Takashi Kagari

Summary

Affiliation: Sankyo Co
Country: Japan

Publications

  1. ncbi request reprint Essential role of Fc gamma receptors in anti-type II collagen antibody-induced arthritis
    Takashi Kagari
    Biological Research Laboratories, Sankyo Co, Ltd, Shinagawa ku, Tokyo, Japan
    J Immunol 170:4318-24. 2003
  2. ncbi request reprint Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: part 3
    Akira Nakao
    Lead Discovery and Optimization Research Laboratories II, Daiichi Sankyo Co, Ltd, 1 16 13 Kitakasai, Edogawa ku, Tokyo 134 8630, Japan
    Bioorg Med Chem Lett 20:4774-8. 2010
  3. ncbi request reprint Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: part 2
    Akira Nakao
    Medicinal Chemistry Research Laboratories II, Daiichi Sankyo Co, Ltd, Edogawa ku, Tokyo134 8630, Japan
    Bioorg Med Chem Lett 20:2435-7. 2010
  4. ncbi request reprint Anti-type II collagen antibody accelerates arthritis via CXCR2-expressing cells in IL-1 receptor antagonist-deficient mice
    Takashi Kagari
    Biological Research Laboratories, Daiichi Sankyo Co Ltd, Tokyo, Japan
    Eur J Immunol 37:2753-63. 2007
  5. ncbi request reprint Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists
    Masayoshi Asano
    Lead Discovery and Optimization Research Laboratories I, Daiichi Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    Bioorg Med Chem Lett 22:3083-8. 2012
  6. doi request reprint Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist
    Tsuyoshi Nakamura
    Lead Discovery and Optimization Research Laboratories I, Daiichi Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    Eur J Med Chem 51:92-8. 2012
  7. pmc Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis
    Daisuke Tanaka
    Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    Immunology 119:195-202. 2006
  8. ncbi request reprint The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis
    Takashi Kagari
    Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    J Immunol 169:1459-66. 2002
  9. ncbi request reprint Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: part 1
    Akira Nakao
    Medicinal Chemistry Research Laboratories II, Daiichi Sankyo Co, Ltd, 1 16 13 Kitakasai, Tokyo 134 8630, Japan
    Bioorg Med Chem Lett 19:4607-10. 2009
  10. ncbi request reprint Synthesis and SAR studies of benzyl ether derivatives as potent orally active S1P1 agonists
    Takashi Tsuji
    Medicinal Chemistry Research Laboratories, Daiichi Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    Bioorg Med Chem 22:4246-56. 2014

Collaborators

  • Keisuke Suzuki
  • Takeshi Fukuda
  • Daisuke Nakai
  • Emi Kamiyama
  • Tetsufumi Koga
  • Takahiro Yamaguchi
  • Y Iwakura
  • Daisuke Tanaka
  • Takaichi Shimozato
  • Tsuyoshi Nakamura
  • Akira Nakao
  • Takahide Nishi
  • Futoshi Nara
  • Yumiko Mizuno
  • Yumi Kawase
  • Yukiko Sekiguchi
  • Masayoshi Asano
  • Hiromi Doi
  • Hiroshi Yuita
  • Keiko Oguchi-Oshima
  • Wataru Tomisato
  • Kazuhiko Tamaki
  • Reina Kaneko
  • Ryotaku Inoue
  • Nobuyuki Ohkawa
  • Takayoshi Nagasaki
  • Kazumasa Aoki
  • Shigeru Ushiyama
  • Takashi Tsuji
  • Takako Kimura
  • Miyuki Nagasaki
  • Hiromi Doi-Komuro
  • Shinichi Inaba
  • Takuya Ikeda
  • Chizuko Yahara
  • Takashi Izumi
  • Masakazu Tamura
  • Taiji Goto
  • Tomohiro Honda
  • Toshiyasu Takemoto
  • Yasuyuki Abe
  • Yoko Urasaki-Kaneno
  • Yoshiyuki Yabe
  • Noriko Masubuchi
  • Hatsumi Nasu
  • Eiko Namba
  • Nobuaki Watanabe
  • Shintaro Nakayama

Detail Information

Publications11

  1. ncbi request reprint Essential role of Fc gamma receptors in anti-type II collagen antibody-induced arthritis
    Takashi Kagari
    Biological Research Laboratories, Sankyo Co, Ltd, Shinagawa ku, Tokyo, Japan
    J Immunol 170:4318-24. 2003
    ..These results suggest that the reason behind the nondevelopment of arthritis in FcRgamma(-/-) BALB/c mice is not due to a disorder in transient cytokine production, but to an irregularity downstream of cytokine production...
  2. ncbi request reprint Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: part 3
    Akira Nakao
    Lead Discovery and Optimization Research Laboratories II, Daiichi Sankyo Co, Ltd, 1 16 13 Kitakasai, Edogawa ku, Tokyo 134 8630, Japan
    Bioorg Med Chem Lett 20:4774-8. 2010
    ..9 mg/kg, p.o.; (viii) analgesic effect on adjuvant-induced arthritic pain in rats: ID(50)=2.9 mg/kg, p.o.). As a result, compound 4a was chosen as a candidate for further pre-clinical studies...
  3. ncbi request reprint Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: part 2
    Akira Nakao
    Medicinal Chemistry Research Laboratories II, Daiichi Sankyo Co, Ltd, Edogawa ku, Tokyo134 8630, Japan
    Bioorg Med Chem Lett 20:2435-7. 2010
    ..44 microM) and compound 3i demonstrated potent inhibitory activity in vivo (inhibition of LPS-induced TNFalpha production in mice, ID(50)=1.42 mg/kg)...
  4. ncbi request reprint Anti-type II collagen antibody accelerates arthritis via CXCR2-expressing cells in IL-1 receptor antagonist-deficient mice
    Takashi Kagari
    Biological Research Laboratories, Daiichi Sankyo Co Ltd, Tokyo, Japan
    Eur J Immunol 37:2753-63. 2007
    ....
  5. ncbi request reprint Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists
    Masayoshi Asano
    Lead Discovery and Optimization Research Laboratories I, Daiichi Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    Bioorg Med Chem Lett 22:3083-8. 2012
    ..In rat on host versus graft reaction (HvGR), the ID(50) value of 24c was determined at 0.07 mg/kg. The pharmacokinetics in rat and monkey is also reported. Compared to compound 3, 24c showed excellent stability against enterobacteria...
  6. doi request reprint Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist
    Tsuyoshi Nakamura
    Lead Discovery and Optimization Research Laboratories I, Daiichi Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    Eur J Med Chem 51:92-8. 2012
    ....
  7. pmc Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis
    Daisuke Tanaka
    Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    Immunology 119:195-202. 2006
    ..These results suggest the important role of chemotactic factors involving C5a and inhibitory G-protein (Gi)-coupled receptors not only in the development, but also in the maintenance of arthritis...
  8. ncbi request reprint The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis
    Takashi Kagari
    Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    J Immunol 169:1459-66. 2002
    ..Because arthritis was also developed in SCID mice, the development of arthritis in the Ab-induced mice model is due to a mechanism that does not involve T or B cells...
  9. ncbi request reprint Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: part 1
    Akira Nakao
    Medicinal Chemistry Research Laboratories II, Daiichi Sankyo Co, Ltd, 1 16 13 Kitakasai, Tokyo 134 8630, Japan
    Bioorg Med Chem Lett 19:4607-10. 2009
    ..86 microM) and in vivo (inhibition of LPS induced TNFalpha production in mice, ID(50)=5.98 mg/kg)...
  10. ncbi request reprint Synthesis and SAR studies of benzyl ether derivatives as potent orally active S1P1 agonists
    Takashi Tsuji
    Medicinal Chemistry Research Laboratories, Daiichi Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    Bioorg Med Chem 22:4246-56. 2014
    ..o.) in rats. ..
  11. doi request reprint Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist
    Tsuyoshi Nakamura
    Lead Discovery and Optimization Research Laboratories I, Daiichi Sankyo Co, Ltd, Shinagawa ku, Tokyo, Japan
    Bioorg Med Chem Lett 22:1788-92. 2012
    ..This observation gives an explanation for the excellent S1P(3)-sparing characteristic of CS-2100...