Research Topics
Species | Hisashi SajiSummaryCountry: Japan Publications
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Detail Information
Publications
Clinical response of large cell neuroendocrine carcinoma of the lung to perioperative adjuvant chemotherapyHisashi Saji
Department of Thoracic Surgery and Oncology, Tokyo Medical University, Nishishinjuku, Shinjuku ku, Japan
Anticancer Drugs 21:89-93. 2010..This should be, therefore, evaluated further in prospective multi-institutional phase II trials...- Gene expression profiling and molecular pathway analysis for the identification of early-stage lung adenocarcinoma patients at risk for early recurrenceHisashi Saji
Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Shinjuku ku, Tokyo 160 0023, Japan
Oncol Rep 29:1902-6. 2013..This comprehensive gene expression and functional pathway analysis identified a distinct molecular pathway, CAMs, that correlated with the early relapse of patients with early-stage lung adenocarcinoma... - Prognostic impact of number of resected and involved lymph nodes at complete resection on survival in non-small cell lung cancerHisashi Saji
Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
J Thorac Oncol 6:1865-71. 2011.... - Outcomes of airway stenting for advanced lung cancer with central airway obstructionHisashi Saji
Department of Thoracic Surgery and Oncology, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
Interact Cardiovasc Thorac Surg 11:425-8. 2010..This study represents a single-institution experience. Although an aggressive strategy of AS is justified in order to improve symptoms and QoL, AS itself did not contribute to survival benefit... 
[A possibility of overcoming local tumor immune tolerance by radiofrequency ablation in combination with intratumoral injection of naïve dendritic cell]Hisashi Saji
Dept of Thoracic Surgery and Oncology, Tokyo Medical University
Gan To Kagaku Ryoho 33:1736-8. 2006..In this report, we demonstrated the mechanism of (4) and (5) by radiofrequency ablation plus IT DC using mouse tumor model...- Do tumours located in the left lower lobe have worse outcomes in lymph node-positive non-small cell lung cancer than tumours in other lobes?Yujin Kudo
Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Tokyo, Japan
Eur J Cardiothorac Surg 42:414-9. 2012..The purpose of this study was to evaluate the impact of tumour lobar location on surgical outcomes as an independent prognostic factor for survival in our non-small cell lung cancer (NSCLC) patient series... - Klotho predicts good clinical outcome in patients with limited-disease small cell lung cancer who received surgeryJitsuo Usuda
Division of Thoracic Surgery, Department of Surgery 1, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
Lung Cancer 74:332-7. 2011..We investigated whether the expression of Klotho, assessed by immunohistochemistry, can predict survival in patients with resected SCLC... - Pathological vascular invasion and tumor differentiation predict cancer recurrence in stage IA non-small-cell lung cancer after complete surgical resectionYoshihisa Shimada
First Department of Surgery, Division, Tokyo Medical University Hospital, Shinjyuku ku, Tokyo, Japan
J Thorac Oncol 7:1263-70. 2012..The objective of the current study was to identify the clinicopathological factors that affect overall prognosis and cancer recurrence of stage IA NSCLC... - Impact of visceral pleural invasion on the survival of patients with non-small cell lung cancerYujin Kudo
Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Japan
Lung Cancer 78:153-60. 2012..In this study, we investigated visceral pleural invasion (VPI) as a poor prognostic factor in patients with non-small cell lung cancer (NSCLC) according to the 7th edition of the TNM classification... - Significance of expression of TGF-beta in pulmonary metastasis in non-small cell lung cancer tissuesHisashi Saji
Pulmonary Oncology Unit, Department of Surgery, Tokyo Medical University, Tokyo, Japan
Ann Thorac Cardiovasc Surg 9:295-300. 2003..006 and p=0.011, respectively). We speculated that TGF-beta expression in tumor infiltrating stromal cells may regulate the occurrence of spontaneous pulmonary metastasis in NSCLC. (Ann Thorac Cardiovasc Surg 2003; 9: 295-300).. - The prognostic impact of main bronchial lymph node involvement in non-small cell lung carcinoma: suggestions for a modification of the staging systemYoshihisa Shimada
Department of Thoracic Surgery and Oncology, Tokyo Medical University, Tokyo, Japan
Ann Thorac Surg 88:1583-8. 2009..Debate exists about the definition of the borderline between N1 and N2 stations. This study evaluated the prognostic effect of N1 disease, especially focused on the significance of the main bronchial node (No. 10) vs N2 disease... 
Retrospective analysis of nodal spread patterns according to tumor location in pathological N2 non-small cell lung cancerYoshihisa Shimada
First Department of Surgery, Tokyo Medical University Hospital, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
World J Surg 36:2865-71. 2012....- The present status of postoperative adjuvant chemotherapy for completely resected non-small cell lung cancerMasahiro Tsuboi
Department of Thoracic Surgery and Oncology, Tokyo Medical University and Hospital, Tokyo, Japan
Ann Thorac Cardiovasc Surg 13:73-7. 2007..Further research is needed to define the role of adjuvant platinum-based chemotherapy and its use, in conjunction with chest radiotherapy as the treatment for patients with resected stages IB and IIIA NSCLC... - Correlation between encoded protein overexpression and copy number of the HER2 gene with survival in non-small cell lung cancerHaruhiko Nakamura
Department of Surgery, Tokyo Medical University Hospital, Tokyo, Japan
Int J Cancer 103:61-6. 2003..Neither gene copy number increase nor overexpression correlated with survival. We conclude that the significance of HER2 status in NSCLC is different from that in breast cancer because high-grade amplification occurs rarely... - cDNA microarray analysis of gene expression in pathologic Stage IA nonsmall cell lung carcinomasHaruhiko Nakamura
Department of Surgery, Tokyo Medical University, Japan
Cancer 97:2798-805. 2003..The relationship between altered gene expression and tumor progression in lung carcinoma has yet to be characterized. Gene expression in pathologic Stage IA nonsmall cell lung carcinoma specimens was analyzed using a cDNA microarray... - Immunologic parameters as significant prognostic factors in lung cancerHaruhiko Nakamura
Department of Surgery, Tokyo Medical University Hospital, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo, Japan
Lung Cancer 37:161-9. 2002..A variety of immunologic indices have prognostic significance for the different types of lung cancer. Among these, the HLA-DR (%) in the peripheral blood is the most reliable factor for squamous cell carcinoma and small cell carcinoma... - Lung cancer patients showing pure ground-glass opacity on computed tomography are good candidates for wedge resectionHaruhiko Nakamura
Department of Surgery, Tokyo Medical University Hospital, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
Lung Cancer 44:61-8. 2004..For peripheral localized bronchioloalveolar carcinoma showing PGGO, wedge resection appears to be the best operation. Definitive study of more patients with longer follow-up is needed... - Peripheral leukocytes with HLA-DR+/CD8- phenotype are associated with prognosis in patients with lung cancerHaruhiko Nakamura
Department of Surgery, Tokyo Medical University Hospital, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo, Japan 160 0023
Anticancer Res 23:4149-52. 2003..We have previously reported that the most significant immunological prognostic factors in patients with lung cancer are the percentages of peripheral HLA-DR+ lymphocytes... - Klotho is a novel biomarker for good survival in resected large cell neuroendocrine carcinoma of the lungJitsuo Usuda
Division of Thoracic Surgery 1, Department of Surgery 1, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
Lung Cancer 72:355-9. 2011..In this study, we focused on the Klotho gene, which is an anti-aging gene known to be a potential tumor suppressor. We investigated whether the immunohistochemical expression of Klotho can predict survival patients with resected LCNEC... - Chromosomal instability detected by fluorescence in situ hybridization in surgical specimens of non-small cell lung cancer is associated with poor survivalHaruhiko Nakamura
Department of Surgery, Tokyo Medical University Hospital, Tokyo 160 0023, Japan
Clin Cancer Res 9:2294-9. 2003..Chromosomal instability (CIN) in non-small cell lung cancer (NSCLC) has yet to be well studied. We examined the relationship between CIN detected by fluorescence in situ hybridization and survival in patients with NSCLC... - Comparison of immunohistochemistry and real-time reverse transcription-polymerase chain reaction to detect expression of carcinoembryonic antigen in lung cancerHaruhiko Nakamura
Department of Surgery, Tokyo Medical University Hospital, Tokyo 160 0023, Japan
Oncol Rep 10:1231-5. 2003..No statistically significant correlation between the serum CEA concentration and the amount of mRNA expression was found (p=0.0932). Real-time RT-PCR is useful to quantify specific mRNA expression from a small piece of tissue... - A case of paravertebral mediastinal chordoma without bone destructionJun Matsubayashi
Department of Anatomic Pathology, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
Skeletal Radiol 41:1641-4. 2012..These results confirmed the tumor to be an extraosseous chordoma in the paravertebral mediastinal region, which is an extremely rare location for a chordoma... - Recent advances in video-assisted thoracoscopic surgery for lung cancerNorihiko Ikeda
Department of Surgery, Tokyo Medical University, Tokyo, Japan
Asian J Endosc Surg 6:9-13. 2013..Moreover, the indications for VATS are expanding to encompass complex procedures such as segmentectomy or sleeve resection. Training and dissemination of the technique and the monitoring of outcomes are necessary... - The incidence and the risk of pneumothorax and chest tube placement after percutaneous CT-guided lung biopsy: the angle of the needle trajectory is a novel predictorHisashi Saji
Department of Surgery, Tokyo Medical University, Tokyo, Japan
Chest 121:1521-6. 2002..CONCLUSIONS: The angle of needle route is a novel predictor of this complication. Our findings suggest that low pneumothorax rates are achieved by combining several techniques to reduce the risk of pneumothorax... - Three dimensional computed tomography lung modeling is useful in simulation and navigation of lung cancer surgeryNorihiko Ikeda
Department of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan
Ann Thorac Cardiovasc Surg 19:1-5. 2013.... - Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human breast carcinomaHisashi Saji
Breast Oncology, Tokyo Metropolitan Komagome Hospital, 3 18 22, Honkomagome, Bunkyo ku, 113 8677, Tokyo, Japan
Cancer Lett 190:191-7. 2003..This series did not demonstrate P-glycoprotein and nuclear YB-1 expression might be one of the useful prognostic marker of breast cancer... - Intracaval and intracardiac extension of invasive thymoma complicated by superior and inferior vena cava syndromeAtsushi Kurata
Department of Molecular Pathology, Tokyo Medical University, Tokyo, Japan
Pathol Int 63:56-62. 2013..To our knowledge, this is the first English report of an autopsy case of intracardiac thymoma extension, and a detailed literature review of similar cases is also presented... - Impact of selective Glisson transection on survival of hepatocellular carcinomaKoji Tsuruta
Department of Surgery, Tokyo Metropolitan Komagome Hospital, First Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan
Hepatogastroenterology 49:1607-10. 2002.... - Systemic antitumor effect of intratumoral injection of dendritic cells in combination with local photodynamic therapyHisashi Saji
Department of Pathology, Stanford University School of Medicine, Palo Alto, California, USA
Clin Cancer Res 12:2568-74. 2006..CONCLUSIONS: PDT + IT-DC induces potent systemic antitumor immunity in mice and should be evaluated in the treatment of human cancer...