Research Topics
Genomes and Genes | Hiroaki MitaSummaryAffiliation: Sapporo Medical University Country: Japan Publications
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Publications
A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growthHiroaki Mita
Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
BMC Cancer 9:198. 2009..In the current study, we used DGS to survey copy-number alterations in gastric cancer cells...
Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cellsAyumi Satoh
First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
Oncogene 23:8876-86. 2004..It thus appears that CIITA methylation is a key mechanism that enables some gastrointestinal cancer cells to escape immune surveillance...- Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancerAyumi Satoh
First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
Cancer Res 63:8606-13. 2003..Moreover, the aberrant methylation of CHFR appears to be a good molecular marker with which to predict the sensitivity of gastric cancers to microtubule inhibitors... 
Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer modelsYasushi Sasaki
Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
Mol Cancer Ther 7:779-87. 2008..These results provide a strong rationale for combining p53 gene therapy and FK228 pretreatment in cancer therapy...- The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancerKimishige Akino
First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Japan
Gastroenterology 129:156-69. 2005..Our aim was to address that question by surveying genetic and epigenetic alterations of Ras-Ras effector genes in CRC cells... - A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cellsMasashi Idogawa
Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
Clin Cancer Res 15:3725-32. 2009..However, p21 also has tumor-suppressive properties. In this study, we developed an adenovirus vector that expresses p53 and suppresses p21 simultaneously to enhance p53-mediated apoptosis... - Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancerToshiro Obata
First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
Clin Cancer Res 9:6410-8. 2003..We found the proapoptotic gene HRK to be a target for hypermethylation in human cancers and examined the role of such methylation in silencing the gene's expression... - Activation of the ribosomal protein L13 gene in human gastrointestinal cancerToshihisa Kobayashi
First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
Int J Mol Med 18:161-70. 2006..We also found that increased expression of the L13 gene correlated with clinical staging in gastric cancers. The results of this study suggest that L13 plays an essential role in the progression of some gastrointestinal malignancies... - Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitorsKazuhiro Ogi
Department of Molecular Biology, Cancer Research Institute, Department of Oral Surgery, Sapporo Medical University, Sapporo, Japan
Cancer Biol Ther 4:773-80. 2005..Our results suggest that CHFR could be a useful molecular target for chemotherapy... - Identification of flotillin-2, a major protein on lipid rafts, as a novel target of p53 family membersYasushi Sasaki
Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Chuo Ku, Sapporo, 060 8556 Japan
Mol Cancer Res 6:395-406. 2008..Thus, in addition to direct transactivation, p53 family member genes enhance a set of cellular processes via lipid rafts... - Epigenetic inactivation of RASSF2 in oral squamous cell carcinomaTakashi Imai
Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo 060 8543, Japan
Cancer Sci 99:958-66. 2008..Our results suggest that epigenetic inactivation of RASSF2 plays an important role in OSCC tumorigenesis, and that RASSF2 may be a useful molecular target for the diagnosis and treatment of OSCC... - Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activationReo Maruyama
First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
Cancer Res 66:4574-83. 2006..Our in silico approach is a powerful method for identification of functional p53 binding sites and p53 target genes that are conserved among humans and other organisms and for further understanding the function of p53 in tumorigenesis... - CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradationLisa Kashima
Department of Medical Genome Sciences, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo 060 8556, Japan
J Biol Chem 287:12975-84. 2012..On the basis of our studies, we demonstrate a significant advantage for use of combinational chemotherapy with PARP inhibitors for cancer cells resistant to microtubule inhibitors... - Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancerMasako Ueno
First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
Tumour Biol 25:134-40. 2004..It thus appears that aberrant methylation of its 5'CGI and histone deacetylation play key roles in silencing SLC5A8 expression in gastric cancers... - p53 family members regulate the expression of the apolipoprotein D geneYasushi Sasaki
Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
J Biol Chem 284:872-83. 2009..These results suggest that apoD induction may mediate the activity of p73 in normal development... - Epigenetic inactivation of TMS1/ASC in ovarian cancerKatsuhiko Terasawa
Departments of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan
Clin Cancer Res 10:2000-6. 2004.... - Identification of the interleukin 4 receptor alpha gene as a direct target for p73Yasushi Sasaki
Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, Sapporo, Japan
Cancer Res 63:8145-52. 2003..We also found that p73beta-transfected tumor cells are sensitive to IL-4-mediated apoptosis. Our data suggest that IL-4Ralpha could mediate, in part, certain immune responses and p73-dependent cell death... - Epigenetic inactivation of CHFR in human tumorsMinoru Toyota
Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo 060 8556, Japan
Proc Natl Acad Sci U S A 100:7818-23. 2003..Taken together, these findings shed light on a pathway by which mitotic checkpoint is bypassed in cancer cells and suggest that inactivation of checkpoint genes is much more widespread than previously suspected... - A case of Ménétrier's disease without Helicobacter pylori infectionTakao Endo
Department of Gastroenterology, Sapporo Shirakaba dai Hospital, Sapporo, Japan
Dig Endosc 24:275-9. 2012..The autopsy also distinguished this H. pylori-negative MD from hyperplastic polyp of the stomach, which is important in clarifying the entity of H. pylori-negative MD...