examine differences between EPO and CEPO in efficacy of cardioprotection against infarction and in activation of pro-survival kinases...
  49. pmc Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure
    Masaya Tanno
    Department of Pharmacology, Sapporo Medical University, Sapporo 060 8556, Japan
    J Biol Chem 285:8375-82. 2010
    ..SIRT1 activators such as resveratrol could be novel therapeutic tools for the treatment of chronic heart failure...
  50. ncbi request reprint Limitation of infarct size by erythropoietin is associated with translocation of Akt to the mitochondria after reperfusion
    Hironori Kobayashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Clin Exp Pharmacol Physiol 35:812-9. 2008
    ....
  51. ncbi request reprint Macrophage colony-stimulating factor treatment after myocardial infarction attenuates left ventricular dysfunction by accelerating infarct repair
    Toshiyuki Yano
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Am Coll Cardiol 47:626-34. 2006
    ..We aimed to determine the effects of macrophage colony-stimulating factor (M-CSF) and granulocyte colony-stimulating factor (G-CSF) treatment on both the repair process and ventricular function after myocardial infarction (MI)...
  52. pmc Elevation of fatty acid-binding protein 4 is predisposed by family history of hypertension and contributes to blood pressure elevation
    Hideki Ota
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Am J Hypertens 25:1124-30. 2012
    ..Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, and atherosclerosis. However, little is known about the role of FABP4 in essential hypertension...
  53. ncbi request reprint Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection
    Yasuhiro Nishino
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 west 1, Chou ku Sapparo 060 8543, Japan
    Cardiovasc Res 61:610-9. 2004
    ..The aim of this study was to determine the role of AMP-activated protein kinase (AMPK) and its link to protein kinase C (PKC) in the late phase of cardioprotection afforded by ischemic preconditioning (PC) against myocardial stunning...
  54. ncbi request reprint Quantitative assessment of left ventricular and left atrial functions by strain rate imaging in diabetic patients with and without hypertension
    Atsuko Muranaka
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Echocardiography 26:262-71. 2009
    ..The aim of this study was to quantitatively assess LA function in diabetic patients with and without HT in combination with LV function...
  55. ncbi request reprint Reduction of endoplasmic reticulum stress by 4-phenylbutyric acid prevents the development of hypoxia-induced pulmonary arterial hypertension
    Masayuki Koyama
    Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan and
    Am J Physiol Heart Circ Physiol 306:H1314-23. 2014
    ..The findings indicate that activation of all branches of the UPR and accompanying inflammation play a major role in the pathogenesis of PAH, and that chemical chaperones are potentially therapeutic agents for PAH. ..
  56. ncbi request reprint Assessment of left ventricular ejection fraction using long-axis systolic function is independent of image quality: a study of tissue Doppler imaging and m-mode echocardiography
    Satoshi Yuda
    Department of Diagnostic Ultrasound and Medical Electronics, Sapporo Medical University School of Medicine, Sapporo, Japan
    Echocardiography 23:846-52. 2006
    ..Furthermore, mitral annulus sites are easy to identify even in patients with poor IQ. The purpose of this study was to determine whether these methods are useful for estimating LVEF in patients with poor IQ...
  57. ncbi request reprint Granulocyte colony stimulating factor/macrophage colony stimulating factor improves postinfarct ventricular function by suppression of border zone remodelling in rats
    Takayuki Miki
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Clin Exp Pharmacol Physiol 31:873-82. 2004
    ..4. The results suggest that G-CSF/M-CSF treatment improves contractile function of the ventricle after infarction, presumably by acceleration of infarct repair and suppression of remodelling in the border zone...
  58. ncbi request reprint Visceral obesity in Japanese patients with metabolic syndrome: reappraisal of diagnostic criteria by CT scan
    Mariko Eguchi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Hypertens Res 30:315-23. 2007
    ..AC(M) of 78 cm appears to be a cutoff level suitable for diagnosing visceral obesity in Japanese females, though further confirmation is needed...
  59. ncbi request reprint Noninvasive assessment of left atrial function by strain rate imaging in patients with hypertension: a possible beneficial effect of renin-angiotensin system inhibition on left atrial function
    Nobuaki Kokubu
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Hypertens Res 30:13-21. 2007
    ..SR imaging can detect LA dysfunction in HT patients and is useful for evaluation of the therapeutic benefit on LA reservoir function...
  60. ncbi request reprint Type 2 diabetes induces subendocardium-predominant reduction in transient outward K+ current with downregulation of Kv4.2 and KChIP2
    Tatsuya Sato
    Department of Cellular Physiology and Signal Transduction, Sapporo Medical University School of Medicine, Sapporo, Japan
    Am J Physiol Heart Circ Physiol 306:H1054-65. 2014
    ..2 and KChIP2 may be involved. Increased Iroquois homeobox 5 expression may underlie Kv4.2 downregulation in T2DM...
  61. pmc Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein
    Atsushi Kuno
    Department of Pharmacology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Biol Chem 288:5963-72. 2013
    ..These findings indicate the pathological significance of p300 up-regulation in the dystrophic heart and indicate that SIRT1 activation has therapeutic potential for dystrophic cardiomyopathy...
  62. ncbi request reprint Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy
    Yusuke S Hori
    Department of Pharmacology, School of Medicine, Sapporo Medical University, Sapporo, Japan
    J Pharmacol Exp Ther 338:784-94. 2011
    ..SIRT1 small interfering RNA also increased the expression of Nox4, p47(phox), and α-SMA in C2C12 cells. Taken together, these findings indicate that SIRT1 activation may be a useful strategy for treating muscular dystrophies...
  63. ncbi request reprint Long-term outcome of implanted cardioverter defibrillators in survivors of out-of-hospital cardiac arrest of cardiac origin
    Daigo Nagahara
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Circ J 70:1128-32. 2006
    ..Little is known about the long-term outcome of implantable cardioverter defibrillator (ICD) therapy in survivors of out-of-hospital cardiac arrest (OHCA)...
  64. ncbi request reprint Assessment of left atrial deformation and synchrony by three-dimensional speckle-tracking echocardiography: comparative studies in healthy subjects and patients with atrial fibrillation
    Atsushi Mochizuki
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Am Soc Echocardiogr 26:165-74. 2013
    ..The aim of this study was to examine whether left atrial (LA) strain and synchrony can be assessed using three-dimensional (3D) speckle-tracking echocardiography (STE) and how 3D STE parameters are modified by atrial fibrillation (AF)...
  65. ncbi request reprint Intracardiac fibroblasts, but not bone marrow derived cells, are the origin of myofibroblasts in myocardial infarct repair
    Toshiyuki Yano
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo 060 8543, Japan
    Cardiovasc Pathol 14:241-6. 2005
    ....
  66. ncbi request reprint Persistent insulin-sensitizing effects of sarpogrelate hydrochloride, a serotonin 2A receptor antagonist, in patients with peripheral arterial disease
    Nobuaki Kokubu
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 060 0061, Japan
    Circ J 70:1451-6. 2006
    ..In the present study the persistent insulin-sensitizing effects of sarpogrelate were investigated in non-diabetic and non-medicated diabetic patients with peripheral artery disease (PAD)...
  67. ncbi request reprint Effects of parental hypertension on longitudinal trends in blood pressure and plasma metabolic profile: mixed-effects model analysis
    Kaneto Mitsumata
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Sapporo 060 8556, Japan
    Hypertension 60:1124-30. 2012
    ....
  68. ncbi request reprint Effects of neutral endopeptidase 24.11 inhibition on myocardial infarct size and ischemic preconditioning in rabbits
    Atsushi Nakano
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo, 060 8556 Japan
    Naunyn Schmiedebergs Arch Pharmacol 366:335-42. 2002
    ..The results of the present study suggest that NEP inhibition does not increase anti-infarct tolerance of the myocardium but significantly enhances cardioprotection of PC via a B(2) receptor-mediated mechanism...
  69. ncbi request reprint Deterioration of renal function by chronic heart failure is associated with congestion and oxidative stress in the tubulointerstitium
    Marenao Tanaka
    The Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan
    Intern Med 50:2877-87. 2011
    ..We examined the hypothesis that renal congestion is responsible for the decline in renal function in patients with heart failure (HF) via tubulointerstitial inflammation...
  70. ncbi request reprint Clinical pathology and treatment of renin-angiotensin system 4. Renin-angiotensin system and insulin resistance
    Kazuaki Shimamoto
    The Second Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Intern Med 46:1303-4. 2007
  71. ncbi request reprint [Treatment for hypertension with metabolic disorders (DM etc)]
    Kazuaki Shimamoto
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine
    Nihon Rinsho 64:513-9. 2006
  72. ncbi request reprint Left ventricular hypertrophy causes different changes in longitudinal, radial, and circumferential mechanics in patients with hypertension: a two-dimensional speckle tracking study
    Hidemichi Kouzu
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Am Soc Echocardiogr 24:192-9. 2011
    ..The aim of this study was to investigate three-directional systolic function and its relationships with left ventricular geometry in asymptomatic hypertensive patients using two-dimensional speckle-tracking imaging...
  73. pmc Emerging beneficial roles of sirtuins in heart failure
    Masaya Tanno
    Second Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Basic Res Cardiol 107:273. 2012
    ..Emerging evidence indicates that the two sirtuins play protective roles in failing hearts. Here, we summarize current knowledge of sirtuin functions in the heart and discuss its translation into therapy for heart failure...
  74. ncbi request reprint Fusion of bone marrow-derived cells with renal tubules contributes to renal dysfunction in diabetic nephropathy
    Tomohisa Yamashita
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    FASEB J 26:1559-68. 2012
    ..These in vivo findings were confirmed by in vitro coculture experiments between isolated renal tubular cells and BMDCs. It was concluded that cell fusion between BMDCs and renal tubular epithelial cells plays a crucial role in DN...
  75. ncbi request reprint Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
    Masaya Tanno
    Department of Pharmacology, Sapporo Medical University, Japan
    J Biol Chem 282:6823-32. 2007
    ..These findings indicate that nucleocytoplasmic shuttling is a novel regulatory mechanism of SIRT1, which may participate in differentiation and in inhibition of cell death...
  76. ncbi request reprint Blockade of angiotensin II type 1 receptors suppressed free radical production and preserved coronary endothelial function in the rabbit heart after myocardial infarction
    Atsushi Kuno
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, Japan
    J Cardiovasc Pharmacol 39:49-57. 2002
    ..In conclusion, long-term AT1 receptor blockade after infarction protects the coronary arteries from endothelial vasomotor dysfunction through suppression of free radical production...
  77. ncbi request reprint [Anti-ischemic tolerance and preconditioning]
    Tetsuji Miura
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine
    Nihon Rinsho 61:142-7. 2003
  78. ncbi request reprint Quantitative measurement of circumferential carotid arterial strain by two-dimensional speckle tracking imaging in healthy subjects
    Satoshi Yuda
    Department of Clinical Laboratory Medicine Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Echocardiography 28:899-906. 2011
    ..We investigated the feasibility and reproducibility of measuring CAS by 2DS and determinants of CAS in healthy subjects...
  79. pmc Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 6:e27356. 2011
    ..We tested the hypothesis that FABP4 level predicts prognosis of patients with end-stage renal disease (ESRD), a group at high risk for atherosclerosis-associated morbidity and mortality...
  80. ncbi request reprint Development and progression of atherosclerotic disease in relation to insulin resistance and hyperinsulinemia
    Tadashi Fujiwara
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Hypertens Res 28:665-70. 2005
    ..The results suggested that insulin resistance is an independent risk factor for coronary artery disease in Japanese subjects, as has also been demonstrated in the case of individuals in Europe and USA...
  81. ncbi request reprint Effect of protein kinase C inhibitors on cardioprotection by ischemic preconditioning depends on the number of preconditioning episodes
    T Miura
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan
    Cardiovasc Res 37:700-9. 1998
    ..This study examined the possibility that the role of PKC in [corrected] PC, and thus the response to PFC inhibitors, may differ depending on how many ischemic episodes are employed to precondition the heart...
  82. ncbi request reprint [Tanno-Sobetsu chou study]
    Kazuaki Shimamoto
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine
    Nihon Rinsho 64:104-7. 2006
  83. ncbi request reprint [Metabolic syndrome]
    Kazuaki Shimamoto
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine
    Nihon Rinsho 67:771-6. 2009
    ..Improvements of these adipocytokines dysfunction by ARB may concern tothe improvement of insulin resistance. The significance of various adipocytokines in insulin resistance and metabolic syndrome is also introduced...
  84. ncbi request reprint Contribution of both the sarcolemmal K(ATP) and mitochondrial K(ATP) channels to infarct size limitation by K(ATP) channel openers: differences from preconditioning in the role of sarcolemmal K(ATP) channels
    M Tanno
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South-1 West-16, Chuo-ku, Sapporo 060-8543, Japan
    Naunyn Schmiedebergs Arch Pharmacol 364:226-32. 2001
    ..Neither HMR1098 nor 5-HD alone modified infarct size. In conclusion, both sarcK(ATP) and mitoK(ATP) channels may contribute to the anti-infarct tolerance afforded by pinacidil and diazoxide...
  85. ncbi request reprint Role of adiponectin in insulin-resistant hypertension and atherosclerosis
    Hideyuki Murakami
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S L, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Hypertens Res 26:705-10. 2003
    ....
  86. ncbi request reprint Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain
    Jun Sakamoto
    Department of Pharmacology, Sapporo Medical University, School of Medicine, S1 W17, Chuo Ku, 060 8556, Sapporo, Japan
    FEBS Lett 556:281-6. 2004
    ..These results suggest new roles of Sir2alpha not only in early embryogenesis but also in cardiogenesis and neurogenesis with a stage-specific manner...
  87. ncbi request reprint Sonoclot coagulation analysis: new bedside monitoring for determination of the appropriate heparin dose during haemodialysis
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Nephrol Dial Transplant 17:1457-62. 2002
    ..We investigated whether a new bedside Sonoclot analysis is useful for determining an appropriate heparin dose during haemodialysis...
  88. ncbi request reprint Early defibrillation and circulatory support can provide better long-term outcomes through favorable neurological recovery in patients with out-of-hospital cardiac arrest of cardiac origin
    Mamoru Hase
    Division of Traumatology and Critical Care Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Circ J 69:1302-7. 2005
    ..The effects of early recovery of circulation (ROC) on neurological recovery and the long-term outcome in patients with OHCA were examined...
  89. ncbi request reprint Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction
    A Tsuchida
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan
    Basic Res Cardiol 96:446-53. 2001
    ..The present study was designed to assess the relationship between the timing of a mitoK(ATP) channel opener, diazoxide, and its infarct size-limiting effect...
  90. ncbi request reprint Limitation of myocardial infarct size by adenosine A1 receptor activation is abolished by protein kinase C inhibitors in the rabbit
    J Sakamoto
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Cardiovasc Res 29:682-8. 1995
    ..The aim was to test whether infarct size limitation by adenosine A1 receptor activation is mediated by protein kinase C...
  91. ncbi request reprint Time window for the contribution of the delta-opioid receptor to cardioprotection by ischemic preconditioning in the rat heart
    A Tsuchida
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Cardiovasc Drugs Ther 12:365-73. 1998
    ....
  92. ncbi request reprint Progression of myocardial infarction in a collateral flow deficient species
    T Miura
    Second Department of Internal Medicine, Sapporo Medical College, Japan
    Jpn Heart J 30:695-708. 1989
    ..Unlike in the dog heart, the infarct of the rabbit heart first appears in the midmyocardium and then progresses towards both the endocardium and epicardium...
  93. ncbi request reprint Hepatocyte growth factor and 24-hour ambulatory blood pressure monitoring
    Yoshihito Hayashi
    Second Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Hypertens Res 25:655-60. 2002
    ..05). The results indicated that there is a relationship between blood pressure measured by ABPM and serum HGF concentration, and that this relationship might be an index of damage to blood vessels in patients with hypertension...
  94. ncbi request reprint Strain rate imaging for noninvasive functional quantification of the left atrium: comparative studies in controls and patients with atrial fibrillation
    Yoshie Inaba
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Am Soc Echocardiogr 18:729-36. 2005
    ..7 +/- 0.8 vs 2.9 +/- 0.9 s -1 ; P < .01). Based on our findings, we conclude that noninvasive quantification of LA function using SR imaging enables evaluation of LA dysfunction due to aging and LA dilatation...
  95. ncbi request reprint [Cardioprotective mechanism of ischemic preconditioning is impaired by postinfarct ventricular remodeling through angiotensin II type 1 receptor activation]
    T Miki
    Second Department of Internal Medicine, Sapporo Medical University, Sapporo
    J Cardiol 37:112-3. 2001
    ..An angiotensin II type 1 receptor blocker is beneficial not only for suppression of ventricular remodeling but also for preservation of the preconditioning mechanism...
  96. ncbi request reprint Role of adenosine receptor activation in myocardial infarct size limitation by ischaemic preconditioning
    A Tsuchida
    Second Department of Internal Medicine, Sapporo Medical College, Japan
    Cardiovasc Res 26:456-61. 1992
    ....
  97. ncbi request reprint Nucleoside transport inhibitors enhance the infarct size-limiting effect of ischemic preconditioning
    M Itoya
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    J Cardiovasc Pharmacol 24:846-52. 1994
    ..5 +/- 5.0% after low-dose dilazep plus PC, 27.6 +/- 4.9% after high-dose dilazep plus PC, and 19.9 +/- 3.6%, after R75231 plus PC).(ABSTRACT TRUNCATED AT 250 WORDS)..
  98. ncbi request reprint [Ischemic heart disease]
    Masahiro Nishihara
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine
    Nihon Rinsho 63:422-5. 2005
  99. ncbi request reprint [Hypertension]
    Kazuaki Shimamoto
    Second Department of Internal Medicine, Sapporo Medical University
    Nihon Rinsho 65:537-42. 2007
  100. ncbi request reprint Improvement of afterload mismatch of left atrial booster pump function with positive inotropic agent
    H Sakai
    Second Department of Internal Medicine, Yamaguchi University School of Medicine, Japan
    J Am Coll Cardiol 37:270-7. 2001
    ..CONCLUSIONS: Dobutamine improved the afterload mismatch of the LA booster pump function. This effect may have been due to the reduction in LV operational chamber stiffness, resulting in an increase in the LA forward ejection into the LV...
  101. ncbi request reprint Influence of timing and magnitude of arterial wave reflection on left ventricular relaxation
    M Yano
    Second Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Am J Physiol Heart Circ Physiol 280:H1846-52. 2001
    ..Thus the time at which WR returns during the cardiac cycle may have an important effect on left ventricular relaxation and coronary flow...