Affiliation: Sanwa Kagaku Kenkyusho Co
- Kallidinogenase normalizes retinal vasopermeability in streptozotocin-induced diabetic rats: potential roles of vascular endothelial growth factor and nitric oxideNoriaki Kato
Pharmaceutical Research Laboratories, Sanwa Kagaku Kenkyusho Co, Ltd, Mie, Japan
Eur J Pharmacol 606:187-90. 2009..The current study showed beneficial effects of kallidinogenase on increased retinal vascular permeability and VEGF in diabetic rats, suggesting that kallidinogenase may be effective for simple retinopathy in patients with diabetes...
- Neurotrophin-3-induced production of nerve growth factor is suppressed in Schwann cells exposed to high glucose: involvement of the polyol pathwayTakeshi Suzuki
Drug Development Research Laboratories, Sanwa Kagaku Kenkyusho Co, Ltd, Mie, Japan
J Neurochem 91:1430-8. 2004..Together, the enhanced polyol pathway activity under high-glucose conditions seems to elicit reduced NT-3-induced NGF production in Schwann cells. Enhanced oxidative stress linked to the polyol pathway activity may mediate this process...
- Long-term treatment with fidarestat suppresses the development of diabetic retinopathy in STZ-induced diabetic ratsNoriaki Kato
Central Research Laboratory, Sanwa Kagaku Kenkyusho Co, Ltd, 363 Shiosaki, Hokusei, Mie 511 0406, Inabe, Japan
J Diabetes Complications 17:374-9. 2003..These results suggest that fidarestat, by virtue of its long-term correction of the accelerated polyol pathway, has a potential role in preventing the progression of diabetic retinopathy...
- Change in blood kinin and plasma porcine pancreatic kallikrein concentrations after oral administration of kallikrein formulation in dogYoshika Yasuda
Pharmaceutical Research Laboratories, Sanwa Kagaku Kenkyusho Co, Ltd, Japan
Biol Pharm Bull 34:1518-21. 2011..6 ng/ml vs. 49.6 ± 1.4 ng/ml; mean ± S.E.M, n = 4, p < 0.05). In conclusion, PPK was considered to be absorbed after oral administration and to exert its pharmacological action via kinins produced by kininogen degradation in dogs...