Kohzoh Imai

Summary

Affiliation: Sapporo Medical University
Country: Japan

Publications

  1. pmc Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology
    Hideaki Tahara
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Transl Med 7:45. 2009
  2. ncbi request reprint Comparing antibody and small-molecule therapies for cancer
    Kohzoh Imai
    Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Nat Rev Cancer 6:714-27. 2006
  3. ncbi request reprint Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics
    Kohzoh Imai
    Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Carcinogenesis 29:673-80. 2008
  4. ncbi request reprint Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells
    Ayumi Satoh
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Oncogene 23:8876-86. 2004
  5. doi request reprint Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
    Mol Cancer Ther 7:779-87. 2008
  6. doi request reprint IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype
    Hiromu Suzuki
    First Department of Internal Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Carcinogenesis 31:342-9. 2010
  7. ncbi request reprint Activation of the ribosomal protein L13 gene in human gastrointestinal cancer
    Toshihisa Kobayashi
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Int J Mol Med 18:161-70. 2006
  8. ncbi request reprint Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer
    Toshiro Obata
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    Clin Cancer Res 9:6410-8. 2003
  9. doi request reprint Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin
    Yasushi Adachi
    First Department of Internal Medicine, Sapporo Medical University, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Carcinogenesis 30:1305-13. 2009
  10. ncbi request reprint The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer
    Kimishige Akino
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Japan
    Gastroenterology 129:156-69. 2005

Detail Information

Publications108 found, 100 shown here

  1. pmc Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology
    Hideaki Tahara
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Transl Med 7:45. 2009
    ..The institution of an interactive consortium for high throughput molecular monitoring of clinical trials with voluntary participation might provide cost-effective solutions...
  2. ncbi request reprint Comparing antibody and small-molecule therapies for cancer
    Kohzoh Imai
    Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Nat Rev Cancer 6:714-27. 2006
    ..We discuss and compare the distinctive properties of these two therapeutic strategies so as to provide a better view for the development of new drugs and the future direction of cancer therapy...
  3. ncbi request reprint Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics
    Kohzoh Imai
    Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Carcinogenesis 29:673-80. 2008
    ..This review addresses recent advances in the field of microsatellite instability research...
  4. ncbi request reprint Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells
    Ayumi Satoh
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Oncogene 23:8876-86. 2004
    ..It thus appears that CIITA methylation is a key mechanism that enables some gastrointestinal cancer cells to escape immune surveillance...
  5. doi request reprint Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
    Mol Cancer Ther 7:779-87. 2008
    ..These results provide a strong rationale for combining p53 gene therapy and FK228 pretreatment in cancer therapy...
  6. doi request reprint IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype
    Hiromu Suzuki
    First Department of Internal Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Carcinogenesis 31:342-9. 2010
    ..Thus, epigenetic inactivation of IGFBP7 appears to play a key role in tumorigenesis of CRCs with CIMP by enabling escape from p53-induced senescence...
  7. ncbi request reprint Activation of the ribosomal protein L13 gene in human gastrointestinal cancer
    Toshihisa Kobayashi
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Int J Mol Med 18:161-70. 2006
    ..We also found that increased expression of the L13 gene correlated with clinical staging in gastric cancers. The results of this study suggest that L13 plays an essential role in the progression of some gastrointestinal malignancies...
  8. ncbi request reprint Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer
    Toshiro Obata
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    Clin Cancer Res 9:6410-8. 2003
    ..We found the proapoptotic gene HRK to be a target for hypermethylation in human cancers and examined the role of such methylation in silencing the gene's expression...
  9. doi request reprint Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin
    Yasushi Adachi
    First Department of Internal Medicine, Sapporo Medical University, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Carcinogenesis 30:1305-13. 2009
    ..Strategies of targeting IGF-IR may have significant therapeutic utility to prevent invasion and progression of human GI carcinomas...
  10. ncbi request reprint The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer
    Kimishige Akino
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Japan
    Gastroenterology 129:156-69. 2005
    ..Our aim was to address that question by surveying genetic and epigenetic alterations of Ras-Ras effector genes in CRC cells...
  11. ncbi request reprint Flat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas
    Taiga Takahashi
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Mod Pathol 20:139-47. 2007
    ..Epigenetic alterations infrequently occurred in flat-type advanced adenomas, suggesting that they have different genetic and epigenetic alterations from those of protruded-type advanced adenomas...
  12. doi request reprint A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells
    Masashi Idogawa
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    Clin Cancer Res 15:3725-32. 2009
    ..However, p21 also has tumor-suppressive properties. In this study, we developed an adenovirus vector that expresses p53 and suppresses p21 simultaneously to enhance p53-mediated apoptosis...
  13. doi request reprint Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers
    Yu Wang
    First Department of Internal Medicine, Sapporo Medical University, W 16 Chuo ku, Sapporo 060 8543, Japan
    J Gastroenterol 45:159-70. 2010
    ..In this study, we sought to test the effectiveness of a practical approach to blocking IGF-IR signaling using RNA interference delivered by recombinant adenoviruses...
  14. doi request reprint Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma
    Hideyasu Takagi
    First Department of Internal Medicine, Sapporo Medical University, S1, W16, Chuo Ku, Sapporo 060 8543, Japan
    J Gastroenterol 43:378-89. 2008
    ..Activation of the Wnt signaling pathway is frequently observed in hepatocellular carcinoma (HCC), though mutation of three of its components, CTNNB1, AXIN1, and AXIN2, is observed substantially less often...
  15. ncbi request reprint Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis
    Katsuhiko Nosho
    First Department of Internal Medicine, Sapporo Medical University, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Clin Cancer Res 10:7950-7. 2004
    ....
  16. ncbi request reprint Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma
    Hiroyuki Yamamoto
    First Department of Internal Medicine, Sapporo Medical University, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Carcinogenesis 25:2353-60. 2004
    ..The results of this study suggest that matrilysin-2, the expression of which is closely correlated with nuclear beta-catenin expression and active MMP-9 activity, plays a key role in the progression of ESCC...
  17. pmc Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer
    Reo Maruyama
    First Department of Internal Medicine, Sapporo Medical University, Sapporo 060 8556, Japan
    Carcinogenesis 29:1312-8. 2008
    ..These results suggest that epigenetic inactivation of RASSF2A is required for tumorigenesis in a subset of gastric cancers...
  18. ncbi request reprint Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer
    Ayumi Satoh
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Cancer Res 63:8606-13. 2003
    ..Moreover, the aberrant methylation of CHFR appears to be a good molecular marker with which to predict the sensitivity of gastric cancers to microtubule inhibitors...
  19. ncbi request reprint Synergistic effect of histone deacetylase inhibitors FK228 and m-carboxycinnamic acid bis-hydroxamide with proteasome inhibitors PSI and PS-341 against gastrointestinal adenocarcinoma cells
    Masaaki Adachi
    Graduate School of Medicine and First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Clin Cancer Res 10:3853-62. 2004
    ....
  20. pmc A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth
    Hiroaki Mita
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    BMC Cancer 9:198. 2009
    ..In the current study, we used DGS to survey copy-number alterations in gastric cancer cells...
  21. ncbi request reprint 2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation
    Huichao Zou
    Division of Molecular Oncology and Molecular Diagnosis, Graduate School of Medicine, First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Clin Cancer Res 12:6532-9. 2006
    ..2-Methoxyestradiol (2ME), an estrogen metabolite, induces apoptosis in various cell types. We investigated whether 2ME pretreatment can radiosensitize colon adenocarcinoma cells...
  22. doi request reprint Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat
    Hiroki Tanaka
    First Department of Internal Medicine, Sapporo Medical University, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    J Gastroenterol 46:143-52. 2011
    ..Therefore, we investigated the role of transplanted MSCs in the repair phase of DSS colitis...
  23. doi request reprint Identification of flotillin-2, a major protein on lipid rafts, as a novel target of p53 family members
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Chuo Ku, Sapporo, 060 8556 Japan
    Mol Cancer Res 6:395-406. 2008
    ..Thus, in addition to direct transactivation, p53 family member genes enhance a set of cellular processes via lipid rafts...
  24. doi request reprint Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma
    Takashi Imai
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo 060 8543, Japan
    Cancer Sci 99:958-66. 2008
    ..Our results suggest that epigenetic inactivation of RASSF2 plays an important role in OSCC tumorigenesis, and that RASSF2 may be a useful molecular target for the diagnosis and treatment of OSCC...
  25. ncbi request reprint Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors
    Kazuhiro Ogi
    Department of Molecular Biology, Cancer Research Institute, Department of Oral Surgery, Sapporo Medical University, Sapporo, Japan
    Cancer Biol Ther 4:773-80. 2005
    ..Our results suggest that CHFR could be a useful molecular target for chemotherapy...
  26. pmc Epigenetic inactivation of CHFR in human tumors
    Minoru Toyota
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo 060 8556, Japan
    Proc Natl Acad Sci U S A 100:7818-23. 2003
    ..Taken together, these findings shed light on a pathway by which mitotic checkpoint is bypassed in cancer cells and suggest that inactivation of checkpoint genes is much more widespread than previously suspected...
  27. ncbi request reprint PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer
    Yoshiyuki Watanabe
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    Clin Cancer Res 13:4786-94. 2007
    ..The aim of the present study was to begin to examine the involvement of epigenetic alteration of PRDM expression in gastric and colorectal cancer...
  28. ncbi request reprint Morphological and transcriptional responses of untransformed intestinal epithelial cells to an oncogenic beta-catenin protein
    Yasuyoshi Naishiro
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 24:3141-53. 2005
    ..The IGFBP2 protein interacts with integrins. Disruption of the multigene network system regulating cell adhesion and cytoskeleton may be crucial in the initiation of colorectal carcinogenesis...
  29. ncbi request reprint Histone deacetylase inhibitors enhance phosphorylation of histone H2AX after ionizing radiation
    YuBin Zhang
    Division of Molecular Oncology and Molecular Diagnosis, Graduate School of Medicine, Sapporo Medical University, Sapporo, Hokkaido, Japan
    Int J Radiat Oncol Biol Phys 65:859-66. 2006
    ....
  30. ncbi request reprint Association of ets-related transcriptional factor E1AF expression with tumour progression and overexpression of MMP-1 and matrilysin in human colorectal cancer
    Shina Horiuchi
    First Department of Internal Medicine, Sapporo Medical University, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    J Pathol 200:568-76. 2003
    ..The results of this study suggest that E1AF, the expression of which is closely correlated with the expression of MMP-1 and matrilysin, plays a key role in the progression of colorectal cancer...
  31. ncbi request reprint Sulindac enhances the proteasome inhibitor bortezomib-mediated oxidative stress and anticancer activity
    Takae Minami
    First Department of Internal Medicine, Graduate School of Medicine, Sapporo Medical University, Sapporo, Japan
    Clin Cancer Res 11:5248-56. 2005
    ..Here, we address whether sulindac enhances the anticancer effects of the proteasome inhibitor bortezomib (PS-341) in colon cancer cells...
  32. ncbi request reprint Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer
    Kimishige Akino
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Cancer Sci 98:88-95. 2007
    ..Taken together, these data suggest that the silencing of DFNA5 occurs frequently in gastric cancer and may play a key role in development and progression of the disease...
  33. ncbi request reprint Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death
    Tamaki Abe
    First Department of Internal Medicine, Sapporo Medical University, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Gastroenterol 40:504-10. 2005
    ..The purpose of the present study, therefore, was to examine the role of epigenetic gene alteration in the resistance to hypoxia-mediated apoptosis among pancreatic cancer cells...
  34. doi request reprint Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer
    Hiroyuki Takamaru
    Department of Molecular Biology, Sapporo Medical University, Chuo Ku, Sapporo, Japan
    Cancer Prev Res (Phila) 5:1203-12. 2012
    ..Collectively, our data suggest that RASGRF1 methylation is significantly involved in an epigenetic field defect in the stomach, and that it could be a useful biomarker to identify individuals at high risk for gastric cancer...
  35. doi request reprint Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers
    Hirokazu Ohashi
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Cancer Sci 103:252-61. 2012
    ..IGF-IR might identify a subset of BTC with a particularly aggressive phenotype and is a candidate therapeutic target in this disease. BMS-536924 might have significant therapeutic utility...
  36. ncbi request reprint Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S 1, W 17, Chuo Ku, Sapporo 060 8556, Japan
    Oncogene 24:5131-6. 2005
    ..We also report here that the PEDF gene contains a response element specific for p63 and p73 in its promoter region and is a direct target of p63 and p73. Collectively, p63 and p73 may be involved in cell fate by inducing PEDF expression...
  37. doi request reprint Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis
    Keiichi Hizaki
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Mod Pathol 24:876-84. 2011
    ..CASR methylation seems to occur at an early stage and progress in colorectal carcinogenesis. The results suggest that epigenetic inactivation of CASR has an important role in colorectal carcinogenesis...
  38. doi request reprint Genetic variants in surfactant, pulmonary-associated protein D (SFTPD) and Japanese susceptibility to ulcerative colitis
    Michihiro Tanaka
    First Department of Internal Medicine, Sapporo Medical University, Chuo Ku, Sapporo, Japan
    Inflamm Bowel Dis 15:918-25. 2009
    ....
  39. ncbi request reprint Identification of the interleukin 4 receptor alpha gene as a direct target for p73
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Res 63:8145-52. 2003
    ..We also found that p73beta-transfected tumor cells are sensitive to IL-4-mediated apoptosis. Our data suggest that IL-4Ralpha could mediate, in part, certain immune responses and p73-dependent cell death...
  40. ncbi request reprint Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers
    Hiroaki Taniguchi
    1First Department of Internal Medicine, Sapporo Medical University, South 1, West 16, Sapporo, Hokkaido 060 8543, Japan
    Oncogene 24:7946-52. 2005
    ..Modulation of the Wnt pathway, through reversal of WIF-1 silencing by demethylating agents, is a potential target for treatment and/or prevention of gastrointestinal cancers...
  41. doi request reprint Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas
    Wenhua Piao
    First Department of Internal Medicine, Sapporo Medical University, Chuo Ku, Sapporo 060 8543, Japan
    Mol Cancer Ther 7:1483-93. 2008
    ..This compound did not influence hybrid receptor formation. Thus, NVP-AEW541 may have significant therapeutic utility in human GI carcinomas both alone and in combination with chemotherapy...
  42. ncbi request reprint Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors
    Takefumi Kikuchi
    First Department of Internal Medicine, Sapporo Medical University, Sapporo 060 8543, Japan
    Oncogene 21:2741-9. 2002
    ..Regional methylation and histone deacetylation thus appear to be crucially involved in the silencing of p57KIP2 expression in human tumors...
  43. doi request reprint Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype
    Eiichiro Yamamoto
    First Department of Internal Medicine, the Research Institute for Frontier Medicine, Sapporo Medical University, Japan
    Am J Pathol 181:1847-61. 2012
    ..Our integrative genomic and epigenetic analysis suggests early onset of CIMP during CRC development and indicates a previously unknown CRC development pathway in which epigenetic instability associates with genomic alterations...
  44. ncbi request reprint Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus
    Masanobu Kusano
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Japan
    Cancer 106:1467-79. 2006
    ..The CpG island methylator phenotype (CIMP), which is characterized by simultaneous methylation of the CpG islands of multiple genes, has been recognized as one of the important mechanisms in gastrointestinal carcinogenesis...
  45. ncbi request reprint Gene amplification and overexpression of PRDM14 in breast cancers
    Noriko Nishikawa
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    Cancer Res 67:9649-57. 2007
    ..That little or no expression of PRDM14 is seen in noncancerous tissues suggests that PRDM14 could be an ideal therapeutic target for the treatment of breast cancer...
  46. ncbi request reprint Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers
    Katsuhiko Nosho
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Carcinogenesis 28:1364-70. 2007
    ..RASSF2 methylation with oncogenic activation is a promising biomarker for predicting invasive potential of pT1 CRCs...
  47. doi request reprint Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer
    Minoru Toyota
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    Cancer Res 68:4123-32. 2008
    ..Our results suggest that miR-34b/c and BTG4 are novel tumor suppressors in CRC and that the miR-34b/c CpG island, which bidirectionally regulates miR-34b/c and BTG4, is a frequent target of epigenetic silencing in CRC...
  48. ncbi request reprint Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors
    Hironobu Sato
    First Department of Internal Medicine, Sapporo Medical University, Sapporo 060 8543, Japan
    Carcinogenesis 28:2459-66. 2007
    ..Our results demonstrate that DKKs are frequent targets of epigenetic silencing in gastrointestinal tumors, and that loss of DKKs may facilitate tumorigenesis through beta-catenin/T-cell factor-independent mechanisms...
  49. ncbi request reprint Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation
    Reo Maruyama
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Cancer Res 66:4574-83. 2006
    ..Our in silico approach is a powerful method for identification of functional p53 binding sites and p53 target genes that are conserved among humans and other organisms and for further understanding the function of p53 in tumorigenesis...
  50. doi request reprint Necessity of early intervention for IgG4-related disease--delayed treatment induces fibrosis progression
    Yui Shimizu
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Rheumatology (Oxford) 52:679-83. 2013
    ..We aimed to retrospectively analyse disease duration, efficacy of treatment with glucocorticoids and results of histopathological examination of submandibular gland specimens to clarify the necessity for early intervention in IgG4-RD...
  51. ncbi request reprint Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling
    Masashi Idogawa
    Chemotherapy Division and ADP Ribosylation in Oncology Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Res 67:911-8. 2007
    ..Identification of the functional interaction of Ku70 as well as PARP-1 with the TCF-4 and beta-catenin transcriptional complex may provide insights into a novel linkage between DNA damage recognition/repair and Wnt signaling...
  52. ncbi request reprint Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability
    Nobuki Miyamoto
    First Department of Internal Medicine, Sapporo Medical University, South 1, West 16, Sapporo, Japan
    Cancer Lett 254:42-53. 2007
    ..The difference may be associated with less aggressive phenotype of these cancers with MSI-H and affect future molecular targeted therapeutics...
  53. ncbi request reprint Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer
    Masako Ueno
    First Department of Internal Medicine, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
    Tumour Biol 25:134-40. 2004
    ..It thus appears that aberrant methylation of its 5'CGI and histone deacetylation play key roles in silencing SLC5A8 expression in gastric cancers...
  54. ncbi request reprint Analysis of gene expression in human colorectal cancer tissues by cDNA array
    Hiroyuki Yamamoto
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    J Gastroenterol 37:83-6. 2002
    ..The development and progression of cancer are accompanied by complex changes in patterns of gene expression. The purpose of this study was to clarify the relevance of macroarray analysis of human colorectal cancer tissues...
  55. doi request reprint Co-expression of laminin β3 and γ2 chains and epigenetic inactivation of laminin α3 chain in gastric cancer
    Masanori Ii
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Hokkaido 060 8543, Japan
    Int J Oncol 39:593-9. 2011
    ..Cancer cell motility appears to be associated with the cyto-plasmic laminin γ2 chain in vitro...
  56. pmc Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers
    Mariko Oki
    First Department of Internal Medicine, Sapporo Medical University, Chuo Ku, Sapporo 060 8543, Japan
    World J Gastroenterol 14:5650-6. 2008
    ..To clarify the expression and role of Ephrin receptor A4 (EphA4) in gastric cancer in relation to clinicopathological characteristics and the expression of fibroblast growth factor receptor 1 (FGFR1) and ephrin ligands...
  57. doi request reprint Genome-wide profiling of chromatin signatures reveals epigenetic regulation of MicroRNA genes in colorectal cancer
    Hiromu Suzuki
    Department of Molecular Biology, First Department of Internal Medicine, Scholarly Information Center, Department of Public Health, and Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Japan
    Cancer Res 71:5646-58. 2011
    ..Our findings offer insight into the association between chromatin signatures and miRNA dysregulation in cancer, and they also suggest that miRNA reexpression may contribute to the effects of epigenetic therapy...
  58. doi request reprint The efficacy of IGF-I receptor monoclonal antibody against human gastrointestinal carcinomas is independent of k-ras mutation status
    Masanori Ii
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Clin Cancer Res 17:5048-59. 2011
    ..In this study, we sought to evaluate the effect of a new monoclonal antibody for IGF-IR, figitumumab (CP-751,871), on the progression of human gastrointestinal carcinomas with/without k-ras mutation...
  59. ncbi request reprint A case of colorectal carcinoma in adenoma analyzed by a cDNA array
    Katsuhiko Nosho
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Int J Colorectal Dis 20:287-91. 2005
    ..To clarify relevant alterations of gene expression associated with adenoma-carcinoma progression, the gene expression profiles of these tumor tissues were analyzed by a cDNA array...
  60. doi request reprint Association between genomic alterations and metastatic behavior of colorectal cancer identified by array-based comparative genomic hybridization
    Takeshi Sawada
    Department of Molecular Biology, Sapporo Medical University, Sapporo, Japan
    Genes Chromosomes Cancer 52:140-9. 2013
    ..Therefore, DNA copy number profiles may be predictive of the metastatic behavior of CRCs...
  61. doi request reprint Risk of malignancies in IgG4-related disease
    Motohisa Yamamoto
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo, Hokkaido 0608543, Japan
    Mod Rheumatol 22:414-8. 2012
    ..0, which was higher than that for the general population. We should be cognizant of the possible existence of malignancies in patients with IgG4-RD at the time of diagnosis and during follow-up care...
  62. ncbi request reprint Association of trypsin expression with tumour progression and matrilysin expression in human colorectal cancer
    Hiroyuki Yamamoto
    First Department of Internal Medicine, Sapporo Medical University, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    J Pathol 199:176-84. 2003
    ..Detection of trypsin expression as well as matrilysin is useful for the prediction of recurrence in and poor prognosis of colorectal cancer patients...
  63. doi request reprint p53 family members regulate the expression of the apolipoprotein D gene
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
    J Biol Chem 284:872-83. 2009
    ..These results suggest that apoD induction may mediate the activity of p73 in normal development...
  64. doi request reprint Association of SLC22A4/5 polymorphisms with steroid responsiveness of inflammatory bowel disease in Japan
    Seiya Nakahara
    First Department of Internal Medicine, Sapporo Medical University, S 1, W 16, Chuo Ku, Sapporo, 060 8543, Japan
    Dis Colon Rectum 51:598-603. 2008
    ..Our goal is personalized steroid therapy adjusted to match individual variations in drug responsiveness in each inflammatory bowel disease patient...
  65. ncbi request reprint Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis
    Katsuhiko Nosho
    First Department of Internal Medicine, Sapporo Medical University, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Carcinogenesis 26:892-9. 2005
    ..The results suggest that E1AF, in conjunction with the expression of MMP-1, MMP-7, COX-2 and iNOS, plays an important role in the early stage of colorectal carcinogenesis...
  66. pmc Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen
    Satoshi Yamaoka
    First Department of Internal Medicine, Sapporo Medical University, Chuo Ku, Sapporo, Japan
    World J Gastroenterol 15:5579-85. 2009
    ..To clarify the significance of JC virus (JCV) T-antigen (T-Ag) expression in human gastric cancer...
  67. ncbi request reprint Diaphragm disease of small intestine diagnosed by double-balloon enteroscopy
    Katsuhiko Nosho
    First Department of Internal Medicine, Sapporo Medical University, Sapporo 060 8543, Japan
    Gastrointest Endosc 62:187-9. 2005
  68. ncbi request reprint Haplotype analysis of UDP-glucuronocyltransferase 2B7 gene (UGT2B7) polymorphisms in healthy Japanese subjects
    Katsuhiko Saito
    Division of Pharmaceutical Health Care and Sciences, Sapporo Medical University, Chuo Ku, Sapporo 060 8543, Japan
    Clin Biochem 39:303-8. 2006
    ..In addition, information about single nucleotide polymorphisms (SNPs) and haplotypes of the UGT2B7 gene that encode the enzyme in the Japanese population is still far from sufficient...
  69. ncbi request reprint Expression of ets-related transcriptional factor E1AF is associated with tumor progression and over-expression of matrilysin in human gastric cancer
    Hiroyuki Yamamoto
    First Department of Internal Medicine, Sapporo Medical University, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Carcinogenesis 25:325-32. 2004
    ..The results of this study suggest that E1AF, the expression of which is closely correlated with the expression of matrilysin, plays a key role in the progression of gastric cancer...
  70. ncbi request reprint Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer
    Takefumi Kikuchi
    First Department of Internal Medicine, Sapporo Medical University, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Int J Cancer 97:272-7. 2002
    ..These results indicate that a subset of gastric cancer with COX-2 methylation evolves through the pathway that is independent of COX-2 expression and that COX-2 inhibitor may not be useful to induce apoptosis in these cases...
  71. ncbi request reprint Increased expression of T-fimbrin gene after DNA damage in CHO cells and inactivation of T-fimbrin by CpG methylation in human colorectal cancer cells
    Yasushi Sasaki
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 6, Chuo Ku, Sapporo, 060 8543, Japan
    Int J Cancer 97:211-6. 2002
    ..These results suggest that downregulation of T-fimbrin may be involved in cancer development through G2/M cell-cycle control in mammalian cells...
  72. ncbi request reprint Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)amino- methyl]benzamide and m-carboxycinnamic acid bis-hydroxamide augment radiation-induced cell death in gastrointestinal adenocarcinoma cells
    YuBin Zhang
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Int J Cancer 110:301-8. 2004
    ..Our results suggest that these HDAC inhibitors may enhance the efficacy of radiation therapy in gastrointestinal cancer cells...
  73. ncbi request reprint Combination of tumor necrosis factor-alpha with sulindac augments its apoptotic potential and suppresses tumor growth of human carcinoma cells in nude mice
    Hiroshi Yasui
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer 97:1412-20. 2003
    ..In the current study, the authors investigated whether sulindac can augment TNF-alpha-mediated apoptosis in other human carcinoma cells and whether it can be applied for in vivo clinical usage...
  74. ncbi request reprint Genetic blockade of the insulin-like growth factor-I receptor: a promising strategy for human pancreatic cancer
    Yongfen Min
    First Department of Internal Medicine, Sapporo Medical University, S 1 W 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Res 63:6432-41. 2003
    ..The antitumor activity of IGF-Ir/dn is mediated through inhibition of Akt-1 and enhances the efficacy of chemotherapy. Adenovirus-IGF-Ir/482st may be a useful anticancer therapeutic for pancreatic cancer...
  75. ncbi request reprint Overexpression of BAD preferentially augments anoikis
    Masashi Idogawa
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Int J Cancer 107:215-23. 2003
    ..Thus, we propose that BAD can serve as a valuable gene therapeutic molecule to inhibit carcinoma progression...
  76. ncbi request reprint Mucin expression profile is related to biological and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas
    Hideto Ito
    First Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Pancreas 30:e96-102. 2005
    ..Biologic and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas (IPMTs) were studied in reference to immunohistochemical mucin (MUC1, MUC2, and MUC5AC) expression...
  77. ncbi request reprint Insulin-like growth factor-I receptor as a marker for prognosis and a therapeutic target in human esophageal squamous cell carcinoma
    Arisa Imsumran
    First Department of Internal Medicine, Sapporo Medical University, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Carcinogenesis 28:947-56. 2007
    ..Therapeutic blockade of IGF-Ir may be a useful anticancer therapeutic for ESCC...
  78. ncbi request reprint The p53 family member genes are involved in the Notch signal pathway
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
    J Biol Chem 277:719-24. 2002
    ..Our findings show an association between the p53 family genes and Notch signaling and suggest a potential molecular mechanism for the involvement of the p53 family genes in normal development...
  79. pmc A candidate targeting molecule of insulin-like growth factor-I receptor for gastrointestinal cancers
    Yasushi Adachi
    First Department of Internal Medicine, Sapporo Medical University, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    World J Gastroenterol 16:5779-89. 2010
    ..Thus, IGF-IR might be a candidate for a molecular therapeutic target in human GI carcinomas...
  80. ncbi request reprint Combination of tumor necrosis factor-alpha with sulindac in human carcinoma cells in vivo
    Hiroshi Yasui
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo, 060 8543, Japan
    Ann N Y Acad Sci 1010:273-7. 2003
    ..Therefore, in combination with sulindac or its metabolites, TNF-alpha may become a potentially useful anti-cancer agent to suppress tumor...
  81. pmc Oxidative stress impairs the heat stress response and delays unfolded protein recovery
    Masaaki Adachi
    Division of Molecular Oncology and Molecular Diagnosis, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 4:e7719. 2009
    ..We now face a high risk of simultaneous exposure to heat and oxidative stress. However, there have been few studies investigating their combined adverse effects on cell viability...
  82. ncbi request reprint [Epigenetic alterations in cancer]
    Minoru Toyota
    Tanpakushitsu Kakusan Koso 51:2043-8. 2006
  83. ncbi request reprint Rapidly growing early gastric cancer with microsatellite instability
    Kentaro Yamashita
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Gastroenterol 38:170-4. 2003
    ..These results suggest that a deficiency of the mismatch repair system played a critical role in the progression of this cancer...
  84. ncbi request reprint Differential roles of alterations of p53, p16, and SMAD4 expression in the progression of intraductal papillary-mucinous tumors of the pancreas
    Shigeru Sasaki
    First Department of Internal Medicine, Sapporo Medical University, Chuo Ku, Japan
    Oncol Rep 10:21-5. 2003
    ..Our results suggest that these alterations accumulate during the progression of IPMTs, reflecting results of analysis of allelic losses that showed a stepwise accumulation of genetic changes during progression...
  85. ncbi request reprint Interferon gamma assay for detecting latent tuberculosis infection in rheumatoid arthritis patients during infliximab administration
    Hiroki Takahashi
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Rheumatol Int 27:1143-8. 2007
    ..Conventional procedures and QFT-G should be employed in parallel, and LTBI should be assumed when one technique gives a positive result...
  86. doi request reprint Correlation of laterally spreading type and JC virus with methylator phenotype status in colorectal adenoma
    Katsuhiko Nosho
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Hum Pathol 39:767-75. 2008
    ..In conclusion, among colorectal adenomas, CIMP-high status was determined by BRAF mutation and not by macroscopic type, unlike CIMP-0. JC virus T-Ag may be important in determining methylator phenotype...
  87. ncbi request reprint Silencing of negative regulator of JAK/STAT in colorectal cancer
    Takao Endo
    First Department of Internal Medicine, Sapporo Medical University
    J Gastroenterol 39:200-1. 2004
  88. ncbi request reprint Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status
    Carla Oliveira
    Institute of Molecular Pathology and Immunology, The University of Porto, IPATIMUP, 4200 465 Porto, Portugal
    Hum Mol Genet 13:2303-11. 2004
    ....
  89. ncbi request reprint Pathologic features of mucin-producing bile duct tumors: two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms
    Hiroaki Shibahara
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Am J Surg Pathol 28:327-38. 2004
    ....
  90. pmc A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells
    Angela H Ting
    Genomic Medicine Institute, Lerner Research Institute, Cleveland, Ohio, USA
    Cancer Res 68:2570-5. 2008
    ..This reactivation is associated with a dramatic loss of localized promoter DNA hypermethylation. Thus, intact DICER is required to maintain full promoter DNA hypermethylation of select epigenetically silenced loci in human cancer cells...
  91. ncbi request reprint [Tailored therapy in gastrointestinal and hepatic cancer--toward ideal medicine through genomic science]
    Kohzoh Imai
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 101:255-63. 2004
  92. ncbi request reprint Expression profiles of non-small cell lung cancers on cDNA microarrays: identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs
    Takefumi Kikuchi
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    Oncogene 22:2192-205. 2003
    ..Our results provide valuable information for eventually identifying predictive markers and novel therapeutic target molecules for this type of cancer...
  93. ncbi request reprint [Gastric cancer and microsatellite instability]
    Fumio Itoh
    First Department of Internal Medicine, Sapporo Medical University
    Nihon Shokakibyo Gakkai Zasshi 99:1043-9. 2002
  94. ncbi request reprint New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy
    Akiko Nakamura
    Department of Pathology, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima, Japan
    J Pathol 197:201-10. 2002
    ..In conclusion, our classification of IPMTs by MUC2 expression pattern may be of value in the better assessment of the biological behaviour of IPMTs and their potential for malignancy...
  95. ncbi request reprint Adenovirus-mediated gene transfer of caspase-8 sensitizes human adenocarcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand
    Hiroshi Yasui
    Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Int J Oncol 26:537-44. 2005
    ..These results suggest that Adv-caspase-8 may be a good combination partner of TRAIL and enables TRAIL to be a more potent anticancer agent in a wide range of adenocarcinoma cells which demonstrate low expression of caspase-8...
  96. ncbi request reprint Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence
    Akinori Takaoka
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 424:516-23. 2003
    ..Our study reveals a hitherto unrecognized link between p53 and IFN-alpha/beta in tumour suppression and antiviral immunity, which may have therapeutic implications...
  97. ncbi request reprint Epigenetics in gastroenterological cancer and prospects for translational research
    Hiromu Suzuki
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 104:1319-28. 2007
  98. ncbi request reprint Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex
    Masashi Idogawa
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 128:1919-36. 2005
    ..We explored the molecular composition of the TCF-4/beta-catenin transcriptional complex by means of proteomics...
  99. pmc Methylation of multiple genes in gastric glands with intestinal metaplasia: A disorder with polyclonal origins
    Mami Mihara
    Carcinogenesis Division, National Cancer Center Research Institute, Tsukiji 5 chome, Tokyo 104, Japan
    Am J Pathol 169:1643-51. 2006
    ....
  100. ncbi request reprint Bmf contributes to histone deacetylase inhibitor-mediated enhancing effects on apoptosis after ionizing radiation
    YuBin Zhang
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1 W 16 Chuo ku, Sapporo 060 8543, Japan
    Apoptosis 11:1349-57. 2006
    ..Taken together, histone hyperacetylation may enhance IR-induced death via activation of Bmf transcription, thereby implying Bmf as a key molecule for HDAC inhibitors (FK228 and CBHA)-mediated enhancing effect on IR-induced cell death...
  101. ncbi request reprint Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors
    Hafid Alazzouzi
    Molecular Oncology and Aging Group, Molecular Biology and Biochemistry Research Center CIBBIM, Valle Hebron Hospital Research Institute, Barcelona, Spain
    Cancer Res 65:10170-3. 2005
    ....