Hiromichi Suzuki

Summary

Affiliation: Saitama Medical School
Country: Japan

Publications

  1. ncbi request reprint [Hemodialysis-associated hypertension; pathophysiology and therapy]
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School
    Nihon Rinsho 62:220-4. 2004
  2. ncbi request reprint Early start of combination therapy with hemodialysis and peritoneal dialysis prolongs survival and reduces cardiovascular events in male patients
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Adv Perit Dial 28:68-73. 2012
  3. doi request reprint Various approaches for vascular health in elderly women
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Clin Exp Hypertens 35:295-9. 2013
  4. ncbi request reprint New modality of dialysis therapy: peritoneal dialysis first and transition to home hemodialysis
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Adv Perit Dial 28:106-11. 2012
  5. doi request reprint Combination therapy with losartan/hydrochlorothiazide for blood pressure reduction and goal attainment in a real-world clinical setting in Japan
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, 38 Morohonngo, Moroyama machi, Iruma gun, Saitama, 350 0495, Japan
    Ther Adv Cardiovasc Dis 6:237-44. 2012
  6. doi request reprint Eplerenone, an aldosterone blocker, is more effective in reducing blood pressure in patients with, than without, metabolic syndrome
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, 38 Morohonngo, Moroyama machi, Iruma gun, Saitama, 350 0495, Japan
    Ther Adv Cardiovasc Dis 6:141-7. 2012
  7. doi request reprint Combination therapy with hemodialysis and peritoneal dialysis
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Contrib Nephrol 177:71-83. 2012
  8. doi request reprint Chronic kidney disease in postmenopausal women
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Iruma gun, Saitama, Japan
    Hypertens Res 35:142-7. 2012
  9. pmc Antihypertensive medication versus health promotion for improving metabolic syndrome in preventing cardiovascular events: a success rate-oriented simulation study
    Yoichi Ohno
    Community Health Science Center, Saitama Medical University, Saitama, Japan
    BMC Med Inform Decis Mak 11:8. 2011
  10. ncbi request reprint An overview of blood pressure regulation associated with the kidney
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School, Moroyama machi, Iruma gun, Saitama, Japan
    Contrib Nephrol 143:1-15. 2004

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint [Hemodialysis-associated hypertension; pathophysiology and therapy]
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School
    Nihon Rinsho 62:220-4. 2004
  2. ncbi request reprint Early start of combination therapy with hemodialysis and peritoneal dialysis prolongs survival and reduces cardiovascular events in male patients
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Adv Perit Dial 28:68-73. 2012
    ..The reasons for those findings have not been fully explained. The present analysis suggests that an early start to HD therapy will prolong the survival of patients on PD, especially men...
  3. doi request reprint Various approaches for vascular health in elderly women
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Clin Exp Hypertens 35:295-9. 2013
    ..In conclusion, measuring PWV and CAP in the clinic in patients with white coat hypertension or masked hypertension may not be an accurate way to measure these parameters...
  4. ncbi request reprint New modality of dialysis therapy: peritoneal dialysis first and transition to home hemodialysis
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Adv Perit Dial 28:106-11. 2012
    ..We suggest that patients who need dialysis therapy consider this new dialysis approach of "PD first and transfer to HHD."..
  5. doi request reprint Combination therapy with losartan/hydrochlorothiazide for blood pressure reduction and goal attainment in a real-world clinical setting in Japan
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, 38 Morohonngo, Moroyama machi, Iruma gun, Saitama, 350 0495, Japan
    Ther Adv Cardiovasc Dis 6:237-44. 2012
    ..This observational study evaluated the efficacy of losartan/hydrochlorothiazide (Lo/HCTZ) in lowering blood pressure (BP) and achieving BP target values...
  6. doi request reprint Eplerenone, an aldosterone blocker, is more effective in reducing blood pressure in patients with, than without, metabolic syndrome
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, 38 Morohonngo, Moroyama machi, Iruma gun, Saitama, 350 0495, Japan
    Ther Adv Cardiovasc Dis 6:141-7. 2012
    ..Recently, the role of aldosterone in metabolic syndrome (MS) has aroused interest and several reports have suggested that aldosterone blockade could be beneficial in reducing blood pressure (BP)...
  7. doi request reprint Combination therapy with hemodialysis and peritoneal dialysis
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Contrib Nephrol 177:71-83. 2012
    ..Combined with several of the previous several reports and our present experience, it is suggested that an early start of HD therapy will prolong the survival rate in patients on CAPD with physically stable conditions...
  8. doi request reprint Chronic kidney disease in postmenopausal women
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Iruma gun, Saitama, Japan
    Hypertens Res 35:142-7. 2012
    ..Future research for prevention of CVD in postmenopausal women with CKD would focus on the biology of vascular calcification as well as bone loss...
  9. pmc Antihypertensive medication versus health promotion for improving metabolic syndrome in preventing cardiovascular events: a success rate-oriented simulation study
    Yoichi Ohno
    Community Health Science Center, Saitama Medical University, Saitama, Japan
    BMC Med Inform Decis Mak 11:8. 2011
    ....
  10. ncbi request reprint An overview of blood pressure regulation associated with the kidney
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School, Moroyama machi, Iruma gun, Saitama, Japan
    Contrib Nephrol 143:1-15. 2004
  11. doi request reprint Cardiovascular outcome of an angiotensin II receptor blocker, candesartan, in Japan
    H Suzuki
    Department of Nephrology, School of Medicine, Faculty of Medicine, Saitama Medical University Community Health Science Center, Saitama Medical School, Saitama, Japan
    Drugs Today (Barc) 46:427-31. 2010
    ..From the analysis of the data obtained, candesartan-based treatment for hypertensive patients with and/or without cardiovascular diseases was effective in the Japanese population, as well as in subjects in Western countries...
  12. ncbi request reprint Effects of an angiotensin II receptor blocker, valsartan, on residual renal function in patients on CAPD
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School, Moroyama, Iruma, Saitama, Japan
    Am J Kidney Dis 43:1056-64. 2004
    ..It is unknown whether antihypertensive drugs affect residual renal function in addition to BP reduction...
  13. ncbi request reprint Angiotensin type 1 receptor blockers in chronic kidney disease
    Hiromichi Suzuki
    Department of Nephrology and Kidney Disease Center, Saitama Medical School, Moroyama machi, Iruma gun, Saitama Prefecture, Japan
    Contrib Nephrol 143:159-66. 2004
  14. doi request reprint Acute kidney injury of non-septic origin requiring dialysis therapy
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Contrib Nephrol 166:31-9. 2010
    ..Currently, it is uncertain when dialysis therapy should start. However, AKI after cardiac surgery should be treated early by continuous hemodialysis...
  15. doi request reprint Application of polymyxin B convalently immobilized fiber in patients with septic shock
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Contrib Nephrol 166:150-7. 2010
    ..As an adsorbent, a polymyxin B convalently immobilized fiber (PMX) was developed. This review discusses, designing of the PMX, its application in clinical practice and the clinical outcomes...
  16. ncbi request reprint Comparison of the effects of angiotensin receptor antagonist, angiotensin converting enzyme inhibitor, and their combination on regression of left ventricular hypertrophy of diabetes type 2 patients on recent onset hemodialysis therapy
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Ther Apher Dial 8:320-7. 2004
    ..Moreover, combination therapy with ACE inhibitors and AT1 antagonists would provide more beneficial effects on LVH in these patients than monotherapy...
  17. doi request reprint Therapeutic efficacy of renin-angiotensin blockade in patients receiving dialysis
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Ther Adv Cardiovasc Dis 3:397-405. 2009
    ....
  18. ncbi request reprint Decline of renal function is associated with proteinuria and systolic blood pressure in the morning in diabetic nephropathy
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Clin Exp Hypertens 27:129-38. 2005
    ..8 +/- 1.5 mg daily. The levels of both blood pressure and proteinuria-creatinine ratio in the morning mainly associate with progression of renal function in diabetic patients with hypertension and nephropathy...
  19. doi request reprint Effect of angiotensin receptor blockers on cardiovascular events in patients undergoing hemodialysis: an open-label randomized controlled trial
    Hiromichi Suzuki
    Department of Nephrology, School of Medicine, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    Am J Kidney Dis 52:501-6. 2008
    ..Although angiotensin receptor blockers (ARBs) reduce cardiovascular disease (CVD) events in patients with diabetes and chronic kidney disease, their effect in patients with kidney failure on HD therapy is not known...
  20. ncbi request reprint Association between beta-blocker use and reduced mortality after vascular surgery in patients with kidney disease
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, 38 Morohongo, Moroyama machi, Irumagun, Saitama 350 0495, Japan
    Nat Clin Pract Nephrol 4:128-9. 2008
  21. ncbi request reprint Effects of candesartan on cardiovascular outcomes in Japanese hypertensive patients
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Hypertens Res 28:307-14. 2005
    ....
  22. ncbi request reprint Sodium and kidney disease
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Contrib Nephrol 155:90-101. 2007
    ..Moreover, a genetic component for salt sensitivity is important in normotensive subjects with a family history of hypertension. In these regards, modulation of salt is of utmost importance in the fields of hypertension and nephrology...
  23. ncbi request reprint The newly developed calcium antagonist, azelnidipine, increases drain volume in continuous ambulatory peritoneal dialysis patients
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Adv Perit Dial 22:18-23. 2006
    ..We therefore suggest that activation of the sympathetic nervous system induced by calcium antagonists may be important in the regulation of drain volume in CAPD patients...
  24. ncbi request reprint Efficacy and safety of ezetimibe and low-dose simvastatin as primary treatment for dyslipidemia in peritoneal dialysis patients
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Adv Perit Dial 26:53-7. 2010
    ..In conclusion, the present study suggests that combined ezetimibe and low-dose statin treatment is a promising approach for safe and effective primary treatment of dyslipidemia in CAPD patients...
  25. ncbi request reprint Continuous hemodiafiltration with polymyxin-B immobilized fiber is effective in patients with sepsis syndrome and acute renal failure
    Hiromichi Suzuki
    Department of Nephrology and Kidney Disease Center, Saitama Medical College, Saitama, Japan
    Ther Apher 6:234-40. 2002
    ..From these data, it is suggested that the combined therapy with PMX and CHDF is effective in improvement of survival rate of patients with septic shock and acute renal failure...
  26. doi request reprint Short- and long-term prognosis of blood pressure and kidney disease in women with a past history of preeclampsia
    Hiromichi Suzuki
    Department of Nephrology, School of Medicine, Faculty of Medicine, Saitama Medical University, 38 Morohongo Moroyama, Iruma, Saitama 350 0495, Japan
    Clin Exp Nephrol 12:102-9. 2008
    ..Taken together with previous results, these findings suggest that hypertension and chronic kidney disease in postmenopausal women are closely associated with a past history of preeclampsia...
  27. ncbi request reprint Selection of the dose of angiotensin converting enzyme inhibitor for patients with diabetic nephropathy depends on the presence or absence of left ventricular hypertrophy
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Hypertens Res 25:865-73. 2002
    ..Our results provide some indications for the use of ACE inhibitors in diabetic patients when renal dysfunction and/or cardiac hypertrophy are present...
  28. ncbi request reprint Thoracoscopic surgery and pleurodesis for pleuroperitoneal communication in patients on continuous ambulatory peritoneal dialysis
    H Okada
    Department of Nephrology, Saitama Medical College, Irumagun, Japan
    Am J Kidney Dis 34:170-2. 1999
    ..After the procedure, both of them had no recurrence of hydrothorax and underwent CAPD safely. We recommend thoracoscopic surgery and pleurodesis as the first choice of therapeutic methods for pleuroperitoneal communication...
  29. ncbi request reprint Effects of eplerenone on heart and kidney in two-kidney, one-clip rats
    Lirong Hao
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Am J Nephrol 24:54-60. 2004
    ....
  30. ncbi request reprint Does cinacalcet HCl, an oral calcimimetic agent for the treatment of secondary hyperparathyroidism, improve arterial stiffness in patients on continuous ambulatory peritoneal dialysis?
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Adv Perit Dial 27:134-9. 2011
    ....
  31. ncbi request reprint Testing a single monthly dose of darbepoetin alpha to maintain hemoglobin levels in continuous ambulatory peritoneal dialysis patients
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Adv Perit Dial 27:60-4. 2011
    ..Once-monthly administration of DA is not always sufficient to maintain hemoglobin levels in patients on CAPD when adequate dialysis therapy is not achieved...
  32. ncbi request reprint Survival of patients over 75 years of age on peritoneal dialysis therapy
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Adv Perit Dial 26:61-6. 2010
    ..Our study demonstrated that cardiac performance at the initiation of PD therapy predicts prognosis in PD patients more than 75 years of age...
  33. ncbi request reprint Role of the renin-angiotensin system in the pathogenesis of peritoneal fibrosis
    Hidetomo Nakamoto
    Department of General Internal Medicine, Saitama Medical School, Saitama, Japan
    Perit Dial Int 28:S83-7. 2008
    ..In the present study, we evaluated the effect of an ARB, olmesartan medoxomil (CS866), on the progression of peritoneal fibrosis in peritoneal dialysis by examining its effect in a model of peritoneal fibrosis in hypertensive rats...
  34. ncbi request reprint Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-beta produced by tubular epithelial cells in response to high glucose
    Tatsuya Kobayashi
    Department of Nephrology, Saitama Medical College, 38 Morohongo, Moroyama machi, Saitama 350 0495, Japan
    Clin Exp Nephrol 9:114-21. 2005
    ....
  35. doi request reprint Aliskiren reduces morning blood pressure in hypertensive patients with diabetic nephropathy on hemodialysis
    Tsuneo Takenaka
    Department of Nephrology, Saitama Medical University, Iruma, Japan
    Clin Exp Hypertens 35:244-9. 2013
    ..Aliskiren reduced both intradialytic blood pressure drops and interdialytic weight gain in patients with DN...
  36. doi request reprint Amlodipine and loop diuretics as the second anti-hypertensive medication for the treatment of hypertension with chronic kidney diseases
    Tsuneo Takenaka
    Department of Nephrology, Saitama Medical University School of Medicine, Iruma Saitama, Japan
    Clin Exp Hypertens 33:210-5. 2011
    ..Calcium antagonists also improved AI more strongly than diuretics. Calcium antagonists appear suited for adding on renin angiotensin system inhibitors to treat hypertension with CKDs...
  37. doi request reprint Zigzagged augmentation index in diabetes
    Tsuneo Takenaka
    Department of Nephrology, Faculty of Medicine, Saitama Medical University, 38 Moro Hongo Moroyama, Iruma, Saitama, Japan
    Clin Exp Hypertens 31:657-68. 2009
    ..Finally, the present results suggest that AI in supine, but not sitting position, is suited for detecting cardiovascular risk in diabetes...
  38. ncbi request reprint Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis
    Hirokazu Okada
    Department of Nephrology, Saitama Medical College, 38 Morohongo, Moroyama machi, Irumagun, Saitama 350 0495, Japan
    J Am Soc Nephrol 16:133-43. 2005
    ..In conclusion, tubular CTGF acts as a downstream mediator of the profibrotic effects of TGF-beta1 in the remnant kidney, which is a promising target for antifibrotic drugs designed to treat TGF-beta1-dependent interstitial fibrosis...
  39. ncbi request reprint Salt and excess food intake produced diabetic nephropathy in Japan
    Hiroshi Takane
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Contrib Nephrol 155:125-35. 2007
    ..These differences should be borne in mind in clinical practice...
  40. ncbi request reprint Intensive blood pressure reduction is beneficial in patients with impaired cardiac function coexisting with chronic renal insufficiency
    Naofumi Ikeda
    Department of Nephrology, Saitama Medical College, Saitama, Japan
    Hypertens Res 25:41-8. 2002
    ..These results suggest that intensive blood pressure reduction might be beneficial in cases complicated by cardiorenal failure...
  41. doi request reprint Aliskiren reduces morning blood pressure in hypertensive patients with diabetic nephropathy
    Tsuneo Takenaka
    Department of Nephrology, Saitama Medical University, Iruma, Saitama, Japan
    Clin Exp Hypertens 34:243-8. 2012
    ..The present data suggest that aliskiren exerts renoprotective actions including reduction in albumin excretion for patients with DN...
  42. doi request reprint Time for reflection predicts the progression of renal dysfunction in patients with nondiabetic chronic kidney disease
    Tsuneo Takenaka
    Department of Nephrology, Saitama Medical University, School of Medicine, 38 Moro Hongo Moroyama, Iruma, Saitama, Japan
    Clin Exp Hypertens 31:220-30. 2009
    ..Finally, the present findings provide the evidence that the arterial stiffness parameter is more sensitive than home blood pressure as an indicator to the progression of chronic kidney disease...
  43. doi request reprint Long-term effects of calcium antagonists on augmentation index in hypertensive patients with chronic kidney disease: a randomized controlled study
    Tsuneo Takenaka
    Department of Nephrology, Saitama Medical University, Faculty of Medicine, Moroyama, Japan takenaka saitama med ac jp
    Am J Nephrol 35:416-23. 2012
    ..Our previous retrospective study showed that benidipine was superior to amlodipine (AM) for reducing proteinuria and preserving the augmentation index (AI) in patients with chronic kidney disease (CKD)...
  44. ncbi request reprint Estrogen and angiotensin II interactions determine cardio-renal damage in Dahl salt-sensitive rats with heart failure
    Rie Hoshi-Fukushima
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Am J Nephrol 28:413-23. 2008
    ..The present study attempted to elucidate the relationship between the process of cardiac remodeling and nephrosclerosis in ovariectomized Dahl salt-sensitive (DSS) rats with myocardial infarction (MI)...
  45. ncbi request reprint Effects of antihypertensive drugs on peritoneal vessels in hypertensive dogs with mild renal insufficiency
    Yuji Ishida
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Adv Perit Dial 19:10-4. 2003
    ....
  46. doi request reprint Seasonal variations of daily changes in blood pressure among hypertensive patients with end-stage renal diseases
    Tsuneo Takenaka
    Saitama Medical University, Department of Nephrology, Iruma Saitama, Japan
    Clin Exp Hypertens 32:227-33. 2010
    ....
  47. ncbi request reprint Hepatocyte growth factor counteracts transforming growth factor-beta1, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice
    Tsutomu Inoue
    Department of Nephrology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    FASEB J 17:268-70. 2003
    ..In conclusion, HGF can block, at least partially, renal fibrogenesis promoted by TGF-beta1 in the remnant kidney, via attenuation of CTGF induction...
  48. doi request reprint Telmisartan lowers home blood pressure and improves insulin resistance without correlation between their changes
    Kazuhiro Kobayashi
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Clin Exp Hypertens 33:100-5. 2011
    ..However, the changes in home SBP and DBP were not correlated with that of HOMA-R. In conclusion, telmisartan lowers home BP and improves insulin resistance without correlation between their changes...
  49. ncbi request reprint Risk factors for vascular complications in patients on peritoneal dialysis
    Hiroshi Arima
    Department of Nephrology, Saitama Medical School, Japan
    Adv Perit Dial 22:192-7. 2006
    ..To help prevent vascular complications, it is important to monitor and manage serum albumin in patients on PD...
  50. ncbi request reprint [Treatment recommendations for various stages in diabetic nephropathy]
    Hiroshi Takane
    Department of Nephrology, Saitama Medical School
    Nihon Rinsho 63:379-83. 2005
  51. ncbi request reprint Angiotensin receptor antagonist regresses left ventricular hypertrophy associated with diabetic nephropathy in dialysis patients
    Yoshihiko Kanno
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    J Cardiovasc Pharmacol 43:380-6. 2004
    ..It is not known whether AT1 antagonists are able to reverse LVH in diabetic patients on dialysis therapy...
  52. ncbi request reprint Role of adhesion molecules in the progression of peritoneal sclerosis
    Hiroe Imai
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Adv Perit Dial 19:180-5. 2003
    ..Treatment with ARB prevents the progression of peritoneal fibrosis and suppresses expression of adhesion molecules in the peritoneum...
  53. ncbi request reprint A selective angiotensin receptor antagonist, Valsartan, produced regression of left ventricular hypertrophy associated with a reduction of arterial stiffness
    Hiromichi Suzuki
    Department of Nephrology and Kidney Disease Center, Saitama Medical School, Moroyama machi, Iruma gun, Saitama, Prefecture, Japan
    Adv Perit Dial 19:59-66. 2003
    ..05). The decrease in LVMi was associated with a reduction in PWV and AI. In CAPD patients with LVH, ARB reduced LVMi in association with alterations in arterial hemodynamics...
  54. ncbi request reprint Residual renal function plays an important role in regulating parathyroid hormone in patients on continuous ambulatory peritoneal dialysis
    Saiko Okada
    Kidney Disease Center, Saitama Medical University, Saitama, Japan
    Adv Perit Dial 23:150-4. 2007
    ..Based on these findings, we suggest that RRF is an important factor for the regulation of Ca-P metabolism in patients on CAPD...
  55. doi request reprint A case report suggesting the occurrence of epithelial-mesenchymal transition in obstructive nephropathy
    Tsutomu Inoue
    Department of Nephrology, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma, Saitama 350 0495, Japan
    Clin Exp Nephrol 13:385-8. 2009
    ..With regard to human obstructive nephropathy, this is the first report which proves that tubular epithelial cells become positive for the fibroblast-specific marker. EMT is probably a common event not only in mouse but also in human...
  56. pmc Poly(ADP-ribose) polymerase-1 enhances transcription of the profibrotic CCN2 gene
    Hirokazu Okada
    Department of Nephrology, Saitama Medical University, 38 Morohongo, Moroyama machi, Irumagun, Saitama 350 0451, Japan
    J Am Soc Nephrol 19:933-42. 2008
    ..This regulatory complex may be a promising target for antifibrotic therapy...
  57. ncbi request reprint Congenic substitution mapping for intracellular Ca2+ in spontaneously hypertensive rats
    Yoichi Ohno
    Department of Internal Medicine, Saitama Municipal Hospital, Saitama, Japan
    Am J Hypertens 20:172-6. 2007
    ....
  58. ncbi request reprint Early estimation of high peritoneal permeability can predict poor prognosis for technique survival in patients on peritoneal dialysis
    Hidetomo Nakamoto
    Department of Nephrology, Saitama Medical School, Japan
    Adv Perit Dial 22:11-7. 2006
    ..We conclude that early estimation of high peritoneal permeability can predict poor outcome for patients on CAPD...
  59. ncbi request reprint Aging is an important risk factor for peritoneal dialysis-associated peritonitis
    Mika Okayama
    Department of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    Adv Perit Dial 28:50-4. 2012
    ..In our study, aging--rather than diabetes mellitus, efficiency of PD, or nutrition status--was an important risk factor for PD-associated peritonitis. Poor PD technique because of advanced age might be one of the reasons for this result...
  60. ncbi request reprint [Treatment for the elderly hypertensive patient with renal insufficiency]
    Kazuhiro Kobayashi
    Department of Nephrology, Saitama Medical School
    Nihon Rinsho 63:1047-51. 2005
    ..As the combination therapy, drugs with inhibition of the renin-angiotensin system such as ACE inhibitor or angiotensin receptor blocker and a calcium antagonist or diuretics are suggested...
  61. ncbi request reprint Erythropoietin resistance in patients on continuous ambulatory peritoneal dialysis
    Hidetomo Nakamoto
    Department of Nephrology, Tokorozawa Kidney Clinic, Saitama, Japan
    Adv Perit Dial 20:111-6. 2004
    ..We conclude that treatment with ACEIs and ARBs induces erythropoietin resistance in patients on CAPD. The inhibitory effect of ARBs on erythropoiesis is less than that of ACEIs...
  62. ncbi request reprint Governance of arteriolar oscillation by ryanodine receptors
    Tsuneo Takenaka
    Dept of Medicine, Nephrology Division, Saitama Medical College, 38 Moro Hongo Moroyama, Iruma, Saitama 350 0495, Japan
    Am J Physiol Regul Integr Comp Physiol 285:R125-31. 2003
    ....
  63. ncbi request reprint Comparison and survival of patients receiving hemodialysis and peritoneal dialysis in a single center
    Kousuke Uchida
    Kidney Disease Center, Saitama Medical University, Saitama, Japan
    Adv Perit Dial 23:144-9. 2007
    ..Moreover, this study suggests the importance of early referral and evaluation of risk factors in individual patients before they are started on dialysis therapy...
  64. pmc Dexamethasone induces connective tissue growth factor expression in renal tubular epithelial cells in a mouse strain-specific manner
    Hirokazu Okada
    Department of Nephrology, Saitama Medical School, 38 Morohongo, Moroyama machi, Irumagun, Saitama 350 0495, Japan
    Am J Pathol 168:737-47. 2006
    ..Thus, glucocorticoid-induced renal fibrogenesis seems to be influenced by genetic background, with the critical DEX-responsive elements in the -897- to -628-bp region of the CTGF promoter...
  65. ncbi request reprint Continuous ambulatory peritoneal dialysis is effective for patients with severe congestive heart failure
    Hiroshi Takane
    Saitama Medical School, Japan
    Adv Perit Dial 22:141-6. 2006
    ..These results suggest that CAPD is a treatment of choice for patients suffering from a combination of congestive heart failure and chronic renal insufficiency...
  66. ncbi request reprint Hypoalbuminemia is an important risk factor of hypotension during hemodialysis
    Hidetomo Nakamoto
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Hemodial Int 10:S10-5. 2006
    ..598, p=0.0016). From these data, we conclude that hypoalbuminemia is a major risk factor of hypotension during HD...
  67. ncbi request reprint Peritoneal dialysis versus hemodialysis: a five-year comparison of survival and effects on the cardiovascular system, erythropoiesis, and calcium metabolism
    Toshihiko Suzuki
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Adv Perit Dial 19:148-54. 2003
    ..Blood pressure and cholesterol level are both likely to be important contributors to mortality and morbidity in renal patients...
  68. ncbi request reprint Selective depletion of fibroblasts preserves morphology and the functional integrity of peritoneum in transgenic mice with peritoneal fibrosing syndrome
    Hirokazu Okada
    Department of Nephrology, Saitama Medical College, Saitama, Japan
    Kidney Int 64:1722-32. 2003
    ..The pathogenesis of PFS is unclear and the role of peritoneal fibroblasts has not been evaluated experimentally...
  69. pmc A possible anti-inflammatory role of angiotensin II type 2 receptor in immune-mediated glomerulonephritis during type 1 receptor blockade
    Hirokazu Okada
    Department of Nephrology, Saitama Medical School, 38 Morohongo, Irumagun, Saitama 350 0495, Japan
    Am J Pathol 169:1577-89. 2006
    ..These results suggest that feedback activation of AT2Rs in tubular epithelium of nephritic kidneys plays an important role in attenuating interstitial inflammation...
  70. ncbi request reprint Angiotensin II type 1 receptor blockade attenuates renal fibrogenesis in an immune-mediated nephritic kidney through counter-activation of angiotensin II type 2 receptor
    Hirokazu Okada
    Department of Nephrology, Saitama Medical College, Saitama, Japan
    Biochem Biophys Res Commun 314:403-8. 2004
    ..In conclusion, counter-activation of AT(2)R by increased Ang II under AT(1)R blockade likely conferred an anti-fibrotic protection in this model...
  71. doi request reprint Arterial wave reflection is elevated in evening hemodialysis patients
    Tsuneo Takenaka
    Department of Nephrology, Saitama Medical University, Iruma, Saitama, Japan
    Clin Exp Hypertens 30:173-81. 2008
    ..It has been reported that daytime hemodialysis patients show better prognosis than evening hemodialysis patients...
  72. ncbi request reprint A five-year comparison of the renal protective effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with non-diabetic nephropathy
    Junko Shoda
    Department of Nephrology, Saitama Medical School, Iruma, Saitama
    Intern Med 45:193-8. 2006
    ..In the present study, the renal protective effects of ACE inhibitors and ARBs were compared over a five-year period in a prospective, randomized, open-blind study in 68 nondiabetic Japanese patients with elevated serum creatinine levels...
  73. doi request reprint Effect of telmisartan and amlodipine on home blood pressure by monitoring newly developed telemedicine system: monitoring test by using telemedicine. Telmisartan's effect on home blood pressure (TelTelbosu)
    Hidetomo Nakamoto
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Clin Exp Hypertens 30:57-67. 2008
    ..TEL has a good effect on home BP for 24 hours compared to AM. This telemedicine system has a great advantage in monitoriong home BP correctly in hypertensive patients...
  74. ncbi request reprint Long-term follow-up of patients treated with a combination of continuous ambulatory peritoneal dialysis and hemodialysis
    Hitoshi Hoshi
    Department of Nephrology, Saitama Medical School, Japan
    Adv Perit Dial 22:136-40. 2006
    ..Our findings suggest that the combined use of CAPD and HD improves solute clearance in CAPD patients who are insufficiently dialyzed...
  75. ncbi request reprint Gastric angiodysplasia in patients undergoing maintenance dialysis
    Koji Tomori
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Adv Perit Dial 19:136-42. 2003
    ..Argon plasma coagulation is an effective treatment for gastric angiodysplasia in patients on dialysis...
  76. ncbi request reprint The effects of antihypertensive agents on the survival rate of polycystic kidney disease in Han:SPRD rats
    Yoshihiko Kanno
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Hypertens Res 25:939-43. 2002
    ..In conclusion, both amlodipine and benazepril significantly improved blood pressure control, urinary protein excretion, and survival rate, possibly due to their enhancement of renal survival...
  77. ncbi request reprint Add-on angiotensin receptor blocker in patients who have proteinuric chronic kidney diseases and are treated with angiotensin-converting enzyme inhibitors
    Yoshihiko Kanno
    Department of Nephrology, Saitama Medical School, 38 Morohongo, Moroyama, Iruma, Saitama, 350 0495 Japan
    Clin J Am Soc Nephrol 1:730-7. 2006
    ..Candesartan with an ACE inhibitor is effective in slowing the progression of renal insufficiency in hypertensive patients with nondiabetic renal disease through reduction of proteinuria...
  78. ncbi request reprint [Large scale clinical trials in prevention of end-stage renal disease due to type 2 diabetes with angiotensin receptor antagonists]
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School
    Nihon Rinsho 60:2040-4. 2002
    ..Moreover, these beneficial effects are independent of the reduction in blood pressure...
  79. ncbi request reprint Qualification of arterial stiffness as a risk factor to the progression of chronic kidney diseases
    Tsuneo Takenaka
    Department of Nephrology, Saitama Medical College, 38 Moro Hongo Moroyama, Iruma Saitama 350 0495, Japan
    Am J Nephrol 25:417-24. 2005
    ..Reflection pressure may influence the clinical course of chronic kidney diseases (CKDs). The relationship between the augmentation index (AI) and progression of non-diabetic CKDs was characterized...
  80. ncbi request reprint [E-COST]
    Yoshihiko Kanno
    Department of Nephrology, Saitama Medical School
    Nihon Rinsho 64:480-5. 2006
  81. ncbi request reprint [Renal parenchymal disease and hypertension]
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School
    Nihon Rinsho 62:503-7. 2004
  82. ncbi request reprint [Evaluation of renal function in hypertensive patients]
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School
    Nihon Rinsho 62:315-20. 2004
  83. ncbi request reprint [Evidence for the benefits of ACE inhibitors and AII antagonists in slowing progressive renal failure in diabetes]
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School
    Nihon Rinsho 60:323-8. 2002
  84. ncbi request reprint [Renin-angiotensin-aldosterone system]
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School
    Nihon Rinsho 62:153-6. 2004
  85. ncbi request reprint [Controversial matters in the guidelines for the therapy of patients with hypertension]
    Hiromichi Suzuki
    Department of Nephrology, Saitama Medical School
    Nihon Rinsho 64:531-5. 2006
  86. pmc Noninvasive evaluation of kidney hypoxia and fibrosis using magnetic resonance imaging
    Tsutomu Inoue
    Department of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    J Am Soc Nephrol 22:1429-34. 2011
    ..Functional MRI can thus contribute to multilateral, noninvasive, in vivo assessment of kidney function...
  87. ncbi request reprint Selection of hemoperfusion therapy for patients with septic shock on the basis of the primary disease
    Yoshihiko Kanno
    Department of Nephrology, Saitama Medical School, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    J Artif Organs 6:205-10. 2003
    ..When a patient with sepsis or septic shock is treated with hemoperfusion, the decision as to whether PMX-F should be given alone or in combination with CHF might be determined on the basis of the primary disease of the patient...
  88. doi request reprint Equipment and monitoring in continuous renal replacement therapy
    Yoshihisa Yamashita
    School of Biomedical Engineering, Faculty of Health and Medical Care, Saitama, Japan
    Contrib Nephrol 166:126-33. 2010
    ..Nevertheless, incidental and accidental errors in human and equipment are sometimes happen. In order to decrease it, the staff understands the system of treatment and is familiar to the routine check point...
  89. ncbi request reprint Effect of diabetes on peritoneal function assessed by personal dialysis capacity test in patients undergoing CAPD
    Hidetomo Nakamoto
    Department of Nephrology, Saitama Medical School, and PDC Study Group in Japan, Saitama, Japan
    Am J Kidney Dis 40:1045-54. 2002
    ..We evaluated differences in individual peritoneal membrane transport function and nutritional status in patients with diabetes mellitus (DM) and nondiabetic (non-DM) patients on continuous ambulatory peritoneal dialysis (CAPD)...
  90. doi request reprint D1-like receptor antagonist inhibits IL-17 expression and attenuates crescent formation in nephrotoxic serum nephritis
    Hirokazu Okada
    Department of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    Am J Nephrol 30:274-9. 2009
    ..Thus, we treated mice with nephrotoxic serum nephritis (NTN) with a D1-like-R antagonist to test whether Th17 cells play a role in this kidney disease...
  91. ncbi request reprint Nutritional assessment by a new method for patients with renal disease
    Yoshihiko Kanno
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Contrib Nephrol 155:29-39. 2007
    ....
  92. doi request reprint Granulomatous interstitial nephritis in chronic lymphocytic leukaemia
    Tsutomu Inoue
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Nephrol Dial Transplant 25:4107-9. 2010
    ..Immunohistochemical analyses of a biopsy specimen revealed invasion of CD20( +) CLL cells, surrounded by reactive T cells, and granuloma formation. Thus, CLL may induce secondary interstitial nephritis as a granulomatous reaction...
  93. ncbi request reprint Clinical strategy for the treatment of hypertension in non-diabetic and diabetic nephropathy in Japan
    Yoshihiko Kanno
    Department of Nephrology, Saitama Medical School, Iruma gun, Saitama, Japan
    Contrib Nephrol 143:145-58. 2004
  94. ncbi request reprint [Coronary artery bypass grafting in patients undergoing chronic hemodialysis: importance of wound healing and hypoproteinemia]
    Kazuhito Imanaka
    Department of Cardiovascular Surgery, Saitama Medical School, Iruma gun, Saitama
    J Cardiol 45:47-51. 2005
    ..Outcome of coronary artery bypass grafting (CABG) in patients undergoing chronic hemodialysis was studied...
  95. pmc Fibroblast expression of an IκB dominant-negative transgene attenuates renal fibrosis
    Tsutomu Inoue
    Department of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    J Am Soc Nephrol 21:2047-52. 2010
    ..Cre;IκBdN mice compared with γGT.Cre;IκBdN mice (P < 0.05). Taken together, these data support a profibrotic role for fibroblasts, but not proximal tubular epithelial cells, in modulating NF-κB activation during renal fibrogenesis...
  96. ncbi request reprint Valsartan cardio-renal protection in patients undergoing coronary angiography complicated with chronic renal insufficiency (VAL-CARP) trial: rationale and design
    Naofumi Ikeda
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Circ J 70:548-52. 2006
    ..In addition, the nature of pharmacological interventions that would benefit the patients before or after procedures such as coronary bypass graft (CABG) and percutaneous coronary intervention (PCI) has not been fully investigated...
  97. ncbi request reprint [Therapy for hypertension associated with kidney disease]
    Hiromichi Suzuki
    Nihon Naika Gakkai Zasshi 92:264-9. 2003
  98. ncbi request reprint Interim evidence of the renoprotective effect of the angiotensin II receptor antagonist losartan versus the calcium channel blocker amlodipine in patients with chronic kidney disease and hypertension: a report of the Japanese Losartan Therapy Intended for
    Yasuhiko Iino
    Second Department of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Clin Exp Nephrol 7:221-30. 2003
    ..The therapeutic strategy for patients with proteinuric CKD and hypertension should therefore be targeted with a view not merely toward blood pressure reduction but also toward renoprotection...
  99. ncbi request reprint Is technique survival on peritoneal dialysis better in Japan?
    Hidetomo Nakamoto
    Department of Nephrology, Saitama Medical School, Japan
    Perit Dial Int 26:136-43. 2006
    ..This may be related to good sanitation and excellent PD training programs. Peritoneal membrane failure continues to be the major challenge for long-term technique survival on PD in Japan...
  100. ncbi request reprint [Diagnosis of and therapy for renal hypertension]
    Hiromichi Suzuki
    Nihon Naika Gakkai Zasshi 93:488-92. 2004
  101. ncbi request reprint Renoprotective effect of losartan in comparison to amlodipine in patients with chronic kidney disease and hypertension--a report of the Japanese Losartan Therapy Intended for the Global Renal Protection in Hypertensive Patients (JLIGHT) study
    Yasuhiko Iino
    Second Department of Medicine, Nippon Medical School, Tokyo, Japan
    Hypertens Res 27:21-30. 2004
    ..We conclude that losartan reduced proteinuria in patients with CKD and hypertension. This positive effect may contribute to the renal protective benefit of losartan, and is beyond the magnitude of BP control...