T Awata

Summary

Affiliation: Saitama Medical School
Country: Japan

Publications

  1. doi request reprint A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Faculty of Medicine, Saitama Medical University, Moroyama machi, Iruma gun, Japan
    Biochem Biophys Res Commun 437:521-5. 2013
  2. ncbi request reprint Evidence for association between the class I subset of the insulin gene minisatellite (IDDM2 locus) and IDDM in the Japanese population
    T Awata
    Fourth Department of Internal Medicine, Saitama Medical School, Japan
    Diabetes 46:1637-42. 1997
  3. ncbi request reprint Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    J Clin Endocrinol Metab 92:1791-5. 2007
  4. ncbi request reprint Functional VEGF C-634G polymorphism is associated with development of diabetic macular edema and correlated with macular retinal thickness in type 2 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School, Saitama, Japan
    Biochem Biophys Res Commun 333:679-85. 2005
  5. ncbi request reprint A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes
    Takuya Awata
    Fourth Department of Internal Medicine, Saitama Medical School, Saitama, Japan
    Diabetes 51:1635-9. 2002
  6. doi request reprint Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese
    Takuya Awata
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    J Clin Endocrinol Metab 94:231-5. 2009
  7. ncbi request reprint Lack of association of the Ala45Thr variant in the BETA2/NEUROD1 with type 1 diabetes in Japanese
    T Awata
    The Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama, Japan
    Diabetes Res Clin Pract 49:61-3. 2000
  8. ncbi request reprint Missense variations of the gene responsible for Wolfram syndrome (WFS1/wolframin) in Japanese: possible contribution of the Arg456His mutation to type 1 diabetes as a nonautoimmune genetic basis
    T Awata
    The Fourth Department of Medicine, Saitama Medical School, Saitama, Japan
    Biochem Biophys Res Commun 268:612-6. 2000
  9. ncbi request reprint Endothelial nitric oxide synthase gene is associated with diabetic macular edema in type 2 diabetes
    Takuya Awata
    The Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama, 350 0495, Japan
    Diabetes Care 27:2184-90. 2004
  10. ncbi request reprint Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy
    Hiroyuki Iizuka
    Division of RI Laboratory, Biomedical Research Center, Saitama Medical University, Saitama, Japan
    Biochem Biophys Res Commun 361:421-6. 2007

Collaborators

Detail Information

Publications48

  1. doi request reprint A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Faculty of Medicine, Saitama Medical University, Moroyama machi, Iruma gun, Japan
    Biochem Biophys Res Commun 437:521-5. 2013
    ....
  2. ncbi request reprint Evidence for association between the class I subset of the insulin gene minisatellite (IDDM2 locus) and IDDM in the Japanese population
    T Awata
    Fourth Department of Internal Medicine, Saitama Medical School, Japan
    Diabetes 46:1637-42. 1997
    ....
  3. ncbi request reprint Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    J Clin Endocrinol Metab 92:1791-5. 2007
    ..It is suggested that insulin autoimmunity plays an important role in the development of type 1 diabetes in humans. However, the association between insulin gene (INS) region (IDDM2) and type 1 diabetes has been uncertain in Asians...
  4. ncbi request reprint Functional VEGF C-634G polymorphism is associated with development of diabetic macular edema and correlated with macular retinal thickness in type 2 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School, Saitama, Japan
    Biochem Biophys Res Commun 333:679-85. 2005
    ..These results demonstrate that the VEGF C-634G polymorphism is a genetic risk factor for ME as well as DR...
  5. ncbi request reprint A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes
    Takuya Awata
    Fourth Department of Internal Medicine, Saitama Medical School, Saitama, Japan
    Diabetes 51:1635-9. 2002
    ..These data suggest that the C(-634)G polymorphism in the 5'UTR of the VEGF gene is a novel genetic risk factor for diabetic retinopathy...
  6. doi request reprint Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese
    Takuya Awata
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    J Clin Endocrinol Metab 94:231-5. 2009
    ..Objective: In line with recent findings, we conducted a replication study of two loci on chromosome 12p13 and 16p13 and assessed their potential associations with thyroid autoimmunity in a Japanese population...
  7. ncbi request reprint Lack of association of the Ala45Thr variant in the BETA2/NEUROD1 with type 1 diabetes in Japanese
    T Awata
    The Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama, Japan
    Diabetes Res Clin Pract 49:61-3. 2000
    ..Our present results do not support a recent report which described an association of the Ala45Thr variant with type 1 diabetes in Japanese...
  8. ncbi request reprint Missense variations of the gene responsible for Wolfram syndrome (WFS1/wolframin) in Japanese: possible contribution of the Arg456His mutation to type 1 diabetes as a nonautoimmune genetic basis
    T Awata
    The Fourth Department of Medicine, Saitama Medical School, Saitama, Japan
    Biochem Biophys Res Commun 268:612-6. 2000
    ..These data suggest that the WFS1 gene may have a role in the development of common type 1 diabetes as a nonautoimmune genetic basis...
  9. ncbi request reprint Endothelial nitric oxide synthase gene is associated with diabetic macular edema in type 2 diabetes
    Takuya Awata
    The Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama, 350 0495, Japan
    Diabetes Care 27:2184-90. 2004
    ..We examined the endothelial nitric oxide (eNOS) gene polymorphisms to assess its possible association with diabetic retinopathy and macular edema...
  10. ncbi request reprint Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy
    Hiroyuki Iizuka
    Division of RI Laboratory, Biomedical Research Center, Saitama Medical University, Saitama, Japan
    Biochem Biophys Res Commun 361:421-6. 2007
    ..These results demonstrate that the PEDF gene, in cooperation with the VEGF gene, may contribute to the development of DR...
  11. ncbi request reprint Pro12Ala substitution in peroxisome proliferator-activated receptor gamma 2 is associated with low adiponectin concentrations in young Japanese men
    Nobuki Takata
    Division of Endocrinoloy and Diabetes, Department of Medicine, Saitama Medical School, Saitama 350 0495, Japan
    Metabolism 53:1548-51. 2004
    ..In conclusion, the Pro12Ala substitution in PPAR gamma 2 may reduce serum adiponectin concentrations in young Japanese men...
  12. pmc Homozygosity haplotype allows a genomewide search for the autosomal segments shared among patients
    Hitoshi Miyazawa
    Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan
    Am J Hum Genet 80:1090-102. 2007
    ..The HH is therefore considered to be useful for the identification of disease susceptibility genes in both single- and multiple-gene diseases...
  13. ncbi request reprint Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB
    Ikuo Inoue
    Fourth Department of Internal Medicine, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 290:131-9. 2002
    ....
  14. ncbi request reprint The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells
    I Inoue
    Fourth Department of Medicine, Saitama Medical School, Japan
    Metabolism 50:3-11. 2001
    ..These results suggest that PPARalpha and PPARgamma gene and protein expression in endothelial cells may play a physiologic role as radical scavengers, although the details of these mechanisms remain to be established...
  15. ncbi request reprint Expression of peroxisome proliferator-activated receptor alpha (PPAR alpha) in primary cultures of human vascular endothelial cells
    I Inoue
    Fourth Department of Medicine, Saitama Medical School, Japan
    Biochem Biophys Res Commun 246:370-4. 1998
    ..These results suggest that the PPAR alpha in endothelial cells may have the same physiological role as the expression of PPAR alpha in the liver...
  16. ncbi request reprint ANGPTL3 is increased in both insulin-deficient and -resistant diabetic states
    Kouichi Inukai
    The Fourth Department of Internal Medicine, Saitama Medical School, Morohongo 38, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 317:1075-9. 2004
    ..Thus, the expression of ANGPTL3 was enhanced in both insulin-deficient and -resistant diabetic states. These results strongly suggest ANGPTL3 to play an important role in hyperlipidemia in diabetes...
  17. ncbi request reprint Efficacy of glimepiride in Japanese type 2 diabetic subjects
    Kouichi Inukai
    Division of Endocrinology and Diabetes, Department of Internal Medicine, Saitama Medical School, 38 Morohongo, Iruma gun, Saitama ken 350 0495, Japan
    Diabetes Res Clin Pract 68:250-7. 2005
    ..A notable finding of this study is that glimepiride was more beneficial in obese than in non-obese Japanese type 2 diabetic patients...
  18. ncbi request reprint Association of the HTRA1 gene variant with age-related macular degeneration in the Japanese population
    Keisuke Mori
    Department of Ophthalmology, Saitama Medical University, Faculty of Medicine, 38 Morohongo, Moroyama, Iruma, Saitama, 350 0495, Japan
    J Hum Genet 52:636-41. 2007
    ....
  19. ncbi request reprint Coding and noncoding variants in the CFH gene and cigarette smoking influence the risk of age-related macular degeneration in a Japanese population
    Keisuke Mori
    Department of Ophthalmology, Saitama Medical School, Moroyama, Iruma, Saitama, Japan
    Invest Ophthalmol Vis Sci 48:5315-9. 2007
    ..The present study was undertaken to investigate whether four coding and noncoding variants of the CFH gene, including rs1410996, are associated with AMD in native, unrelated Japanese patients...
  20. ncbi request reprint A promoter in the novel exon of hPPARgamma directs the circadian expression of PPARgamma
    Seiichiro Takahashi
    Department of Diabetes and Endocrinology, Saitama Medical University, Saitama 350 0495, Japan
    J Atheroscler Thromb 17:73-83. 2010
    ..Herein, we show that expression levels of the novel PPARgamma transcript exhibit circadian oscillation. To study the mechanisms controlling PPARgamma expression, a novel PPARgamma gene promoter was cloned and characterized...
  21. ncbi request reprint CLOCK/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor (PPAR) response element
    Ikuo Inoue
    Fourth Department of Medicine, Research Center for Genomic Medicine, Saitama Medical School, Saitama, Japan
    J Atheroscler Thromb 12:169-74. 2005
    ..After deletion of the PPRE from the CRBPII construct, CLOCK/BMAL1 did not affect transactivation. CLOCK/BMAL1 transactivates PPAR target genes via the PPRE...
  22. ncbi request reprint Identification of a novel WFS1 mutation (AFF344-345ins) in Japanese patients with Wolfram syndrome
    Kouichi Inukai
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School, Morohongo 38, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Diabetes Res Clin Pract 69:136-41. 2005
    ..As only the two family members homozygous for the mutation showed WFS, these data support the notion that this mutation is the cause of WFS...
  23. ncbi request reprint Retrospective, observation study: Quantitative and qualitative effect of ezetimibe and HMG-CoA reductase inhibitors on LDL-cholesterol: are there disappearance thresholds for small, dense LDL and IDL?
    Ikuo Inoue
    Division of Endcrinology and Diabetics, Saitama Medical University, Saitama, Japan
    Recent Pat Cardiovasc Drug Discov 5:143-52. 2010
    ..The thershold for small dense LDL indicates the IDL1 plus IDL2 when LDL2 and LDL3 were not detectable, while the thershold for IDL indicates the LDL1 when IDL1, IDL2 and LDL3 were not detectable...
  24. ncbi request reprint Regulation of adiponectin receptor gene expression in diabetic mice
    Kouichi Inukai
    Division of Endocrinology and Diabetes, Deptartment of Internal Medicine, Saitama Medical School, Saitama 350 0495, Japan
    Am J Physiol Endocrinol Metab 288:E876-82. 2005
    ..Our results indicate that regulation of AdipoR1, but not that of AdipoR2, may be involved in glucose and lipid metabolism in diabetic states...
  25. ncbi request reprint Glimepiride enhances intrinsic peroxisome proliferator-activated receptor-gamma activity in 3T3-L1 adipocytes
    Kouichi Inukai
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School, Iruma gun, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 328:484-90. 2005
    ..Analysis of triglyceride contents revealed glimepiride to promote differentiation of 3T3-L1 adipocytes. These results indicate that glimepiride has the potential to induce PPAR gamma activity, thereby improving insulin resistance...
  26. doi request reprint Phenotype and genotype characteristics of age-related macular degeneration in a Japanese population
    Keisuke Mori
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 117:928-38. 2010
    ..To describe phenotype and genotype characteristics of age-related macular degeneration (AMD) in Japanese patients...
  27. ncbi request reprint Apoptosis of endothelial cells may be mediated by genes of peroxisome proliferator-activated receptor gamma 1 (PPARgamma 1) and PPARalpha genes
    Ikuo Inoue
    Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    J Atheroscler Thromb 10:99-108. 2003
    ..Co-transfection of PPARgamma 1 and PPARalpha protected the HUVEC apoptosis. The results suggest that the apoptosis of endothelial cells may be mediated by genes of PPARgamma1 and PPARalpha...
  28. ncbi request reprint Diabetic ketoacidosis in a case of pheochromocytoma
    C Ishii
    The Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyama machi, Saitama 350 0495, Iruma gun, Japan
    Diabetes Res Clin Pract 54:137-42. 2001
    ....
  29. ncbi request reprint Rapid and simple profiling of lipoproteins by polyacrylamide-gel disc electrophoresis to determine the heterogeneity of low-density lipoproteins (LDLs) including small, dense LDL
    Takanari Nakano
    Department of Biochemistry, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    Recent Pat Cardiovasc Drug Discov 4:31-6. 2009
    ..This article discusses several methods for simple and rapid lipid profiling and outlines some recent patents relevant to the methods...
  30. doi request reprint Involvement of low adiponectin levels in impaired glucose tolerance
    Youhei Nakashima
    Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Moroyama, Iruma gun, Saitama, 350 0495, Japan
    Metabolism 57:1350-4. 2008
    ....
  31. ncbi request reprint Regulation of PPAR gamma transcriptional activity in 3T3-L1 adipocytes
    Masaki Watanabe
    Saitama Medical School Research Center for Genomic Medicine, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 300:429-36. 2003
    ..Interestingly, PI 3-kinase overexpression resulted in a marked decrease in PPAR gamma activity. These observations have important implications for understanding the regulation of PPAR gamma transcriptional activity...
  32. ncbi request reprint Acarbose ameliorates atherogenecity of low-density lipoprotein in patients with impaired glucose tolerance
    Ikuo Inoue
    Department of Diabetic and Endocrinology, Saitama Medical School, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Metabolism 55:946-52. 2006
    ..The present findings suggest that acarbose treatment reduces the risk of cardiovascular diseases by ameliorating the atherogenecity of LDL...
  33. ncbi request reprint Acarbose improves fibrinolytic activity in patients with impaired glucose tolerance
    Yuichi Shinoda
    Department of Biochemistry, Saitama Medical School, Saitama 350 0495, Japan
    Metabolism 55:935-9. 2006
    ....
  34. ncbi request reprint [HLA genes and prediction of type 1 diabetes]
    Takuya Awata
    Fourth Department of Internal Medicine, Saitama Medical School
    Nihon Rinsho 60:37-41. 2002
  35. ncbi request reprint [Adiponectin receptor regulation in diabetic states]
    Kouichi Inukai
    Division of Endocrinology and Diabetes, Department of Internal Medicine, Saitama Medical University
    Nihon Rinsho 65:2125-30. 2007
    ..In contrast, AdipoR2 expression was not significantly altered in diabetic states. Our results indicate that regulation of AdipoR1, but not AdipoR2, may be involved in glucose and lipid metabolism in diabetic states...
  36. pmc Adiponectin upregulates ferritin heavy chain in skeletal muscle cells
    Yuichi Ikegami
    Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Saitama, Japan
    Diabetes 58:61-70. 2009
    ....
  37. ncbi request reprint LKB1, an upstream AMPK kinase, regulates glucose and lipid metabolism in cultured liver and muscle cells
    Kenta Imai
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School, Iruma gun, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 351:595-601. 2006
    ..These results demonstrate that LKB1 is a crucial regulator of AMPK activation in muscle and liver cells and, therefore, that LKB1 activity is potentially of importance to our understanding of glucose and lipid metabolism...
  38. ncbi request reprint Activating effect of momordin, extract of bitter melon (Momordica Charantia L.), on the promoter of human PPARdelta
    Masatoshi Sasa
    Department of Diabetes and Endocrinology, Saitama Medical University, Japan
    J Atheroscler Thromb 16:888-92. 2009
    ....
  39. ncbi request reprint SH3 domain of the phosphatidylinositol 3-kinase regulatory subunit is responsible for the formation of a sequestration complex with insulin receptor substrate-1
    Yuichi Ikegami
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, Morohongo 38, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 365:433-8. 2008
    ..In conclusion, our study revealed the SH3 domain of PI 3-kinase to play a critical role in intracellular localizations, including formation of foci with IRS-1 in response to insulin...
  40. ncbi request reprint Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis
    Fotini K Kavvoura
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Endocrinol Metab 92:3162-70. 2007
    ....
  41. ncbi request reprint Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
    Am J Med Genet A 140:586-93. 2006
    ..In conclusion, the type 1 diabetes association with PTPN22 is confirmed, but it cannot be attributed solely to the +1858C > T variant. The promoter -1123G > C SNP is a more likely causative variant in PTPN22...
  42. ncbi request reprint Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations
    Shinsuke Noso
    Department of Endocrinology, Diabetes and Metabolism, Kinki University School of Medicine, 377 2 Ohno Higashi, Sayama shi, Osaka 589 8511, Japan
    Ann N Y Acad Sci 1079:41-6. 2006
    ..0 x 10(-6)), but indicated significant heterogeneity in the genetic effect of the SUMO4 gene on type 1 diabetes among diverse ethnic groups. These observations indicated the association of SUMO4 with type 1 diabetes in Asian populations...
  43. ncbi request reprint Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population
    Masako Tsurumaru
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Endocrinol Metab 91:3138-43. 2006
    ..Recently, an association of a single nucleotide polymorphism, 163A>G encoding M55V, in the gene SUMO4, which has been shown to be a negative feedback regulator for nuclear factor kappaB, has been reported in type 1 diabetes...
  44. ncbi request reprint The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan
    Hiroshi Ikegami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Endocrinol Metab 91:1087-92. 2006
    ..The low incidence of type 1 diabetes in Asian countries, however, makes it difficult to perform large-scale studies in Asia...
  45. ncbi request reprint Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes
    Shinsuke Noso
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Diabetes 54:3582-6. 2005
    ..These data indicate that the MAP3K7IP2/SUMO4 locus in the IDDM5 interval is associated with type 1 diabetes in Asian populations...
  46. ncbi request reprint Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population
    Naoko Iwasaki
    Diabetes Center, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, 162 8666, Japan
    J Hum Genet 50:92-8. 2005
    ..82 and 0.80, respectively; P=0.04 and 0.02). Thus, variation in the calpain-10 gene may affect risk of type 2 diabetes in Japanese, especially in older individuals...
  47. ncbi request reprint VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
    Diether Lambrechts
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology and Department of Neurology, University Hospital Gasthuisberg, KU Leuven, Leuven, B 3000, Belgium
    Nat Genet 34:383-94. 2003
    ..These findings indicate that VEGF is a modifier of motoneuron degeneration in human ALS and unveil a therapeutic potential of Vegfa for stressed motoneurons in mice...
  48. ncbi request reprint Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in Japanese
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Autoimmun 30:207-11. 2008
    ..Based upon these results, we propose that it may be worthwhile to focus on subjects with the BB genotype of this gene polymorphism as having high risk for type 1 diabetes...