Y Odagaki

Summary

Affiliation: Saitama Medical School
Country: Japan

Publications

  1. ncbi request reprint Pharmacological characterization of M1 muscarinic acetylcholine receptor-mediated Gq activation in rat cerebral cortical and hippocampal membranes
    Yuji Odagaki
    Department of Psychiatry, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama machi, Iruma gun, Saitama, 350 0495, Japan
    Naunyn Schmiedebergs Arch Pharmacol 386:937-47. 2013
  2. doi request reprint Group II metabotropic glutamate receptor-mediated activation of G-proteins in rat hippocampal and striatal membranes
    Yuji Odagaki
    Department of Psychiatry, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Neurosci Lett 539:22-6. 2013
  3. doi request reprint Muscarinic acetylcholine receptor-mediated activation of G(q) in rat brain membranes determined by guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding using an anti-G protein scintillation proximity assay
    Yuji Odagaki
    Department of Psychiatry, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    J Neural Transm 119:525-32. 2012
  4. doi request reprint Functional coupling between metabotropic glutamate receptors and G-proteins in rat cerebral cortex assessed by guanosine-5'-O-(3-[(35)S]thio)triphosphate binding assay
    Yuji Odagaki
    Department of Psychiatry, Faculty of Medicine, Saitama Medical University, Moroyama machi, Iruma gun, Japan
    Basic Clin Pharmacol Toxicol 109:175-85. 2011
  5. ncbi request reprint Atypical neuroleptic malignant syndrome or serotonin toxicity associated with atypical antipsychotics?
    Yuji Odagaki
    Department of Psychiatry, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    Curr Drug Saf 4:84-93. 2009
  6. ncbi request reprint 5-HT1A receptor agonist properties of antipsychotics determined by [35S]GTPgammaS binding in rat hippocampal membranes
    Yuji Odagaki
    Department of Psychiatry, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    Clin Exp Pharmacol Physiol 34:462-6. 2007
  7. ncbi request reprint Dopamine D2 receptor-mediated G protein activation assessed by agonist-stimulated [35S]guanosine 5'-O-(gamma-thiotriphosphate) binding in rat striatal membranes
    Yuji Odagaki
    Department of Psychiatry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1304-12. 2006
  8. ncbi request reprint 5-HT-stimulated [35S]guanosine-5'-O-(3-thio)triphosphate binding as an assay for functional activation of G proteins coupled with 5-HT1B receptors in rat striatal membranes
    Yuji Odagaki
    Department of Psychiatry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Staitama 350 0495, Japan
    Naunyn Schmiedebergs Arch Pharmacol 372:335-45. 2006
  9. ncbi request reprint 5-HT1A receptor-mediated G protein activation assessed by [35S]GTPgammaS binding in rat cerebral cortex
    Yuji Odagaki
    Department of Psychiatry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Staitama 350 0495, Japan
    Eur J Pharmacol 521:49-58. 2005
  10. ncbi request reprint Detailed pharmacological characterization of 5-HT1A-receptor-mediated [35S]GTP gamma S binding in rat hippocampal membranes
    Yuji Odagaki
    Department of Psychiatry, Saitama Medical School, Saitama 350 0495, Japan
    J Pharmacol Sci 98:66-76. 2005

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Pharmacological characterization of M1 muscarinic acetylcholine receptor-mediated Gq activation in rat cerebral cortical and hippocampal membranes
    Yuji Odagaki
    Department of Psychiatry, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama machi, Iruma gun, Saitama, 350 0495, Japan
    Naunyn Schmiedebergs Arch Pharmacol 386:937-47. 2013
    ..These data provide a comprehensive pharmacological profile of the Gq-coupled M1 mAChR subtype natively expressed at physiological levels in rat cerebral cortex and hippocampus. ..
  2. doi request reprint Group II metabotropic glutamate receptor-mediated activation of G-proteins in rat hippocampal and striatal membranes
    Yuji Odagaki
    Department of Psychiatry, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Neurosci Lett 539:22-6. 2013
    ..It is concluded that [(35)S]GTPγS binding assay is applicable to rat hippocampal and striatal membranes to detect functional activation of Gαi/o proteins coupled with mGlu2 receptors...
  3. doi request reprint Muscarinic acetylcholine receptor-mediated activation of G(q) in rat brain membranes determined by guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding using an anti-G protein scintillation proximity assay
    Yuji Odagaki
    Department of Psychiatry, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    J Neural Transm 119:525-32. 2012
    ....
  4. doi request reprint Functional coupling between metabotropic glutamate receptors and G-proteins in rat cerebral cortex assessed by guanosine-5'-O-(3-[(35)S]thio)triphosphate binding assay
    Yuji Odagaki
    Department of Psychiatry, Faculty of Medicine, Saitama Medical University, Moroyama machi, Iruma gun, Japan
    Basic Clin Pharmacol Toxicol 109:175-85. 2011
    ..Taken altogether, l-glutamate-stimulated [(35)S]GTPγS binding serves as a useful functional assay for the activation of NEM-sensitive G(i/o) -mediated group II mGlu receptors in rat cerebral cortical membranes...
  5. ncbi request reprint Atypical neuroleptic malignant syndrome or serotonin toxicity associated with atypical antipsychotics?
    Yuji Odagaki
    Department of Psychiatry, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    Curr Drug Saf 4:84-93. 2009
    ..The practical and flexible way to consider and manage such cases with updated knowledge derived from basic research should be warranted to be beneficial to our patients...
  6. ncbi request reprint 5-HT1A receptor agonist properties of antipsychotics determined by [35S]GTPgammaS binding in rat hippocampal membranes
    Yuji Odagaki
    Department of Psychiatry, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    Clin Exp Pharmacol Physiol 34:462-6. 2007
    ..6. These results provide important information concerning the relevance of 5-HT1A receptor partial agonist properties in the treatment for schizophrenic patients with most, if not all, of atypical antipsychotic drugs...
  7. ncbi request reprint Dopamine D2 receptor-mediated G protein activation assessed by agonist-stimulated [35S]guanosine 5'-O-(gamma-thiotriphosphate) binding in rat striatal membranes
    Yuji Odagaki
    Department of Psychiatry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1304-12. 2006
    ....
  8. ncbi request reprint 5-HT-stimulated [35S]guanosine-5'-O-(3-thio)triphosphate binding as an assay for functional activation of G proteins coupled with 5-HT1B receptors in rat striatal membranes
    Yuji Odagaki
    Department of Psychiatry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Staitama 350 0495, Japan
    Naunyn Schmiedebergs Arch Pharmacol 372:335-45. 2006
    ..5-HT-stimulated [35S]GTPgammaS binding to rat striatal membranes serves as a simple but useful method of investigating the functional interaction between the native 5-HT1B receptors and their coupled G proteins in this brain region...
  9. ncbi request reprint 5-HT1A receptor-mediated G protein activation assessed by [35S]GTPgammaS binding in rat cerebral cortex
    Yuji Odagaki
    Department of Psychiatry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Staitama 350 0495, Japan
    Eur J Pharmacol 521:49-58. 2005
    ..This method is a useful tool for investigating functional coupling between postsynaptic 5-HT1A receptors and G proteins in cerebral cortical membranes...
  10. ncbi request reprint Detailed pharmacological characterization of 5-HT1A-receptor-mediated [35S]GTP gamma S binding in rat hippocampal membranes
    Yuji Odagaki
    Department of Psychiatry, Saitama Medical School, Saitama 350 0495, Japan
    J Pharmacol Sci 98:66-76. 2005
    ....
  11. ncbi request reprint Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding
    Yuji Odagaki
    Department of Psychiatry, Saitama Medical School, Moroyama machi, Iruma gun, Saitama, Japan
    J Psychopharmacol 19:235-41. 2005
    ....
  12. ncbi request reprint Identification of galpha subtype(s) involved in gamma-aminobutyric acid(B) receptor-mediated high-affinity guanosine triphosphatase activity in rat cerebral cortical membranes
    Y Odagaki
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, 060 8638, Sapporo, Japan
    Neurosci Lett 297:137-41. 2001
    ..These results, in conjunction with the data in our previous reconstitution study, indicate that Gi2alpha is a main transducer of GABA(B) receptor-mediated signaling in rat cerebral cortex...
  13. ncbi request reprint Stimulation of high-affinity GTPase activity through group II metabotropic glutamate receptors in rat hippocampal and striatal membranes
    Y Odagaki
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Jpn J Pharmacol 84:399-404. 2000
    ....
  14. ncbi request reprint Cyclic AMP-mediated signaling components are upregulated in the prefrontal cortex of depressed suicide victims
    Y Odagaki
    Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Brain Res 898:224-31. 2001
    ..These results indicate that the components of cyclic AMP signaling are upregulated in a coordinated manner in brains of depressed suicides and that this alteration is not related to antidepressant treatment...
  15. ncbi request reprint Epinephrine- and thrombin-stimulated high-affinity GTPase activity in platelet membranes from patients with psychiatric disorders
    Yuji Odagaki
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Psychiatry Res 112:111-9. 2002
    ..The functional coupling efficiency of G proteins with receptors appears intact, at least between alpha(2A)-adrenergic receptors and G(i2), and between thrombin receptors and G(q), in platelets from patients with psychiatric disorders...
  16. ncbi request reprint Gamma-hydroxybutyric acid, unlike gamma-aminobutyric acid, does not stimulate Gi/Go proteins in rat brain membranes
    Yuji Odagaki
    Department of Psychiatry, Saitama Medical School, Saitama, Japan
    Basic Clin Pharmacol Toxicol 94:89-98. 2004
    ..These results indicate that gamma-hydroxybutyric acid receptors, if any, are not associated with G-proteins, at least Gi/Go family...
  17. ncbi request reprint Lack of G protein-coupled sigma receptors in rat brain membranes: receptor-mediated high-affinity GTPase activity and [35S]GTPgammaS binding studies
    Y Odagaki
    Department of Psychiatry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama, Japan
    J Neural Transm 112:873-83. 2005
    ..It is concluded that sigma receptors are not coupled to heterotrimeric G proteins, at least those of Gi/o type...
  18. doi request reprint Pharmacological characterization of alpha2D-adrenergic receptor-mediated [35S]GTPgammaS binding in rat cerebral cortical membranes
    Yuji Odagaki
    Department of Psychiatry, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Pharmacol Res 57:435-44. 2008
    ....
  19. ncbi request reprint Open pergolide treatment of tricyclic and heterocyclic antidepressant-resistant depression
    T Izumi
    Department of Psychiatry, Hokkaido University School of Medicine, North 15, West 7, Kita ku, 060 8638, Sapporo, Japan
    J Affect Disord 61:127-32. 2000
    ..Recently, a dopamine hypothesis of depression was put forward, and several studies have demonstrated that direct and indirect dopamine agonists have antidepressant effects...
  20. ncbi request reprint Effects of lithium on the beta-adrenergic receptor-adenylate cyclase system in rat cerebral cortical membranes
    Y Odagaki
    Department of Psychiatry and Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    Jpn J Pharmacol 55:407-14. 1991
    ..These results indicate that chronic lithium treatment induces subsensitivity in the beta-adrenoceptor-adenylate cyclase system, for which down-regulation of beta-adrenergic receptors is chiefly responsible...