Junji Kato

Summary

Affiliation: Sapporo Medical University
Country: Japan

Publications

  1. pmc Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach
    Makoto Yoshida
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 7:e39545. 2012
  2. pmc Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms
    M Kobune
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Blood Cancer J 2:e87. 2012
  3. ncbi request reprint Iron/IRP-1-dependent regulation of mRNA expression for transferrin receptor, DMT1 and ferritin during human erythroid differentiation
    Junji Kato
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Hematol 35:879-87. 2007
  4. ncbi request reprint Ethanol induces transforming growth factor-alpha expression in hepatocytes, leading to stimulation of collagen synthesis by hepatic stellate cells
    Junji Kato
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Alcohol Clin Exp Res 27:58S-63S. 2003
  5. ncbi request reprint Recent advance in molecular iron metabolism: translational disorders of ferritin
    Junji Kato
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Int J Hematol 76:208-12. 2002
  6. ncbi request reprint Treatment of hepatocellular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5-fluorouracil in mice
    Tamotsu Sagawa
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Hepatology 48:828-40. 2008
  7. ncbi request reprint Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells
    Masayoshi Kobune
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Hematol 36:1121-31. 2008
  8. ncbi request reprint Augmentation of antitumor effects of p53 gene therapy by combination with HDAC inhibitor
    Rishu Takimoto
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Biol Ther 4:421-8. 2005
  9. doi request reprint Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer
    Yasushi Sato
    Fourth Department of Internal Medicine, School of Medicine, Sapporo Medical University, South 1 West 16, Chuo Ku, Sapporo, Japan
    Cancer Chemother Pharmacol 66:721-8. 2010
  10. ncbi request reprint A phase II study of neoadjuvant combination chemotherapy with docetaxel, cisplatin, and S-1 for locally advanced resectable gastric cancer: nucleotide excision repair (NER) as potential chemoresistance marker
    Masahiro Hirakawa
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Chemother Pharmacol 71:789-97. 2013

Collaborators

Detail Information

Publications98

  1. pmc Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach
    Makoto Yoshida
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 7:e39545. 2012
    ..This modality represents a new strategy for pancreatic cancer cell-targeting therapy...
  2. pmc Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms
    M Kobune
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Blood Cancer J 2:e87. 2012
    ..This indicates that suppression of stromal HHIP could be associated with the proliferation of AML/MDS cells...
  3. ncbi request reprint Iron/IRP-1-dependent regulation of mRNA expression for transferrin receptor, DMT1 and ferritin during human erythroid differentiation
    Junji Kato
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Hematol 35:879-87. 2007
    ..We investigated iron regulatory protein (IRP)-dependent expression of transferrin receptor (TfR), divalent metal transporter-1 (DMT1) and ferritin during erythroid differentiation system using an in vitro three-phase liquid culture...
  4. ncbi request reprint Ethanol induces transforming growth factor-alpha expression in hepatocytes, leading to stimulation of collagen synthesis by hepatic stellate cells
    Junji Kato
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Alcohol Clin Exp Res 27:58S-63S. 2003
    ..The aim of the current study was to characterize and identify this factor...
  5. ncbi request reprint Recent advance in molecular iron metabolism: translational disorders of ferritin
    Junji Kato
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Int J Hematol 76:208-12. 2002
    ..This review summarizes the current understanding of the translational disorders caused by IRE mutations in ferritin mRNA...
  6. ncbi request reprint Treatment of hepatocellular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5-fluorouracil in mice
    Tamotsu Sagawa
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Hepatology 48:828-40. 2008
    ..Survival of the tumor-bearing mice treated with these three agents was significantly longer than that of control mice. Moreover, the tumor completely disappeared with the repeated injection of these agents...
  7. ncbi request reprint Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells
    Masayoshi Kobune
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Hematol 36:1121-31. 2008
    ..In this study, we examined the effect of human stromal interactions on the properties of CB Lin(-)CD34(-) cells...
  8. ncbi request reprint Augmentation of antitumor effects of p53 gene therapy by combination with HDAC inhibitor
    Rishu Takimoto
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Biol Ther 4:421-8. 2005
    ..Thus SB was shown to be an efficient potentiator of p53 gene therapy for cancer...
  9. doi request reprint Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer
    Yasushi Sato
    Fourth Department of Internal Medicine, School of Medicine, Sapporo Medical University, South 1 West 16, Chuo Ku, Sapporo, Japan
    Cancer Chemother Pharmacol 66:721-8. 2010
    ..We evaluated the activity and toxicity of docetaxel, cisplatin, and S-1 (DCS) combination chemotherapy in patients with unresectable metastatic gastric cancer...
  10. ncbi request reprint A phase II study of neoadjuvant combination chemotherapy with docetaxel, cisplatin, and S-1 for locally advanced resectable gastric cancer: nucleotide excision repair (NER) as potential chemoresistance marker
    Masahiro Hirakawa
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Chemother Pharmacol 71:789-97. 2013
    ..This study was performed to evaluate the efficacy and safety of neoadjuvant DCS chemotherapy for locally advanced resectable gastric cancer...
  11. ncbi request reprint Prolonged survival of mice with multiple liver metastases of human colon cancer by intravenous administration of replicable E1B-55K-deleted adenovirus with E1A expressed by CEA promoter
    Tamotsu Sagawa
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Mol Ther 10:1043-50. 2004
    ..Thus, the systemic administration of AdCEAp/Rep was considered to be effective on multiple liver metastases of CEA-positive colon cancer in a xenograft model...
  12. ncbi request reprint Ex vivo expansion of G-CSF-mobilized peripheral blood CD133+ progenitor cells on coculture with human stromal cells
    Yutaka Kawano
    Fourth Dept of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Hematol 34:150-8. 2006
    ..Our objective was to assess the efficacy of PB CD133(+) cells in our coculture system using human telomerized stromal (HTS) cells...
  13. ncbi request reprint Indian hedgehog gene transfer augments hematopoietic support of human stromal cells including NOD/SCID-beta2m-/- repopulating cells
    Masayoshi Kobune
    Department of Molecular Medicine, Sapporo Medical University Chuo ku S1, W17, Sapporo, 060 8556, Japan
    Blood 104:1002-9. 2004
    ..These results indicate that Ihh gene transfer could enhance the primitive hematopoietic support ability of human stromal cells...
  14. ncbi request reprint Ex vivo large-scale generation of human platelets from cord blood CD34+ cells
    Takuya Matsunaga
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, S1W17, Sapporo, Japan
    Stem Cells 24:2877-87. 2006
    ..Thus, this culture system may be applicable for large-scale generation of PLTs for future clinical use...
  15. ncbi request reprint Telomerized human bone marrow-derived cell clones maintain the phenotype of hematopoietic-supporting osteoblastic and myofibroblastic stromal cells after long-term culture
    Masayoshi Kobune
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Exp Hematol 33:1544-53. 2005
    ..Our objective was to investigate the phenotype and hematopoietic-support of the human telomerized stromal cell (HTS) in clonal level...
  16. ncbi request reprint A phase I/II study of nedaplatin and 5-fluorouracil with concurrent radiotherapy in patients with esophageal cancer
    Yasushi Sato
    Fourth Department of Internal Medicine, Sapporo Medical University, South 1 West 16, Chuo Ku, 060 8543, Sapporo, Japan
    Cancer Chemother Pharmacol 58:570-6. 2006
    ..The purpose of the phase II trial is to determine efficacy and further define the side effect profile...
  17. ncbi request reprint [A case of resection of synchronous multiple liver metastases from colorectal cancer after hepatic infusion chemotherapy and systemic chemotherapy]
    Tamotsu Sagawa
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Gan To Kagaku Ryoho 34:1481-4. 2007
    ..Though multiple liver metastases were unresectable at the time of the first examination, hepatectomy was possible followed by hepatic arterial infusion chemotherapy and systemic chemotherapy...
  18. doi request reprint Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neoplasms
    Tsuyoshi Hayashi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Gastroenterol 44:964-75. 2009
    ..Clinical trials of chemoprevention have been conducted for a wide variety of malignancies...
  19. ncbi request reprint Adenoviral vector-mediated transfer of the Indian hedgehog gene modulates lymphomyelopoiesis in vivo
    Masayoshi Kobune
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Chuo Ku, South 1, West 16 Sapporo, Hokkaido 060 8556, Japan
    Stem Cells 26:534-42. 2008
    ..Thus, modulation of the hedgehog signaling pathway may provide a therapeutic strategy to stimulate lymphomyelopoiesis in vivo...
  20. ncbi request reprint Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells
    Hiroki Chiba
    Forth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Hematol 32:1194-203. 2004
    ..Our objective was to investigate the expression and significance of Wnt proteins in adult human hematopoietic-supporting stromal cells...
  21. ncbi request reprint Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid
    Atsushi Nobuoka
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Gastroenterology 127:428-43. 2004
    ....
  22. ncbi request reprint Decrease of Smad4 gene expression in patients with essential thrombocythaemia may cause an escape from suppression of megakaryopoiesis by transforming growth factor-beta1
    Hiroyuki Kuroda
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Br J Haematol 124:211-20. 2004
    ..Thus it was surmised that one of the mechanisms for impaired sensitivity of CFU-MK to TGF-beta1 is the reduced expression of Smad4...
  23. ncbi request reprint Expansion of CD34+ cells on telomerized human stromal cells without losing erythroid-differentiation potential in a serum-free condition
    Masayoshi Kobune
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Int J Hematol 81:18-25. 2005
    ..Our hTERT-stromal expansion protocol may contribute to the construction of a system for large-scale, long-term production of erythroid cells...
  24. ncbi request reprint [Reactivation of hepatitis B virus due to rituximab plus CHOP after preemptive lamivudine administration in a patient with diffuse large B-cell lymphoma]
    Kaoru Ono
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Gan To Kagaku Ryoho 34:1509-12. 2007
    ..Clinically, she was experiencing acute hepatitis due to HBV reactivation. She was then treated with LAM and interferon-beta immediately. Her HBV-DNA levels soon decreased, and liver function improved...
  25. doi request reprint Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis
    Takehiro Kukitsu
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Clin Cancer Res 14:48-54. 2008
    ....
  26. doi request reprint Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells
    Masayoshi Kobune
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Hokkaido, 060 8543, Japan
    Cancer Sci 100:948-55. 2009
    ..These results suggest that aberrant Hh pathway activation is a feature of some CD34+ myeloid leukemic cells and Hh inhibitors may have a therapeutic role in the treatment of AML...
  27. doi request reprint A phase I trial of arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for unresectable biliary tract cancer
    Tsuyoshi Hayashi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Hokkaido 060 8556, Japan
    Int J Clin Oncol 17:491-7. 2012
    ..Because further therapeutic improvements are required, we conducted a phase I study of arterial infusion chemotherapy using a combination of gemcitabine and 5-fluorouracil...
  28. ncbi request reprint Ex vivo large-scale generation of human red blood cells from cord blood CD34+ cells by co-culturing with macrophages
    Akihito Fujimi
    4th Department of Internal Medicine, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Japan
    Int J Hematol 87:339-50. 2008
    ..Thus, this method may be useful for generating an alternative RBC supply for transfusions, investigating infectious agents that target erythroid cells, and as a general in vitro hematopoietic model system...
  29. ncbi request reprint Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion
    Yasushi Sato
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, 060 8543, Japan
    Blood 106:756-63. 2005
    ..In conclusion, we have demonstrated that MSCs are the most potent component in hepatic differentiation, as revealed by directly xenografting into rat livers...
  30. ncbi request reprint Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia
    Takuya Matsunaga
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 0061, Japan
    Nat Med 9:1158-65. 2003
    ..4% for 15 VLA-4-positive patients. Thus, the interaction between VLA-4 on leukemic cells and fibronectin on stromal cells may be crucial in bone marrow MRD and AML prognosis...
  31. ncbi request reprint [Effective CDDP arterial infusion with DSM for liver metastasis of malignant melanoma complicating DIC due to intratumoral hemorrhage--a case report]
    Kohichi Takada
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Gan To Kagaku Ryoho 35:1803-5. 2008
    ..Moreover, it was shown that arterial infusion with DSM was effective for liver metastasis of melanoma...
  32. ncbi request reprint Increased hepatic oxidative DNA damage in patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma
    Shingo Tanaka
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Gastroenterol 48:1249-58. 2013
    ..In this study, we investigated the involvement of oxidative DNA damage in hepatocarcinogenesis in patients with NASH...
  33. ncbi request reprint [Fifth-line chemotherapy for metastatic gastric cancer--a case responding to modified FOLFOX 6]
    Tamotsu Sagawa
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Gan To Kagaku Ryoho 34:1467-71. 2007
    ..mFOLFOX 6 used for the oxaliplatin-based therapy. After 2 courses of mFOLFOX 6, he showed a partial response. Oxaliplatin-based treatment was thought to be promising for previously CDDP-treated patients with unresectable gastric cancers...
  34. ncbi request reprint Wnt3/RhoA/ROCK signaling pathway is involved in adhesion-mediated drug resistance of multiple myeloma in an autocrine mechanism
    Masayoshi Kobune
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Mol Cancer Ther 6:1774-84. 2007
    ..Thus, the Wnt3 signaling pathway could be a promising molecular target to overcome CAM-DR of myeloma cells...
  35. ncbi request reprint Inhibition of type I procollagen production by tRNAVal CTE-HSP47 ribozyme
    Seiya Hagiwara
    The 4th Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Gene Med 5:784-94. 2003
    ..Therefore, we have tried to suppress its function to inhibit these various types of collagen...
  36. doi request reprint Intermittent administration of recombinant human soluble thrombomodulin successfully controlled chronic disseminated intravascular coagulation in a patient with dissecting aortic aneurysm on an outpatient basis
    Satoshi Iyama
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Blood Coagul Fibrinolysis 23:548-50. 2012
    ..We report herein a case of chronic DIC complicated with dissecting aortic aneurysm, whose resolution of chronic DIC achieved by 6 consecutive days of rTM has been maintained by once a week administration of rTM on an outpatient basis...
  37. doi request reprint A Phase I trial of arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for unresectable advanced pancreatic cancer after vascular supply distribution via superselective embolization
    Koji Miyanishi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Hokkaido, Japan
    Jpn J Clin Oncol 38:268-74. 2008
    ..We conducted a Phase I trial of arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for advanced pancreatic cancer after vascular supply distribution via superselective embolization...
  38. pmc Essential role of protein kinase C zeta in transducing a motility signal induced by superoxide and a chemotactic peptide, fMLP
    Kageaki Kuribayashi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo 060 8543, Japan
    J Cell Biol 176:1049-60. 2007
    ..1, or a specific inhibitor of RhoGTPase in SASH1, hPMs, and J774.1. These results suggest a new approach for manipulation of inflammation as well as tumor cell invasion by targeting this novel signaling pathway...
  39. doi request reprint Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone
    Yasushi Sato
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, 060 8543, Japan
    Nat Biotechnol 26:431-42. 2008
    ..The efficacy of the approach using both acute and chronic models of liver fibrosis suggests its therapeutic potential for reversing human liver cirrhosis...
  40. ncbi request reprint Amelioration of murine dextran sulfate sodium-induced colitis by ex vivo extracellular superoxide dismutase gene transfer
    Takatomi Oku
    Department of Internal Medicine Section 4, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Inflamm Bowel Dis 12:630-40. 2006
    ..Extracellular superoxide dismutase (EC-SOD), an isozyme of SODs, is known to function mainly in body fluids. We investigated the efficacy of an ex vivo EC-SOD gene transfer into dextran sulfate sodium (DSS)-induced colitis mice...
  41. doi request reprint Improvement of iron-mediated oxidative DNA damage in patients with transfusion-dependent myelodysplastic syndrome by treatment with deferasirox
    Shohei Kikuchi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Free Radic Biol Med 53:643-8. 2012
    ..Thus, excess iron could contribute to the pathophysiology of MDS and iron chelation therapy could improve the oxidative DNA damage in MDS patients...
  42. ncbi request reprint Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C
    Junji Kato
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Sapporo 060 8543, Japan
    J Gastroenterol 42:830-6. 2007
    ..However, it has not been determined whether continuation of iron depletion therapy for CHC favorably influences its progression to hepatocellular carcinoma (HCC)...
  43. ncbi request reprint Recovery of neutrophil count by ganciclovir in patients with chronic idiopathic neutropenia associated with cytomegalovirus infection in bone marrow stromal cells
    Yasuo Hirayama
    Department of Internal Medicine, Higashi Sapporo Hospital, Shiroishiku Higashisapporo, Sapporo, Japan
    Int J Hematol 79:337-9. 2004
    ..In conclusion, the etiology in some cases of CIN is speculated to be infection by CMV in bone marrow stromal cells, and treatment with ganciclovir may be effective in treating such patients...
  44. ncbi request reprint A patient with TP53 germline mutation developed Bowen's disease and myelodysplastic syndrome with myelofibrosis after chemotherapy against ovarian cancer
    Kageaki Kuribayashi
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Intern Med 44:490-5. 2005
    ..No therapeutic effects of low dose melphalan or cyclosporine A on MDS were observed, however one month of 30 mg/day prednisolone administration induced a hematological response...
  45. ncbi request reprint Increased expression of angiogenin in hepatocellular carcinoma in correlation with tumor vascularity
    Hiroyuki Hisai
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Clin Cancer Res 9:4852-9. 2003
    ..However, the role of ANG on the development of HCC remains unknown. The present study was designed to examine the implication of ANG in the neovascularization of human HCC...
  46. ncbi request reprint [Reappearance of t(12;17)-positive primary myelofibrosis following Ph+ CML cell reduction by imatinib]
    Naoko Araki
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Rinsho Ketsueki 48:518-23. 2007
    ....
  47. ncbi request reprint [Tuberculous pleuritis with onset of refractory pleural effusion after chemoradiotherapy for esophageal cancer]
    Masahiro Hirakawa
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Nihon Shokakibyo Gakkai Zasshi 108:231-7. 2011
    ..It is also necessary to consider the possible onset of tuberculous pleuritis, in particular, in patients with a history of tuberculosis infection...
  48. ncbi request reprint [Cholangiocarcinoma with bile duct adenoma and hamartoma-like lesion in the bile duct]
    Sho Takahashi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Nihon Shokakibyo Gakkai Zasshi 107:461-9. 2010
    ..In the Glisson's capsule around the tumor, there was also a bile duct hamartoma...
  49. ncbi request reprint Thrombopoietin concentrations in peripheral blood correlated with platelet numbers in two patients with thrombocytopenia by chronic graft-versus-host disease
    Yasuo Hirayama
    Department of Internal Medicine, Higashi Sapporo Hospital, Sapporo, Japan
    Am J Hematol 73:285-9. 2003
    ..TGF-beta concentrations were normal during all periods in which measurements were carried out. Thus, our results suggest that one mechanism of thrombocytopenia in patients with cGVHD is low TPO production by BM cells...
  50. ncbi request reprint [An advanced metastatic breast cancer patient successfully treated with combination therapy including docetaxel, doxorubicin and cyclophosphamide (TAC) as salvage therapy]
    Yasushi Sato
    Fourth Dept of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Gan To Kagaku Ryoho 35:471-3. 2008
    ..Metastatic lesions almost disappeared after 4 cycles of TAC. TAC therapy was considered to be acceptable as salvage therapy for a metastatic male breast cancer patient...
  51. ncbi request reprint Apoptosis supercedes necrosis in mitochondrial DNA-depleted Jurkat cells by cleavage of receptor-interacting protein and inhibition of lysosomal cathepsin
    Tsutomu Sato
    Department of Internal Medicine Section 4, Sapporo Medical University, School of Medicine, Sapporo, Japan
    J Immunol 181:197-207. 2008
    ..Activities of cathepsins B and D in the lysate of necrotic rho0 cells were inhibited by the addition of apoptotic parental Jurkat cell lysate. Thus, apoptosis may supercede necrosis...
  52. ncbi request reprint [Enteropathy-type T-cell lymphoma with CD8 and CD56 expression]
    Tsutomu Sato
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Rinsho Ketsueki 47:645-9. 2006
    ..Although ETL usually occurs as a complication of celiac disease, malabsorption and anti-gliadin antibodies, which are normally present in celiac disease, were not observed in this patient...
  53. ncbi request reprint Reversal of multiple drug resistance in cholangiocarcinoma by the glutathione S-transferase-pi-specific inhibitor O1-hexadecyl-gamma-glutamyl-S-benzylcysteinyl-D-phenylglycine ethylester
    Takaharu Nakajima
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Pharmacol Exp Ther 306:861-9. 2003
    ..In conclusion, our results demonstrated that GSTP1-1 is a resistance factor for anticancer drugs in cholangiocarcinoma and that C16C2, a GSTP1-1-specific inhibitor, is a potent agent against the resistance...
  54. doi request reprint Rapid on-site evaluation by endosonographer during endoscopic ultrasound-guided fine needle aspiration for pancreatic solid masses
    Tsuyoshi Hayashi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    J Gastroenterol Hepatol 28:656-63. 2013
    ..One of the solutions may be ROSE by endosonographer. The aim was to examine whether diagnostic accuracy increases through ROSE by endosonographer using our cytological criteria...
  55. ncbi request reprint Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors
    Takeshi Terui
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Res 63:8948-54. 2003
    ..It was, therefore, concluded that acetylation of the p53 molecule at residues 320 and 373, giving rise to up-regulation of PIG3 and NOXA, is one of the mechanisms for induction of apoptosis by HDAC inhibitors in cancer cells...
  56. ncbi request reprint Successful treatment by fibrin glue sealant for pneumothorax with chronic GVHD resistant to autologous blood patch pleurodesis
    Satoshi Iyama
    The Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Intern Med 51:2011-4. 2012
    ..In our limited experience, we believe the best success could be achieved when this method is used to treat persistent pneumothorax with cGVHD...
  57. doi request reprint Prognostic significance of serum ferritin level at diagnosis in myelodysplastic syndrome
    Shohei Kikuchi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Int J Hematol 95:527-34. 2012
    ..2 M, P = 0.002). Further, leukemia-free survival (LFS) was significantly longer in the low SF group than the high SF group (P = 0.010). Baseline SF level may, therefore, be a prognostic factor for overall survival and LFS in MDS patients...
  58. ncbi request reprint A case of ulcerative colitis accompanied with myelodysplastic syndrome successfully treated by cyclosporine
    Sho Takahashi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 108:1405-12. 2011
    ..Myelodysplastic syndrome (MDS, RAEB-1) was then revealed after bone marrow biopsy. A high blood CsA concentration may cause the improvement of UC and MDS conditions...
  59. doi request reprint Novel missense mutation in the TMPRSS6 gene in a Japanese female with iron-refractory iron deficiency anemia
    Tsutomu Sato
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Int J Hematol 94:101-3. 2011
    ....
  60. ncbi request reprint Telomerized human multipotent mesenchymal cells can differentiate into hematopoietic and cobblestone area-supporting cells
    Masayoshi Kobune
    Dept of Molecular Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Hematol 31:715-22. 2003
    ..To compare the hematopoietic support provided by telomerized human mesenchymal stem cells (MSCs) and telomerized MSC-derived stromal cells...
  61. doi request reprint Establishment of a simple test for iron absorption from the gastrointestinal tract
    Masayoshi Kobune
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Int J Hematol 93:715-9. 2011
    ..Thus, the SFC-based OIAT may represent a viable screening test for the evaluation of gastrointestinal iron absorption...
  62. ncbi request reprint Plasma glutathione S-Transferase P1-1 as a prognostic factor in patients with advanced non-Hodgkin's lymphoma (stages III and IV)
    Tatsuro Katahira
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Clin Cancer Res 10:7934-40. 2004
    ....
  63. ncbi request reprint Endoscopic findings of enteropathy-type T-cell lymphoma by double-balloon enteroscopy and capsule endoscopy
    Yasushi Sato
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Dig Endosc 22:243-5. 2010
    ..Double-balloon enteroscopy and capsule endoscopy may be useful tools for diagnosing and monitoring the effects of therapy in patients with ETL...
  64. ncbi request reprint [A family of attenuated familial adenomatous polyposis (AFAP)]
    Yasushi Sato
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 102:453-8. 2005
  65. doi request reprint Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes
    Hirotoshi Ishiwatari
    Fourth Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Gut 62:1328-39. 2013
    ..This treatment was investigated for pancreatic fibrosis induced by dibutyltin dichloride (DBTC) and cerulein in rats...
  66. ncbi request reprint Chemoprevention of colorectal cancer
    Yoshiro Niitsu
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, 060 8543 Sapporo, Japan
    Cancer Chemother Pharmacol 54:S40-3. 2004
    ..We have shown that the number of ACF was significantly reduced in patients treated with sulindac. We are currently proceeding with a randomized, double-blind, chemopreventive trial targeting ACF...
  67. ncbi request reprint [Essential thrombocythemia associated with incomplete type intestinal Behçet disease during hydroxyurea treatment]
    Masayoshi Kobune
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Rinsho Ketsueki 46:1136-40. 2005
    ..He was thus diagnosed as having intestinal tract-type Behçet disease. After withdrawal of the hydroxyurea administration, the intestinal ulcers, oral aphthous ulcers and genital ulcers improved...
  68. doi request reprint Argon plasma coagulation treatment of hemorrhagic radiation proctopathy: the optimal settings for application and long-term outcome
    Yasushi Sato
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, South 1 West 16, Chuo Ku, 060 8543 Sapporo, Japan
    Gastrointest Endosc 73:543-9. 2011
    ..Recently it was reported that argon plasma coagulation (APC) is effective for HRP. However, previous studies documented complications such as ulcers, strictures, and perforations in as many as 20% of APC-treated patients...
  69. doi request reprint Iron chelator deferasirox rescued mice from Fas-induced fulminant hepatitis
    Tsutomu Sato
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Hepatol Res 41:660-7. 2011
    ....
  70. ncbi request reprint Gamma/delta T-cell lymphoma of duodenal bulb: a case report
    Hiroki Chiba
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Gastrointest Endosc 58:616-20. 2003
  71. ncbi request reprint Case report of a focal nodular hyperplasia-like nodule present in cirrhotic liver
    Sho Takahashi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Hepatol Res 38:521-8. 2008
    ..There has been no report of well-differentiated HCC with a central scar, and this case was presumed to be an FNH-like nodule with dysplasia physically associated with cirrhotic tissue...
  72. ncbi request reprint [Superior mesenteric and portal vein thrombosis in a polycythemia vera patient with JAK2 mutation]
    Naoko Araki
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Rinsho Ketsueki 48:554-8. 2007
    ..Anticoagulation therapy delivered intravenously via the superior mesenteric vein dramatically improved her symptoms and liver function. She is currently on anticoagulation therapy in our outpatient clinic...
  73. ncbi request reprint [Evaluation of the efficacy of liposomal amphotericin B]
    Satoshi Iyama
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Kansenshogaku Zasshi 84:182-6. 2010
    ..However, L-AMB had fewer side effects, so the agent was considered useful for the treatment of hematologic disease patients who either had mycosis or carried a risk for fungal infection...
  74. ncbi request reprint Role of endotoxin in NF-kappaB activation by ethanol in rat hepatocytes
    Hiroshi Matsumoto
    Department of Legal Medicine, Sapporo Medical University School of Medicine, Japan
    Alcohol Clin Exp Res 26:6S-10S. 2002
    ..Endotoxin plays an important role in the progression of alcoholic liver injury. However, the role of endotoxin in acute activation of NF-kappaB by ethanol remains unclear...
  75. ncbi request reprint E1B-55K-deleted adenovirus expressing E1A-13S by AFP-enhancer/promoter is capable of highly specific replication in AFP-producing hepatocellular carcinoma and eradication of established tumor
    Minoru Takahashi
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, 060 8543, Japan
    Mol Ther 5:627-34. 2002
    ..Furthermore, this virus was capable of complete eradication of a preestablished HuH7-cell tumor by a single intratumoral injection of 10(8) plaque-forming units (pfu) of AdAFPep/Rep. Thus, AdAFPep/Rep may be applicable for clinical use...
  76. ncbi request reprint A case of Gardner syndrome with a mutation at codon 1556 of APC: a suggested case of genotype-phenotype correlation in dental abnormality
    Takatomi Oku
    Department of Internal Medicine Section 4, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Eur J Gastroenterol Hepatol 16:101-5. 2004
    ....
  77. ncbi request reprint [Mucinous cystic adenoma of the pancreas with short-term morphological changes due to hemorrhage]
    Tsuyoshi Hayashi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Nihon Shokakibyo Gakkai Zasshi 106:1783-91. 2009
    ..Histopathologic examinations revealed mucinous cystic adenoma. Remains of intracystic hemorrhage were evident and short-term morphological changes were presumed to be associated with hemorrhage...
  78. ncbi request reprint [A case of solitary fibrous tumor of the pancreas]
    Hirotoshi Ishiwatari
    4th Department of Internal Medicine, Sapporo Medical University
    Nihon Shokakibyo Gakkai Zasshi 106:1078-85. 2009
    ..Immunohistochemically, the tumor cells were positive for CD34 and Bcl-2. Based on the light microscopic morphology and immunostaining profile, the tumor was classified as a solitary fibrous tumor (SFT) of the pancreas...
  79. ncbi request reprint Granulocyte-colony stimulating factor enhances the expression of transforming growth factor-beta mRNA in CD4-positive peripheral blood lymphocytes in the donors for allogeneic peripheral blood stem cell transplantation
    Yasuo Hirayama
    Fourth Department Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Am J Hematol 69:138-40. 2002
    ..This elevation is considered to be one additive mechanism of repression of acute GVHD after allo-PBSCT...
  80. ncbi request reprint [Abnormal iron metabolism and carcinogenesis]
    Junji Kato
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 102:552-8. 2005
  81. ncbi request reprint Ratio of transferrin (Tf) to Tf-receptor complex in circulation differs depending on Tf iron saturation
    Junji Kato
    The Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Clin Chem 48:181-3. 2002
  82. ncbi request reprint Interleukin-11 as an osteoprotegerin-inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis
    Tsutomu Sato
    Department of Internal Medicine Section 4, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Am J Hematol 77:62-6. 2004
    ..The OPG-inducing activity of the culture medium was neutralized by the anti-interleukin-11 (IL-11) antibody. These results indicate that IL-11 produced by the blasts was a causative factor of the OS observed in this patient...
  83. ncbi request reprint Induction of heat shock protein 47 synthesis by TGF-beta and IL-1 beta via enhancement of the heat shock element binding activity of heat shock transcription factor 1
    Hiroyoshi Sasaki
    Department of Internal Medicine Section 4 and Clinical Diagnosis Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Sapporo 060 8543, Japan
    J Immunol 168:5178-83. 2002
    ..Thus, HSP47 could well be a good candidate for molecular targeting in controlling tissue fibrosis, given that both principal fibrinogenetic cytokines (TGF-beta, IL-1beta) are commonly involved in its induction through HSF1 trimerization...
  84. ncbi request reprint [Anemia in patients with cancer]
    Masayoshi Kobune
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Nihon Rinsho 66:524-9. 2008
    ..On the other hand, in Europe and America, erythropoietic agents such as erythropoietin and novel erythropoiesis stimulating protein (NESP) have been clinically used for anemia in patients with cancer...
  85. ncbi request reprint [A case of intraductal papillary mucinous neoplasm with internal pancreatic fistula causing left ureteral obstruction]
    Sho Takahashi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 104:1236-44. 2007
    ..Follow-up 6 months later showed that extrapancreatic spreading of the low density area had markedly regressed without any change in the ureteral obstruction...
  86. ncbi request reprint [A case of successful management of refractory ascites by transjugular intrahepatic portosystemic shunting (TIPS) in Budd-Chiari syndrome associated with alcoholic liver fibrosis]
    Sho Takahashi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 99:1085-91. 2002
  87. ncbi request reprint Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subunit (hTERT)-transfected human stromal cells
    Yutaka Kawano
    Department of Molecular Medicine, Sapporo Medical University, Japan
    Blood 101:532-40. 2003
    ..These results indicate that this hTERT-stromal cell line could be useful for ex vivo expansion of hematopoietic progenitor/stem cells and for analyzing the microenvironment of human bone marrow...
  88. ncbi request reprint Iron accumulation in alcoholic liver diseases
    Yutaka Kohgo
    Third Department of Internal Medicine, Asahikawa Medical College, and Fourth Department of Internal Medicine, Sapporo Medical University, Japan
    Alcohol Clin Exp Res 29:189S-93S. 2005
    ..Another possibility is an increase of intestinal iron absorption. Our recent finding regarding the increase of pro-hepcidin serum in alcoholic patients with high serum ferritin support this assumption...
  89. ncbi request reprint [Factor XI deficiency caused by a mutation of Gly400Val]
    Tsutomu Sato
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
    Rinsho Ketsueki 48:148-50. 2007
    ..We herein report on a Japanese family with factor XI deficiency caused by Gly400Val mutation...
  90. ncbi request reprint [A case of hepatosplenic gammadelta T-cell lymphoma associated hemophagocytic syndrome]
    Satoshi Iyama
    Fourth Dept of Internal Medicine, Sapporo Medical University, School of Medicine
    Gan To Kagaku Ryoho 35:1623-7. 2008
    ..A postmortem examination revealed massive infiltration of activated macrophages with hemophagocytosis in the spleen, liver, bone marrow and perisplenic lymph nodes...
  91. ncbi request reprint Report of an autopsy case of colon cancer with amyotrophic lateral sclerosis
    Yasushi Sato
    Fourth Department of Internal Medicine, Sapporo Medical University
    Nihon Shokakibyo Gakkai Zasshi 104:1365-70. 2007
    ..In this case the neurological syndrome was not affected by cancer therapy. Thus our case does not support the hypothesis that ALS in associated with cancer and the relationship between both disorders remains uncertain...
  92. ncbi request reprint [A case of metastatic liver tumor from colorectal carcinoma--continued arterial infusion chemotherapy through a microcatheter located in replaced right hepatic artery]
    Kunihiro Takanashi
    Fourth Dept of Internal Medicine, Sapporo Medical University School of Medicine
    Gan To Kagaku Ryoho 31:1415-7. 2004
    ..Then, we somehow were able to put a microcatheter into the replaced right hepatic artery (rRHA), and could restart arterial infusion chemotherapy. We continued this procedure for over a year without any complication...
  93. ncbi request reprint Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance
    Yutaka Kohgo
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Midorigaoka Higashi 2 1, Asahikawa 078 8510, Japan
    World J Gastroenterol 13:4699-706. 2007
    ..In porphyria cutanea tarda, iron is secondarily accumulated in the liver...
  94. ncbi request reprint Transferrin receptor in tissue and serum: updated clinical significance of soluble receptor
    Yutaka Kohgo
    Third Department of Internal Medicine, Asahikawa Medical College, Hokkaido, Japan
    Int J Hematol 76:213-8. 2002
    ....
  95. ncbi request reprint Recovery of cells with a normal karyotype in a refractory anaemia patient with monosomy 7-positive cells after long-term administration of cyclosporin A
    Yasuo Hirayama
    Br J Haematol 121:376-7. 2003
  96. doi request reprint Dysregulation of systemic iron metabolism in alcoholic liver diseases
    Yutaka Kohgo
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    J Gastroenterol Hepatol 23:S78-81. 2008
    ..The common mechanism for hepatic iron deposition and the triggering role of iron may be present in the development of ALD and non-alcoholic fatty liver disease/NASH...
  97. ncbi request reprint A significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: a multicenter, prospective, randomized, controlled trial in Japan
    Motoyoshi Yano
    Third Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsuruma cho, Showa Ku, 466 8550, Nagoya, Japan
    J Gastroenterol 39:570-4. 2004
    ..This study aimed to test whether iron removal by repeated phlebotomy improves serum alanine aminotransferase (ALT) levels in patients with CHC...