K Fujiwara

Summary

Affiliation: Saitama Medical School
Country: Japan

Publications

  1. doi request reprint Can carboplatin replace cisplatin for intraperitoneal use?
    K Fujiwara
    Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka City, Saitama, Japan
    Int J Gynecol Cancer 18:29-32. 2008
  2. doi request reprint Principle and evolving role of intraperitoneal chemotherapy in ovarian cancer
    Keiichi Fujiwara
    Saitama Medical University International Medical Center, Department of Gynecologic Oncology, 1397 1 Yamane, Hidaka City, Saitama 350 1298, Japan
    Expert Opin Pharmacother 14:1797-806. 2013
  3. doi request reprint Clinical trials of neoadjuvant chemotherapy for ovarian cancer: what do we gain after an EORTC trial and after two additional ongoing trials are completed?
    Keiichi Fujiwara
    Department of Gynecologic Oncology, Saitama Medical School International Medical Center, 1397 1 Yamane, Hidaka City, Saitama, 350 1298, Japan
    Curr Oncol Rep 15:197-200. 2013
  4. doi request reprint Phase II study of intraperitoneal carboplatin with intravenous paclitaxel in patients with suboptimal residual epithelial ovarian or primary peritoneal cancer: a Sankai Gynecology Cancer Study Group Study
    Keiichi Fujiwara
    Department of Gynecologic Oncology, Saitama Medical University, International Medical Center, Hidaka, Saitama, Japan
    Int J Gynecol Cancer 19:834-7. 2009
  5. doi request reprint A randomized Phase II/III trial of 3 weekly intraperitoneal versus intravenous carboplatin in combination with intravenous weekly dose-dense paclitaxel for newly diagnosed ovarian, fallopian tube and primary peritoneal cancer
    Keiichi Fujiwara
    Department of Gynecologic Oncology, Saitama Medical University International Medical Center, 1397 1 Yamane, Hidaka City, Saitama 350 1298, Japan
    Jpn J Clin Oncol 41:278-82. 2011
  6. ncbi request reprint Principles and practice of intraperitoneal chemotherapy for ovarian cancer
    K Fujiwara
    Department of Obstetrics and Gynecology, Saitama Medical University, 38 Morohongo, Moroyama, Iruma, Saitama 350 0495, Japan
    Int J Gynecol Cancer 17:1-20. 2007
  7. ncbi request reprint Preliminary toxicity analysis of intraperitoneal carboplatin in combination with intravenous paclitaxel chemotherapy for patients with carcinoma of the ovary, peritoneum, or fallopian tube
    K Fujiwara
    Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki City, Japan
    Int J Gynecol Cancer 15:426-31. 2005
  8. doi request reprint Combination chemotherapy of intraperitoneal carboplatin and intravenous paclitaxel in suboptimally debulked epithelial ovarian cancer
    S Nagao
    Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Yamane, Hidaka City, Japan
    Int J Gynecol Cancer 18:1210-4. 2008
  9. ncbi request reprint The platelet-sparing effect of paclitaxel is not related to changes in the pharmacokinetics of carboplatin
    K Fujiwara
    Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki City, Japan
    Cancer Chemother Pharmacol 47:22-6. 2001
  10. ncbi request reprint Hormonal function after ovarian transposition to the abdominal subcutaneous fat tissue
    S Nagao
    Department of Obstetrics and Gynecology, Kawasaki Medical School, 577 Matsushima, Kurashiki City 701 0192, Japan
    Int J Gynecol Cancer 16:121-4. 2006

Collaborators

Detail Information

Publications40

  1. doi request reprint Can carboplatin replace cisplatin for intraperitoneal use?
    K Fujiwara
    Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka City, Saitama, Japan
    Int J Gynecol Cancer 18:29-32. 2008
    ..In this review article, we discuss why IP chemotherapy using carboplatin has been ignored and its future potential...
  2. doi request reprint Principle and evolving role of intraperitoneal chemotherapy in ovarian cancer
    Keiichi Fujiwara
    Saitama Medical University International Medical Center, Department of Gynecologic Oncology, 1397 1 Yamane, Hidaka City, Saitama 350 1298, Japan
    Expert Opin Pharmacother 14:1797-806. 2013
    ..p. chemotherapy for optimally debulked advanced stage ovarian cancer in 2006, i.p. chemotherapy has not been widely accepted by the gynecologic oncology community, mainly because of its toxicities...
  3. doi request reprint Clinical trials of neoadjuvant chemotherapy for ovarian cancer: what do we gain after an EORTC trial and after two additional ongoing trials are completed?
    Keiichi Fujiwara
    Department of Gynecologic Oncology, Saitama Medical School International Medical Center, 1397 1 Yamane, Hidaka City, Saitama, 350 1298, Japan
    Curr Oncol Rep 15:197-200. 2013
    ..However, the results of those two trials must be carefully assessed, because the quality of debulking surgery would significantly affect survival, and may make the interpretation of the trial results more confusing and difficult...
  4. doi request reprint Phase II study of intraperitoneal carboplatin with intravenous paclitaxel in patients with suboptimal residual epithelial ovarian or primary peritoneal cancer: a Sankai Gynecology Cancer Study Group Study
    Keiichi Fujiwara
    Department of Gynecologic Oncology, Saitama Medical University, International Medical Center, Hidaka, Saitama, Japan
    Int J Gynecol Cancer 19:834-7. 2009
    ..To assess the antitumor efficacy and safety of 2 treatment modalities: intraperitoneal carboplatin combined with intravenous (IV) paclitaxel...
  5. doi request reprint A randomized Phase II/III trial of 3 weekly intraperitoneal versus intravenous carboplatin in combination with intravenous weekly dose-dense paclitaxel for newly diagnosed ovarian, fallopian tube and primary peritoneal cancer
    Keiichi Fujiwara
    Department of Gynecologic Oncology, Saitama Medical University International Medical Center, 1397 1 Yamane, Hidaka City, Saitama 350 1298, Japan
    Jpn J Clin Oncol 41:278-82. 2011
    ..The first 120 patients will be evaluated for the feasibility of intraperitoneal arm and a total of 746 patients will be enrolled in a Phase III study...
  6. ncbi request reprint Principles and practice of intraperitoneal chemotherapy for ovarian cancer
    K Fujiwara
    Department of Obstetrics and Gynecology, Saitama Medical University, 38 Morohongo, Moroyama, Iruma, Saitama 350 0495, Japan
    Int J Gynecol Cancer 17:1-20. 2007
    ..In this review article, we discuss the principles and clinical aspects of IP chemotherapy and also discuss the current problems and future perspectives in IP chemotherapy...
  7. ncbi request reprint Preliminary toxicity analysis of intraperitoneal carboplatin in combination with intravenous paclitaxel chemotherapy for patients with carcinoma of the ovary, peritoneum, or fallopian tube
    K Fujiwara
    Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki City, Japan
    Int J Gynecol Cancer 15:426-31. 2005
    ..6%; 6.5, 44.4%; 7, 25.0%; and 7.5, 80%. G4 thrombocytopenia did not occur. A dose of carboplatin between AUC = 6 and 7 with IV paclitaxel at 175 mg/m2 is warranted for further evaluation...
  8. doi request reprint Combination chemotherapy of intraperitoneal carboplatin and intravenous paclitaxel in suboptimally debulked epithelial ovarian cancer
    S Nagao
    Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Yamane, Hidaka City, Japan
    Int J Gynecol Cancer 18:1210-4. 2008
    ..Combination chemotherapy of IP carboplatin and IV paclitaxel is effective and safe in suboptimally debulked ovarian cancer, and further evaluation is warranted...
  9. ncbi request reprint The platelet-sparing effect of paclitaxel is not related to changes in the pharmacokinetics of carboplatin
    K Fujiwara
    Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki City, Japan
    Cancer Chemother Pharmacol 47:22-6. 2001
    ..To determine whether the platelet-sparing effect of paclitaxel is related to changes in pharmacology of carboplatin...
  10. ncbi request reprint Hormonal function after ovarian transposition to the abdominal subcutaneous fat tissue
    S Nagao
    Department of Obstetrics and Gynecology, Kawasaki Medical School, 577 Matsushima, Kurashiki City 701 0192, Japan
    Int J Gynecol Cancer 16:121-4. 2006
    ..002). Although the procedure of OTAFT may somewhat affect the ovarian function, the transposed ovary in postmenopausal women presumably still secrete a small amount of estrogen which is equivalent to an estrogen level by HRT...
  11. ncbi request reprint Local radiation therapy for localized relapsed or refractory ovarian cancer patients with or without symptoms after chemotherapy
    K Fujiwara
    Department of Obstetrics and Gynecology, Kawasaki Medical School, 577 Matsushima, Kurashiki City 701 0192, Japan
    Int J Gynecol Cancer 12:250-6. 2002
    ....
  12. ncbi request reprint Role of magnetic resonance imaging (MRI) in early cervical cancer
    K Fujiwara
    Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki City, Japan
    Gan To Kagaku Ryoho 27:576-81. 2000
    ..Negative findings on T2 and/or dynamic MRI indicated non-invasive or early invasive cervical diseases < or = 5 mm. The dynamic technique provided only limited additional value in the detection of early invasive cervical carcinoma...
  13. pmc Surgery for endometrial cancers with suspected cervical involvement: is radical hysterectomy needed (a GOTIC study)?
    M Takano
    Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
    Br J Cancer 109:1760-5. 2013
    ..Radical hysterectomy is recommended for endometrial adenocarcinoma patients with suspected gross cervical involvement. However, the efficacy of operative procedure has not been confirmed...
  14. ncbi request reprint Supernumerary ovary found by ultrasonogram and FSH measurement after an extensive operation for a yolk sac tumor of the ovary
    K Fujiwara
    Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki City, Japan
    Gynecol Obstet Invest 48:138-40. 1999
    ....
  15. ncbi request reprint Change in the localization of heat shock protein 27 (HSP 27) in BG-1 human ovarian cancer cells following treatment by the ether lipid ET-18-OCH3
    K Fujiwara
    Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki City, Japan
    Anticancer Res 19:181-7. 1999
    ..These results indicate that change of the localization of HSP27 may play an important role as a component of the signal transduction pathways affected by ether lipids...
  16. ncbi request reprint Paclitaxel inhibits expression of heat shock protein 27 in ovarian and uterine cancer cells
    Y Tanaka
    Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki City, Japan
    Int J Gynecol Cancer 14:616-20. 2004
    ..Paclitaxel completely inhibited the expression of HSP27. The results of this study indicated that paclitaxel may possess unique mechanisms able to overcome drug resistance by inhibiting HSP27 expression...
  17. ncbi request reprint The mechanisms of hepatic sinusoidal endothelial cell regeneration: a possible communication system associated with vascular endothelial growth factor in liver cells
    S Mochida
    Third Department of Internal Medicine, Saitama Medical School, Japan
    J Gastroenterol Hepatol 13:S1-5. 1998
    ..Also, VEGF derived from activated Kupffer cells, hepatic macrophages and stellate cells may be involved in this proliferation in injured rat liver...
  18. ncbi request reprint Expression of cyclooxygenase-2 in human hyperplastic gastric polyps
    H Bamba
    First Dept of Internal Medicine, Saitama Medical Center, Saitama Medical School, Kamoda Kawagoe, Saitama, Japan
    J Exp Clin Cancer Res 22:425-30. 2003
    ..These results suggest that COX-2 in mesenchymal cells induced by H. pylori may play an important role in the tumorigenesis of human hyperplastic gastric polyps...
  19. ncbi request reprint Effect of rebamipide on prostaglandin receptors-mediated increase of inflammatory cytokine production by macrophages
    H Bamba
    First Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Saitama, Japan
    Aliment Pharmacol Ther 18:113-8. 2003
    ..Effects of PGs on the production of other cytokines such as interleukin (IL)-6 and IL-8 have been controversial...
  20. ncbi request reprint Deranged blood coagulation equilibrium as a factor of massive liver necrosis following endotoxin administration in partially hepatectomized rats
    S Mochida
    Third Department of Internal Medicine, Saitama Medical School, Saitama, Japan
    Hepatology 29:1532-40. 1999
    ..The destruction of sinusoidal endothelial cells as well as hepatocytes may occur as a result of microcirculatory disturbance caused by such sinusoidal fibrin deposition...
  21. ncbi request reprint Prostaglandins up-regulate vascular endothelial growth factor production through distinct pathways in differentiated U937 cells
    H Bamba
    First Department of Internal Medicine, Saitama Medical Center, Saitama, 350 8550, Japan
    Biochem Biophys Res Commun 273:485-91. 2000
    ..These results suggest that PGs dramatically increased VEGF production by activated macrophages through specific PGE receptor and PPARgamma-mediated processes and that PGs may thereby promote tumor growth through VEGF production...
  22. ncbi request reprint Review article: COX-2, prostanoids and colon cancer
    S Ota
    Third Department of Internal Medicine, Saitama Medical School, Moroyama machi, Iruma gum, Japan
    Aliment Pharmacol Ther 16:102-6. 2002
    ....
  23. ncbi request reprint Small cell carcinoma of the endometrium: report of three cases and literature review
    A Katahira
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Int J Gynecol Cancer 14:1018-23. 2004
    ..Small cell carcinoma of the endometrium is extremely rare. Aim. We reported three cases of this rare tumor and reviewed the literature...
  24. doi request reprint Vaginal cuff dehiscence after total laparoscopic hysterectomy: examination on 677 cases
    T Hada
    Department of Obstetrics and Gynecology, Kurashiki Medical Center, Kurashiki, Okayama, Japan
    Asian J Endosc Surg 4:20-5. 2011
    ....
  25. ncbi request reprint Effect of simple omentoplasty and omentopexy in the prevention of complications after pelvic lymphadenectomy
    K Fujiwara
    Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki City, Japan
    Int J Gynecol Cancer 13:61-6. 2003
    ..9%) and persisted for more than 6 months in two patients (3.1%). We conclude that this simple technique of omentoplasty and omentopexy appeared to be effective in reducing the incidence of complications after pelvic lymphadenectomy...
  26. ncbi request reprint A clinical study of Japanese patients with ulcer induced by low-dose aspirin and other non-steroidal anti-inflammatory drugs
    S Nakashima
    Department of Gastroenterology and Hepatology, Saitama Medical School, Iruma gun, Saitama, Japan
    Aliment Pharmacol Ther 21:60-6. 2005
    ..The incidence and severity of non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastro-duodenal ulcer have not been extensively studied in Japan...
  27. ncbi request reprint Apoptosis in dissociation between DNA synthesis and cellular functions of activated hepatic stellate cells--a study with carbon tetrachloride-induced rat liver injury
    N Osada
    Third Department of Internal Medicine, Saitama Medical School, 38 Morohongo, Moroyama-cho, Iruma-gun, Saitama, 350-0495, Japan
    Biochem Biophys Res Commun 282:524-8. 2001
    ..We conclude that apoptosis developed in activated hepatic stellate cells both in vitro and in vivo, and this may contribute to the discrepancy between DNA synthesis and cellular functions of the cells...
  28. ncbi request reprint 3rd International Ovarian Cancer Consensus Conference: outstanding issues for future consideration
    G Stuart
    NCIC CTG, Canada
    Ann Oncol 16:viii36-viii38. 2005
  29. ncbi request reprint Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease
    J M van der Walt
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 60:1189-91. 2003
    ..The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals)...
  30. ncbi request reprint Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain
    H Hosokawa
    Department of Structural Analysis, National Cardiovascular Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565, Japan
    Brain Res 838:158-65. 1999
    ..The discrepancy between the distribution of mRNA and its translation product suggests a regional difference in the translation rate of the CAT3 transcript...
  31. ncbi request reprint Increased urinary phosphate excretion in pseudohypoparathyroidism type II with long-term treatment with phosphodiesterase inhibitor
    T Mano
    Department of Internal Medicine, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan
    Horm Metab Res 31:602-5. 1999
    ..These data imply that cAMP responsiveness to renal tubular phosphate reabsorption should be more strictly elucidated in the patient with PHP type II...
  32. ncbi request reprint [Two cases of acute eosinophilic pneumonia--analyses of cytokines in BALF before and after treatment]
    S Fujiuchi
    Department of Respiratory Medicine, National Dohoku Hospital, 7 Hanasaki, Asahikawa 070-8644, Japan
    Nihon Kokyuki Gakkai Zasshi 39:60-5. 2001
    ..In addition, we also speculated that the CD4/CD8 ratio in BALF from patients with AEP may be affected whether a patient has an atopic background or not...
  33. ncbi request reprint Lymph folliculitis in ulcerative colitis
    M Chiba
    First Dept. of Internal Medicine, Akita University School of Medicine, Akita Red Cross Hospital, Akita City, Japan
    Scand J Gastroenterol 36:332-6. 2001
    ..In addition, the need for microbiology targeting lymph follicles of the large bowel and appendix is stressed in order to disclose the casual microbial agents in ulcerative colitis...
  34. doi request reprint A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes
    A Yada
    Biological Research Laboratories IV, Daiichi Sankyo Co, Ltd, Tokyo, Japan
    Ann Oncol 19:1060-7. 2008
    ..v. administered. The combination effects of CS-1008 with gemcitabine or docetaxel (Taxotere) against MIA PaCa-2 or NCI-H2122 were evaluated in vivo, respectively...
  35. ncbi request reprint Actual invasive potential of human hepatocellular carcinoma revealed by in situ gelatin zymography
    T Kaneyoshi
    Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
    Clin Cancer Res 7:4027-32. 2001
    ..Furthermore, it suggests the importance of the activation mechanism of gelatinolytic enzymes in the invasion and metastasis of HCCs...
  36. ncbi request reprint Clinical trials in ovarian carcinoma: requirements for standard approaches and regimens
    T Thigpen
    Department of Medicine, Division of Oncology, University of Mississippi Medical Center, Jackson 39216, USA
    Ann Oncol 16:viii13-viii19. 2005
  37. ncbi request reprint Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1
    J A Copland
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 33224, USA
    Oncogene 25:2304-17. 2006
    ..We demonstrated that RS5444, a thiazolidinedione (Tzd) derivative, alone or in combination with paclitaxel, may provide therapeutic benefit to patients diagnosed with ATC...
  38. ncbi request reprint 2004 consensus statements on the management of ovarian cancer: final document of the 3rd International Gynecologic Cancer Intergroup Ovarian Cancer Consensus Conference (GCIG OCCC 2004)
    A Du Bois
    Department of Gynecology and Gynecologic Oncology, Wiesbaden, Germany
    Ann Oncol 16:viii7-viii12. 2005
  39. ncbi request reprint Clinical trials in gynecological cancer
    E L Trimble
    National Cancer Institute Cancer Therapy Evaluation Program, Bethesda, MD, USA
    Int J Gynecol Cancer 17:547-56. 2007
    ..Other critical issues include support from government and charities and government regulations...