M Furuhashi

Summary

Affiliation: Sapporo Medical University
Country: Japan

Publications

  1. pmc Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
    Masato Furuhashi
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 447:959-65. 2007
  2. pmc Circulating levels of fatty acid-binding protein family and metabolic phenotype in the general population
    Shutaro Ishimura
    Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 8:e81318. 2013
  3. pmc Elevation of fatty acid-binding protein 4 is predisposed by family history of hypertension and contributes to blood pressure elevation
    Hideki Ota
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Am J Hypertens 25:1124-30. 2012
  4. pmc Lipid chaperones and metabolic inflammation
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Int J Inflam 2011:642612. 2011
  5. pmc Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 6:e27356. 2011
  6. ncbi request reprint Utility of serum ratio of heart-type fatty acid-binding protein to myoglobin for cardiac damage regardless of renal dysfunction
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Circ J 68:656-9. 2004
  7. ncbi request reprint Possible impairment of transcardiac utilization of adiponectin in patients with type 2 diabetes
    Masato Furuhashi
    Sapporo Medical University School of Medicine, Second Department of Internal Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Diabetes Care 27:2217-21. 2004
  8. ncbi request reprint Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivity
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Hypertens 22:1977-82. 2004
  9. ncbi request reprint Liddle's syndrome caused by a novel mutation in the proline-rich PY motif of the epithelial sodium channel beta-subunit
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    J Clin Endocrinol Metab 90:340-4. 2005
  10. ncbi request reprint Low adiponectin level in young normotensive men with a family history of essential hypertension
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Hypertens Res 28:141-6. 2005

Collaborators

Detail Information

Publications26

  1. pmc Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
    Masato Furuhashi
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 447:959-65. 2007
    ..Our findings demonstrate that targeting aP2 with small-molecule inhibitors is possible and can lead to a new class of powerful therapeutic agents to prevent and treat metabolic diseases such as type 2 diabetes and atherosclerosis...
  2. pmc Circulating levels of fatty acid-binding protein family and metabolic phenotype in the general population
    Shutaro Ishimura
    Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 8:e81318. 2013
    ..However, recent studies have shown that FABPs can be secreted from cells into circulation. Here we examined determinants and roles of circulating FABPs in a general population...
  3. pmc Elevation of fatty acid-binding protein 4 is predisposed by family history of hypertension and contributes to blood pressure elevation
    Hideki Ota
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Am J Hypertens 25:1124-30. 2012
    ..Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, and atherosclerosis. However, little is known about the role of FABP4 in essential hypertension...
  4. pmc Lipid chaperones and metabolic inflammation
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Int J Inflam 2011:642612. 2011
    ..Here, we discuss the molecular and cellular basis of the roles of FABPs, especially FABP4 and FABP5, in metaflammation and related diseases including obesity, diabetes, and atherosclerosis...
  5. pmc Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 6:e27356. 2011
    ..We tested the hypothesis that FABP4 level predicts prognosis of patients with end-stage renal disease (ESRD), a group at high risk for atherosclerosis-associated morbidity and mortality...
  6. ncbi request reprint Utility of serum ratio of heart-type fatty acid-binding protein to myoglobin for cardiac damage regardless of renal dysfunction
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Circ J 68:656-9. 2004
    ..We evaluated the utility of F/M in hemodialysis patients compared to control subjects...
  7. ncbi request reprint Possible impairment of transcardiac utilization of adiponectin in patients with type 2 diabetes
    Masato Furuhashi
    Sapporo Medical University School of Medicine, Second Department of Internal Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Diabetes Care 27:2217-21. 2004
    ..Circulating adiponecin levels are reduced in states of insulin resistance such as type 2 diabetes. We examined transcardiac utilization of adiponectin in patients with and without type 2 diabetes...
  8. ncbi request reprint Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivity
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Hypertens 22:1977-82. 2004
    ..We investigated the effect of RAS blockade on insulin sensitivity, adipocyte size, and intramuscular lipid content in fructose-fed rats (FFR) as a model of insulin-resistant hypertension...
  9. ncbi request reprint Liddle's syndrome caused by a novel mutation in the proline-rich PY motif of the epithelial sodium channel beta-subunit
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    J Clin Endocrinol Metab 90:340-4. 2005
    ..These findings provide additional clinical evidence that a conserved PY motif is critically important for the regulation of ENaC activity...
  10. ncbi request reprint Low adiponectin level in young normotensive men with a family history of essential hypertension
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Hypertens Res 28:141-6. 2005
    ..Phenotype of reduced adiponectin level as an earlier penetrance may be especially useful in genetic analyses of insulin resistance and essential hypertension...
  11. ncbi request reprint Circulating resistin levels in essential hypertension
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Clin Endocrinol (Oxf) 59:507-10. 2003
    ..Most of the data obtained in previous studies are restricted to mRNA levels in tissues...
  12. ncbi request reprint Right bundle branch block and coved-type ST-segment elevation mimicked by acute cholecystitis
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Circ J 67:802-4. 2003
    ..Intravenous administration of pilsicainide, a pure sodium channel blocker, could reproduce the Brugada-type ST shift. This is the first report of the Brugada-type ST shift occurring in association with acute cholecystitis...
  13. ncbi request reprint Sonoclot coagulation analysis: new bedside monitoring for determination of the appropriate heparin dose during haemodialysis
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Nephrol Dial Transplant 17:1457-62. 2002
    ..We investigated whether a new bedside Sonoclot analysis is useful for determining an appropriate heparin dose during haemodialysis...
  14. ncbi request reprint Fenofibrate improves insulin sensitivity in connection with intramuscular lipid content, muscle fatty acid-binding protein, and beta-oxidation in skeletal muscle
    M Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    J Endocrinol 174:321-9. 2002
    ....
  15. pmc Prevalence of asymptomatic ST segment elevation in right precordial leads with right bundle branch block (Brugada-type ST shift) among the general Japanese population
    M Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 0061, Japan
    Heart 86:161-6. 2001
    ..To examine the modality and morbidity of asymptomatic ST segment elevation in leads V1 to V3 with right bundle branch block (Brugada-type ST shift)...
  16. ncbi request reprint Insulin sensitivity and lipid metabolism in human CD36 deficiency
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Diabetes Care 26:471-4. 2003
    ..The association between CD36 deficiency and insulin resistance remains controversial. We investigated glucose and lipid metabolism in human CD36 deficiency...
  17. ncbi request reprint Serum ratio of heart-type fatty acid-binding protein to myoglobin. A novel marker of cardiac damage and volume overload in hemodialysis patients
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Nephron Clin Pract 93:C69-74. 2003
    ..We evaluated whether the serum ratio of hFABP to myoglobin (F/M) might be a useful marker for assessing cardiac damage in hemodialysis patients...
  18. ncbi request reprint Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Hypertension 42:76-81. 2003
    ..These results suggest that hypoadiponectinemia is related to insulin resistance in essential hypertension and that RAS blockade increases adiponectin concentrations with improvement in insulin sensitivity...
  19. ncbi request reprint Tissue-specific impairment of insulin signaling in vasculature and skeletal muscle of fructose-fed rats
    Masaya Hyakukoku
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Hypertens Res 26:169-76. 2003
    ..Thus PI3-K pathway may be one of the factors underlying the onset of cardiovascular disease in patients with insulin resistance...
  20. ncbi request reprint Role of adiponectin in insulin-resistant hypertension and atherosclerosis
    Hideyuki Murakami
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S L, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Hypertens Res 26:705-10. 2003
    ....
  21. ncbi request reprint The effect of tumor necrosis factor-alpha on tissue specificity and selectivity to insulin signaling
    Koichi Yamaguchi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Hypertens Res 26:389-96. 2003
    ....
  22. ncbi request reprint Myocardial iodine-123-metaiodobenzylguanidine (123I-MIBG) imaging in Brugada syndrome
    Masato Furuhashi
    Circulation 106:e59-60; author reply e59-60. 2002
  23. pmc Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice
    Masato Furuhashi
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 118:2640-50. 2008
    ....
  24. pmc Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis
    Kathryn E Wellen
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell 129:537-48. 2007
    ..We conclude that STAMP2 participates in integrating inflammatory and metabolic responses and thus plays a key role in systemic metabolic homeostasis...
  25. ncbi request reprint Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes
    Kazuhisa Maeda
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cell Metab 1:107-19. 2005
    ....
  26. ncbi request reprint Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    Umut Ozcan
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Science 313:1137-40. 2006
    ..Our results demonstrate that chemical chaperones enhance the adaptive capacity of the ER and act as potent antidiabetic modalities with potential application in the treatment of type 2 diabetes...