Research Topics
Genomes and Genes | Yuichi NakamuraSummaryAffiliation: Saitama Medical School Country: Japan Publications
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Detail Information
Publications
A novel five-way translocation t(7;11;9;22;9)(q22;q13;q34;q11.2;q34) involving Ph chromosome in a patient of chronic myeloid leukemia: a case reportSho Yokota
Department of Hematology, Saitama Medical University Hospital, 38 Moro Hongo, Moroyama machi, Iruma gun, Saitama, 350 0495, Japan
Mol Cytogenet 5:20. 2012..Good response with imatinib therapy suggested that a single-event rearrangement was involved in the chromosomal changes...
Plasma cell granuloma of the sigmoid colon associated with diverticular disease and accompanying IgM-type monoclonal gammopathyYuichi Nakamura
Department of Hematology, Saitama Medical University, Saitama
Intern Med 49:227-30. 2010..Recurrent inflammatory process with diverticular disease was considered as a pathogenesis of the pseudoneoplasm and a possible cause of monoclonal proliferation of IgM-producing lymphoid cells in this case...- A molecular analysis of biclonal follicular lymphoma: further evidence for bone marrow origin and clonal selectionYuichi Nakamura
Department of Hematology, Saitama Medical University, Saitama, Japan
Eur J Haematol 82:398-403. 2009..Our study provides further evidence that FL clones, originating from common progenitor cells, can be developed independently at different sites and with different IgL expression after immune selection... 
The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphomaYuichi Nakamura
Department of Hematology, Saitama Medical University, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
Cancer Genet Cytogenet 182:144-9. 2008..The GAS5 gene on chromosome 1q25 is the second BCL6 partner, to the SNHG5 on 6q15, which is classified as a non-protein-coding multiple snoRNA host and 5'-TOP class gene...- Leukemia-related transcription factor TEL accelerates differentiation of Friend erythroleukemia cellsKazuo Waga
Department of Hematology, Dokkyo University School of Medicine, Tochigi, Japan
Oncogene 22:59-68. 2003..Endogenous TEL mRNA was found to increase during the first 3 days in differentiating MEL cells and drastically decrease thereafter. All these data suggest that TEL might play some role in erythroid cell differentiation... - TEL/AML1 shows dominant-negative effects over TEL as well as AML1Hisako Gunji
Department of Hematology, Dokkyo University School of Medicine, Tochigi 321-0293, Japan
Biochem Biophys Res Commun 322:623-30. 2004..All these data indicate that TEL/AML1 exerts dominant-interfering effects on both AML1 and TEL, and that expression of TEL/AML1 could result in inactivation of TEL's tumor suppressive functions in t(12;21)-carrying leukemia... - Cloning and characterization of the novel chimeric gene TEL/PTPRR in acute myelogenous leukemia with inv(12)(p13q13)Fumihiko Nakamura
Department of Hematology, Dokkyo University School of Medicine, Tochigi, Japan
Cancer Res 65:6612-21. 2005..Loss of tumor suppressive function of wild-type TEL and maintenance of STAT3-mediated signal could at least partly contribute to the leukemogenesis caused by inv(12)(p13q13)... - [Aplastic anemia complicated with ulcerative colitis]Tsuneyuki Shimada
Department of Hematology, Saitama Medical University Hospital
Rinsho Ketsueki 53:224-8. 2012.... - [Case with hairy cell leukemia-Japanese variant following radiotherapy for orbital adnexal MALT lymphoma]Yuichi Nakamura
Department of Hematology, Saitama Medical University Hospital
Rinsho Ketsueki 51:1674-9. 2010..This appears to be the first reported case of HCL-Jv associated with other lymphoid tumor. Further analysis is needed to clarify the risk of secondary malignancy in HCL-Jv... - Functional regulation of TEL by p38-induced phosphorylationHonoka Arai
Department of Hematology, Dokkyo University School of Medicine, 321 0293, Tochigi, Japan
Biochem Biophys Res Commun 299:116-25. 2002..These data indicate that TEL's functions are potentially regulated by p38 which is activated by various kinds of stresses. TEL could be a constituent downstream of the specific MAP kinase in the signal transduction system... - A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell BodiesHidekazu Kayano
Department of Pathology, Faculty of Medicine, Saitama Medical University, 38 Moro Hongoh, Moroyama, Iruma gun, Saitama 350 0495, Japan
Bone Marrow Res 2011:814372. 2011..The observed clonal expansion with plasmacytic differentiation may have occurred under the influence of HCV with HP infection... - Monocytic leukemia with CALM/AF10 rearrangement showing mediastinal emphysemaFumihiko Nakamura
Department of Hematology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan
Am J Hematol 72:138-42. 2003..Monocytic leukemias with CALM/AF10 fusion are frequently associated with mediastinal invasion. We need to pay special attention to such a complication, even if the chest X-ray is normal at presentation... - Serum levels of Thl/Th2 cytokines, angiogenic growth factors, and other prognostic factors in young adult patients with hemophagocytic syndromeIkuo Murohashi
Department of Medical Technology, Saitama Prefectural University, Saitama, Japan
Lab Hematol 12:71-4. 2006..Taken together, our findings suggest that both IL-18 and IL-10, but not IL-12, may play important roles in young adult patients with HPS via enhancing and suppressing Th1 immune responses, respectively... - Expression of the TEL/EVI1 fusion transcript in a patient with chronic myelogenous leukemia with t(3;12)(q26;p13)Yuichi Nakamura
Department of Hematology, Dokkyo University School of Medicine, Tochigi, Japan
Am J Hematol 69:80-2. 2002.... - N-ras and p53 gene mutations in Japanese patients with myeloproliferative disordersShigeharu Tsurumi
Department of Hematology, Dokkyo University School of Medicine, Tochigi, Japan
Am J Hematol 71:131-3. 2002..These data suggested that disruptions of both genes are extremely rare in MPD in chronic phase and that loss of functions in the p53 gene could be involved in progression of MPD such as PV and ET... - SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidaseMasaaki Nagai
Department of Biochemistry and Internal Medicine, Niigata University School of Medicine, 1 757 Asahimachidori, Niigata 951 8510, Japan
Biochem Biophys Res Commun 295:74-80. 2002..Another deletion analysis showed that the sequence -207 to -192 bp was also active and it contained nuclear factor Y (NF-Y) binding site. Both sites might play critical roles in sterol mediated regulation of SE gene... - Diffuse nodular lymphoid hyperplasia of the large bowel without hypogammaglobulinemia or malabsorption syndrome: a case report and literature reviewShigeki Tomita
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
Int J Surg Pathol 10:297-302. 2002..The present case appears to be an essentially benign condition bearing a resemblance, both clinically and histologically, to malignant lymphoma, and from which it can be distinguished by use of immunohistochemical or molecular analysis... - Extranodal diffuse follicular center lymphoma mimicking mantle cell lymphoma of the intestineShigeki Tomita
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Shimo-tsuga, Tochigi, Japan
Am J Hematol 74:287-9. 2003..Moreover, a cytogenetic study showed a translocation at (14;18)(q32;q21). Finally, this case was diagnosed as diffuse FCL, although the tumor was mimicking mantle cell lymphoma...