Osamu Honmou

Summary

Affiliation: Sapporo Medical University
Country: Japan

Publications

  1. doi request reprint Mesenchymal stem cells: therapeutic outlook for stroke
    Osamu Honmou
    Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University, South 1st, West 16th, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Trends Mol Med 18:292-7. 2012
  2. pmc Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke
    Osamu Honmou
    Department of Neural Repair and Therapeutics, Sapporo Medical University, South 1st, West 16th, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Brain 134:1790-807. 2011
  3. ncbi request reprint [Consequence of intellectual property and consortium project in neurosurgery]
    Osamu Honmou
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Japan
    No Shinkei Geka 32:571-7. 2004
  4. ncbi request reprint Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model
    Kazuhiko Kurozumi
    Department of Molecular Medicine, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo 060 8556, Japan
    Mol Ther 11:96-104. 2005
  5. doi request reprint Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia
    Wei Zheng
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1310:8-16. 2010
  6. pmc Optimization of a therapeutic protocol for intravenous injection of human mesenchymal stem cells after cerebral ischemia in adult rats
    Yoshinori Omori
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1236:30-8. 2008
  7. doi request reprint Therapeutic time window of mesenchymal stem cells derived from bone marrow after cerebral ischemia
    Katsuya Komatsu
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1334:84-92. 2010
  8. doi request reprint Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia
    Kentaro Toyama
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Exp Neurol 216:47-55. 2009
  9. pmc Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia
    Toshiyuki Onda
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    J Cereb Blood Flow Metab 28:329-40. 2008
  10. pmc Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat
    Yoshifumi Horita
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    J Neurosci Res 84:1495-504. 2006

Collaborators

Detail Information

Publications29

  1. doi request reprint Mesenchymal stem cells: therapeutic outlook for stroke
    Osamu Honmou
    Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University, South 1st, West 16th, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Trends Mol Med 18:292-7. 2012
    ..Here, we review the reparative and protective properties of transplanted MSCs in stroke models, describe initial human studies on intravenous MSC delivery in stroke, and provide a perspective on prospects for future progress with MSCs...
  2. pmc Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke
    Osamu Honmou
    Department of Neural Repair and Therapeutics, Sapporo Medical University, South 1st, West 16th, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Brain 134:1790-807. 2011
    ....
  3. ncbi request reprint [Consequence of intellectual property and consortium project in neurosurgery]
    Osamu Honmou
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Japan
    No Shinkei Geka 32:571-7. 2004
  4. ncbi request reprint Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model
    Kazuhiko Kurozumi
    Department of Molecular Medicine, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo 060 8556, Japan
    Mol Ther 11:96-104. 2005
    ..Thus, MSC transfected with the BDNF or GDNF gene resulted in improved function and reduced ischemic damage in a rat model of MCAO. These data suggest that gene-modified cell therapy may be a useful approach for the treatment of stroke...
  5. doi request reprint Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia
    Wei Zheng
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1310:8-16. 2010
    ..Enzyme-linked immunosorbent assay (ELISA) of the hippocampus revealed an increase in BDNF in hMSC-treated group. These data suggest that intravenous delivery of hMSC may have a therapeutic effect in global cerebral ischemia...
  6. pmc Optimization of a therapeutic protocol for intravenous injection of human mesenchymal stem cells after cerebral ischemia in adult rats
    Yoshinori Omori
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1236:30-8. 2008
    ..Thus, differences in functional outcome in the hMSC transplantation subgroups are not likely the result of differences in angiogenesis, but rather from differences in neuroprotective effects...
  7. doi request reprint Therapeutic time window of mesenchymal stem cells derived from bone marrow after cerebral ischemia
    Katsuya Komatsu
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1334:84-92. 2010
    ....
  8. doi request reprint Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia
    Kentaro Toyama
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Exp Neurol 216:47-55. 2009
    ..These results suggest that intravenous administration of hMSCs transfected with the angiopoietin-1 and VEGF gene using a fiber-mutant adenovirus vector may represent a new strategy for the treatment of ischemia...
  9. pmc Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia
    Toshiyuki Onda
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    J Cereb Blood Flow Metab 28:329-40. 2008
    ....
  10. pmc Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat
    Yoshifumi Horita
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    J Neurosci Res 84:1495-504. 2006
    ....
  11. ncbi request reprint Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy
    Hirofumi Hamada
    Department of Molecular Medicine, Sapporo Medical University, Sapporo 060 8556, Japan
    Cancer Sci 96:149-56. 2005
    ..Gene therapy employing MSC as a tissue-protecting and targeting cytoreagent would be a promising approach...
  12. pmc Mesenchymal stem cells derived from peripheral blood protects against ischemia
    Ryo Ukai
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    J Neurotrauma 24:508-20. 2007
    ..The therapeutic benefits of both MSC-treated groups were similar. These data suggest that PMSCs derived from peripheral blood could be an important cell source of cell therapy for stroke...
  13. ncbi request reprint Autologous transplantation of expanded neural precursor cells into the demyelinated monkey spinal cord
    Shinichi Oka
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1030:94-102. 2004
    ....
  14. ncbi request reprint A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats
    Satoshi Iihoshi
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, South 1st, West 16th, Chuo, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1007:1-9. 2004
    ..These findings suggest that early intervention with intravenous administration of autologous mononuclear cells from bone marrow can reduce lesion size in the MCAO model in the rat, and improve functional outcome...
  15. doi request reprint Expression of aquaporin-4 augments cytotoxic brain edema after traumatic brain injury during acute ethanol exposure
    Ryuichi Katada
    Department of Legal Medicine and Molecular Alcohology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Am J Pathol 180:17-23. 2012
    ..These findings suggest that ethanol induces up-regulation of AQP4, leading to brain edema. The accumulation of AQP4 may play an important role in the augmentation of brain edema after TBI under ethanol consumption...
  16. pmc Magnetic resonance lactate and lipid signals in rat brain after middle cerebral artery occlusion model
    Kuniaki Harada
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1134:206-13. 2007
    ..Thus, adjustment of the echo time is essential to analyze the metabolites in acute cerebral infarction, which may be useful in both the clinic and laboratory...
  17. doi request reprint Intravenous administration of mesenchymal stem cells derived from bone marrow after contusive spinal cord injury improves functional outcome
    Misuzu Osaka
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Brain Res 1343:226-35. 2010
    ....
  18. pmc Neural differentiation potential of peripheral blood- and bone-marrow-derived precursor cells
    Sangnyon Kim
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1123:27-33. 2006
    ..After withdrawal of the mitogens, these cells could differentiate into neurofilament-positive neurons or GFAP-positive glia. Thus, our findings suggest the potential use of PMSCs for a cell therapy in CNS diseases...
  19. doi request reprint Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model
    Junpei Suzuki
    Division of Radiology, Sapporo Medical University Hospital, Sapporo 060 8556, Japan
    Brain Res 1497:15-22. 2013
    ..These results suggest that the presence of a bilateral signal in sensorimotor cortex as detected by fMRI was more predictive of improved functional outcome than lesion volume alone...
  20. pmc Effect of transplantation of bone marrow-derived mesenchymal stem cells on mice infected with prions
    Chang Hyun Song
    Laboratory of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Virol 83:5918-27. 2009
    ....
  21. doi request reprint Prior ethanol injection promotes brain edema after traumatic brain injury
    Ryuichi Katada
    Department of Legal Medicine and Molecular Alcohology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Neurotrauma 26:2015-25. 2009
    ..In addition, antioxidant treatment at 3 h post-injury significantly attenuated some markers of oxidative stress, mortality, and volume of edema at 24 h after ethanol treatment and contusion...
  22. doi request reprint Spinal cord infarct as the initial clinical presentation of intravascular malignant lymphomatosis
    He Liu
    Department of Neurosurgery, Sapporo Medical University School of Medicine, South 1st, West 16th, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    J Clin Neurosci 16:570-3. 2009
    ..IML can be an important differential diagnosis of progressive paraparesis of unknown etiology...
  23. ncbi request reprint Optimization of three-dimensional time-of-flight magnetic resonance angiography of the intracranial arteries
    Kuniaki Harada
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Neurol Med Chir (Tokyo) 46:523-8; discussion 528. 2006
    ..The half position method can provide better MR angiograms in certain brain regions of younger people, and in all brain regions in older patients...
  24. ncbi request reprint [A cell therapy for stroke]
    Osamu Honmou
    Department of Neurosurgery, Sapporo Medical University School of Medicine
    Nihon Rinsho 64:664-6. 2006
  25. ncbi request reprint Telomerized human multipotent mesenchymal cells can differentiate into hematopoietic and cobblestone area-supporting cells
    Masayoshi Kobune
    Dept of Molecular Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Hematol 31:715-22. 2003
    ..To compare the hematopoietic support provided by telomerized human mesenchymal stem cells (MSCs) and telomerized MSC-derived stromal cells...
  26. doi request reprint Mesenchymal stem cells transmigrate across brain microvascular endothelial cell monolayers through transiently formed inter-endothelial gaps
    Takashi Matsushita
    Department of Neurology, School of Medicine, Sapporo Medical University, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Neurosci Lett 502:41-5. 2011
    ..These results show that our in vitro culture system consisting of BMECs and MSCs is useful for investigating the molecular and cellular mechanisms underlying MSC transmigration across the BBB...
  27. ncbi request reprint BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model
    Kazuhiko Kurozumi
    Department of Molecular Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Mol Ther 9:189-97. 2004
    ..These data suggest that MSC transfected with the BDNF gene may be useful in the treatment of cerebral ischemia and may represent a new strategy for the treatment of stroke...
  28. ncbi request reprint T2 reversed fast spin-echo image and enhanced three-dimensional surface MR angiography for the diagnosis of cerebral arteriovenous malformations
    Sumiyoshi Tanabe
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Clin Neurosci 9:6-10. 2002
    ..Indeed, these imaging methods supply clinically relevant data that is difficult to obtain with conventional neuro-imaging and provide better details of lesions, informing surgical planning and decision-making...
  29. pmc Comparative analysis of remyelinating potential of focal and intravenous administration of autologous bone marrow cells into the rat demyelinated spinal cord
    Michio Inoue
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Glia 44:111-8. 2003
    ....