Tohru Abe

Summary

Affiliation: Saitama Medical School
Country: Japan

Publications

  1. ncbi request reprint TCR zeta mRNA with an alternatively spliced 3'-untranslated region detected in systemic lupus erythematosus patients leads to the down-regulation of TCR zeta and TCR/CD3 complex
    Kensei Tsuzaka
    Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Kamoda 1981, Kawagoe, Saitama 350 8550, Japan
    J Immunol 171:2496-503. 2003
  2. ncbi request reprint TCRzeta mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients
    Kensei Tsuzaka
    Division of Rheumatology, Department of Internal Medicine, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350 8550, Japan
    Springer Semin Immunopathol 28:185-93. 2006
  3. ncbi request reprint DNA microarray gene expression profile of T cells with the splice variants of TCRzeta mRNA observed in systemic lupus erythematosus
    Kensei Tsuzaka
    Division of Rheumatology, Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Saitama, Japan
    J Immunol 176:949-56. 2006
  4. ncbi request reprint A splice variant of the TCR zeta mRNA lacking exon 7 leads to the down-regulation of TCR zeta, the TCR/CD3 complex, and IL-2 production in systemic lupus erythematosus T cells
    Kensei Tsuzaka
    Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Kawagoe, Saitama, Japan
    J Immunol 174:3518-25. 2005
  5. ncbi request reprint Down-regulation of Fas-ligand mRNA in Sjögren's syndrome patients with enlarged exocrine glands
    Kensei Tsuzaka
    Division of Rheumatology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan
    Autoimmunity 40:497-502. 2007
  6. ncbi request reprint Critical role of the fifth domain of E-cadherin for heterophilic adhesion with alpha E beta 7, but not for homophilic adhesion
    Kiyono Shiraishi
    Project Research Laboratory, Research Center for Genomic Medicine, Saitama Medical Center, Saitama Medical School, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
    J Immunol 175:1014-21. 2005
  7. doi request reprint Conservative sequences in 3'UTR of TCRzeta mRNA regulate TCRzeta in SLE T cells
    Kensei Tsuzaka
    Division of Rheumatology, Department of Internal Medicine, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350 8550, Japan
    Biochem Biophys Res Commun 367:311-7. 2008
  8. pmc Impact of trough serum level on radiographic and clinical response to infliximab plus methotrexate in patients with rheumatoid arthritis: results from the RISING study
    Tsutomu Takeuchi
    Division of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350 8550, Japan
    Mod Rheumatol 19:478-87. 2009
  9. ncbi request reprint Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy
    Keiko Yoshimoto
    Division of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350 8550, Japan
    Int Immunol 18:1189-96. 2006
  10. pmc Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjögren's syndrome
    Keiko Yoshimoto
    Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Arthritis Res Ther 13:R170. 2011

Detail Information

Publications19

  1. ncbi request reprint TCR zeta mRNA with an alternatively spliced 3'-untranslated region detected in systemic lupus erythematosus patients leads to the down-regulation of TCR zeta and TCR/CD3 complex
    Kensei Tsuzaka
    Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Kamoda 1981, Kawagoe, Saitama 350 8550, Japan
    J Immunol 171:2496-503. 2003
    ..Thus, the lower stability of zetamRNA/as-3'UTR, which is predominant in SLE T cells, may be responsible for the reduced expression of the TCR/CD3 complex, including zeta protein, in SLE T cells...
  2. ncbi request reprint TCRzeta mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients
    Kensei Tsuzaka
    Division of Rheumatology, Department of Internal Medicine, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350 8550, Japan
    Springer Semin Immunopathol 28:185-93. 2006
    ..Another 16 genes were up-regulated and included genes associated with membranous proteins and cell damage granules, including the genes encoding poliovirus-receptor-related 2, syndecan-1, and granzyme A...
  3. ncbi request reprint DNA microarray gene expression profile of T cells with the splice variants of TCRzeta mRNA observed in systemic lupus erythematosus
    Kensei Tsuzaka
    Division of Rheumatology, Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Saitama, Japan
    J Immunol 176:949-56. 2006
    ..Identification of these responsive genes in T cells in which the zeta and TCR/CD3 complexes were down-regulated may help to better understand the pathogenesis of systemic lupus erythematosus...
  4. ncbi request reprint A splice variant of the TCR zeta mRNA lacking exon 7 leads to the down-regulation of TCR zeta, the TCR/CD3 complex, and IL-2 production in systemic lupus erythematosus T cells
    Kensei Tsuzaka
    Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Kawagoe, Saitama, Japan
    J Immunol 174:3518-25. 2005
    ..Thus, the lower stability of zeta mRNA/exon 7(-) might also be responsible for the reduced expression of the TCR/CD3 complex, including zeta protein, in SLE T cells...
  5. ncbi request reprint Down-regulation of Fas-ligand mRNA in Sjögren's syndrome patients with enlarged exocrine glands
    Kensei Tsuzaka
    Division of Rheumatology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan
    Autoimmunity 40:497-502. 2007
    ....
  6. ncbi request reprint Critical role of the fifth domain of E-cadherin for heterophilic adhesion with alpha E beta 7, but not for homophilic adhesion
    Kiyono Shiraishi
    Project Research Laboratory, Research Center for Genomic Medicine, Saitama Medical Center, Saitama Medical School, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
    J Immunol 175:1014-21. 2005
    ....
  7. doi request reprint Conservative sequences in 3'UTR of TCRzeta mRNA regulate TCRzeta in SLE T cells
    Kensei Tsuzaka
    Division of Rheumatology, Department of Internal Medicine, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350 8550, Japan
    Biochem Biophys Res Commun 367:311-7. 2008
    ..8 mutants. In conclusion, CS1 and CS2 may be responsible for the regulation of zeta and TCR/CD3 through the stability of zeta mRNA in SLE T cells...
  8. pmc Impact of trough serum level on radiographic and clinical response to infliximab plus methotrexate in patients with rheumatoid arthritis: results from the RISING study
    Tsutomu Takeuchi
    Division of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350 8550, Japan
    Mod Rheumatol 19:478-87. 2009
    ..The magnitudes of both efficacies were correlated with the trough serum infliximab level (ClinicalTrials.gov number: NCT00691028)...
  9. ncbi request reprint Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy
    Keiko Yoshimoto
    Division of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350 8550, Japan
    Int Immunol 18:1189-96. 2006
    ....
  10. pmc Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjögren's syndrome
    Keiko Yoshimoto
    Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Arthritis Res Ther 13:R170. 2011
    ..We focused on B-cell-activating factor of the TNF family (BAFF) and IL-6 because they are both produced by monocytes and are known to be involved in the pathogenesis of pSS...
  11. doi request reprint Effect of interleukin-2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF) in human peripheral blood mononuclear cells
    Katsuya Suzuki
    Division of Rheumatology and Clinical Immunology, Department of Medicine, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350 8550, Japan
    Cytokine 44:44-8. 2008
    ..Persistent over-production of IL-2 might lead to up-regulation of BAFF synthesis in PBMCs in pathological conditions such as lupus...
  12. ncbi request reprint Altered expression of the T cell receptor-CD3 complex in systemic lupus erythematosus
    Tsutomu Takeuchi
    Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Kawagoe, Saitama, Japan
    Int Rev Immunol 23:273-91. 2004
    ..We review the possible role of the TCR zeta defects in autoimmunity and discuss how the splicing variants lead to downregulated protein expression of TCR zeta chain...
  13. doi request reprint Phase II dose-response study of abatacept in Japanese patients with active rheumatoid arthritis with an inadequate response to methotrexate
    Tsutomu Takeuchi
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Mod Rheumatol 23:226-35. 2013
    ..The objective of this study was to assess the response to abatacept at doses of 2 mg/kg and 10 mg/kg compared to placebo in patients with active rheumatoid arthritis (RA) with an inadequate clinical response to methotrexate (MTX)...
  14. pmc Baseline tumour necrosis factor alpha levels predict the necessity for dose escalation of infliximab therapy in patients with rheumatoid arthritis
    Tsutomu Takeuchi
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Ann Rheum Dis 70:1208-15. 2011
    ..To investigate the possible role of baseline plasma tumour necrosis factor alpha levels (baseline-TNF) on the clinical response to infliximab in patients with rheumatoid arthritis (RA)...
  15. ncbi request reprint A multicenter, double-blind, randomized, placebo controlled trial of infliximab combined with low dose methotrexate in Japanese patients with rheumatoid arthritis
    Tohru Abe
    Saitama Medical Center and the Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan
    J Rheumatol 33:37-44. 2006
    ..Extended treatment with infliximab was conducted in an open-label trial (OLT)...
  16. ncbi request reprint Diagnostic significance of serum soluble transferrin receptors in various anemic diseases: the first multi-institutional joint study in Japan
    Akira Matsuda
    First Department of Internal Medicine, Saitama Medical School, 38 Morohongo Moroyama, Iruma gun, Saitama 350 0495, Japan
    Haematologia (Budap) 32:225-38. 2002
    ..In conclusion, the serum sTfR concentration is a useful diagnostic tool for discrimination between IDA and ACD, and between AA and MDS-RA, and for the detection of iron deficiency in CRF patients in the Japanese population...
  17. ncbi request reprint 2. Role of adhesion molecules in vasculitis syndrome
    Tsutomu Takeuchi
    The Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Kawagoe
    Intern Med 41:41-4. 2002
  18. ncbi request reprint Long-term safety study of iguratimod in patients with rheumatoid arthritis
    Masako Hara
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    Mod Rheumatol 17:10-6. 2007
    ..The rate was 46.9% at week 28 and 41.0% at week 52. To use iguratimod safely for a long time, patients should be observed closely for adverse reactions such as increased hepatic enzymes...
  19. ncbi request reprint Efficacy and safety of iguratimod compared with placebo and salazosulfapyridine in active rheumatoid arthritis: a controlled, multicenter, double-blind, parallel-group study
    Masako Hara
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    Mod Rheumatol 17:1-9. 2007
    ..The study results suggest that iguratimod could become a new option for the treatment of rheumatoid arthritis...