Takashi Kojima

Summary

Affiliation: Sapporo Medical University
Country: Japan

Publications

  1. doi request reprint Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells
    Kazuaki Nomura
    Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Respir Res 15:21. 2014
  2. ncbi request reprint Expression of tricellulin in epithelial cells and non-epithelial cells
    Takashi Kojima
    Department of Cell Science, Research Institute of Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Histol Histopathol 28:1383-92. 2013
  3. pmc Regulation of tight junctions in upper airway epithelium
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Biomed Res Int 2013:947072. 2013
  4. doi request reprint Targeting claudin-4 in human pancreatic cancer
    Takashi Kojima
    Sapporo Medical University School of Medicine, Department of Pathology, Sapporo, Japan
    Expert Opin Ther Targets 16:881-7. 2012
  5. doi request reprint Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Japan
    Ann N Y Acad Sci 1257:85-92. 2012
  6. ncbi request reprint Tight junction proteins and signal transduction pathways in hepatocytes
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Histol Histopathol 24:1463-72. 2009
  7. doi request reprint Downregulation of tight junction-associated MARVEL protein marvelD3 during epithelial-mesenchymal transition in human pancreatic cancer cells
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Cell Res 317:2288-98. 2011
  8. ncbi request reprint Inhibition of MAP kinase activity moderates changes in expression and function of Cx32 but not claudin-1 during DNA synthesis in primary cultures of rat hepatocytes
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, S1, W17, Sapporo 060 8556, Japan
    Med Electron Microsc 37:101-13. 2004
  9. ncbi request reprint Role of the p38 MAP-kinase signaling pathway for Cx32 and claudin-1 in the rat liver
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Commun Adhes 10:437-43. 2003
  10. doi request reprint c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Cell Physiol 225:720-33. 2010

Detail Information

Publications103 found, 100 shown here

  1. doi request reprint Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells
    Kazuaki Nomura
    Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Respir Res 15:21. 2014
    ..P. aeruginosa is also implicated in prolonged chronic rhinosinusitis. However, the effects of P. aeruginosa elastase (PE) against the barrier formed by human nasal epithelial cells (HNECs) remain unknown...
  2. ncbi request reprint Expression of tricellulin in epithelial cells and non-epithelial cells
    Takashi Kojima
    Department of Cell Science, Research Institute of Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Histol Histopathol 28:1383-92. 2013
    ....
  3. pmc Regulation of tight junctions in upper airway epithelium
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Biomed Res Int 2013:947072. 2013
    ..This paper summarizes the recent progress in our understanding of the regulation of tight junctions in the upper airway epithelium under normal, allergic, and RSV-infected conditions...
  4. doi request reprint Targeting claudin-4 in human pancreatic cancer
    Takashi Kojima
    Sapporo Medical University School of Medicine, Department of Pathology, Sapporo, Japan
    Expert Opin Ther Targets 16:881-7. 2012
    ..The cytotoxic effects of CPE and monoclonal antibodies against claudin-4 are useful as novel therapeutic tools for pancreatic cancer...
  5. doi request reprint Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Japan
    Ann N Y Acad Sci 1257:85-92. 2012
    ..In the marvel family of normal HPDE cells and pancreatic cancer cells, tricellulin was upregulated via a c-Jun N-terminal kinase pathway, and marvelD3 was downregulated during Snail-induced epithelial-mesenchymal transition...
  6. ncbi request reprint Tight junction proteins and signal transduction pathways in hepatocytes
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Histol Histopathol 24:1463-72. 2009
    ..This review focuses on recent findings about the relationship between tight junction proteins and signal transduction pathways in hepatocytes...
  7. doi request reprint Downregulation of tight junction-associated MARVEL protein marvelD3 during epithelial-mesenchymal transition in human pancreatic cancer cells
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Cell Res 317:2288-98. 2011
    ..In conclusion, marvelD3 is transcriptionally downregulated in Snail-induced EMT during the progression for the pancreatic cancer...
  8. ncbi request reprint Inhibition of MAP kinase activity moderates changes in expression and function of Cx32 but not claudin-1 during DNA synthesis in primary cultures of rat hepatocytes
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, S1, W17, Sapporo 060 8556, Japan
    Med Electron Microsc 37:101-13. 2004
    ..Furthermore, Cx32, but not claudin-1, protein may be a target of activated MAP kinase in hepatocytes...
  9. ncbi request reprint Role of the p38 MAP-kinase signaling pathway for Cx32 and claudin-1 in the rat liver
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Commun Adhes 10:437-43. 2003
    ..Changes of gap and tight junctions during liver regeneration and cholestasis are shown to be in part controlled via the p38 MAP-kinase signaling pathway and are independent of cell growth...
  10. doi request reprint c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Cell Physiol 225:720-33. 2010
    ....
  11. ncbi request reprint Transforming growth factor-beta induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Liver Int 28:534-45. 2008
    ..In mature hepatocytes during EMT induced by TGF-beta, changes in the expression of tight junction proteins and the fence function indicated that epithelial cell polarity remains unclear...
  12. doi request reprint Expression and function of claudins in hepatocytes
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Methods Mol Biol 762:233-44. 2011
    ....
  13. ncbi request reprint Regulation of the blood-biliary barrier: interaction between gap and tight junctions in hepatocytes
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, S1, W17, Sapporo 060 8556, Japan
    Med Electron Microsc 36:157-64. 2003
    ..In this review, we introduce the interaction and regulation between gap and tight junctions of hepatocytes in vitro and discuss the regulatory mechanisms of the "blood-biliary barrier" to study the molecular pathogenesis of cholestasis...
  14. ncbi request reprint Connexins induce and maintain tight junctions in epithelial cells
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Membr Biol 217:13-9. 2007
    ..These results suggest that connexins can induce and maintain tight junctions in both GJIC-dependent and -independent manners in epithelial cells...
  15. ncbi request reprint Cx32 but not Cx26 is associated with tight junctions in primary cultures of rat hepatocytes
    T Kojima
    Department of Pathology, Cancer Research Institute, Sapporo, 060 8556, Japan
    Exp Cell Res 263:193-201. 2001
    ....
  16. ncbi request reprint TPA induced expression and function of human connexin 26 by post-translational mechanisms in stably transfected neuroblastoma cells
    T Kojima
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, USA
    Cell Struct Funct 24:435-41. 1999
    ..These results suggest that induction of exogenous Cx26 in neuroblastoma cells by TPA treatment is controlled by post-translational mechanisms...
  17. ncbi request reprint Cx32 formation and/or Cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytic cell line
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 276:40-51. 2002
    ..These results indicate that Cx32 formation and/or Cx32-mediated intercellular communication may participate in the formation of functional tight junctions and actin organization...
  18. ncbi request reprint Growth-suppressive function of human connexin32 in a conditional immortalized mouse hepatocyte cell line
    T Kojima
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    In Vitro Cell Dev Biol Anim 37:589-98. 2001
    ..Cx32 transfectants using a conditional immortalized mouse hepatocyte may be useful for examining the mechanisms of growth and differentiation in hepatocytes by gap junction expression...
  19. ncbi request reprint p38 MAP-kinase regulates function of gap and tight junctions during regeneration of rat hepatocytes
    Toshinobu Yamamoto
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17, Sapporo 060 8556, Japan
    J Hepatol 42:707-18. 2005
    ..The role of the stress responsitive MAP-kinase, p38 MAP-kinase, signaling pathway in function of gap and tight junctions was examined during regeneration of rat hepatocytes in vivo and in vitro...
  20. ncbi request reprint Phosphorylation of ezrin enhances microvillus length via a p38 MAP-kinase pathway in an immortalized mouse hepatic cell line
    Mengdong Lan
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17 Sapporo 060 8556, Japan
    Exp Cell Res 312:111-20. 2006
    ..These results suggested that phosphorylation of ezrin via the p38 MAP-kinase signaling pathway might be involved in the formation of microvilli during development of epithelial cell polarization...
  21. ncbi request reprint IL-1beta regulates expression of Cx32, occludin, and claudin-2 of rat hepatocytes via distinct signal transduction pathways
    Toshinobu Yamamoto
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Cell Res 299:427-41. 2004
    ..These results demonstrate that MAP-kinase, p38 MAP-kinase, and PI3-kinase are distinctly involved in the regulation of hepatic gap and tight junctions during the acute-phase response to IL-1beta...
  22. ncbi request reprint Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis
    Masaki Murata
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Tissue Res 319:341-7. 2005
    ..These results suggest that Cx32 expression is in part related to induction of tight junctions through modulation of MAGI-1 expression in an immortalized mouse hepatic cell line...
  23. ncbi request reprint Changes of gap and tight junctions during differentiation of human nasal epithelial cells using primary human nasal epithelial cells and primary human nasal fibroblast cells in a noncontact coculture system
    Jun ichi Koizumi
    Department of Otolaryngology, Sapporo Medical University School of Medicine, S1 W17, Sapporo, Japan
    J Membr Biol 218:1-7. 2007
    ....
  24. ncbi request reprint Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions
    Masafumi Imamura
    Department of Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Cell Res 313:1951-62. 2007
    ..These results suggest that expression of claudin-2 in rodent hepatocytes may play a specific role as controlling the size of paracellular permeability in the barrier to keep bile in bile canaculi...
  25. doi request reprint Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro
    Tsuyoshi Ohkuni
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Med Mol Morphol 42:204-11. 2009
    ....
  26. doi request reprint Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells
    Tsuyoshi Ohkuni
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Toxicol Appl Pharmacol 250:29-38. 2011
    ..The control of TLR3-mediated signaling pathways in HNECs may be important not only in infection by viral dsRNA but also in autoimmune diseases caused by endogenous dsRNA released from necrotic cells...
  27. ncbi request reprint Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells
    Satoshi Hirakawa
    Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Med Virol 85:2141-50. 2013
    ..MMP-10 may play an important role in the pathogenesis of RSV diseases and it has the potential to be a novel marker and therapeutic target for RSV infection...
  28. ncbi request reprint Connexin 26 expression prevents down-regulation of barrier and fence functions of tight junctions by Na+/K+-ATPase inhibitor ouabain in human airway epithelial cell line Calu-3
    Mitsuru Go
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17 Sapporo 060 8556, Japan
    Exp Cell Res 312:3847-56. 2006
    ..These results suggest that Cx26 expression, but not the mediated intercellular communication, may regulate tight junction barrier and fence functions in human airway epithelial cell line Calu-3...
  29. pmc The nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilli
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Cell Biol 175:971-80. 2006
    ..We conclude that HNF4alpha acts as a morphogen to trigger microvillus formation...
  30. ncbi request reprint Oncogenic Raf-1 regulates epithelial to mesenchymal transition via distinct signal transduction pathways in an immortalized mouse hepatic cell line
    Mengdong Lan
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17, Sapporo 060 8556, Japan
    Carcinogenesis 25:2385-95. 2004
    ..Expression and localization of occludin recovered slightly on treatment with PP2. Thus, oncogenic Raf-1 regulates EMT via distinct MAP kinase, p38 MAP kinase and c-Src tyrosine kinase signal pathways in the mouse hepatic cell line...
  31. doi request reprint Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells
    Ryuta Kamekura
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Tissue Res 338:283-93. 2009
    ....
  32. ncbi request reprint Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP
    Tamotsu Soma
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 300:202-12. 2004
    ..cAMP decreased the claudin-5-based endothelial barrier, strongly suggesting that other tight-junction molecule(s) are required to elevate endothelial barrier functions in response to cAMP...
  33. ncbi request reprint Induction of claudins in passaged hTERT-transfected human nasal epithelial cells with an extended life span
    Makoto Kurose
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Tissue Res 330:63-74. 2007
    ..Our results indicate that hTERT-transfected human nasal epithelial cells with an extended lifespan can be used as an indispensable and stable model for studying the regulation of claudins in human nasal epithelium...
  34. ncbi request reprint Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4alpha
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 302:11-21. 2005
    ....
  35. doi request reprint PPARgamma agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells
    Noriko Ogasawara
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Pharmacol Res 61:489-98. 2010
    ....
  36. doi request reprint Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancer cells
    Tatsuya Ito
    Department of Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Cell Biochem 112:1761-72. 2011
    ..Our findings suggest that in human pancreatic cancer cells, Cldn18 is primarily regulated at the transcriptional level via specific PKC signaling pathways and modified by DNA methylation...
  37. pmc Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells
    Kazufumi Obata
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 8:e70225. 2013
    ....
  38. doi request reprint Protein kinase Cα inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer
    Daisuke Kyuno
    Department of Surgery, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Carcinogenesis 34:1232-43. 2013
    ..Thus, PKCα inhibitors may be potential therapeutic agents against the malignancy of human pancreatic cancer cells...
  39. pmc Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells
    Hiroshi Yamaguchi
    Department of Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Am J Pathol 177:698-712. 2010
    ..Treatment with small interfering RNAs of ELF3 prevented up-regulation of claudin-7 by TPA. These data suggest that tight junctions of normal HPDE cells were at least in part regulated via a PKC signal pathway by transcriptional control...
  40. ncbi request reprint Expression profiles and functional implications of p53-like transcription factors in thymic epithelial cell subtypes
    Tomoki Kikuchi
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Int Immunol 16:831-41. 2004
    ....
  41. doi request reprint Protein kinase Cα inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4
    Daisuke Kyuno
    Department of Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Tissue Res 346:369-81. 2011
    ..PKCα inhibitors might represent potential therapeutic agents against human pancreatic cancer cells by use of CPE cytotoxicity via claudin-4...
  42. ncbi request reprint Glial cell-derived cytokines attenuate the breakdown of vascular integrity in diabetic retinopathy
    Nami Nishikiori
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Diabetes 56:1333-40. 2007
    ..These findings reveal that glial cell-derived cytokines such as GDNF and VEGF regulate BRB function, implying that the glial cell can be a possible therapeutic target in diabetic retinopathy...
  43. doi request reprint Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro
    Ken ichi Takano
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Mol Histol 39:265-73. 2008
    ..These results indicate that the epithelial barrier of the human adenoid is stably maintained by expression of tight junction proteins in the epithelium including Ck20-positive M-like cells...
  44. ncbi request reprint Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells
    Kunihiko Nagasawa
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Cell Physiol 208:123-32. 2006
    ..These findings suggest that Cx40- and/or Cx43-based gap junctions might be required to maintain the endothelial barrier function without altering the expression and localization of the tight-junction components analyzed...
  45. doi request reprint Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells
    Ryuta Kamekura
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Histochem Cell Biol 133:339-48. 2010
    ..These findings indicate that TSLP induces expression of tight junction protein claudin-7 in DCs via NF-kappaB as well as via TLRs and may control tight junctions of DCs to preserve the epithelial barrier during allergic inflammation...
  46. doi request reprint Effects of Clostridium perfringens enterotoxin via claudin-4 on normal human pancreatic duct epithelial cells and cancer cells
    Hiroshi Yamaguchi
    Department of Surgery, Sapporo Medical University School of Medicine, Sapporo, 060 8556, Japan
    Cell Mol Biol Lett 16:385-97. 2011
    ....
  47. ncbi request reprint Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization
    Seiro Satohisa
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Exp Cell Res 310:66-78. 2005
    ....
  48. doi request reprint Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids
    Noriko Ogasawara
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Acta Otolaryngol 131:116-23. 2011
    ..This review summarizes the recent progress in our understanding of how M cells and DCs control the epithelial barrier in the adenoids...
  49. ncbi request reprint Down-regulation of survival signaling through MAPK and Akt in occludin-deficient mouse hepatocytes in vitro
    Masaki Murata
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17 Sapporo 060 8556, Japan
    Exp Cell Res 310:140-51. 2005
    ..These findings show that occludin plays a crucial role in claudin-2-dependent TJ function and the apoptosis involving MAPK and Akt signaling pathways in hepatocytes...
  50. doi request reprint Induction of JAM-A during differentiation of human THP-1 dendritic cells
    Noriko Ogasawara
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Biochem Biophys Res Commun 389:543-9. 2009
    ..These findings indicated that the induction of JAM-A occurred during differentiation of human THP-1 DCs and was independent of PPAR-gamma and the p38 MAPK pathway...
  51. ncbi request reprint Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells
    Makoto Osanai
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Cancer Sci 98:1557-62. 2007
    ..These data suggest that the methylator phenotype of claudin-6 may at least partially contribute to enhanced tumorigenic and invasive properties of breast carcinoma cells...
  52. pmc IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway
    Naoko Hatakeyama
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, S1, W17, Sapporo, 060 8556, Japan
    Cell Tissue Res 334:243-54. 2008
    ....
  53. pmc Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions
    Akira Takasawa
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Tissue Res 351:73-84. 2013
    ..Thus, the dynamic behavior of tricellulin during the destruction and formation of TJs under various extracellular calcium conditions seems to be closely associated with the barrier and fence functions of TJs...
  54. pmc Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes
    Hiroki Fujita
    Departments of Pathology and Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Mol Biol Cell 19:1912-21. 2008
    ..These findings strongly suggest that claudin-2- and/or claudin-12-based tight junctions form paracellular Ca(2+) channels in intestinal epithelia, and they highlight a novel mechanism behind vitamin D-dependent calcium homeostasis...
  55. doi request reprint Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells
    Seiichi Son
    Departments of Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Histochem Cell Biol 131:411-24. 2009
    ..These results suggest that claudin-2 may affect not only the bile canalicular seal but also bile canalicular formation...
  56. ncbi request reprint Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine
    Hiroki Fujita
    Dept of Pathology, Sapporo Medical University School of Medicine, S1, W17, Sapporo 060 8556, Japan
    J Histochem Cytochem 54:933-44. 2006
    ..This manuscript contains online supplemental material available at http://www.jhc.org. Please visit this article online to view these materials...
  57. ncbi request reprint HLA-DR- and CD11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitis
    Ken ichi Takano
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Histochem Cytochem 53:611-9. 2005
    ..These results indicate that DCs may easily access antigens beyond epithelial tight junctions in the human nasal mucosa of allergic rhinitis...
  58. doi request reprint Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation
    Jun ichi Koizumi
    Department of Otolaryngology, Sapporo Medical University School of Medicine, S1 W17 Sapporo 060 8556, Japan
    Mol Pharmacol 74:432-42. 2008
    ..These results suggest that TPA-induced PKC signaling enhances the barrier function of human nasal epithelial cells via transcriptional up-regulation of tight junction proteins, and the mechanisms may contribute to a drug delivery system...
  59. doi request reprint Mucosal immune barrier and antigen-presenting system in human nasal epithelial cells
    Tetsuo Himi
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Adv Otorhinolaryngol 72:28-30. 2011
    ..In this lecture, I will talk about the novel mechanisms in host defense in terms of innate immunity of the nasal mucosa from the point of view of the mucosal barrier function...
  60. ncbi request reprint Epigenetic silencing of occludin promotes tumorigenic and metastatic properties of cancer cells via modulations of unique sets of apoptosis-associated genes
    Makoto Osanai
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Res 66:9125-33. 2006
    ....
  61. ncbi request reprint Expression patterns of claudin family of tight-junction proteins in the mouse prostate
    Naoyuki Sakai
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Histochem Cell Biol 127:457-62. 2007
    ..These findings provide basic information for elucidating the significance of claudins in prostate diseases, including prostate cancers...
  62. ncbi request reprint Hepatocyte nuclear factor (HNF)-4alpha triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 286:288-97. 2003
    ..These findings indicate that HNF-4alpha triggers de novo formation of functional tight junctions and establishment of epithelial cell polarity...
  63. doi request reprint Claudin-4-targeted therapy using Clostridium perfringens enterotoxin for prostate cancer
    Toshihiro Maeda
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Prostate 72:351-60. 2012
    ..We investigated the potential of Cldn-targeted therapy using CPE...
  64. doi request reprint Pulmonary collectins play distinct roles in host defense against Mycobacterium avium
    Shigeru Ariki
    Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Immunol 187:2586-94. 2011
    ..Furthermore, the number of bacteria phagocytosed by macrophages was significantly increased in the presence of SP-D. These data indicate that pulmonary collectins play critical roles in host defense against M. avium...
  65. ncbi request reprint A novel monoclonal antibody against the second extracellular loop of occludin disrupts epithelial cell polarity
    Yuichi Tokunaga
    Department of Pathology, Sapporo Medical University School of Medicine, S1, W17, Sapporo 060 8556, Japan
    J Histochem Cytochem 55:735-44. 2007
    ....
  66. doi request reprint Respiratory syncytial virus infection and the tight junctions of nasal epithelial cells
    Hiroyuki Tsutsumi
    Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan
    Adv Otorhinolaryngol 72:153-6. 2011
    ..These findings suggest that RSV infection induces polarity in the infected cells. This polarity could facilitate cellular secretion of propagated RSV, thereby spreading the infection...
  67. doi request reprint Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells
    Tamaki Okabayashi
    Department of Microbiology, Sapporo Medical University School of Medicine, S1 W17, Chuo Ku, Sapporo, Hokkaido 060 8556, Japan
    Virus Res 160:360-6. 2011
    ..These data indicate that IFN-λ, but not IFN-β/α, contributes to the main first line defense via RIG-I-dependent pathway against respiratory virus infection in NECs...
  68. pmc A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells
    Tomoyuki Masaki
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Mol Biol Cell 22:2144-56. 2011
    ..The control of this pathway in HNECs may be useful not only for prevention of replication and budding of RSV, but also in therapy for RSV-induced respiratory pathogenesis...
  69. ncbi request reprint Cellular retinoic acid bioavailability determines epithelial integrity: Role of retinoic acid receptor alpha agonists in colitis
    Makoto Osanai
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Sapporo, Japan
    Mol Pharmacol 71:250-8. 2007
    ..Our results suggest that cellular RA bioavailability determines the epithelial integrity, because it is a critical regulator for barrier protection during mucosal injuries...
  70. ncbi request reprint Hepatocyte nuclear factor (HNF)-4alpha induces expression of endothelial Fas ligand (FasL) to prevent cancer cell transmigration: a novel defense mechanism of endothelium against cancer metastasis
    Makoto Osanai
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo 060 8556
    Jpn J Cancer Res 93:532-41. 2002
    ..These results raise the possibility that HNF-4alpha is involved in regulating cancer cell transmigration by modulating the Fas-FasL system...
  71. ncbi request reprint Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways
    Tsutomu Ishizaki
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 290:275-88. 2003
    ....
  72. ncbi request reprint Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions
    Masato Fujibe
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 295:36-47. 2004
    ..These findings indicate that Thr203 of claudin-1 is required to enhance the barrier function of claudin-1-based tight junctions, probably via its phosphorylation and subsequent integration into tight junctions...
  73. ncbi request reprint Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells
    Makoto Osanai
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Sci 98:1027-34. 2007
    ..These findings suggest that the loss of occludin expression is at least partially involved in the senescence-escape program during mammary tumorigenesis...
  74. ncbi request reprint Cellular networks of human thymic medullary stromas coordinated by p53-related transcription factors
    Shingo Ichimiya
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    J Histochem Cytochem 54:1277-89. 2006
    ....
  75. ncbi request reprint Expression and function of tight junctions in the crypt epithelium of human palatine tonsils
    Mitsuru Go
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Histochem Cytochem 52:1627-38. 2004
    ..These studies suggest unique expression of tight junctions in human palatine tonsillar epithelium, and the crypt epithelium may possess an epithelial barrier different from that of the surface epithelium...
  76. ncbi request reprint Glyceraldehyde-derived advanced glycation end-products preferentially induce VEGF expression and reduce GDNF expression in human astrocytes
    Hideaki Miyajima
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Biochem Biophys Res Commun 330:361-6. 2005
    ..These results indicate that glyceraldehyde-derived AGE is the biologically active substance for astrocytes by regulating the VEGF and GDNF expression, which is causally contributing to an increase in the permeability of the BBB...
  77. ncbi request reprint Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains
    Nami Nishikiori
    Departments of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Invest Ophthalmol Vis Sci 48:2224-9. 2007
    ....
  78. doi request reprint Impaired cutaneous wound healing in mice lacking tetranectin
    Kousuke Iba
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Wound Repair Regen 17:108-12. 2009
    ..At 21 days after the injury, the wound healed and was covered with an epidermis. These results supported the fact that tetranectin may play a role in the wound healing process...
  79. ncbi request reprint Tight junctions and human diseases
    Norimasa Sawada
    Department of Pathology, Sapporo Medical University School of Medicine, S1, W17, Sapporo 060 8556, Japan
    Med Electron Microsc 36:147-56. 2003
    ..Some pathogenic bacteria and viruses target and affect the tight-junction function, leading to diseases. In this review, the relationship between tight junctions and human diseases is summarized...
  80. ncbi request reprint Transmembrane proteins of tight junctions
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Biochim Biophys Acta 1778:588-600. 2008
    ..We provide an overview of recent progress in studies on these proteins and highlight their roles and regulation, as well as their functional significance in human diseases...
  81. ncbi request reprint The acid-sensing ion channel 2 (ASIC2) of ciliated cells in the developing rat nasal septum
    Shin Kikuchi
    Department of Anatomy, Sapporo Medical University School of Medicine, Japan
    Arch Histol Cytol 73:81-9. 2010
    ..On the other hand, ASIC2, especially ASIC2b, may function for the survival and retention of ciliated cells of the nasal septum against dynamic changes in the pH environment at birth...
  82. ncbi request reprint The significance of interferon-gamma-triggered internalization of tight-junction proteins in inflammatory bowel disease
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Sci STKE 2006:pe1. 2006
    ....
  83. ncbi request reprint Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer
    Ayumi Satoh
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Cancer Res 63:8606-13. 2003
    ..Moreover, the aberrant methylation of CHFR appears to be a good molecular marker with which to predict the sensitivity of gastric cancers to microtubule inhibitors...
  84. pmc Tricellulin is expressed in autotypic tight junctions of peripheral myelinating Schwann cells
    Shin Kikuchi
    Department of Anatomy, Sapporo Medical University School of Medicine, West 17, South 1, Chuo Ku, Sapporo 060 8556, Japan
    J Histochem Cytochem 58:1067-73. 2010
    ..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  85. ncbi request reprint The p53 family member genes are involved in the Notch signal pathway
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
    J Biol Chem 277:719-24. 2002
    ..Our findings show an association between the p53 family genes and Notch signaling and suggest a potential molecular mechanism for the involvement of the p53 family genes in normal development...
  86. ncbi request reprint p73 is expressed in human thymic epithelial cells
    Shingo Ichimiya
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    J Histochem Cytochem 50:455-62. 2002
    ..Because p73 has the capacity to be a transactivator like p53, it may contribute to T-cell development in the context of TEC biology as regulated in the cell cycle and apoptosis...
  87. pmc Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growth
    Kaku Sawada
    Departments of Biochemistry, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Biol Chem 285:8434-43. 2010
    ..pneumophila and suppress intracellular growth of the phagocytosed bacteria. The promotion of lysosomal fusion with Legionella-containing phagosomes constitutes a likely mechanism of L. pneumophila growth suppression by the collectins...
  88. ncbi request reprint Significance of 32-kDa cathepsin L secreted from cancer cells
    Yoko Hashimoto
    Department of Biochemistry, School of Dentistry, Aichi Gakuin University, Chikusa ku, Nagoya, Japan
    Cancer Biother Radiopharm 21:217-24. 2006
    ..Based on the foregoing, there are good reasons to speculate that the 32-kDa cathepsin L found in HT 1080 cell medium is involved in cancer invasion and metastasis...
  89. ncbi request reprint Role of Ca2+-binding motif in cytotoxicity induced by Clostridium perfringens iota-toxin
    Keiko Kobayashi
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro, Tokushima 7708514, Japan
    Microb Pathog 44:265-70. 2008
    ..The result indicates that the conserved Ca(2+)-binding motif in the N-terminal region of Ib plays a role in the interaction of Ib with Ia in the presence of Ca(2+)...
  90. ncbi request reprint Fluid shear stress remodels expression and function of junctional proteins in cultured bone cells
    Mia M Thi
    New York Center for Biomedical Engineering, City College of the City University of New York, New York, 10031, USA
    Am J Physiol Cell Physiol 284:C389-403. 2003
    ..Such disconnection from the bone cell network may provide part of the signal whereby the disconnected cells or the remaining network initiate focal bone remodeling...
  91. ncbi request reprint Physicochemical characterization of tamoxifen citrate pseudopolymorphs, methanolate and ethanolate
    Takashi Kojima
    Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashi Nada, Kobe, Japan
    Chem Pharm Bull (Tokyo) 55:407-11. 2007
    ....
  92. ncbi request reprint Comparison between bovine bone and porcine skin gelatins in their effects on murine cell proliferation
    Tatsuro Koide
    Health Research Center, Aichi Gakuin University, Nisshin city, Aichi Pref, Japan
    Cancer Biother Radiopharm 17:371-7. 2002
    ..In both cases, fetal calf serum (FCS) was required. PS gelatin suppressed proliferation of spleen cells and of RL male symbol 1 cells without FCS...
  93. ncbi request reprint Comparison of EphA receptor tyrosine kinases and ephrinA ligand expression to EphB-ephrinB in vascularized corneas
    Takashi Kojima
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL 60612, USA
    Cornea 26:569-78. 2007
    ....
  94. ncbi request reprint Effect of gelatins on human cancer cells in vitro
    Takashi Kojima
    Department of Surgery, Aichi Gakuin University School of Dentistry, Chikusa ku, Nagoya, Japan
    Cancer Biother Radiopharm 18:147-55. 2003
    ..In conclusion, PS gelatin suppress the proliferation of human tumor cell lines in vitro. The antiproliferative activity of PS gelatin might not be attributed to trapping growth factors or autocrine mediators...
  95. ncbi request reprint Physicochemical properties of tamoxifen hemicitrate sesquihydrate
    Takashi Kojima
    Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashinada, Kobe 658 8558, Japan
    Int J Pharm 352:146-51. 2008
    ....
  96. ncbi request reprint Rapid and sensitive determination of tryptophan, serotonin and psychoactive tryptamines by thin-layer chromatography/fluorescence detection
    Noriyuki Kato
    Scientific Crime Laboratory, Kanagawa Prefectural Police Headquarters, 155 1 Yamashita cho, Naka ku, Yokohama, Kanagawa 231 0023, Japan
    J Chromatogr A 1145:229-33. 2007
    ..The detection limits of Trp, 5-HT and PATs were in the range from 0.01 microg to 0.06 microg. This method was effectively applied to the detection of confiscated PAT powder and PAT in abusers' urine samples...
  97. pmc Neostatin-7 regulates bFGF-induced corneal lymphangiogenesis
    Takashi Kojima
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    FEBS Lett 582:2515-20. 2008
    ..Understanding the mechanism of neostatin-7/collagen XVIII on corneal lymphangiogenesis may provide therapeutic interventions to treat lymphangiogenesis-related disorders, such as lymphedema, transplantation rejection and cancers...
  98. ncbi request reprint Abnormal protein profiles in tears with dry eye syndrome
    Yoshiki Ohashi
    Department of Ophthalmology, Tokyo Dental College, Ichikawa, Chiba, Japan
    Am J Ophthalmol 136:291-9. 2003
    ..To verify the hypothesis that protein concentrations, such as lactoferrin, epidermal growth factor (EGF), and aquaporin 5 (AQP5), in tears are abnormal in patients with dry eye...
  99. ncbi request reprint Clinical evaluation of the arched blade for cataract surgery
    Takashi Kojima
    Department of Ophthalmology, Social Insurance Chukyo Hospital, Aichi, Japan
    Acta Ophthalmol Scand 83:306-11. 2005
    ..To evaluate the efficacy of the arched blade for making clear corneal incisions in cataract surgery...