M Muramatsu

Summary

Affiliation: Saitama Medical School
Country: Japan

Publications

  1. ncbi request reprint Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III
    Y Yao
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 04, Japan
    J Biol Chem 271:32881-5. 1996
  2. ncbi request reprint Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem
    A Orimo
    Department of Biochemistry, Saitama Medical School, Saitama, 350 0495, Japan
    Genomics 69:143-9. 2000
  3. ncbi request reprint Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity
    A Fukushima
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun Saitama 350 0495, Japan
    J Biol Chem 273:25840-9. 1998
  4. pmc Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human
    S Ogawa
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Nucleic Acids Res 26:3505-12. 1998
  5. ncbi request reprint Molecular cloning and characterization of mouse EBAG9, homolog of a human cancer associated surface antigen: expression and regulation by estrogen
    F Tsuchiya
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama, 350 0495, Japan
    Biochem Biophys Res Commun 284:2-10. 2001
  6. pmc The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2
    M Nishimoto
    Department of Biochemistry, Saitama Medical School, Iruma gun, Saitama 350 0495, Japan
    Mol Cell Biol 19:5453-65. 1999
  7. pmc Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein
    S Inoue
    Department of Biochemistry, Saitama Medical School, Japan
    Proc Natl Acad Sci U S A 90:11117-21. 1993
  8. ncbi request reprint Molecular cloning of rat efp: expression and regulation in primary osteoblasts
    S Inoue
    Department of Biochemistry, Saitama Medical School, 38 Moro Hongo, Moroyama machi, Iruma gun, Saitama, 350 0495, Japan
    Biochem Biophys Res Commun 261:412-8. 1999
  9. ncbi request reprint Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis
    S Ogawa
    Department of Biochemistry, Saitama Medical School, 38 Moro Hongo, Saitama, Moroyama machi, Iruma gun, 350 0495, Japan
    Biochem Biophys Res Commun 251:515-9. 1998
  10. pmc RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription
    K Hanada
    Department of Biochemistry, University of Tokyo School of Medicine, Japan
    EMBO J 15:2217-26. 1996

Collaborators

Detail Information

Publications86

  1. ncbi request reprint Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III
    Y Yao
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 04, Japan
    J Biol Chem 271:32881-5. 1996
    ..These results suggest that higher eukaryotic RNA polymerase I conserves two distinct alpha-related subunits that function to associate with each other in an early stage of RNA polymerase I assembly...
  2. ncbi request reprint Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem
    A Orimo
    Department of Biochemistry, Saitama Medical School, Saitama, 350 0495, Japan
    Genomics 69:143-9. 2000
    ..These findings suggest that RNF21 is a downstream gene that may mediate interferon's biological action...
  3. ncbi request reprint Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity
    A Fukushima
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun Saitama 350 0495, Japan
    J Biol Chem 273:25840-9. 1998
    ....
  4. pmc Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human
    S Ogawa
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Nucleic Acids Res 26:3505-12. 1998
    ....
  5. ncbi request reprint Molecular cloning and characterization of mouse EBAG9, homolog of a human cancer associated surface antigen: expression and regulation by estrogen
    F Tsuchiya
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama, 350 0495, Japan
    Biochem Biophys Res Commun 284:2-10. 2001
    ..These findings suggest that EBAG9 is an in vivo estrogen-responsive gene that inhibits the cell growth...
  6. pmc The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2
    M Nishimoto
    Department of Biochemistry, Saitama Medical School, Iruma gun, Saitama 350 0495, Japan
    Mol Cell Biol 19:5453-65. 1999
    ..Furthermore, our analyses reveal that these properties are dictated by the unique ability of the Oct-3/4 POU-homeodomain that recognizes a variant of the Octamer motif in the UTF1 regulatory element...
  7. pmc Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein
    S Inoue
    Department of Biochemistry, Saitama Medical School, Japan
    Proc Natl Acad Sci U S A 90:11117-21. 1993
    ..Thus, the genomic binding-site cloning may be applicable for isolation of the target genes of other transcription factors...
  8. ncbi request reprint Molecular cloning of rat efp: expression and regulation in primary osteoblasts
    S Inoue
    Department of Biochemistry, Saitama Medical School, 38 Moro Hongo, Moroyama machi, Iruma gun, Saitama, 350 0495, Japan
    Biochem Biophys Res Commun 261:412-8. 1999
    ..These findings suggest the possible involvement of the efp in the differentiation of osteoblastic cells...
  9. ncbi request reprint Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis
    S Ogawa
    Department of Biochemistry, Saitama Medical School, 38 Moro Hongo, Saitama, Moroyama machi, Iruma gun, 350 0495, Japan
    Biochem Biophys Res Commun 251:515-9. 1998
    ..Structural similarity raises the possibilities that the terf gene might be also involved in carcinogenesis or cell transformation...
  10. pmc RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription
    K Hanada
    Department of Biochemistry, University of Tokyo School of Medicine, Japan
    EMBO J 15:2217-26. 1996
    ....
  11. ncbi request reprint Structural analyses of the UTF1 gene encoding a transcriptional coactivator expressed in pluripotent embryonic stem cells
    M Nishimoto
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama, 350 0495, Japan
    Biochem Biophys Res Commun 285:945-53. 2001
    ..Chromosomal mapping analyses locate the gene at 7F5, the syntenic region of the human chromosome (10q26) where the human UTF1 gene is located...
  12. ncbi request reprint Regulation of mouse UBF gene by multiple growth-related control elements
    T Nishimura
    Department of Biochemistry, University of Tokyo Faculty of Medicine, Japan
    Biochem Biophys Res Commun 205:1217-25. 1994
    ..Among serum response elements, members located between -1182 and -343 are indeed responsive to serum, suggesting their important role in the high expression of mUBF under cell growth conditions...
  13. ncbi request reprint Multiple regulatory elements and binding proteins of the 5'-flanking region of the human estrogen-responsive finger protein (efp) gene
    K Ikeda
    Department of Biochemistry, Saitama Medical School, Moroyama, Japan
    Biochem Biophys Res Commun 236:765-71. 1997
    ..These findings suggest that the human efp promoter is regulated by multiple elements and their interacting factors, and the E-box near the transcription initiation site is essential for the basal promoter activity...
  14. ncbi request reprint Promoter analysis and chromosomal mapping of human EBAG9 gene
    K Ikeda
    Department of Biochemistry, Saitama Medical School, Moroyama, Iruma gun, Saitama, 350 0495, Japan
    Biochem Biophys Res Commun 273:654-60. 2000
    ..These findings suggest that the human EBAG9 might be involved in carcinogenesis as an estrogen responsive gene...
  15. ncbi request reprint Chromosome mapping of RNF16 and rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family
    S Ogawa
    Department of Biochemistry, Saitama Medical School, Saitama, Japan
    Cytogenet Cell Genet 89:56-8. 2000
    ....
  16. pmc Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor alpha
    A Orimo
    Department of Biochemistry, Saitama Medical School, 38 Moro Hongo, Moroyama machi, Iruma gun, Saitama, 350 0451, Japan
    Proc Natl Acad Sci U S A 96:12027-32. 1999
    ..These results suggest that efp is essential for the normal estrogen-induced cell proliferation and uterine swelling as one of the direct targets of estrogen receptor alpha...
  17. ncbi request reprint Isolation and characterization of the fission yeast gene Sprpa12+ reveals that the conserved C-terminal zinc-finger region is dispensable for the function of its product
    Y Imazawa
    Department of Biochemistry, Saitama Medical School, Moroyama, Japan
    Mol Gen Genet 264:852-9. 2001
    ..cerevisiae and S. pombe. Finally, the analysis of mutants suggests that SpRPA12 requires the zinc-finger domain in the N-terminal region but not the one in the C-terminal region for its function...
  18. ncbi request reprint Efp as a primary estrogen-responsive gene in human breast cancer
    K Ikeda
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama, Japan
    FEBS Lett 472:9-13. 2000
    ..These results suggest that the efp can mediate estrogen actions such as cell growth in human breast cancer as a primary responsive gene...
  19. ncbi request reprint Carboxy-terminally truncated form of a coactivator UTF1 stimulates transcription from a variety of gene promoters through the TATA Box
    A Fukushima
    Department of Biochemistry, Saitama Medical School, 38 Morohongo Moroyama Iruma gun, Saitama, 350 0495, Japan
    Biochem Biophys Res Commun 258:519-23. 1999
    ....
  20. ncbi request reprint Molecular cloning, localization, and developmental expression of mouse brain finger protein (Bfp)/ZNF179: distribution of bfp mRNA partially coincides with the affected areas of Smith-Magenis syndrome
    A Orimo
    Department of Biochemistry, Department of Psychiatry, Institute of Laboratory Animal Science, Saitama Medical School, 38 Moro Hongo, Moroyama machi, Iruma gun, Saitama, 350 04, Japan
    Genomics 54:59-69. 1998
    ..These findings suggest a possibility that Bfp might be involved in the pathogenesis of Smith-Magenis syndrome as a regulator protein related to neural differentiation and function...
  21. pmc p300-mediated acetylation facilitates the transfer of histone H2A-H2B dimers from nucleosomes to a histone chaperone
    T Ito
    Department of Biochemistry, Saitama Medical School, Morohongo, Moroyama cho, Iruma gun, Saitama 350 0495 Japan
    Genes Dev 14:1899-907. 2000
    ..Thus, transcription from chromatin templates is ordered and sequential, with precise timing and roles for ATP-dependent chromatin remodeling, subsequent histone acetylation, and alterations in nucleosome structure...
  22. ncbi request reprint A novel RING finger protein, BFP, predominantly expressed in the brain
    S Inoue
    Department of Biochemistry, Saitama Medical School, Japan
    Biochem Biophys Res Commun 240:8-14. 1997
    ..Interestingly, the bfp is induced during retinoic acid-mediated differentiation of P19 embryonal carcinoma cells into neural cells. These findings suggest the possible involvement of bfp in some aspects of neural cell regulation...
  23. ncbi request reprint Reconstitution of recombinant TFIIH that can mediate activator-dependent transcription
    A Fukuda
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama, Iruma-gun, Saitama 350-0495, Japan
    Genes Cells 6:707-19. 2001
    ..Recombinant TFIIH reconstituted from this baculovirus system should be useful for analysis of the mechanisms of activation by GAL4-VP16...
  24. ncbi request reprint Molecular cloning of testis-abundant finger Protein/Ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC
    A Orimo
    Department of Biochemistry, Institute of Laboratory Animal Science, Saitama Medical School, 38 Moro Hongo, Moroyama machi, Iruma gun, Saitama, 350 0495, Japan
    Biochem Biophys Res Commun 276:45-51. 2000
    ..2 proteins such as RFP, RFB30/HERF1, AFP, and HZF had been localized. These findings demonstrate that several RBCC-B30.2 proteins including tfp, which are non-HLA proteins, are clustered within the class I region of the human MHC...
  25. ncbi request reprint A novel class of murine POU gene predominantly expressed in central nervous system
    K Okamoto
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    J Biol Chem 268:7449-57. 1993
    ..These two mRNA species are generated by alternative splicing by utilizing an unusual splice acceptor site: CCTCCCTCTG/. Emb mRNA expressed in testis, on the other hand, encodes a smaller protein lacking most of the amino-terminal region...
  26. ncbi request reprint Isolation and characterization of cDNA encoding mouse RNA polymerase II subunit RPB14
    Y Nishi
    Department of Biochemistry, Saitama Medical School, Iruma gun, Japan
    Gene 187:165-70. 1997
    ..A possible role of the alpha-motif [Dequard-Chablat, M., Riva, M., Carles, C. and Sentenac, A., J. Biol. Chem. 266 (1991) 15300-15307] in the protein-protein interaction between mRPA40 and mRPB14 is also discussed...
  27. ncbi request reprint The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro
    S Ogawa
    Department of Biochemistry, Saitama Medical School, Japan
    Biochem Biophys Res Commun 243:122-6. 1998
    ..Protein interaction between ER alpha and ER beta was demonstrated in vitro by GST pull-down assay and in vivo by immunoprecipitation. Thus, this study indicates that ER alpha and ER beta can interact in vivo, cross-signaling each other...
  28. ncbi request reprint Isolation and characterization of the fission yeast gene rpa42+, which encodes a subunit shared by RNA polymerases I and III
    Y Imazawa
    Department of Biochemistry, Saitama Medical School, Iruma gun, Japan
    Mol Gen Genet 262:749-57. 1999
    ..pombe and S. cerevisiae, and suggest that heterodimer formation between them is essential for the assembly of RNA polymerases I and III in eukaryotes...
  29. ncbi request reprint Cancer-associated myofibroblasts possess various factors to promote endometrial tumor progression
    A Orimo
    Department of Biochemistry, Saitama Medical School, 38 Moro Hongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Clin Cancer Res 7:3097-105. 2001
    ..These findings suggest directly that the myofibroblasts might participate in the progression of tumor cells in terms of cancer cell growth stimulation and also activated initiation of angiogenesis...
  30. ncbi request reprint Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family
    S Inoue
    Department of Biochemistry, Saitama Medical School, Japan
    Genomics 25:581-3. 1995
    ..1 and that mouse Efp is located at 11C. These results provide additional evidence that the mouse 11C region displays conserved synteny with the 17q23.1 region of the human genome...
  31. ncbi request reprint Species-specific interaction of transcription factor p70 with the rDNA core promoter
    K Yamamoto
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Saitama, Moroyama, Iruma-gun, 350-0495, Japan
    Biochem Biophys Res Commun 281:1001-5. 2001
    ..In contrast, human p70 no longer bound to the human core promoter when mouse SL1 was used. Thus, a species-specific interaction between p70 and SL1 may be involved in the promoter selection for rDNA transcription...
  32. ncbi request reprint A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells
    K Okamoto
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Cell 60:461-72. 1990
    ..We suggest that Oct-3 is a novel octamer binding transcription factor that is developmentally regulated during mouse embryogenesis...
  33. ncbi request reprint Organization and expression of mouse Hox3 cluster genes
    J Goto
    Department of Biochemistry, School of Medicine, University of Tokyo, Japan
    Mol Gen Genet 239:41-8. 1993
    ..6 and Hox3.5 during embryogenesis revealed that the relationship between relative position in the Hox3 cluster and expression domain along antero-posterior axis appears similar to that seen for members of the other Hox clusters...
  34. ncbi request reprint High conservation of subunit composition of RNA polymerase I(A) between yeast and mouse and the molecular cloning of mouse RNA polymerase I 40-kDa subunit RPA40
    C Z Song
    Department of Biochemistry, University of Tokyo School of Medicine, Japan
    J Biol Chem 269:26976-81. 1994
    ..The high conservation of this subunit among distant eukaryotes and different RNA polymerases suggests functional importance of this protein as a core subunit...
  35. ncbi request reprint Estrogen receptors: how do they control reproductive and nonreproductive functions?
    M Muramatsu
    Future Program Research Division, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama, 350 0495, Japan
    Biochem Biophys Res Commun 270:1-10. 2000
    ..This approach, which has been most difficult, will now become more popular in future as newer technologies for this develop...
  36. ncbi request reprint Structure and expression of the rat c-jun messenger RNA: tissue distribution and increase during chemical hepatocarcinogenesis
    M Sakai
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Cancer Res 49:5633-7. 1989
    ..We have also determined c-jun expression during chemical hepatocarcinogenesis and demonstrated increased expression of mRNA in the precancerous lesion, hyperplastic nodules, as well as in the primary hepatocellular carcinomas...
  37. pmc UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells
    A Okuda
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    EMBO J 17:2019-32. 1998
    ..Thus, UTF1 displays many of the hallmark characteristics expected for a tissue-specific transcriptional coactivator that works in early embryogenesis...
  38. ncbi request reprint Protein interaction cloning in yeast of the mouse third largest RNA polymerase II subunit, mRPB31
    I V Korobko
    Department of Biochemistry, Saitama Medical School, Moroyama, Iruma gun, Japan
    Gene 185:1-4. 1997
    ..Indeed, in the yeast two-hybrid system, mRPB31 was shown to fail to form homodimer...
  39. pmc Isolation of estrogen-responsive genes with a CpG island library
    T Watanabe
    Department of Biochemistry, Saitama Medical School, Japan
    Mol Cell Biol 18:442-9. 1998
    ..We therefore propose that the CpG-GBS method described here for isolation of the DNA binding site from the CpG island library would be useful for identification of novel target genes of certain transcription factors...
  40. ncbi request reprint Molecular cloning, structure, and expression of mouse estrogen-responsive finger protein Efp. Co-localization with estrogen receptor mRNA in target organs
    A Orimo
    Department of Biochemistry, Saitama Medical School, Japan
    J Biol Chem 270:24406-13. 1995
    ..5-day embryos by whole mount in situ hybridization. These findings raise the possibility that efp is an estrogen-responsive gene that mediates estrogen action in various target organs...
  41. ncbi request reprint Multistep chromatin assembly on supercoiled plasmid DNA by nucleosome assembly protein-1 and ATP-utilizing chromatin assembly and remodeling factor
    T Nakagawa
    Division of Gene Structure and Function, Saitama Medical School Research Center for Genomic Medicine, Morohongo, Moroyama cho, Iruma gun, Saitama 350 0495, Japan
    J Biol Chem 276:27384-91. 2001
    ..These results suggest a model for the ordered deposition of histones and the arrangement of nucleosomes during chromatin assembly in vivo...
  42. pmc Multiple regulatory elements and phorbol 12-O-tetradecanoate 13-acetate responsiveness of the rat placental glutathione transferase gene
    M Sakai
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 85:9456-60. 1988
    ..The results are discussed in terms of the specific derepression of GST-P gene during hepatocarcinogenesis in the rat...
  43. ncbi request reprint Structure and expression of a human class pi glutathione S-transferase messenger RNA
    T Kano
    Department of Biochemistry, University of Tokyo Faculty of Medicine, Japan
    Cancer Res 47:5626-30. 1987
    ..The results indicate that the mode of the expression of GST-pi in humans is different from that of GST-P in rats...
  44. pmc The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer
    H Okazawa
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    EMBO J 10:2997-3005. 1991
    ..We suggest that RARE1 is a critical cis element for oct3 gene expression in embryonic stem cells and for the RA-mediated repression...
  45. pmc Cloning and structural analysis of cDNA and the gene for mouse transcription factor UBF
    K Hisatake
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Nucleic Acids Res 19:4631-7. 1991
    ..The mRNA of mUBF1 was expressed one half of the mUBF2 in quiescent mouse fibroblasts but reached the same amount in growing state...
  46. ncbi request reprint Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3)
    N Ueki
    Helix Research Institute, Chiba, Japan
    J Hum Genet 44:193-6. 1999
    ..Mapping of a crucial gene in modulating the STAT3 signaling pathway may provide new clues to the understanding of malignancies or genetic disorders caused by this chromosome region...
  47. ncbi request reprint Gene cloning and overexpression of a geranylgeranyl diphosphate synthase of an extremely thermophilic bacterium, Thermus thermophilus
    C Ohto
    Bio Research Laboratory, Toyota Motor Corporation, Japan
    Biosci Biotechnol Biochem 63:261-70. 1999
    ..thermophilus GGPP synthase was excluded from the group of bacterial type GGPP synthases and lacked the insertion amino acid residues in the first aspartate-rich motif as do archaeal and eukaryotic short-chain prenyltransferases...
  48. ncbi request reprint Isolation of a cDNA for a novel human RING finger protein gene, RNF18, by the virtual transcribed sequence (VTS) approach(1)
    T Yoshikawa
    Biological Technology Laboratory, Helix Research Institute, Kisarazu, Chiba, Japan
    Biochim Biophys Acta 1493:349-55. 2000
    ..Taken together, the VTS approach should provide a novel cDNA cloning strategy for isolating unidentified genes, which are not found even in EST databases but are detectable computationally...
  49. ncbi request reprint Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1)
    N Seki
    Genome Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Hum Genet 43:268-71. 1998
    ..Based on PCR-assisted analysis of a radiation hybrid panel and fluorescence in situ hybridization, HIP1R was localized to the q24 region of chromosome 12...
  50. ncbi request reprint NOLP: identification of a novel human nucleolar protein and determination of sequence requirements for its nucleolar localization
    N Ueki
    Biological Technology Laboratory, Helix Research Institute, Inc, 1532 3 Yana, Chiba, Kisarazu shi, 292 0812, Japan
    Biochem Biophys Res Commun 252:97-102. 1998
    ..These results suggest that this novel nucleolar protein has at least two distinct domains for directing to different subnuclear destinations...
  51. ncbi request reprint Molecular cloning of a rat 49-kDa TBP-interacting protein (TIP49) that is highly homologous to the bacterial RuvB
    M Kanemaki
    Department of Biology, Faculty of Science, Chiba University, Inage Ku, Japan
    Biochem Biophys Res Commun 235:64-8. 1997
    ..These findings suggest that TIP49 is a putative ATP-dependent DNA helicase...
  52. ncbi request reprint Molecular cloning of a novel 120-kDa TBP-interacting protein
    S Yogosawa
    Department of Biology, Faculty of Science, Chiba University, Japan
    Biochem Biophys Res Commun 229:612-7. 1996
    ..This novel TBP-binding protein is considered to participate in transcription regulation through the interaction with TBP...
  53. ncbi request reprint Methylation and downregulated expression of mac25/insulin-like growth factor binding protein-7 is associated with liver tumorigenesis in SV40T/t antigen transgenic mice, screened by restriction landmark genomic scanning for methylation (RLGS-M)
    S Komatsu
    Core Research for Evolutional Science and Technology CREST of Japan Science and Technology Corporation, Tsukuba Life Science Center, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 267:109-17. 2000
    ....
  54. ncbi request reprint cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region
    N Seki
    Genome Research Group, National Institute Radiological Sciences, Chiba, Japan
    J Hum Genet 45:31-7. 2000
    ..The putative RII binding motif in AKAP95 was not conserved in NAKAP95. A reverse transcription coupled (RT)-PCR experiment revealed that the NAKAP95 gene was transcribed ubiquitously in various human tissues...
  55. ncbi request reprint cDNA cloning of a human RAB26-related gene encoding a Ras-like GTP-binding protein on chromosome 16p13.3 region
    N Seki
    Genome Research Group, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    J Hum Genet 45:309-14. 2000
    ..3 region between markers WI-7742 and WI-3061. The RAB26-related gene consists of eight exons that span about 44kb of the genome DNA...
  56. ncbi request reprint cDNA cloning of a new member of the Ras superfamily, RAB9-like, on the human chromosome Xq22.1-q22.3 region
    N Seki
    Helix Research Institute, Kisarazu, Chiba, Japan
    J Hum Genet 45:318-22. 2000
    ..A database search revealed that the gene is divided into three exons and spans approximately 7.2kb of the genome DNA of chromosome Xq22.1-q22.3 region...
  57. ncbi request reprint Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation
    N Okazaki
    Helix Research Institute, 1532 3 Yana, Kisarazu City, Chiba 292 0812, Japan
    Brain Res Mol Brain Res 85:1-12. 2000
    ..These results suggest that the interaction of ULK1 and GABARAP is important to vesicle transport and axonal elongation in mammalian neurons...
  58. ncbi request reprint Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
    P Revy
    INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Cell 102:565-75. 2000
    ..The phenotype observed in HIGM2 patients (and in AID-/- mice) demonstrates the absolute requirement for AID in several crucial steps of B cell terminal differentiation necessary for efficient antibody responses...
  59. ncbi request reprint cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein
    N Seki
    National Institute of Radiological Sciences, Chiba, Japan
    J Hum Genet 45:38-42. 2000
    ..The complete genomic organization of RNF10 was determined to consist of 17 exons spanning at least 40kb in the genome...
  60. ncbi request reprint Cloning full-length, cap-trapper-selected cDNAs by using the single-strand linker ligation method
    Y Shibata
    RIKEN Tsukuba Institute, Ibaraki, Japan
    Biotechniques 30:1250-4. 2001
    ..Further, our method tags ss cDNAs more efficiently than does the traditional RNA ligase reaction...
  61. ncbi request reprint cDNA cloning of a human brain finger protein, BFP/ZNF179, a member of the RING finger protein family
    N Seki
    Genome Research Group, National Institute of Radiological Sciences, Chiba, Japan
    DNA Res 6:353-6. 1999
    ..Reverse transcriptase polymerase chain reaction analysis of various human tissues indicated that BFP/ZNF179 is predominantly expressed in brain...
  62. ncbi request reprint cDNA cloning, tissue expression, and chromosomal assignment of a mouse gene, encoding a 127 kDa UV-damaged DNA binding protein which is defective in XPE cells
    N Seki
    Genome Research Group, National Institute of Radiological Sciences, Chiba, Japan
    DNA Res 6:319-22. 1999
    ..The gene was mapped to near the public locus D19Mit22 region of mouse chromosome 19...
  63. ncbi request reprint Structures of the rat proteasomal ATPases: determination of highly conserved structural motifs and rules for their spacing
    Y Makino
    Department of Biology, Faculty of Science, Chiba University, Japan
    Biochem Biophys Res Commun 220:1049-54. 1996
    ..The spacing between individual motifs was strictly conserved in the rat ATPases. These findings suggest a common function of the rat proteasomal ATPases in ATP-dependent RNA/DNA unwinding...
  64. pmc Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor
    H Chiba
    Department of Microbiology, Institute of Medical Science, University of Tokyo, Japan
    Nucleic Acids Res 22:1815-20. 1994
    ..No enhancement was observed for promoters which do not respond to nuclear receptors. We suggest that global transcriptional coactivators equivalent to the yeast SWI/SNF complex exist in mammalian cells...
  65. ncbi request reprint Molecular cloning of a mouse counterpart for human TGF-beta type I receptor
    T Tomoda
    Department of Molecular and Developmental Biology, University of Tokyo, Japan
    Biochem Biophys Res Commun 198:1054-62. 1994
    ..The extracellular domain is 90% homologous with a deletion and an insertion of four amino acid residues. ESK2 also binds to TGF-beta in the presence of TGF beta RII, indicating that ESK2 is the mouse counterpart for human TGF beta RI...
  66. ncbi request reprint The use of restriction landmark genomic scanning to scan the mouse genome for endogenous loci with imprinted patterns of methylation
    H Shibata
    RIKEN Tsukuba Life Science Center, Ibaraki, Japan
    Electrophoresis 16:210-7. 1995
    ..Irlgs 1 and 3 are B6- and D2-specific loci that had the same strain distribution pattern which mapped to the central region of chromosome 9.(ABSTRACT TRUNCATED AT 250 WORDS)..
  67. ncbi request reprint The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons
    S Hirotsune
    Genome Science Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Nat Genet 10:77-83. 1995
    ..Our findings offer an explanation for how the reeler mutant phenotype causes a disturbance of the complex architecture of the neuronal network...
  68. pmc Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver
    Y Mizukami
    Proc Natl Acad Sci U S A 80:3958-62. 1983
    ..These base substitutions occur in relatively limited regions of the sequences. Most of them are found in exons 6, 7, 8, and 9; most frequently in exon 7...
  69. ncbi request reprint The nucleotide sequence of human fibroblast interferon cDNA
    T Taniguchi
    Gene 10:11-5. 1980
    ..The data reported predict the hitherto unknown amino acid sequence of human fibroblast interferon and its putative signal peptide...
  70. pmc Molecular cloning and nucleotide sequences of the complementary DNAs to chicken skeletal muscle myosin two alkali light chain mRNAs
    Y Nabeshima
    Nucleic Acids Res 10:6099-110. 1982
    ..These findings are discussed in relation to the structures of the genes for A1 and A2 mRNA...
  71. pmc Molecular cloning and characterization of rat estrogen receptor cDNA
    S Koike
    Nucleic Acids Res 15:2499-513. 1987
    ..Southern blot analysis of genomic DNA with ER cDNA as a probe has shown that related sequences are present in the genome...
  72. pmc Cloning and the nucleotide sequence of rat glutathione S-transferase P cDNA
    Y Suguoka
    Nucleic Acids Res 13:6049-57. 1985
    ..The very large increase of this mRNA in chemically induced hepatocellular carcinoma suggests a characteristic derepression of this gene during hepatocarcinogenesis...
  73. ncbi request reprint Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2
    M B Paumen
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Biochem Biophys Res Commun 231:523-5. 1997
    ..Full-length CPT I was required for binding to Bcl-2. Direct protein interaction was confirmed in a GST binding assay and in coimmunoprecipitations using two different kinds of anti-Bcl-2 antibodies...
  74. ncbi request reprint Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51
    J Yan
    Helix Research Institute, Chiba, Japan
    Biochem Biophys Res Commun 246:222-7. 1998
    ..We propose that ULK1, UNC-51 and a yeast protein kinase Apg1p comprise a novel subfamily of protein kinase, which is structurally conserved among eukaryotes...
  75. ncbi request reprint Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment
    H Kuroyanagi
    Department of Molecular Genetics, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo, 173 0015, Japan
    Genomics 51:76-85. 1998
    ..elegans. Both FISH and RH mapping confirmed the regional localization of ULK1 to human chromosome 12q24.3...
  76. ncbi request reprint Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains
    J Yan
    Helix Research Institute, 1532 3 Yana, Kisarazu, Chiba, 292 0812, Japan
    Oncogene 18:5850-9. 1999
    ..These results suggest that ULK2 is involved in a previously uncharacterized signaling pathway in mammalian cells...
  77. ncbi request reprint Detection and cloning of an X-linked locus associated with a NotI site that is not methylated on mouse inactivated X chromosome by the RLGS-M method
    S Takada
    Graduate School of Environmental Earth Science, Hokkaido University, North 10 West 5 Kita ku, Sapporo, 060 0810, Japan
    Genomics 61:92-100. 1999
    ..Taking advantage of genomic polymorphisms present between MSM and C3H/He, we showed that murine Orf1 is mapped to the proximal region of the X chromosome. Despite the unmethylation of the NotI site, Orf1 is subject to X inactivation...
  78. ncbi request reprint Isolation, tissue expression, and chromosomal assignment of a human LIM protein gene, showing homology to rat enigma homologue (ENH)
    N Ueki
    Biological Technology Laboratory, Helix Research Institute, Chiba, Japan
    J Hum Genet 44:256-60. 1999
    ....
  79. ncbi request reprint Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
    M Muramatsu
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 274:18470-6. 1999
    ..Taken together, these findings suggest that AID is a new member of the RNA-editing deaminase family and may play a role in genetic events in the germinal center B cell...
  80. ncbi request reprint Substrate recognition by Ca2+/Calmodulin-dependent protein kinase kinase. Role of the arg-pro-rich insert domain
    H Tokumitsu
    Helix Research Institute, Inc, 1532 3 Yana, Kisarazu shi, Chiba 292 0812, Japan
    J Biol Chem 274:15803-10. 1999
    ..These results indicate that the RP-domain in CaM-KK is critical for recognition of downstream CaM-kinases but not for its catalytic activity (i.e. autophosphorylation) and PKB activation...
  81. ncbi request reprint Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif
    N Ueki
    Biological Technology Laboratory, Helix Research Institute, 1532 3 Yana, Kisarazu, Chiba 292 0812, Japan
    Biochim Biophys Acta 1445:232-6. 1999
    ..3-q31.1 region by PCR-based analyses with both a human/rodent monochromosomal hybrid cell panel and a radiation hybrid mapping panel. Furthermore, the gene consists of nine exons that span about 20 kb of genome DNA...
  82. ncbi request reprint Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2
    N Ueki
    Helix Research Institute, Chiba, Japan
    J Hum Genet 44:112-5. 1999
    ..3 and 10q24-q25 regions, respectively. Mapping of a pair of developmentally important genes may provide new clues to the understanding of genetic disorders caused by these chromosome regions...
  83. ncbi request reprint Cloning of a novel rat gene, DB83, that encodes a putative membrane protein
    T Nakadai
    Department of Biology, Faculty of Science, Chiba University, Japan
    DNA Res 5:315-7. 1998
    ..The db83 gene was highly expressed in the liver and significantly in brain, lungs and kidneys. We suggest that DB83 is a tissue-specific putative membrane protein. p6..
  84. ncbi request reprint Human leukocyte and fibroblast interferons are structurally related
    T Taniguchi
    Nature 285:547-9. 1980
    ..We conclude that the two genes were derived from a common ancestor...
  85. ncbi request reprint Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene
    N Seki
    Genome Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Hum Genet 43:202-5. 1998
    ..The chromosome localization of the gene in the 1q23 region was determined by a monochromosomal hybrid panel and a radiation hybrid panel...
  86. ncbi request reprint Demonstration of a testis-specific trans-acting factor Tet-1 in vitro that binds to the promoter of the mouse protamine 1 gene
    T Tamura
    Department of Biochemistry, Saitama Medical School, Japan
    J Biol Chem 267:4327-32. 1992
    ..Although the first 8-mer in the Tet-1 11-mer shares homology with the cyclic AMP-responsive element, Tet-1 is demonstrated to be distinct from known cAMP-responsive element-binding factors...