Tetsuji Miura


Affiliation: Sapporo Medical University
Country: Japan


  1. Miura T, Tanno M. The mPTP and its regulatory proteins: final common targets of signalling pathways for protection against necrosis. Cardiovasc Res. 2012;94:181-9 pubmed publisher
  2. Oshima H, Miki T, Kuno A, Mizuno M, Sato T, Tanno M, et al. Empagliflozin, an SGLT2 inhibitor, reduced the mortality rate after acute myocardial infarction with modification of cardiac metabolomes and anti-oxidants in diabetic rats. J Pharmacol Exp Ther. 2018;: pubmed publisher
    ..The results suggest that empagliflozin prevents DM-induced increase in post-MI mortality possibly by protective modification of cardiac energy metabolism and anti-oxidant proteins. ..
  3. Miki T, Tobisawa T, Sato T, Tanno M, Yano T, Akasaka H, et al. Does glycemic control reverse dispersion of ventricular repolarization in type 2 diabetes?. Cardiovasc Diabetol. 2014;13:125 pubmed publisher
    ..Increased heterogeneity of ventricular repolarization in type 2 diabetic patients was not reduced during the relatively short follow-up period despite significantly improved glycemic control. ..
  4. Tatekoshi Y, Tanno M, Kouzu H, Abe K, Miki T, Kuno A, et al. Translational regulation by miR-301b upregulates AMP deaminase in diabetic hearts. J Mol Cell Cardiol. 2018;119:138-146 pubmed publisher
    ..The miR-301b-AMPD3 axis may be a novel therapeutic target for intervening enegy metabolism in diabetic hearts. ..
  5. request reprint
    Miura T, Nishihara M, Miki T. Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in myocardial protection against ischemia/reperfusion injury. J Pharmacol Sci. 2009;109:162-7 pubmed
    ..Thus, GSK-3beta appears to be a target of novel therapy for cardioprotection upon reperfusion. ..
  6. Kouzu H, Miki T, Tanno M, Kuno A, Yano T, Itoh T, et al. Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart. J Mol Cell Cardiol. 2015;80:136-45 pubmed publisher
    ..These results suggest that ATP depletion due to excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies ventricular stiffening during acute pressure overloading in T2DM hearts. ..
  7. Yano T, Shimoshige S, Miki T, Tanno M, Mochizuki A, Fujito T, et al. Clinical impact of myocardial mTORC1 activation in nonischemic dilated cardiomyopathy. J Mol Cell Cardiol. 2016;91:6-9 pubmed publisher
  8. Nishizawa K, Yano T, Tanno M, Miki T, Kuno A, Tobisawa T, et al. Chronic Treatment With an Erythropoietin Receptor Ligand Prevents Chronic Kidney Disease-Induced Enlargement of Myocardial Infarct Size. Hypertension. 2016;68:697-706 pubmed publisher
    ..In conclusion, the results suggest that a CERA prevents CKD-induced susceptibility of the myocardium to ischemia/reperfusion injury by restoration of Akt-mediated signaling possibly via normalized malate-aspartate shuttle flux. ..
  9. Tobisawa T, Yano T, Tanno M, Miki T, Kuno A, Kimura Y, et al. Insufficient activation of Akt upon reperfusion because of its novel modification by reduced PP2A-B55α contributes to enlargement of infarct size by chronic kidney disease. Basic Res Cardiol. 2017;112:31 pubmed publisher

More Information


  1. request reprint
    Miura T, Yano T, Naitoh K, Nishihara M, Miki T, Tanno M, et al. Delta-opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-epsilon-mediated phosphorylation of connexin 43. Am J Physiol Heart Circ Physiol. 2007;293:H1425-31 pubmed
  2. Ohno K, Kuno A, Murase H, Muratsubaki S, Miki T, Tanno M, et al. Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal toll-like receptors in rats. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00205.2017 pubmed publisher
    ..The results suggest that DM increases susceptibility to AKI after acute MI by augmented activation of renal TLRs and that TLR1/TLR2-mediated signaling mediates KIM-1 upregulation after MI. ..
  3. Tanno M, Kuno A, Ishikawa S, Miki T, Kouzu H, Yano T, et al. Translocation of glycogen synthase kinase-3β (GSK-3β), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with voltage-dependent anion channel 2 (VDAC2). J Biol Chem. 2014;289:29285-96 pubmed publisher
    ..These results demonstrate that GSK-3β translocates from the cytosol to mitochondria in a kinase activity- and VDAC2-dependent manner in which an N-terminal domain of GSK-3β may function as a mitochondrial targeting sequence. ..
  4. Murase H, Kuno A, Miki T, Tanno M, Yano T, Kouzu H, et al. Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats. Cardiovasc Diabetol. 2015;14:103 pubmed publisher
    ..The results indicate that vildagliptin reduces T2DM-induced increase in post-MI acute mortality possibly by restoring the autophagic response through attenuation of Bcl-2-Beclin-1 interaction. ..
  5. Ogasawara M, Yano T, Tanno M, Abe K, Ishikawa S, Miki T, et al. Suppression of autophagic flux contributes to cardiomyocyte death by activation of necroptotic pathways. J Mol Cell Cardiol. 2017;108:203-213 pubmed publisher
    ..The mPTP is unlikely to play a major role in execution of necroptosis in cardiomyocytes. ..
  6. Muratsubaki S, Kuno A, Tanno M, Miki T, Yano T, Sugawara H, et al. Suppressed autophagic response underlies augmentation of renal ischemia/reperfusion injury by type 2 diabetes. Sci Rep. 2017;7:5311 pubmed publisher
    ..Collectively, these findings indicate that suppressed autophagic activation in proximal tubules by impaired AMPK/ULK1 signaling and upregulated mTORC1 activation underlies T2DM-induced worsening of renal I/R injury. ..