Affiliation: Saitama Medical School
- Dose-related attenuation of cardiac sympathetic nerve activity and intracardiac conduction with thoracic epidural clonidine in alpha-chloralose-anesthetized catsKenji Ohashi
Department of Anesthesiology and Intensive Care Medicine, Osaka City University Medical School, Osaka, Japan
Osaka City Med J 48:45-58. 2002..Vagal facilitation played no role in suppression of the sinoatrial and AV nodal functions...
- Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in miceTakashi Mori
Institute of Laboratory Animal Science, Department of Neurosurgery, Saitama Medical Center School, Kawagoe, Saitama, Japan
J Neuropathol Exp Neurol 62:280-91. 2003..Taken together, our results show that apoE affects the outcome of acute brain damage in an isoform-specific fashion (apoE4 > apoE3 = apoE2) in genetically engineered mice...
- Arundic Acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic miceTakashi Mori
Institute of Medical Science, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama 350 8550, Japan
J Pharmacol Exp Ther 318:571-8. 2006..Based on the above results, arundic acid is considered to deserve further exploration as a promising therapeutic agent for AD...
- Prevention of chemotherapy-induced alopecia by the anti-death FNK proteinNaomi Nakashima-Kamimura
Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki City, Kanagawa, Japan
Life Sci 82:218-25. 2008..Thus, PTD-FNK represents potential to develop a useful method for preventing CIA in cancer patients...
- Methylene blue modulates Î²-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic miceTakashi Mori
From the Departments of Biomedical Sciences and Pathology, Saitama Medical Center and University, Kawagoe, Saitama 350 8550, Japan
J Biol Chem 289:30303-17. 2014..These results underscore the potential for oral MB treatment against AD-related cerebral amyloidosis by modulating the amyloidogenic pathway. ..
- Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic miceTakashi Mori
Department of Biomedical Sciences, Saitama Medical Center and University, Kawagoe, Saitama, Japan
PLoS ONE 8:e55774. 2013..Collectively, these results highlight that FA is a β-secretase modulator with therapeutic potential against AD...
- Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic miceTakashi Mori
Department of Biomedical Sciences, Saitama Medical Center and University, Kawagoe, Saitama 350 8550, Japan
J Biol Chem 287:6912-27. 2012..Taken together, these results raise the possibility that dietary supplementation with TA may be prophylactic for AD by inhibiting β-secretase activity and neuroinflammation and thereby mitigating AD pathology...
- Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in miceTakashi Mori
Institute of Laboratory Animal Science, Saitama Medical Center School, Kawagoe, Saitama, Japan
J Cereb Blood Flow Metab 24:646-56. 2004..Taken together, these data show that the apoE4 isoform acts to aggravate delayed infarct expansion and peri-infarct reactive astrocytosis during the subacute phase of pMCAO in genetically engineered apoE-KI mice...
- Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemiaTakashi Mori
Institute of Medical Science, Saitama Medical Center University, 1981 Kamoda, Kawagoe, Saitama 350 8550, Japan
Stroke 39:2114-21. 2008..Furthermore, we have suggested that the astrocyte-derived protein S100B may be important in these pathogenic events. However, the causal relationship between S100B and exacerbation of brain damage in vivo remains to be elucidated...
- Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's diseaseTakashi Mori
Department of Medical Science, Saitama Medical Center and University, Kawagoe, Saitama, Japan
Glia 58:300-14. 2010....
- Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in miceTakashi Mori
Institute of Medical Science, Saitama Medical Center School, Kawagoe, Japan
J Cereb Blood Flow Metab 25:748-62. 2005..Thus, pharmacological modulation of astrocytic activation may confer a novel therapeutic strategy for ischemic brain damage, particularly in APOE epsilon4 carriers...
- Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part I: enhanced astrocytic synthesis of s-100beta in the periinfarct area precedes delayed infarct expansionToru Matsui
Department of Neurosurgery and Institute of Laboratory Animal Science, Saitama Medical Center School, Kawagoe, Saitama, Japan
J Cereb Blood Flow Metab 22:711-22. 2002....
- Attenuation of a delayed increase in the extracellular glutamate level in the peri-infarct area following focal cerebral ischemia by a novel agent ONO-2506Takashi Mori
Institute of Laboratory Animal Science, Saitama Medical Center School, 1981 Kamoda, Kawagoe, Saitama 350 8550, Japan
Neurochem Int 45:381-7. 2004....
- Neuroprotective efficacy of selective brain hypothermia induced by a novel external cooling device on permanent cerebral ischemia in ratsTamiki Taniguchi
Department of Neurosurgery, Saitama Medical Center School, 1981 Kamoda, Kawagoe, Saitama, Japan
Neurol Res 27:613-9. 2005..This study was aimed at examining whether hypothermia is neuroprotective against permanent cerebral ischemia in rats...
- Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer miceWilliam V Nikolic
Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
Stem Cells Dev 17:423-39. 2008..Increased microglial phagocytic activity in this scenario was inhibited by addition of recombinant CD40L protein. These data suggest that HUCBC infusion mitigates AD-like pathology by disrupting CD40L activity...
- Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early Narito Tateishi
Minase Research Institute, Ono Pharmaceutical Co Ltd, Shimamoto, Mishima, Osaka, Japan
J Cereb Blood Flow Metab 22:723-34. 2002..Pharmacologic modulation of astrocytic activation may confer a novel therapeutic strategy against stroke...
- Abeta N-terminal-end specific antibody reduced beta-amyloid in Alzheimer-model miceYuko Horikoshi
Gunma University School of Health Sciences, Maebashi, Gunma 371 8514, Japan
Biochem Biophys Res Commun 325:384-7. 2004..Above results provide an insight into the further therapeutic intervention in AD with few adverse effects...
- Role of CD40 ligand in amyloidosis in transgenic Alzheimer's miceJun Tan
The Roskamp Institute, Department of Psychiatry, University of South Florida, 3515 East Fletcher Avenue, Tampa, Florida 33613, USA
Nat Neurosci 5:1288-93. 2002..These findings suggest several possible mechanisms underlying mitigation of AD pathology in response to CD40L depletion, and validate the CD40-CD40L interaction as a target for therapeutic intervention in AD...
- [Ischemic brain damage and glial activation]Takao Asano
Institute of Medical Science, Saitama Medical Center
Nihon Rinsho 64:161-5. 2006
- Protection against ischemic brain injury by protein therapeuticsSadamitsu Asoh
Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School, Kawasaki City, Kanagawa 211 8533, Japan
Proc Natl Acad Sci U S A 99:17107-12. 2002..These results suggest that PTD-FNK has a potential for clinical utility as a protein therapeutic strategy to prevent cell death in the brain...
- Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathologyTerrence Town
Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520 8011, USA
Nat Med 14:681-7. 2008..Taken together, our results suggest that blockade of TGF-beta-Smad2/3 signaling in peripheral macrophages represents a new therapeutic target for Alzheimer's disease...
- Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid(1-42)Terrence Town
Roskamp Institute, University of South Florida, 3515 E Fletcher Avenue, Tampa, FL 33613, USA
J Neuroimmunol 132:49-59. 2002..Taken together, these results show enhanced Th2 and down-regulated Th1 immunity following immune challenge with Abeta(1-42)...
- Isoflurane modulation of neuronal nicotinic acetylcholine receptors expressed in human embryonic kidney cellsMegumi Yamashita
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
Anesthesiology 102:76-84. 2005..The authors studied the effects of isoflurane as compared with sevoflurane and halothane on the human alpha4beta2 nAChRs expressed in human embryonic kidney cells...
- Combination therapy with transductive anti-death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in ratKen ichiro Katsura
Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
J Neurochem 106:258-70. 2008..We propose that this combination therapy would provide a synergistic protective effect by both drugs, reducing adverse the effects of FK506...
- Enhanced cognitive activity--over and above social or physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivityJennifer R Cracchiolo
The Johnnie B Byrd Alzheimer s Center and Research Institute, Tampa, FL 33613, USA
Neurobiol Learn Mem 88:277-94. 2007..Thus, our data suggest that humans who emphasize a high lifelong level of cognitive activity (over and above social and physical activities) will attain the maximal environmental protection against AD...
- Systemic administration of interleukin-4 expressing plasmid DNA delays the development of glomerulonephritis and prolongs survival in lupus-prone female NZB x NZW F1 miceToshiharu Hayashi
Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677 1, Yoshida, Yamaguchi, 753 8515, Japan
Nephrol Dial Transplant 22:3131-8. 2007..The present study examined the effects of administration of interleukin (IL)-4 (Th2 cytokine) expressing plasmid DNA (IL-4pDNA) on the development of glomerulonephritis and survival in lupus-prone female NZB x NZW (B/W)F1 mice...
- Epidural clonidine suppresses the baroreceptor-sympathetic response depending on isoflurane concentrations in catsYoshikazu Ikeda
Department of Anesthesiology and Intensive Care Medicine, Osaka City University Medical School, Osaka, Japan
Anesth Analg 97:748-54. 2003..0 MAC but may offer certain advantages compared with epidural lidocaine during 0.5 MAC isoflurane by virtue of preserving baroreflex sensitivity when inadvertent hypotension occurs...
- Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic miceKavon Rezai-Zadeh
Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, Florida 33613, USA
J Neurosci 25:8807-14. 2005..These data raise the possibility that EGCG dietary supplementation may provide effective prophylaxis for AD...
- Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine productionRyan T Mott
Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA
Glia 46:369-79. 2004..Furthermore, we show that neurons secrete CD22, which functions as an inhibitor of microglial proinflammatory cytokine production...
- CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptideKirk P Townsend
Neuroimmunology Laboratory, Department of Psychiatry, University of South Florida College of Medicine, Tampa, USA
Eur J Immunol 35:901-10. 2005..These data provide a mechanistic explanation for our previous work showing decreased microgliosis associated with diminished cerebral Abeta/beta-amyloid pathology when blocking CD40 signaling in transgenic Alzheimer's mice...
- CD40 is expressed and functional on neuronal cellsJun Tan
The Roskamp Institute, Department of Psychiatry, University of South Florida, 3515 East Fletcher Avenue, Tampa, FL 33613, USA
EMBO J 21:643-52. 2002..These changes occur with age, and are clearly evident at 16 months. Taken together, these data demonstrate a role of CD40 in neuronal development, maintenance and protection in vitro and in vivo...