Hisashi Saji

Summary

Country: Japan

Publications

  1. doi request reprint Clinical response of large cell neuroendocrine carcinoma of the lung to perioperative adjuvant chemotherapy
    Hisashi Saji
    Department of Thoracic Surgery and Oncology, Tokyo Medical University, Nishishinjuku, Shinjuku ku, Japan
    Anticancer Drugs 21:89-93. 2010
  2. pmc Virtual segmentectomy based on high-quality three-dimensional lung modelling from computed tomography images
    Hisashi Saji
    Department of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan
    Interact Cardiovasc Thorac Surg 17:227-32. 2013
  3. doi request reprint Gene expression profiling and molecular pathway analysis for the identification of early-stage lung adenocarcinoma patients at risk for early recurrence
    Hisashi Saji
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Shinjuku ku, Tokyo 160 0023, Japan
    Oncol Rep 29:1902-6. 2013
  4. doi request reprint A proposal for combination of total number and anatomical location of involved lymph nodes for nodal classification in non-small cell lung cancer
    Hisashi Saji
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Chest 143:1618-25. 2013
  5. doi request reprint Prognostic impact of number of resected and involved lymph nodes at complete resection on survival in non-small cell lung cancer
    Hisashi Saji
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    J Thorac Oncol 6:1865-71. 2011
  6. doi request reprint Outcomes of airway stenting for advanced lung cancer with central airway obstruction
    Hisashi Saji
    Department of Thoracic Surgery and Oncology, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Interact Cardiovasc Thorac Surg 11:425-8. 2010
  7. ncbi request reprint [A possibility of overcoming local tumor immune tolerance by radiofrequency ablation in combination with intratumoral injection of naïve dendritic cell]
    Hisashi Saji
    Dept of Thoracic Surgery and Oncology, Tokyo Medical University
    Gan To Kagaku Ryoho 33:1736-8. 2006
  8. doi request reprint Do tumours located in the left lower lobe have worse outcomes in lymph node-positive non-small cell lung cancer than tumours in other lobes?
    Yujin Kudo
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Eur J Cardiothorac Surg 42:414-9. 2012
  9. doi request reprint Klotho predicts good clinical outcome in patients with limited-disease small cell lung cancer who received surgery
    Jitsuo Usuda
    Division of Thoracic Surgery, Department of Surgery 1, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Lung Cancer 74:332-7. 2011
  10. ncbi request reprint Significance of expression of TGF-beta in pulmonary metastasis in non-small cell lung cancer tissues
    Hisashi Saji
    Pulmonary Oncology Unit, Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 9:295-300. 2003

Detail Information

Publications34

  1. doi request reprint Clinical response of large cell neuroendocrine carcinoma of the lung to perioperative adjuvant chemotherapy
    Hisashi Saji
    Department of Thoracic Surgery and Oncology, Tokyo Medical University, Nishishinjuku, Shinjuku ku, Japan
    Anticancer Drugs 21:89-93. 2010
    ..This should be, therefore, evaluated further in prospective multi-institutional phase II trials...
  2. pmc Virtual segmentectomy based on high-quality three-dimensional lung modelling from computed tomography images
    Hisashi Saji
    Department of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan
    Interact Cardiovasc Thorac Surg 17:227-32. 2013
    ..The aim of this study was to demonstrate the feasibility and efficacy of a novel simulation software called, virtual segmentectomy...
  3. doi request reprint Gene expression profiling and molecular pathway analysis for the identification of early-stage lung adenocarcinoma patients at risk for early recurrence
    Hisashi Saji
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Shinjuku ku, Tokyo 160 0023, Japan
    Oncol Rep 29:1902-6. 2013
    ..This comprehensive gene expression and functional pathway analysis identified a distinct molecular pathway, CAMs, that correlated with the early relapse of patients with early-stage lung adenocarcinoma...
  4. doi request reprint A proposal for combination of total number and anatomical location of involved lymph nodes for nodal classification in non-small cell lung cancer
    Hisashi Saji
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Chest 143:1618-25. 2013
    ..However, it remains unknown whether the total number or anatomic location of involved LNs is a superior prognostic factor...
  5. doi request reprint Prognostic impact of number of resected and involved lymph nodes at complete resection on survival in non-small cell lung cancer
    Hisashi Saji
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    J Thorac Oncol 6:1865-71. 2011
    ....
  6. doi request reprint Outcomes of airway stenting for advanced lung cancer with central airway obstruction
    Hisashi Saji
    Department of Thoracic Surgery and Oncology, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Interact Cardiovasc Thorac Surg 11:425-8. 2010
    ..This study represents a single-institution experience. Although an aggressive strategy of AS is justified in order to improve symptoms and QoL, AS itself did not contribute to survival benefit...
  7. ncbi request reprint [A possibility of overcoming local tumor immune tolerance by radiofrequency ablation in combination with intratumoral injection of naïve dendritic cell]
    Hisashi Saji
    Dept of Thoracic Surgery and Oncology, Tokyo Medical University
    Gan To Kagaku Ryoho 33:1736-8. 2006
    ..In this report, we demonstrated the mechanism of (4) and (5) by radiofrequency ablation plus IT DC using mouse tumor model...
  8. doi request reprint Do tumours located in the left lower lobe have worse outcomes in lymph node-positive non-small cell lung cancer than tumours in other lobes?
    Yujin Kudo
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Eur J Cardiothorac Surg 42:414-9. 2012
    ..The purpose of this study was to evaluate the impact of tumour lobar location on surgical outcomes as an independent prognostic factor for survival in our non-small cell lung cancer (NSCLC) patient series...
  9. doi request reprint Klotho predicts good clinical outcome in patients with limited-disease small cell lung cancer who received surgery
    Jitsuo Usuda
    Division of Thoracic Surgery, Department of Surgery 1, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Lung Cancer 74:332-7. 2011
    ..We investigated whether the expression of Klotho, assessed by immunohistochemistry, can predict survival in patients with resected SCLC...
  10. ncbi request reprint Significance of expression of TGF-beta in pulmonary metastasis in non-small cell lung cancer tissues
    Hisashi Saji
    Pulmonary Oncology Unit, Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 9:295-300. 2003
    ..006 and p=0.011, respectively). We speculated that TGF-beta expression in tumor infiltrating stromal cells may regulate the occurrence of spontaneous pulmonary metastasis in NSCLC. (Ann Thorac Cardiovasc Surg 2003; 9: 295-300)..
  11. doi request reprint The prognostic impact of main bronchial lymph node involvement in non-small cell lung carcinoma: suggestions for a modification of the staging system
    Yoshihisa Shimada
    Department of Thoracic Surgery and Oncology, Tokyo Medical University, Tokyo, Japan
    Ann Thorac Surg 88:1583-8. 2009
    ..Debate exists about the definition of the borderline between N1 and N2 stations. This study evaluated the prognostic effect of N1 disease, especially focused on the significance of the main bronchial node (No. 10) vs N2 disease...
  12. doi request reprint Pathological vascular invasion and tumor differentiation predict cancer recurrence in stage IA non-small-cell lung cancer after complete surgical resection
    Yoshihisa Shimada
    First Department of Surgery, Division, Tokyo Medical University Hospital, Shinjyuku ku, Tokyo, Japan
    J Thorac Oncol 7:1263-70. 2012
    ..The objective of the current study was to identify the clinicopathological factors that affect overall prognosis and cancer recurrence of stage IA NSCLC...
  13. doi request reprint Impact of visceral pleural invasion on the survival of patients with non-small cell lung cancer
    Yujin Kudo
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Japan
    Lung Cancer 78:153-60. 2012
    ..In this study, we investigated visceral pleural invasion (VPI) as a poor prognostic factor in patients with non-small cell lung cancer (NSCLC) according to the 7th edition of the TNM classification...
  14. doi request reprint Prognostic factors and the significance of treatment after recurrence in completely resected stage I non-small cell lung cancer
    Yoshihisa Shimada
    Department of Surgery I, Tokyo Medical University Hospital, Tokyo, Japan
    Chest 143:1626-34. 2013
    ....
  15. pmc Retrospective analysis of nodal spread patterns according to tumor location in pathological N2 non-small cell lung cancer
    Yoshihisa Shimada
    First Department of Surgery, Tokyo Medical University Hospital, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    World J Surg 36:2865-71. 2012
    ....
  16. ncbi request reprint The present status of postoperative adjuvant chemotherapy for completely resected non-small cell lung cancer
    Masahiro Tsuboi
    Department of Thoracic Surgery and Oncology, Tokyo Medical University and Hospital, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 13:73-7. 2007
    ..Further research is needed to define the role of adjuvant platinum-based chemotherapy and its use, in conjunction with chest radiotherapy as the treatment for patients with resected stages IB and IIIA NSCLC...
  17. doi request reprint Klotho is a novel biomarker for good survival in resected large cell neuroendocrine carcinoma of the lung
    Jitsuo Usuda
    Division of Thoracic Surgery 1, Department of Surgery 1, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Lung Cancer 72:355-9. 2011
    ..In this study, we focused on the Klotho gene, which is an anti-aging gene known to be a potential tumor suppressor. We investigated whether the immunohistochemical expression of Klotho can predict survival patients with resected LCNEC...
  18. ncbi request reprint Correlation between encoded protein overexpression and copy number of the HER2 gene with survival in non-small cell lung cancer
    Haruhiko Nakamura
    Department of Surgery, Tokyo Medical University Hospital, Tokyo, Japan
    Int J Cancer 103:61-6. 2003
    ..Neither gene copy number increase nor overexpression correlated with survival. We conclude that the significance of HER2 status in NSCLC is different from that in breast cancer because high-grade amplification occurs rarely...
  19. ncbi request reprint cDNA microarray analysis of gene expression in pathologic Stage IA nonsmall cell lung carcinomas
    Haruhiko Nakamura
    Department of Surgery, Tokyo Medical University, Japan
    Cancer 97:2798-805. 2003
    ..The relationship between altered gene expression and tumor progression in lung carcinoma has yet to be characterized. Gene expression in pathologic Stage IA nonsmall cell lung carcinoma specimens was analyzed using a cDNA microarray...
  20. ncbi request reprint Immunologic parameters as significant prognostic factors in lung cancer
    Haruhiko Nakamura
    Department of Surgery, Tokyo Medical University Hospital, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo, Japan
    Lung Cancer 37:161-9. 2002
    ..A variety of immunologic indices have prognostic significance for the different types of lung cancer. Among these, the HLA-DR (%) in the peripheral blood is the most reliable factor for squamous cell carcinoma and small cell carcinoma...
  21. ncbi request reprint Lung cancer patients showing pure ground-glass opacity on computed tomography are good candidates for wedge resection
    Haruhiko Nakamura
    Department of Surgery, Tokyo Medical University Hospital, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Lung Cancer 44:61-8. 2004
    ..For peripheral localized bronchioloalveolar carcinoma showing PGGO, wedge resection appears to be the best operation. Definitive study of more patients with longer follow-up is needed...
  22. ncbi request reprint Peripheral leukocytes with HLA-DR+/CD8- phenotype are associated with prognosis in patients with lung cancer
    Haruhiko Nakamura
    Department of Surgery, Tokyo Medical University Hospital, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo, Japan 160 0023
    Anticancer Res 23:4149-52. 2003
    ..We have previously reported that the most significant immunological prognostic factors in patients with lung cancer are the percentages of peripheral HLA-DR+ lymphocytes...
  23. doi request reprint Proposal on incorporating blood vessel invasion into the T classification parts as a practical staging system for stage I non-small cell lung cancer
    Yujin Kudo
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Japan
    Lung Cancer 81:187-93. 2013
    ..We investigated blood vessel invasion (BVI) as a possible negative prognostic factor in patients with stage I non-small cell lung cancer (NSCLC) according to the 7th edition of the TNM classification...
  24. ncbi request reprint Comparison of immunohistochemistry and real-time reverse transcription-polymerase chain reaction to detect expression of carcinoembryonic antigen in lung cancer
    Haruhiko Nakamura
    Department of Surgery, Tokyo Medical University Hospital, Tokyo 160 0023, Japan
    Oncol Rep 10:1231-5. 2003
    ..No statistically significant correlation between the serum CEA concentration and the amount of mRNA expression was found (p=0.0932). Real-time RT-PCR is useful to quantify specific mRNA expression from a small piece of tissue...
  25. ncbi request reprint Chromosomal instability detected by fluorescence in situ hybridization in surgical specimens of non-small cell lung cancer is associated with poor survival
    Haruhiko Nakamura
    Department of Surgery, Tokyo Medical University Hospital, Tokyo 160 0023, Japan
    Clin Cancer Res 9:2294-9. 2003
    ..Chromosomal instability (CIN) in non-small cell lung cancer (NSCLC) has yet to be well studied. We examined the relationship between CIN detected by fluorescence in situ hybridization and survival in patients with NSCLC...
  26. doi request reprint Recent advances in video-assisted thoracoscopic surgery for lung cancer
    Norihiko Ikeda
    Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Asian J Endosc Surg 6:9-13. 2013
    ..Moreover, the indications for VATS are expanding to encompass complex procedures such as segmentectomy or sleeve resection. Training and dissemination of the technique and the monitoring of outcomes are necessary...
  27. ncbi request reprint Three dimensional computed tomography lung modeling is useful in simulation and navigation of lung cancer surgery
    Norihiko Ikeda
    Department of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 19:1-5. 2013
    ....
  28. doi request reprint A phase III randomized trial of lobectomy versus limited resection for small-sized peripheral non-small cell lung cancer (JCOG0802/WJOG4607L)
    Kenichi Nakamura
    Department of Thoracic Surgery, Kanagawa Cancer Center, 1 1 2, Nakao, Asahi ku, Yokohama 241 0815, Japan
    Jpn J Clin Oncol 40:271-4. 2010
    ..This study is one of the first intergroup studies in Japan between the Japan Clinical Oncology Group and the West Japan Oncology Group...
  29. doi request reprint A case of paravertebral mediastinal chordoma without bone destruction
    Jun Matsubayashi
    Department of Anatomic Pathology, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Skeletal Radiol 41:1641-4. 2012
    ..These results confirmed the tumor to be an extraosseous chordoma in the paravertebral mediastinal region, which is an extremely rare location for a chordoma...
  30. ncbi request reprint The incidence and the risk of pneumothorax and chest tube placement after percutaneous CT-guided lung biopsy: the angle of the needle trajectory is a novel predictor
    Hisashi Saji
    Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Chest 121:1521-6. 2002
    ..The aims of this study were to estimate the risk of pneumothorax in patients undergoing CT-guided lung biopsy, and to determine which factors affect its occurrence...
  31. doi request reprint Intracaval and intracardiac extension of invasive thymoma complicated by superior and inferior vena cava syndrome
    Atsushi Kurata
    Department of Molecular Pathology, Tokyo Medical University, Tokyo, Japan
    Pathol Int 63:56-62. 2013
    ..To our knowledge, this is the first English report of an autopsy case of intracardiac thymoma extension, and a detailed literature review of similar cases is also presented...
  32. ncbi request reprint Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human breast carcinoma
    Hisashi Saji
    Breast Oncology, Tokyo Metropolitan Komagome Hospital, 3 18 22, Honkomagome, Bunkyo ku, 113 8677, Tokyo, Japan
    Cancer Lett 190:191-7. 2003
    ..This series did not demonstrate P-glycoprotein and nuclear YB-1 expression might be one of the useful prognostic marker of breast cancer...
  33. ncbi request reprint Impact of selective Glisson transection on survival of hepatocellular carcinoma
    Koji Tsuruta
    Department of Surgery, Tokyo Metropolitan Komagome Hospital, First Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    Hepatogastroenterology 49:1607-10. 2002
    ....
  34. ncbi request reprint Systemic antitumor effect of intratumoral injection of dendritic cells in combination with local photodynamic therapy
    Hisashi Saji
    Department of Pathology, Stanford University School of Medicine, Palo Alto, California, USA
    Clin Cancer Res 12:2568-74. 2006
    ....