Hideki Chiba

Summary

Affiliation: Sapporo Medical University
Country: Japan

Publications

  1. ncbi request reprint The significance of interferon-gamma-triggered internalization of tight-junction proteins in inflammatory bowel disease
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Sci STKE 2006:pe1. 2006
  2. pmc The nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilli
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Cell Biol 175:971-80. 2006
  3. ncbi request reprint Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4alpha
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 302:11-21. 2005
  4. ncbi request reprint Transmembrane proteins of tight junctions
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Biochim Biophys Acta 1778:588-600. 2008
  5. ncbi request reprint Hepatocyte nuclear factor (HNF)-4alpha triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 286:288-97. 2003
  6. ncbi request reprint Phosphorylation of ezrin enhances microvillus length via a p38 MAP-kinase pathway in an immortalized mouse hepatic cell line
    Mengdong Lan
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17 Sapporo 060 8556, Japan
    Exp Cell Res 312:111-20. 2006
  7. ncbi request reprint p38 MAP-kinase regulates function of gap and tight junctions during regeneration of rat hepatocytes
    Toshinobu Yamamoto
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17, Sapporo 060 8556, Japan
    J Hepatol 42:707-18. 2005
  8. ncbi request reprint Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis
    Masaki Murata
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Tissue Res 319:341-7. 2005
  9. ncbi request reprint IL-1beta regulates expression of Cx32, occludin, and claudin-2 of rat hepatocytes via distinct signal transduction pathways
    Toshinobu Yamamoto
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Cell Res 299:427-41. 2004
  10. ncbi request reprint Transforming growth factor-beta induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Liver Int 28:534-45. 2008

Collaborators

Detail Information

Publications56

  1. ncbi request reprint The significance of interferon-gamma-triggered internalization of tight-junction proteins in inflammatory bowel disease
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Sci STKE 2006:pe1. 2006
    ....
  2. pmc The nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilli
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Cell Biol 175:971-80. 2006
    ..We conclude that HNF4alpha acts as a morphogen to trigger microvillus formation...
  3. ncbi request reprint Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4alpha
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 302:11-21. 2005
    ....
  4. ncbi request reprint Transmembrane proteins of tight junctions
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Biochim Biophys Acta 1778:588-600. 2008
    ..We provide an overview of recent progress in studies on these proteins and highlight their roles and regulation, as well as their functional significance in human diseases...
  5. ncbi request reprint Hepatocyte nuclear factor (HNF)-4alpha triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 286:288-97. 2003
    ..These findings indicate that HNF-4alpha triggers de novo formation of functional tight junctions and establishment of epithelial cell polarity...
  6. ncbi request reprint Phosphorylation of ezrin enhances microvillus length via a p38 MAP-kinase pathway in an immortalized mouse hepatic cell line
    Mengdong Lan
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17 Sapporo 060 8556, Japan
    Exp Cell Res 312:111-20. 2006
    ..These results suggested that phosphorylation of ezrin via the p38 MAP-kinase signaling pathway might be involved in the formation of microvilli during development of epithelial cell polarization...
  7. ncbi request reprint p38 MAP-kinase regulates function of gap and tight junctions during regeneration of rat hepatocytes
    Toshinobu Yamamoto
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17, Sapporo 060 8556, Japan
    J Hepatol 42:707-18. 2005
    ..The role of the stress responsitive MAP-kinase, p38 MAP-kinase, signaling pathway in function of gap and tight junctions was examined during regeneration of rat hepatocytes in vivo and in vitro...
  8. ncbi request reprint Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis
    Masaki Murata
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Tissue Res 319:341-7. 2005
    ..These results suggest that Cx32 expression is in part related to induction of tight junctions through modulation of MAGI-1 expression in an immortalized mouse hepatic cell line...
  9. ncbi request reprint IL-1beta regulates expression of Cx32, occludin, and claudin-2 of rat hepatocytes via distinct signal transduction pathways
    Toshinobu Yamamoto
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Cell Res 299:427-41. 2004
    ..These results demonstrate that MAP-kinase, p38 MAP-kinase, and PI3-kinase are distinctly involved in the regulation of hepatic gap and tight junctions during the acute-phase response to IL-1beta...
  10. ncbi request reprint Transforming growth factor-beta induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Liver Int 28:534-45. 2008
    ..In mature hepatocytes during EMT induced by TGF-beta, changes in the expression of tight junction proteins and the fence function indicated that epithelial cell polarity remains unclear...
  11. ncbi request reprint Inhibition of MAP kinase activity moderates changes in expression and function of Cx32 but not claudin-1 during DNA synthesis in primary cultures of rat hepatocytes
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, S1, W17, Sapporo 060 8556, Japan
    Med Electron Microsc 37:101-13. 2004
    ..Furthermore, Cx32, but not claudin-1, protein may be a target of activated MAP kinase in hepatocytes...
  12. ncbi request reprint Changes of gap and tight junctions during differentiation of human nasal epithelial cells using primary human nasal epithelial cells and primary human nasal fibroblast cells in a noncontact coculture system
    Jun ichi Koizumi
    Department of Otolaryngology, Sapporo Medical University School of Medicine, S1 W17, Sapporo, Japan
    J Membr Biol 218:1-7. 2007
    ....
  13. ncbi request reprint Oncogenic Raf-1 regulates epithelial to mesenchymal transition via distinct signal transduction pathways in an immortalized mouse hepatic cell line
    Mengdong Lan
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17, Sapporo 060 8556, Japan
    Carcinogenesis 25:2385-95. 2004
    ..Expression and localization of occludin recovered slightly on treatment with PP2. Thus, oncogenic Raf-1 regulates EMT via distinct MAP kinase, p38 MAP kinase and c-Src tyrosine kinase signal pathways in the mouse hepatic cell line...
  14. ncbi request reprint Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions
    Masafumi Imamura
    Department of Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Exp Cell Res 313:1951-62. 2007
    ..These results suggest that expression of claudin-2 in rodent hepatocytes may play a specific role as controlling the size of paracellular permeability in the barrier to keep bile in bile canaculi...
  15. ncbi request reprint Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells
    Kunihiko Nagasawa
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Cell Physiol 208:123-32. 2006
    ..These findings suggest that Cx40- and/or Cx43-based gap junctions might be required to maintain the endothelial barrier function without altering the expression and localization of the tight-junction components analyzed...
  16. ncbi request reprint Connexin 26 expression prevents down-regulation of barrier and fence functions of tight junctions by Na+/K+-ATPase inhibitor ouabain in human airway epithelial cell line Calu-3
    Mitsuru Go
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17 Sapporo 060 8556, Japan
    Exp Cell Res 312:3847-56. 2006
    ..These results suggest that Cx26 expression, but not the mediated intercellular communication, may regulate tight junction barrier and fence functions in human airway epithelial cell line Calu-3...
  17. ncbi request reprint Induction of claudins in passaged hTERT-transfected human nasal epithelial cells with an extended life span
    Makoto Kurose
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Tissue Res 330:63-74. 2007
    ..Our results indicate that hTERT-transfected human nasal epithelial cells with an extended lifespan can be used as an indispensable and stable model for studying the regulation of claudins in human nasal epithelium...
  18. doi request reprint Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells
    Ryuta Kamekura
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Tissue Res 338:283-93. 2009
    ....
  19. ncbi request reprint Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization
    Seiro Satohisa
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Exp Cell Res 310:66-78. 2005
    ....
  20. ncbi request reprint Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP
    Tamotsu Soma
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 300:202-12. 2004
    ..cAMP decreased the claudin-5-based endothelial barrier, strongly suggesting that other tight-junction molecule(s) are required to elevate endothelial barrier functions in response to cAMP...
  21. pmc IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway
    Naoko Hatakeyama
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, S1, W17, Sapporo, 060 8556, Japan
    Cell Tissue Res 334:243-54. 2008
    ....
  22. ncbi request reprint Glial cell-derived cytokines attenuate the breakdown of vascular integrity in diabetic retinopathy
    Nami Nishikiori
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Diabetes 56:1333-40. 2007
    ..These findings reveal that glial cell-derived cytokines such as GDNF and VEGF regulate BRB function, implying that the glial cell can be a possible therapeutic target in diabetic retinopathy...
  23. ncbi request reprint Down-regulation of survival signaling through MAPK and Akt in occludin-deficient mouse hepatocytes in vitro
    Masaki Murata
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17 Sapporo 060 8556, Japan
    Exp Cell Res 310:140-51. 2005
    ..These findings show that occludin plays a crucial role in claudin-2-dependent TJ function and the apoptosis involving MAPK and Akt signaling pathways in hepatocytes...
  24. ncbi request reprint Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells
    Makoto Osanai
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Cancer Sci 98:1557-62. 2007
    ..These data suggest that the methylator phenotype of claudin-6 may at least partially contribute to enhanced tumorigenic and invasive properties of breast carcinoma cells...
  25. pmc Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes
    Hiroki Fujita
    Departments of Pathology and Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Mol Biol Cell 19:1912-21. 2008
    ..These findings strongly suggest that claudin-2- and/or claudin-12-based tight junctions form paracellular Ca(2+) channels in intestinal epithelia, and they highlight a novel mechanism behind vitamin D-dependent calcium homeostasis...
  26. ncbi request reprint Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine
    Hiroki Fujita
    Dept of Pathology, Sapporo Medical University School of Medicine, S1, W17, Sapporo 060 8556, Japan
    J Histochem Cytochem 54:933-44. 2006
    ..This manuscript contains online supplemental material available at http://www.jhc.org. Please visit this article online to view these materials...
  27. ncbi request reprint Tight junction proteins and signal transduction pathways in hepatocytes
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Histol Histopathol 24:1463-72. 2009
    ..This review focuses on recent findings about the relationship between tight junction proteins and signal transduction pathways in hepatocytes...
  28. doi request reprint Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation
    Jun ichi Koizumi
    Department of Otolaryngology, Sapporo Medical University School of Medicine, S1 W17 Sapporo 060 8556, Japan
    Mol Pharmacol 74:432-42. 2008
    ..These results suggest that TPA-induced PKC signaling enhances the barrier function of human nasal epithelial cells via transcriptional up-regulation of tight junction proteins, and the mechanisms may contribute to a drug delivery system...
  29. doi request reprint Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro
    Ken ichi Takano
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Mol Histol 39:265-73. 2008
    ..These results indicate that the epithelial barrier of the human adenoid is stably maintained by expression of tight junction proteins in the epithelium including Ck20-positive M-like cells...
  30. ncbi request reprint Expression patterns of claudin family of tight-junction proteins in the mouse prostate
    Naoyuki Sakai
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Histochem Cell Biol 127:457-62. 2007
    ..These findings provide basic information for elucidating the significance of claudins in prostate diseases, including prostate cancers...
  31. doi request reprint Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells
    Seiichi Son
    Departments of Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Histochem Cell Biol 131:411-24. 2009
    ..These results suggest that claudin-2 may affect not only the bile canalicular seal but also bile canalicular formation...
  32. ncbi request reprint Hepatocyte nuclear factor (HNF)-4alpha induces expression of endothelial Fas ligand (FasL) to prevent cancer cell transmigration: a novel defense mechanism of endothelium against cancer metastasis
    Makoto Osanai
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo 060 8556
    Jpn J Cancer Res 93:532-41. 2002
    ..These results raise the possibility that HNF-4alpha is involved in regulating cancer cell transmigration by modulating the Fas-FasL system...
  33. ncbi request reprint Cellular retinoic acid bioavailability determines epithelial integrity: Role of retinoic acid receptor alpha agonists in colitis
    Makoto Osanai
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Sapporo, Japan
    Mol Pharmacol 71:250-8. 2007
    ..Our results suggest that cellular RA bioavailability determines the epithelial integrity, because it is a critical regulator for barrier protection during mucosal injuries...
  34. ncbi request reprint Role of the p38 MAP-kinase signaling pathway for Cx32 and claudin-1 in the rat liver
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Commun Adhes 10:437-43. 2003
    ..Changes of gap and tight junctions during liver regeneration and cholestasis are shown to be in part controlled via the p38 MAP-kinase signaling pathway and are independent of cell growth...
  35. ncbi request reprint Epigenetic silencing of occludin promotes tumorigenic and metastatic properties of cancer cells via modulations of unique sets of apoptosis-associated genes
    Makoto Osanai
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Res 66:9125-33. 2006
    ....
  36. pmc The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells
    Kotaro Sugimoto
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 8:e75106. 2013
    ..Furthermore, similar results were obtained in mouse embryonic stem cells. Thus, we have uncovered that the Cldn6 functions as a novel cue to induce epithelial differentiation. ..
  37. ncbi request reprint Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways
    Tsutomu Ishizaki
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 290:275-88. 2003
    ....
  38. ncbi request reprint Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells
    Makoto Osanai
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Sci 98:1027-34. 2007
    ..These findings suggest that the loss of occludin expression is at least partially involved in the senescence-escape program during mammary tumorigenesis...
  39. ncbi request reprint A novel monoclonal antibody against the second extracellular loop of occludin disrupts epithelial cell polarity
    Yuichi Tokunaga
    Department of Pathology, Sapporo Medical University School of Medicine, S1, W17, Sapporo 060 8556, Japan
    J Histochem Cytochem 55:735-44. 2007
    ....
  40. ncbi request reprint Glyceraldehyde-derived advanced glycation end-products preferentially induce VEGF expression and reduce GDNF expression in human astrocytes
    Hideaki Miyajima
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Biochem Biophys Res Commun 330:361-6. 2005
    ..These results indicate that glyceraldehyde-derived AGE is the biologically active substance for astrocytes by regulating the VEGF and GDNF expression, which is causally contributing to an increase in the permeability of the BBB...
  41. doi request reprint Claudin-4-targeted therapy using Clostridium perfringens enterotoxin for prostate cancer
    Toshihiro Maeda
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Prostate 72:351-60. 2012
    ..We investigated the potential of Cldn-targeted therapy using CPE...
  42. ncbi request reprint Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains
    Nami Nishikiori
    Departments of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Invest Ophthalmol Vis Sci 48:2224-9. 2007
    ....
  43. ncbi request reprint Tight junctions and human diseases
    Norimasa Sawada
    Department of Pathology, Sapporo Medical University School of Medicine, S1, W17, Sapporo 060 8556, Japan
    Med Electron Microsc 36:147-56. 2003
    ..Some pathogenic bacteria and viruses target and affect the tight-junction function, leading to diseases. In this review, the relationship between tight junctions and human diseases is summarized...
  44. ncbi request reprint [Molecular mechanism of formation and regulation of the blood-tissue barrier]
    Hideki Chiba
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Fukuoka Igaku Zasshi 95:139-45. 2004
  45. ncbi request reprint Cx32 formation and/or Cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytic cell line
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 276:40-51. 2002
    ..These results indicate that Cx32 formation and/or Cx32-mediated intercellular communication may participate in the formation of functional tight junctions and actin organization...
  46. ncbi request reprint Regulation of the blood-biliary barrier: interaction between gap and tight junctions in hepatocytes
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, S1, W17, Sapporo 060 8556, Japan
    Med Electron Microsc 36:157-64. 2003
    ..In this review, we introduce the interaction and regulation between gap and tight junctions of hepatocytes in vitro and discuss the regulatory mechanisms of the "blood-biliary barrier" to study the molecular pathogenesis of cholestasis...
  47. ncbi request reprint Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions
    Masato Fujibe
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Exp Cell Res 295:36-47. 2004
    ..These findings indicate that Thr203 of claudin-1 is required to enhance the barrier function of claudin-1-based tight junctions, probably via its phosphorylation and subsequent integration into tight junctions...
  48. ncbi request reprint Hyperstimulation and a gonadotropin-releasing hormone agonist modulate ovarian vascular permeability by altering expression of the tight junction protein claudin-5
    Yoshimitsu Kitajima
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Japan
    Endocrinology 147:694-9. 2006
    ....
  49. ncbi request reprint Barrier function of microvessels and roles of glial cell line-derived neurotrophic factor in the rat testis
    Yasuhiro Kamimura
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Med Electron Microsc 35:139-45. 2002
    ..Because this relation between GDNF and GFR alpha1 is similar to that observed in the BBB, we hypothesize that GDNF is a general regulator of tight junctions of the endothelium forming a blood-tissue barrier in a paracrine fashion...
  50. ncbi request reprint Bile canalicular barrier function and expression of tight-junctional molecules in rat hepatocytes during common bile duct ligation
    Yasunari Takakuwa
    Department of Pathology, Sapporo Medical University School of Medicine, S1 W17, Chuo Ku, Sapporo 060 8556, Japan
    Cell Tissue Res 307:181-9. 2002
    ..The early phase of bile stasis employed in this study is thought to be an indispensable approach for understanding the precise regulation of tight junctions...
  51. ncbi request reprint Hypermethylation-modulated downregulation of claudin-7 expression promotes the progression of colorectal carcinoma
    Fumihito Nakayama
    Division of Pathology, Department of Pathology and Microbiology, Kobe University Graduate School of Medicine, Kobe, Japan
    Pathobiology 75:177-85. 2008
    ..The expression of tight junction-related transmembrane protein claudin-7 (CLDN7) and its regulatory mechanism were investigated in colorectal carcinomas (CRCs)...
  52. ncbi request reprint Reduced expression of claudin-7 correlates with invasion and metastasis in squamous cell carcinoma of the esophagus
    Yu Usami
    Division of Surgical Pathology, Department of Biomedical Informatics, Kobe University, Graduate School of Medicine, Kobe 650 0017, Japan
    Hum Pathol 37:569-77. 2006
    ..Thus, claudin-7 can be a novel marker for the prediction of lymph node metastasis...
  53. doi request reprint Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma
    Shinya Satake
    Division of Pathology, Department of Pathology and Microbiology, Kobe University Graduate School of Medicine, Kobe, Japan
    Pathol Int 58:156-63. 2008
    ..8-fold), whereas no induction of the other claudins was detected. These findings suggest that Cdx2 plays an important role in the regulation of intestinal claudin expression not only in gastric mucosa with IM but also GC...
  54. ncbi request reprint Heterogeneous expression of claudin-4 in human colorectal cancer: decreased claudin-4 expression at the invasive front correlates cancer invasion and metastasis
    Junya Ueda
    Division of Surgical Pathology, Department of Biomedical Informatics, Kobe University Graduate School of Medicine, Kobe, Japan
    Pathobiology 74:32-41. 2007
    ..The aim of this study is to investigate the significance of claudin-4 expression in CRC and its association with clinicopathological factors...
  55. doi request reprint Evidence for multiple peroxisome proliferator-activated receptor gamma transcripts in bone: fine-tuning by hormonal regulation and mRNA stability
    Claudia Bruedigam
    Department of Internal Medicine, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    FEBS Lett 582:1618-24. 2008
    ....
  56. ncbi request reprint Gastric and intestinal claudin expression at the invasive front of gastric carcinoma
    Yoshiko Matsuda
    Division of Surgical Pathology, Department of Biomedical Informatics, Kobe University Graduate School of Medicine, Kobe, Japan
    Cancer Sci 98:1014-9. 2007
    ..Classification of gastric cancers using gastric and intestinal claudins is a good biomarker for assessing the risk of poor prognosis...