Shigehiro Katayama

Summary

Affiliation: Saitama Medical School
Country: Japan

Publications

  1. ncbi request reprint Effect of captopril or imidapril on the progression of diabetic nephropathy in Japanese with type 1 diabetes mellitus: a randomized controlled study (JAPAN-IDDM)
    Shigehiro Katayama
    Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyamacho, Irumagun, Saitama 350 0495, Japan
    Diabetes Res Clin Pract 55:113-21. 2002
  2. doi request reprint In half of hypertensive diabetics, co-administration of a calcium channel blocker and an angiotensin-converting enzyme inhibitor achieved a target blood pressure of <130/80 mmHg: the azelnidipine and temocapril in hypertensive patients with type 2 diab
    Shigehiro Katayama
    Division of Endocrinology and Diabetes, Department of Medicine, School of Medicine, Saitama Medical University, Saitama, Japan
    Hypertens Res 31:1499-508. 2008
  3. ncbi request reprint Is renoprotection by angiotensin receptor blocker dependent on blood pressure?: the Saitama Medical School, Albuminuria Reduction in Diabetics with Valsartan (STAR) study
    Shigehiro Katayama
    Division of Endocrinology and Diabetes, Department of Medicine, School of Medicine, Saitama Medical University, Saitama, Japan
    Hypertens Res 30:529-33. 2007
  4. pmc Low transition rate from normo- and low microalbuminuria to proteinuria in Japanese type 2 diabetic individuals: the Japan Diabetes Complications Study (JDCS)
    S Katayama
    Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, 38 Morohongo, Moroyama cho, Iruma gun, Saitama 350 0495, Japan
    Diabetologia 54:1025-31. 2011
  5. ncbi request reprint Importance of blood pressure control in patients with diabetes mellitus
    Shigehiro Katayama
    The Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyamacho, Saitama 350 0495, Iruma, Japan
    J Diabetes Complications 16:87-91. 2002
  6. doi request reprint Phenotype and genotype characteristics of age-related macular degeneration in a Japanese population
    Keisuke Mori
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 117:928-38. 2010
  7. doi request reprint Complement factor H and high-temperature requirement A-1 genotypes and treatment response of age-related macular degeneration
    Takashi Tsuchihashi
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 118:93-100. 2011
  8. ncbi request reprint Functional VEGF C-634G polymorphism is associated with development of diabetic macular edema and correlated with macular retinal thickness in type 2 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School, Saitama, Japan
    Biochem Biophys Res Commun 333:679-85. 2005
  9. doi request reprint A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Faculty of Medicine, Saitama Medical University, Moroyama machi, Iruma gun, Japan
    Biochem Biophys Res Commun 437:521-5. 2013
  10. ncbi request reprint Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy
    Hiroyuki Iizuka
    Division of RI Laboratory, Biomedical Research Center, Saitama Medical University, Saitama, Japan
    Biochem Biophys Res Commun 361:421-6. 2007

Detail Information

Publications92

  1. ncbi request reprint Effect of captopril or imidapril on the progression of diabetic nephropathy in Japanese with type 1 diabetes mellitus: a randomized controlled study (JAPAN-IDDM)
    Shigehiro Katayama
    Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyamacho, Irumagun, Saitama 350 0495, Japan
    Diabetes Res Clin Pract 55:113-21. 2002
    ..to clarify and confirm the renoprotective effects of ACEIs in Japanese type 1 diabetics...
  2. doi request reprint In half of hypertensive diabetics, co-administration of a calcium channel blocker and an angiotensin-converting enzyme inhibitor achieved a target blood pressure of <130/80 mmHg: the azelnidipine and temocapril in hypertensive patients with type 2 diab
    Shigehiro Katayama
    Division of Endocrinology and Diabetes, Department of Medicine, School of Medicine, Saitama Medical University, Saitama, Japan
    Hypertens Res 31:1499-508. 2008
    ..No adverse events caused safety problems. In conclusion, combination therapy using azelnidipine and temocapril is an effective treatment for hypertensive diabetics...
  3. ncbi request reprint Is renoprotection by angiotensin receptor blocker dependent on blood pressure?: the Saitama Medical School, Albuminuria Reduction in Diabetics with Valsartan (STAR) study
    Shigehiro Katayama
    Division of Endocrinology and Diabetes, Department of Medicine, School of Medicine, Saitama Medical University, Saitama, Japan
    Hypertens Res 30:529-33. 2007
    ....
  4. pmc Low transition rate from normo- and low microalbuminuria to proteinuria in Japanese type 2 diabetic individuals: the Japan Diabetes Complications Study (JDCS)
    S Katayama
    Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, 38 Morohongo, Moroyama cho, Iruma gun, Saitama 350 0495, Japan
    Diabetologia 54:1025-31. 2011
    ..The aim of the study was to determine the transition rate and factors associated with the progression of normo- and low microalbuminuria to diabetic nephropathy (overt proteinuria)...
  5. ncbi request reprint Importance of blood pressure control in patients with diabetes mellitus
    Shigehiro Katayama
    The Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyamacho, Saitama 350 0495, Iruma, Japan
    J Diabetes Complications 16:87-91. 2002
  6. doi request reprint Phenotype and genotype characteristics of age-related macular degeneration in a Japanese population
    Keisuke Mori
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 117:928-38. 2010
    ..To describe phenotype and genotype characteristics of age-related macular degeneration (AMD) in Japanese patients...
  7. doi request reprint Complement factor H and high-temperature requirement A-1 genotypes and treatment response of age-related macular degeneration
    Takashi Tsuchihashi
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 118:93-100. 2011
    ....
  8. ncbi request reprint Functional VEGF C-634G polymorphism is associated with development of diabetic macular edema and correlated with macular retinal thickness in type 2 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School, Saitama, Japan
    Biochem Biophys Res Commun 333:679-85. 2005
    ..These results demonstrate that the VEGF C-634G polymorphism is a genetic risk factor for ME as well as DR...
  9. doi request reprint A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Faculty of Medicine, Saitama Medical University, Moroyama machi, Iruma gun, Japan
    Biochem Biophys Res Commun 437:521-5. 2013
    ....
  10. ncbi request reprint Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy
    Hiroyuki Iizuka
    Division of RI Laboratory, Biomedical Research Center, Saitama Medical University, Saitama, Japan
    Biochem Biophys Res Commun 361:421-6. 2007
    ..These results demonstrate that the PEDF gene, in cooperation with the VEGF gene, may contribute to the development of DR...
  11. doi request reprint Antioxidant treatment with alpha-tocopherol improves erectile function in hypertensive rats
    Masayuki Ushiyama
    Fourth Department of Internal Medicine, Saitama Medical School, Saitama, Japan
    Hypertens Res 31:1007-13. 2008
    ..This, in turn, indicates that antioxidant therapy may play a role in treatment for ED in hypertensive patients...
  12. doi request reprint Involvement of low adiponectin levels in impaired glucose tolerance
    Youhei Nakashima
    Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Moroyama, Iruma gun, Saitama, 350 0495, Japan
    Metabolism 57:1350-4. 2008
    ....
  13. doi request reprint Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese
    Takuya Awata
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    J Clin Endocrinol Metab 94:231-5. 2009
    ..Objective: In line with recent findings, we conducted a replication study of two loci on chromosome 12p13 and 16p13 and assessed their potential associations with thyroid autoimmunity in a Japanese population...
  14. ncbi request reprint Effects of telmisartan on insulin resistance in Japanese type 2 diabetic patients
    Masaki Watanabe
    Department of Endocrinology and Diabetes, Saitama Medical University, Saitama, Japan
    Intern Med 49:1843-7. 2010
    ..The aim of the present study was to investigate whether the PPARgamma enhancing activity of telmisartan is exerted clinically in diabetic patients...
  15. doi request reprint Analysis of the HLA and non-HLA susceptibility loci in Japanese type 1 diabetes
    Hisakuni Yamashita
    Department of Endocrinology and Diabetes, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    Diabetes Metab Res Rev 27:844-8. 2011
    ..We previously reported the associations of human leukocyte antigen (HLA) (DRB1 and DQB1), INS, CTLA4, IL2RA, ERBB3 and CLEC16A with Japanese type 1 diabetes (T1D). In this study, we jointly analysed these loci in addition to IFIH1 and IL7R...
  16. ncbi request reprint Erectile dysfunction in hypertensive rats results from impairment of the relaxation evoked by neurogenic carbon monoxide and nitric oxide
    Masayuki Ushiyama
    Fourth Department of Internal Medicine, Saitama Medical School, Saitama, Japan
    Hypertens Res 27:253-61. 2004
    ..These findings suggest that CO regulates the relaxation evoked by EFS in the rat corpus cavernosum, and that ED in hypertension in rats results from an impairment of the relaxation induced by neurogenic CO and NO...
  17. ncbi request reprint Efficacy of glimepiride in Japanese type 2 diabetic subjects
    Kouichi Inukai
    Division of Endocrinology and Diabetes, Department of Internal Medicine, Saitama Medical School, 38 Morohongo, Iruma gun, Saitama ken 350 0495, Japan
    Diabetes Res Clin Pract 68:250-7. 2005
    ..A notable finding of this study is that glimepiride was more beneficial in obese than in non-obese Japanese type 2 diabetic patients...
  18. ncbi request reprint A promoter in the novel exon of hPPARgamma directs the circadian expression of PPARgamma
    Seiichiro Takahashi
    Department of Diabetes and Endocrinology, Saitama Medical University, Saitama 350 0495, Japan
    J Atheroscler Thromb 17:73-83. 2010
    ..Herein, we show that expression levels of the novel PPARgamma transcript exhibit circadian oscillation. To study the mechanisms controlling PPARgamma expression, a novel PPARgamma gene promoter was cloned and characterized...
  19. ncbi request reprint Glimepiride enhances intrinsic peroxisome proliferator-activated receptor-gamma activity in 3T3-L1 adipocytes
    Kouichi Inukai
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School, Iruma gun, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 328:484-90. 2005
    ..Analysis of triglyceride contents revealed glimepiride to promote differentiation of 3T3-L1 adipocytes. These results indicate that glimepiride has the potential to induce PPAR gamma activity, thereby improving insulin resistance...
  20. doi request reprint Associations of cigarette smoking but not serum fatty acids with age-related macular degeneration in a Japanese population
    Sho Kabasawa
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 118:1082-8. 2011
    ..To assess modifiable environmental risk factors and protective factors for age-related macular degeneration (AMD) in a native Japanese population...
  21. ncbi request reprint Pro12Ala substitution in peroxisome proliferator-activated receptor gamma 2 is associated with low adiponectin concentrations in young Japanese men
    Nobuki Takata
    Division of Endocrinoloy and Diabetes, Department of Medicine, Saitama Medical School, Saitama 350 0495, Japan
    Metabolism 53:1548-51. 2004
    ..In conclusion, the Pro12Ala substitution in PPAR gamma 2 may reduce serum adiponectin concentrations in young Japanese men...
  22. ncbi request reprint ANGPTL3 is increased in both insulin-deficient and -resistant diabetic states
    Kouichi Inukai
    The Fourth Department of Internal Medicine, Saitama Medical School, Morohongo 38, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 317:1075-9. 2004
    ..Thus, the expression of ANGPTL3 was enhanced in both insulin-deficient and -resistant diabetic states. These results strongly suggest ANGPTL3 to play an important role in hyperlipidemia in diabetes...
  23. ncbi request reprint Treatment with hypotensive agents affects the impaired relaxation of the penile corpus cavernosum in hypertensive rats
    Masayuki Ushiyama
    Fourth Department of Internal Medicine, Saitama Medical School, Saitama, Japan
    Hypertens Res 29:523-32. 2006
    ..These findings indicate that amlodipine and imidapril may ameliorate the decreased relaxation of cavernous smooth muscle in the setting of hypertension...
  24. pmc Adiponectin upregulates ferritin heavy chain in skeletal muscle cells
    Yuichi Ikegami
    Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Saitama, Japan
    Diabetes 58:61-70. 2009
    ....
  25. ncbi request reprint Acarbose ameliorates atherogenecity of low-density lipoprotein in patients with impaired glucose tolerance
    Ikuo Inoue
    Department of Diabetic and Endocrinology, Saitama Medical School, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Metabolism 55:946-52. 2006
    ..The present findings suggest that acarbose treatment reduces the risk of cardiovascular diseases by ameliorating the atherogenecity of LDL...
  26. ncbi request reprint Hypoglycemic effects of colestimide on type 2 diabetic patients with obesity
    Tamotsu Neda
    Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Saitama 350 0495, Japan
    Endocr J 59:239-46. 2012
    ..These results suggests that, in obese patients with type 2 diabetes, the mechanism underlying improved glycemic control with colestimide treatment involves enhanced β cell activity rather than improved insulin resistance...
  27. ncbi request reprint Coding and noncoding variants in the CFH gene and cigarette smoking influence the risk of age-related macular degeneration in a Japanese population
    Keisuke Mori
    Department of Ophthalmology, Saitama Medical School, Moroyama, Iruma, Saitama, Japan
    Invest Ophthalmol Vis Sci 48:5315-9. 2007
    ..The present study was undertaken to investigate whether four coding and noncoding variants of the CFH gene, including rs1410996, are associated with AMD in native, unrelated Japanese patients...
  28. doi request reprint A possible role of lysophospholipids produced by calcium-independent phospholipase A(2) in membrane-raft budding and fission
    Takanari Nakano
    Department of Biochemistry, Faculty of Medicine, Saitama Medical University, Saitama 350 0455, Japan
    Biochim Biophys Acta 1788:2222-8. 2009
    ..Brush borders are enriched with membrane-rafts and undergo rapid turnover; thus, PLA(2) may be involved in the regulatory mechanism in membrane dynamism. Further, iPLA(2) may provide a therapeutic target for viral infections...
  29. ncbi request reprint Regulation of adiponectin receptor gene expression in diabetic mice
    Kouichi Inukai
    Division of Endocrinology and Diabetes, Deptartment of Internal Medicine, Saitama Medical School, Saitama 350 0495, Japan
    Am J Physiol Endocrinol Metab 288:E876-82. 2005
    ..Our results indicate that regulation of AdipoR1, but not that of AdipoR2, may be involved in glucose and lipid metabolism in diabetic states...
  30. ncbi request reprint Combined treatment with an AT1 receptor blocker and angiotensin converting enzyme inhibitor has an additive effect on inhibiting neointima formation via improvement of nitric oxide production and suppression of oxidative stress
    Shinji Yagi
    Fourth Department of Internal Medicine, Saitama Medical School, Saitama, Japan
    Hypertens Res 27:129-35. 2004
    ..These results suggest that the combination of an ARB and an ACEI exerts an additive inhibitory effect, presumably through an increase in production and bioavailability of NO from the endothelium...
  31. ncbi request reprint Rapid and simple profiling of lipoproteins by polyacrylamide-gel disc electrophoresis to determine the heterogeneity of low-density lipoproteins (LDLs) including small, dense LDL
    Takanari Nakano
    Department of Biochemistry, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    Recent Pat Cardiovasc Drug Discov 4:31-6. 2009
    ..This article discusses several methods for simple and rapid lipid profiling and outlines some recent patents relevant to the methods...
  32. ncbi request reprint Identification of a novel WFS1 mutation (AFF344-345ins) in Japanese patients with Wolfram syndrome
    Kouichi Inukai
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School, Morohongo 38, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Diabetes Res Clin Pract 69:136-41. 2005
    ..As only the two family members homozygous for the mutation showed WFS, these data support the notion that this mutation is the cause of WFS...
  33. ncbi request reprint [Pathophysiological conditions progressing from impaired glucose tolerance: high blood pressure]
    Shigehiro Katayama
    Division of Endocrinology and Diabetes, Department of Internal Medicine, Saitama Medical School
    Nihon Rinsho 63:242-5. 2005
  34. ncbi request reprint Effect of cilnidipine on insulin sensitivity in patients with essential hypertension
    Shinji Yagi
    Fourth Department of Medicine, Saitama Medical School, Saitama, Japan
    Hypertens Res 26:383-7. 2003
    ..2 vs. 332 +/- 33.6 pg/ml). Our results suggest that cilnidipine improves insulin sensitivity, possibly due to its exerting a vasodilatory action without stimulating sympathetic nervous activity...
  35. ncbi request reprint Characterization of the epitopes specific for the monoclonal antibody 9F5-3a and quantification of oxidized HDL in human plasma
    Takanori Nakajima
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama, Saitama 350 0495, Japan
    Ann Clin Biochem 41:309-15. 2004
    ..We previously isolated a monoclonal antibody, 9F5-3a, that is specific for HDL oxidized by CuSO(4)...
  36. ncbi request reprint Heme oxygenase-1 in vascular smooth muscle cells counteracts cardiovascular damage induced by angiotensin II
    Toshisuke Morita
    Department of Laboratory Medicine, Toho University, School of Medicine, 6 11 1, Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    Curr Neurovasc Res 2:113-20. 2005
    ..The evidence presented in the current study indicates that vascular HO-1 exerts its protective effect against cardiovascular damage, possibly through the inhibition of oxidative stress...
  37. pmc Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration
    Takanari Nakano
    Department of Biochemistry, Biomedical Research Center, Saitama Medical University, Saitama, Japan
    Am J Physiol Gastrointest Liver Physiol 297:G207-14. 2009
    ..These data show that lysoPC accelerates the formation of L-IAP from BBM-IAP, followed by enhanced IAP synthesis, suggesting the role that lysoPC might play in the turnover of brush-border proteins...
  38. ncbi request reprint Endothelial nitric oxide synthase gene is associated with diabetic macular edema in type 2 diabetes
    Takuya Awata
    The Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama, 350 0495, Japan
    Diabetes Care 27:2184-90. 2004
    ..We examined the endothelial nitric oxide (eNOS) gene polymorphisms to assess its possible association with diabetic retinopathy and macular edema...
  39. ncbi request reprint Effects of a low dose of indapamide, a diuretic, given daily or every-other-day on blood pressure and metabolic parameters
    Munemichi Inaba
    Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyama cho, Iruma gun, Saitama 350 0495, Japan
    Hypertens Res 27:141-5. 2004
    ..These results suggest that a low dose of indapamide given every day or every other day is effective in lowering BP and does not result in metabolic derangements...
  40. ncbi request reprint Acarbose improves fibrinolytic activity in patients with impaired glucose tolerance
    Yuichi Shinoda
    Department of Biochemistry, Saitama Medical School, Saitama 350 0495, Japan
    Metabolism 55:935-9. 2006
    ....
  41. ncbi request reprint [Treatment of hypertension in diabetics]
    Shigehiro Katayama
    The Fourth Department of Medicine, Saitama Medical School
    Nihon Rinsho 62:448-51. 2004
  42. doi request reprint Predictive power of home blood pressure and clinic blood pressure in hypertensive patients with impaired glucose metabolism and diabetes
    Yuichi Noguchi
    Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Moroyama, Japan
    J Hypertens 31:1593-602. 2013
    ..We evaluated the predictive power of home blood pressure and clinic blood pressure based on the long-term cardiovascular outcome in hypertensive patients with and without impaired glucose metabolism (IGM)...
  43. doi request reprint Clostridium butyricum MIYAIRI 588 improves high-fat diet-induced non-alcoholic fatty liver disease in rats
    Makoto Seo
    Department of Biochemistry, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma, Saitama, 350 0495, Japan
    Dig Dis Sci 58:3534-44. 2013
    ..The aim of the present study was to examine the improving effect of Clostridium butyricum MIYAIRI 588 (CBM588), a probiotic in clinical use for antibiotic-associated diarrhea, against high-fat diet (HFD)-induced fatty liver in rats...
  44. ncbi request reprint [Guidelines for the treatment of hypertension in diabetics]
    Shigehiro Katayama
    Fourth Department of Medicine, Saitama Medical School
    Nihon Rinsho 61:1194-8. 2003
    ..Recent guideline made by Japan Diabetes Society in 2003 lowered the target blood pressure furthermore to less than 130/80 mmHg and added angiotensin receptor blockers as one of the firstline hypotensive agents...
  45. ncbi request reprint [Renoprotective effect of Blood pressure control on progression of diabetic retinopathies]
    Shigehiro Katayama
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School
    Nihon Rinsho 63:389-93. 2005
  46. pmc Lysophosphatidylcholine for efficient intestinal lipid absorption and lipoprotein secretion in caco-2 cells
    Takanari Nakano
    Department of Biochemistry, Faculty of Medicine, Saitama Medical University, Saitama 350 0495, Japan
    J Clin Biochem Nutr 45:227-34. 2009
    ....
  47. ncbi request reprint Activating effect of momordin, extract of bitter melon (Momordica Charantia L.), on the promoter of human PPARdelta
    Masatoshi Sasa
    Department of Diabetes and Endocrinology, Saitama Medical University, Japan
    J Atheroscler Thromb 16:888-92. 2009
    ....
  48. ncbi request reprint Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    J Clin Endocrinol Metab 92:1791-5. 2007
    ..It is suggested that insulin autoimmunity plays an important role in the development of type 1 diabetes in humans. However, the association between insulin gene (INS) region (IDDM2) and type 1 diabetes has been uncertain in Asians...
  49. ncbi request reprint Apoptosis of endothelial cells may be mediated by genes of peroxisome proliferator-activated receptor gamma 1 (PPARgamma 1) and PPARalpha genes
    Ikuo Inoue
    Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    J Atheroscler Thromb 10:99-108. 2003
    ..Co-transfection of PPARgamma 1 and PPARalpha protected the HUVEC apoptosis. The results suggest that the apoptosis of endothelial cells may be mediated by genes of PPARgamma1 and PPARalpha...
  50. doi request reprint Cerebral antioxidant enzyme increase associated with learning deficit in type 2 diabetes rats
    Rie Suge
    Department of Physiology, Saitama Medical University, Moroyama, Iruma gun, Saitama, Japan
    Brain Res 1481:97-106. 2012
    ..These results suggest that diabetes-induced brain impairment, which results in learning deficits, may have occurred before the appearance of the symptoms of overt diabetes...
  51. ncbi request reprint [Adiponectin receptor regulation in diabetic states]
    Kouichi Inukai
    Division of Endocrinology and Diabetes, Department of Internal Medicine, Saitama Medical University
    Nihon Rinsho 65:2125-30. 2007
    ..In contrast, AdipoR2 expression was not significantly altered in diabetic states. Our results indicate that regulation of AdipoR1, but not AdipoR2, may be involved in glucose and lipid metabolism in diabetic states...
  52. pmc Statins Activate Human PPARalpha Promoter and Increase PPARalpha mRNA Expression and Activation in HepG2 Cells
    Makoto Seo
    Department of Biochemistry, Faculty of Medicine, Saitama Medical University, Saitama 350 0495, Japan
    PPAR Res 2008:316306. 2008
    ..In summary, these data demonstrate that PPARalpha production and activation are upregulated through the PPARalpha promoter activity by statin treatment...
  53. ncbi request reprint CLOCK/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor (PPAR) response element
    Ikuo Inoue
    Fourth Department of Medicine, Research Center for Genomic Medicine, Saitama Medical School, Saitama, Japan
    J Atheroscler Thromb 12:169-74. 2005
    ..After deletion of the PPRE from the CRBPII construct, CLOCK/BMAL1 did not affect transactivation. CLOCK/BMAL1 transactivates PPAR target genes via the PPRE...
  54. ncbi request reprint The possible therapeutic actions of peroxisome proliferator-activated receptor alpha (PPAR alpha) agonists, PPAR gamma agonists, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, angiotensin converting enzyme (ACE) inhibitors and calci
    Ikuo Inoue
    Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Curr Drug Targets Cardiovasc Haematol Disord 4:35-52. 2004
    ....
  55. doi request reprint Free immunoglobulin light chain: its biology and implications in diseases
    Takanari Nakano
    Department of Biochemistry, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    Clin Chim Acta 412:843-9. 2011
    ..In this review, we attempt to give a comprehensive view about the biological roles of free IgLC together with the gene expression, secretion, antigen-binding ability, and its metabolic characteristics...
  56. ncbi request reprint SH3 domain of the phosphatidylinositol 3-kinase regulatory subunit is responsible for the formation of a sequestration complex with insulin receptor substrate-1
    Yuichi Ikegami
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, Morohongo 38, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 365:433-8. 2008
    ..In conclusion, our study revealed the SH3 domain of PI 3-kinase to play a critical role in intracellular localizations, including formation of foci with IRS-1 in response to insulin...
  57. pmc Noninvasive evaluation of kidney hypoxia and fibrosis using magnetic resonance imaging
    Tsutomu Inoue
    Department of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    J Am Soc Nephrol 22:1429-34. 2011
    ..Functional MRI can thus contribute to multilateral, noninvasive, in vivo assessment of kidney function...
  58. ncbi request reprint Induction of heme oxygenase-1 in monocytes suppresses angiotensin II-elicited chemotactic activity through inhibition of CCR2: role of bilirubin and carbon monoxide generated by the enzyme
    Toshisuke Morita
    Department of Laboratory Medicine, Toho University, School of Medicine, Tokyo, Japan
    Antioxid Redox Signal 5:439-47. 2003
    ..Exogenously applied bilirubin and carbon monoxide mimicked the inhibitory effect of HO-1 on the chemotactic response. These findings suggest that monocytic HO-1 might be a new therapeutic target for atherosclerosis...
  59. ncbi request reprint [Osteoporosis and intake of carbohydrates]
    Konosuke Nakayama
    Saitama Medical School, Department of Endocrinology and Diabetes, Japan
    Clin Calcium 15:680-3. 2005
    ..Some indigestible carbohydrates, such as inulin and oligofructose, are shown to increase the availability of minerals from foods, and thus can be beneficial to bone mass...
  60. pmc Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXRalpha-Regulated and CLOCK/BMAL1-Regulated Systems
    Koh Ichi Nakamura
    Department of Biochemistry, Saitama Medical University, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    PPAR Res 2008:348610. 2008
    ..These results suggest that there may be crosstalk between the PPARs/RXRalpha-regulated system and the CLOCK/BMAL1-regulated system...
  61. ncbi request reprint Involvement of intestinal alkaline phosphatase in serum apolipoprotein B-48 level and its association with ABO and secretor blood group types
    Takanari Nakano
    Department of Biochemistry, Saitama Medical School, Japan
    Biochem Biophys Res Commun 341:33-8. 2006
    ..In addition, ABO blood type classification in apoB-48 measurement would improve the diagnostic value in the evaluation of metabolic syndrome...
  62. ncbi request reprint [Insulin and blood pressure regulation]
    Shigehiro Katayama
    Fourth Department of Medicine, Saitama Medical School
    Nihon Rinsho 61:1076-9. 2003
  63. ncbi request reprint [Oxidative stress marker]
    Shigehiro Katayama
    Division of Endocrinology and Diabetes, Department of Medicine, School of Medicine, Faculty of Medicine, Saitama Medical University
    Nihon Rinsho 64:142-6. 2006
  64. ncbi request reprint Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1
    Masahito Matsumoto
    Department of Molecular Biology, Saitama Medical School, Saitama, Japan
    J Biol Chem 279:45969-79. 2004
    ..These results suggest that the RANKL-induced cathepsin K gene expression is cooperatively regulated by the combination of the transcription factors and p38 MAP kinase in a gradual manner...
  65. ncbi request reprint Retrospective, observation study: Quantitative and qualitative effect of ezetimibe and HMG-CoA reductase inhibitors on LDL-cholesterol: are there disappearance thresholds for small, dense LDL and IDL?
    Ikuo Inoue
    Division of Endcrinology and Diabetics, Saitama Medical University, Saitama, Japan
    Recent Pat Cardiovasc Drug Discov 5:143-52. 2010
    ..The thershold for small dense LDL indicates the IDL1 plus IDL2 when LDL2 and LDL3 were not detectable, while the thershold for IDL indicates the LDL1 when IDL1, IDL2 and LDL3 were not detectable...
  66. ncbi request reprint A patient with severe hypertriglyceridemia associated with anemia and hypoalbuminemia
    Ikuo Inoue
    Fourth Department of Internal Medicine, Saitama Medical School, Moroyama, Iruma gun, Japan
    J Atheroscler Thromb 10:192-201. 2003
    ..This is the first reported case of abrupt onset of severe hypertriglyceridemia resulting in suppression of bone marrow and liver function...
  67. ncbi request reprint Carbon monoxide regulates blood pressure cooperatively with nitric oxide in hypertensive rats
    Masayuki Ushiyama
    Laboratory of Medicine, School of Medicine, Toho University, 6 11 1 Omori Nishi, Ota ku, Tokyo 146 8541, Japan
    Heart Vessels 16:189-95. 2002
    ..The effect of CO in the regulation of blood pressure is augmented, resulting in increased expression of HO gene when the function and/or production of NO is impaired...
  68. ncbi request reprint A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes
    Takuya Awata
    Fourth Department of Internal Medicine, Saitama Medical School, Saitama, Japan
    Diabetes 51:1635-9. 2002
    ..These data suggest that the C(-634)G polymorphism in the 5'UTR of the VEGF gene is a novel genetic risk factor for diabetic retinopathy...
  69. ncbi request reprint [Clinical significance of calcium channel blocker in patients with metabolic syndrome]
    Shigehiro Katayama
    Division of Endocrinology and Meatbolism, Department of Medicine, Saitama Medical School
    Clin Calcium 15:1657-62. 2005
    ..It seems to be very important to select hypotensive agents which improve insulin sensitivity in hypertensive patients with "Metabolic Syndrome"...
  70. doi request reprint Dopamine D1-like receptor antagonist, SCH23390, exhibits a preventive effect on diabetes mellitus that occurs naturally in NOD mice
    Kumiko Hashimoto
    Department of Allergy and Immunology, Saitama Medical University, Saitama, 38 Morohongo, Moroyama, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 383:460-3. 2009
    ..These findings indicate that antagonizing D1-like-R suppresses IL-17 expression, thereby leading to a decreased occurrence of NOD...
  71. ncbi request reprint [Hypertension in diabetics]
    Shigehiro Katayama
    Fourth Department of Medicine, Saitama Medical School
    Nihon Rinsho 60:411-7. 2002
  72. ncbi request reprint Regulation of PPAR gamma transcriptional activity in 3T3-L1 adipocytes
    Masaki Watanabe
    Saitama Medical School Research Center for Genomic Medicine, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 300:429-36. 2003
    ..Interestingly, PI 3-kinase overexpression resulted in a marked decrease in PPAR gamma activity. These observations have important implications for understanding the regulation of PPAR gamma transcriptional activity...
  73. ncbi request reprint Carboxy terminus of glucose transporter 3 contains an apical membrane targeting domain
    Kouichi Inukai
    Fourth Department of Internal Medicine, Saitama Medical School, Japan
    Mol Endocrinol 18:339-49. 2004
    ..We conclude that the targeting of GLUT3 to the apical cell surface in MDCK cells is regulated by a unique cytosolic sorting motif...
  74. ncbi request reprint [Treatment of hypertension to prevent cardiovascular disease in diabetics]
    Shigehiro Katayama
    Department of Endocrinology and Diabetes, Faculty of Medicine, School of Medicine, Saitama Medical University
    Nihon Rinsho 68:898-902. 2010
    ..Long-acting Ca channel blocker or a small dosage of thiazide diuretic is recommended as the second line hypotensive agents in JSH2009...
  75. ncbi request reprint [Pharmacological therapeutics for the metabolic syndrome]
    Shigehiro Katayama
    Division of Endocrinology and Diabetes, Department of Medicine, School of Medicine, Saitama Medical University
    Nihon Rinsho 64:594-8. 2006
  76. ncbi request reprint Interaction between 3' untranslated region of calcitonin receptor messenger ribonucleic acid (RNA) and adenylate/uridylate (AU)-rich element binding proteins (AU-rich RNA-binding factor 1 and Hu antigen R)
    Shigemitsu Yasuda
    Fourth Department of Internal Medicine, Saitama Medical School, Japan
    Endocrinology 145:1730-8. 2004
    ..These results suggest that AUF1 p40, HuR, and the 3'UTR of the CTR mRNA transcript could be involved in posttranscriptional regulation of CTR mRNA expression...
  77. ncbi request reprint LKB1, an upstream AMPK kinase, regulates glucose and lipid metabolism in cultured liver and muscle cells
    Kenta Imai
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School, Iruma gun, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 351:595-601. 2006
    ..These results demonstrate that LKB1 is a crucial regulator of AMPK activation in muscle and liver cells and, therefore, that LKB1 activity is potentially of importance to our understanding of glucose and lipid metabolism...
  78. ncbi request reprint [Endocrine diseases with hypertension]
    Shigehiro Katayama
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School
    Nihon Rinsho . 2006
  79. ncbi request reprint Glycated high-density lipoprotein regulates reactive oxygen species and reactive nitrogen species in endothelial cells
    Toshiyuki Matsunaga
    Department of Biochemistry, Saitama Medical School, Moroyama, Saitama, Japan
    Metabolism 52:42-9. 2003
    ..Taking all of the above findings together, gly-ox-HDL may lead to the deterioration of vascular function through altered production of reactive oxygen species and reactive nitrogen species in endothelial cells...
  80. ncbi request reprint Detection of low titre TBII in patients with Graves' disease using recombinant human TSH receptor
    Nils G Morgenthaler
    Research Laboratories, BRAHMS AG, Biotechnology Center, Berlin, Germany
    Clin Endocrinol (Oxf) 57:193-8. 2002
    ....
  81. ncbi request reprint [Recent trends in diabetic complications in Japan]
    Hirohito Sone
    Nihon Naika Gakkai Zasshi 93:2427-34. 2004
  82. ncbi request reprint VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
    Diether Lambrechts
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology and Department of Neurology, University Hospital Gasthuisberg, KU Leuven, Leuven, B 3000, Belgium
    Nat Genet 34:383-94. 2003
    ..These findings indicate that VEGF is a modifier of motoneuron degeneration in human ALS and unveil a therapeutic potential of Vegfa for stressed motoneurons in mice...
  83. ncbi request reprint Preventing microalbuminuria in patients with diabetes: rationale and design of the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study
    Hermann Haller
    Nephrology Section, Hanover Medical School, Hanover, Germany
    J Hypertens 24:403-8. 2006
    ..The ROADMAP study will answer the question whether an ARB can prevent or delay the onset of microalbuminuria and whether this translates into protection against cardiovascular events and renal disease...
  84. ncbi request reprint Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis
    Fotini K Kavvoura
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Endocrinol Metab 92:3162-70. 2007
    ....
  85. ncbi request reprint Is the diagnosis of metabolic syndrome useful for predicting cardiovascular disease in asian diabetic patients? Analysis from the Japan Diabetes Complications Study
    Hirohito Sone
    Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan 305 8575
    Diabetes Care 28:1463-71. 2005
    ....
  86. doi request reprint Microalbuminuria reduction with telmisartan in normotensive and hypertensive Japanese patients with type 2 diabetes: a post-hoc analysis of The Incipient to Overt: Angiotensin II Blocker, Telmisartan, Investigation on Type 2 Diabetic Nephropathy (INNOVATI
    Hirofumi Makino
    Department of Medicine and Clinical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hypertens Res 31:657-64. 2008
    ..Telmisartan is shown to be safe and well tolerated in these patients...
  87. ncbi request reprint [Revised criteria for the early diagnosis of diabetic nephropathy]
    Shigeki Inomat
    Japanese Society of Nephrology
    Nihon Jinzo Gakkai Shi 47:767-9. 2005
    ..4) Renal hypertrophy and elevated urinary type IV collagen may indicate the existence of diabetic renal disease. 5) Microalbuminuria originating in non-diabetic diseases should be excluded...
  88. ncbi request reprint Prevalence and risk factors for erectile dysfunction in Japanese diabetics
    Hideyuki Sasaki
    The First Department of Medicine, Wakayama Medical University, Kimiidera 811 1, Wakayama, P O 641 8509, Japan
    Diabetes Res Clin Pract 70:81-9. 2005
    ..These findings suggest that ED is a significant problem in Japanese men with diabetes, and that specific risk factors increase the prevalence of ED. Furthermore, the survey results expose national attitudes toward treatment of ED...
  89. ncbi request reprint Prevention of transition from incipient to overt nephropathy with telmisartan in patients with type 2 diabetes
    Hirofumi Makino
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 Okayama, Japan
    Diabetes Care 30:1577-8. 2007
  90. ncbi request reprint [Prevalence and incidence of diabetic microangiopathy in Japan]
    Hirohito Sone
    University of Tsukuba Institute of Clinical Medicine
    Nihon Rinsho 63:18-22. 2005
  91. ncbi request reprint [A study about normal values of urinary type IV collagen concentration--aim at constructing a diagnostic guideline for diabetic nephropathy]
    Hideto Sakai
    Nihon Jinzo Gakkai Shi 44:427-31. 2002
  92. ncbi request reprint Guidelines for treatment of hypertension in the elderly--2002 revised version
    Toshio Ogihara
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertens Res 26:1-36. 2003