Hiroaki Mita

Summary

Affiliation: Sapporo Medical University
Country: Japan

Publications

  1. pmc A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth
    Hiroaki Mita
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    BMC Cancer 9:198. 2009
  2. ncbi request reprint Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells
    Ayumi Satoh
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Oncogene 23:8876-86. 2004
  3. ncbi request reprint Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer
    Ayumi Satoh
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Cancer Res 63:8606-13. 2003
  4. doi request reprint Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
    Mol Cancer Ther 7:779-87. 2008
  5. ncbi request reprint The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer
    Kimishige Akino
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Japan
    Gastroenterology 129:156-69. 2005
  6. doi request reprint A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells
    Masashi Idogawa
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    Clin Cancer Res 15:3725-32. 2009
  7. ncbi request reprint Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer
    Toshiro Obata
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    Clin Cancer Res 9:6410-8. 2003
  8. ncbi request reprint Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors
    Kazuhiro Ogi
    Department of Molecular Biology, Cancer Research Institute, Department of Oral Surgery, Sapporo Medical University, Sapporo, Japan
    Cancer Biol Ther 4:773-80. 2005
  9. ncbi request reprint Activation of the ribosomal protein L13 gene in human gastrointestinal cancer
    Toshihisa Kobayashi
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Int J Mol Med 18:161-70. 2006
  10. doi request reprint Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma
    Takashi Imai
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo 060 8543, Japan
    Cancer Sci 99:958-66. 2008

Collaborators

Detail Information

Publications20

  1. pmc A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth
    Hiroaki Mita
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    BMC Cancer 9:198. 2009
    ..In the current study, we used DGS to survey copy-number alterations in gastric cancer cells...
  2. ncbi request reprint Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells
    Ayumi Satoh
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Oncogene 23:8876-86. 2004
    ..It thus appears that CIITA methylation is a key mechanism that enables some gastrointestinal cancer cells to escape immune surveillance...
  3. ncbi request reprint Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer
    Ayumi Satoh
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Cancer Res 63:8606-13. 2003
    ..Moreover, the aberrant methylation of CHFR appears to be a good molecular marker with which to predict the sensitivity of gastric cancers to microtubule inhibitors...
  4. doi request reprint Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
    Mol Cancer Ther 7:779-87. 2008
    ..These results provide a strong rationale for combining p53 gene therapy and FK228 pretreatment in cancer therapy...
  5. ncbi request reprint The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer
    Kimishige Akino
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Japan
    Gastroenterology 129:156-69. 2005
    ..Our aim was to address that question by surveying genetic and epigenetic alterations of Ras-Ras effector genes in CRC cells...
  6. doi request reprint A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells
    Masashi Idogawa
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    Clin Cancer Res 15:3725-32. 2009
    ..However, p21 also has tumor-suppressive properties. In this study, we developed an adenovirus vector that expresses p53 and suppresses p21 simultaneously to enhance p53-mediated apoptosis...
  7. ncbi request reprint Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer
    Toshiro Obata
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    Clin Cancer Res 9:6410-8. 2003
    ..We found the proapoptotic gene HRK to be a target for hypermethylation in human cancers and examined the role of such methylation in silencing the gene's expression...
  8. ncbi request reprint Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors
    Kazuhiro Ogi
    Department of Molecular Biology, Cancer Research Institute, Department of Oral Surgery, Sapporo Medical University, Sapporo, Japan
    Cancer Biol Ther 4:773-80. 2005
    ..Our results suggest that CHFR could be a useful molecular target for chemotherapy...
  9. ncbi request reprint Activation of the ribosomal protein L13 gene in human gastrointestinal cancer
    Toshihisa Kobayashi
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Int J Mol Med 18:161-70. 2006
    ..We also found that increased expression of the L13 gene correlated with clinical staging in gastric cancers. The results of this study suggest that L13 plays an essential role in the progression of some gastrointestinal malignancies...
  10. doi request reprint Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma
    Takashi Imai
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo 060 8543, Japan
    Cancer Sci 99:958-66. 2008
    ..Our results suggest that epigenetic inactivation of RASSF2 plays an important role in OSCC tumorigenesis, and that RASSF2 may be a useful molecular target for the diagnosis and treatment of OSCC...
  11. doi request reprint Identification of flotillin-2, a major protein on lipid rafts, as a novel target of p53 family members
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Chuo Ku, Sapporo, 060 8556 Japan
    Mol Cancer Res 6:395-406. 2008
    ..Thus, in addition to direct transactivation, p53 family member genes enhance a set of cellular processes via lipid rafts...
  12. ncbi request reprint Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation
    Reo Maruyama
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Cancer Res 66:4574-83. 2006
    ..Our in silico approach is a powerful method for identification of functional p53 binding sites and p53 target genes that are conserved among humans and other organisms and for further understanding the function of p53 in tumorigenesis...
  13. pmc CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation
    Lisa Kashima
    Department of Medical Genome Sciences, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo 060 8556, Japan
    J Biol Chem 287:12975-84. 2012
    ..On the basis of our studies, we demonstrate a significant advantage for use of combinational chemotherapy with PARP inhibitors for cancer cells resistant to microtubule inhibitors...
  14. ncbi request reprint Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer
    Masako Ueno
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    Tumour Biol 25:134-40. 2004
    ..It thus appears that aberrant methylation of its 5'CGI and histone deacetylation play key roles in silencing SLC5A8 expression in gastric cancers...
  15. doi request reprint p53 family members regulate the expression of the apolipoprotein D gene
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
    J Biol Chem 284:872-83. 2009
    ..These results suggest that apoD induction may mediate the activity of p73 in normal development...
  16. ncbi request reprint Epigenetic inactivation of TMS1/ASC in ovarian cancer
    Katsuhiko Terasawa
    Departments of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan
    Clin Cancer Res 10:2000-6. 2004
    ....
  17. ncbi request reprint Hepatic portal venous gas in pancreatic solitary metastasis from an esophageal squamous cell carcinoma
    Takeshi Sawada
    Division of Gastroenterology, Sapporo Shirakaba dai Hospital, Sapporo, Japan
    Hepatobiliary Pancreat Dis Int 12:103-5. 2013
    ..Pancreatic solitary metastasis without local extension is also rare in esophageal squamous cell carcinoma...
  18. ncbi request reprint Identification of the interleukin 4 receptor alpha gene as a direct target for p73
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Res 63:8145-52. 2003
    ..We also found that p73beta-transfected tumor cells are sensitive to IL-4-mediated apoptosis. Our data suggest that IL-4Ralpha could mediate, in part, certain immune responses and p73-dependent cell death...
  19. pmc Epigenetic inactivation of CHFR in human tumors
    Minoru Toyota
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo 060 8556, Japan
    Proc Natl Acad Sci U S A 100:7818-23. 2003
    ..Taken together, these findings shed light on a pathway by which mitotic checkpoint is bypassed in cancer cells and suggest that inactivation of checkpoint genes is much more widespread than previously suspected...
  20. doi request reprint A case of Ménétrier's disease without Helicobacter pylori infection
    Takao Endo
    Department of Gastroenterology, Sapporo Shirakaba dai Hospital, Sapporo, Japan
    Dig Endosc 24:275-9. 2012
    ..The autopsy also distinguished this H. pylori-negative MD from hyperplastic polyp of the stomach, which is important in clarifying the entity of H. pylori-negative MD...