Toru Ishikawa

Summary

Affiliation: Saiseikai Kumamoto Hospital
Country: Japan

Publications

  1. ncbi request reprint Hepatic arterial infusion chemotherapy with cisplatin before radical local treatment of early hepatocellular carcinoma (JIS score 0/1) improves survival
    T Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan
    Ann Oncol 25:1379-84. 2014
  2. ncbi request reprint Prevalence of Howell-Jolly bodies caused by partial splenic embolization for portal hypertension
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Japan
    Intern Med 52:1765-8. 2013
  3. pmc Radiofrequency ablation during continuous saline infusion can extend ablation margins
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950 1104, Japan
    World J Gastroenterol 19:1278-82. 2013
  4. doi request reprint Surfactant protein-D is more useful than Krebs von den Lungen 6 as a marker for the early diagnosis of interstitial pneumonitis during pegylated interferon treatment for chronic hepatitis C
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan
    Hepatogastroenterology 59:2260-3. 2012
  5. doi request reprint Combination PEG-IFN a-2b/ribavirin therapy following treatment of hepatitis C virus-associated hepatocellular carcinoma is capable of improving hepatic functional reserve and survival
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Nigata Second Hospital, Niigata, Japan
    Hepatogastroenterology 59:529-32. 2012
  6. ncbi request reprint Histopathology of the tissue adhering to the multiple tine expandable electrodes used for radiofrequency ablation of hepatocellular carcinoma predicts local recurrence
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Japan
    Intern Med 51:2683-8. 2012
  7. pmc Early administration of branched-chain amino acid granules
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950 1104, Japan
    World J Gastroenterol 18:4486-90. 2012
  8. pmc Can zinc enhance response interferon therapy for patients with HCV-related liver disease?
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950 1104, Japan
    World J Gastroenterol 18:3196-200. 2012
  9. pmc Branched-chain amino acids to tyrosine ratio value as a potential prognostic factor for hepatocellular carcinoma
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, 280 7 Teraji, Niigata 950 1104, Japan
    World J Gastroenterol 18:2005-8. 2012
  10. ncbi request reprint Therapeutic efficacy of continuous arterial infusion of the protease inhibitor and the antibiotics and via celiac and superior mesenteric artery for severe acute pancreatitis--pilot study
    Toru Ishikawa
    Department of Gastroenterology, Saiseikai Niigata Second Hospital, Niigata, Japan
    Hepatogastroenterology 56:524-8. 2009

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Hepatic arterial infusion chemotherapy with cisplatin before radical local treatment of early hepatocellular carcinoma (JIS score 0/1) improves survival
    T Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan
    Ann Oncol 25:1379-84. 2014
    ....
  2. ncbi request reprint Prevalence of Howell-Jolly bodies caused by partial splenic embolization for portal hypertension
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Japan
    Intern Med 52:1765-8. 2013
    ..To date, whether HJBs appear following partial splenic embolization (PSE) has not been investigated. Therefore, we examined the prevalence of HJBs in patients who have undergone PSE...
  3. pmc Radiofrequency ablation during continuous saline infusion can extend ablation margins
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950 1104, Japan
    World J Gastroenterol 19:1278-82. 2013
    ..To determine whether fluid injection during radiofrequency ablation (RFA) can increase the coagulation area...
  4. doi request reprint Surfactant protein-D is more useful than Krebs von den Lungen 6 as a marker for the early diagnosis of interstitial pneumonitis during pegylated interferon treatment for chronic hepatitis C
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan
    Hepatogastroenterology 59:2260-3. 2012
    ..Hence, the predictors of interstitial pneumonitis have not been elucidated...
  5. doi request reprint Combination PEG-IFN a-2b/ribavirin therapy following treatment of hepatitis C virus-associated hepatocellular carcinoma is capable of improving hepatic functional reserve and survival
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Nigata Second Hospital, Niigata, Japan
    Hepatogastroenterology 59:529-32. 2012
    ..We investigated therapeutic response and hepatic functional reserve improvement in patients receiving PEG-IFN a-2b/RBV after curative HCC treatment...
  6. ncbi request reprint Histopathology of the tissue adhering to the multiple tine expandable electrodes used for radiofrequency ablation of hepatocellular carcinoma predicts local recurrence
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Japan
    Intern Med 51:2683-8. 2012
    ..To assess the ability to predict the local recurrence of hepatocellular carcinoma by analyzing tissues adhering to the radiofrequency ablation probe after complete ablation...
  7. pmc Early administration of branched-chain amino acid granules
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950 1104, Japan
    World J Gastroenterol 18:4486-90. 2012
    ..This review discusses data regarding the effect of early administration of BCAA granules based on the ratio of BCAA to BTR on prognosis in patients with cirrhosis...
  8. pmc Can zinc enhance response interferon therapy for patients with HCV-related liver disease?
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950 1104, Japan
    World J Gastroenterol 18:3196-200. 2012
    ..Treatment options for patients who have relapsed or are refractory to treatment with PEG-IFN and RBV therefore need to be critically assessed. This paper overviews the relationship between chronic liver disease and zinc metabolism...
  9. pmc Branched-chain amino acids to tyrosine ratio value as a potential prognostic factor for hepatocellular carcinoma
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, 280 7 Teraji, Niigata 950 1104, Japan
    World J Gastroenterol 18:2005-8. 2012
    ..This manuscript examines the literature to clarify whether BTR can serve as a prognostic factor for treatment of HCC...
  10. ncbi request reprint Therapeutic efficacy of continuous arterial infusion of the protease inhibitor and the antibiotics and via celiac and superior mesenteric artery for severe acute pancreatitis--pilot study
    Toru Ishikawa
    Department of Gastroenterology, Saiseikai Niigata Second Hospital, Niigata, Japan
    Hepatogastroenterology 56:524-8. 2009
    ..Continuous regional arterial infusion of protease inhibitors and antibiotics were developed in Japan. We evaluated whether arterial infusion both celiac artery and superior mesenteric artery for this disease would reduce mortality...
  11. pmc Clinical features of hepatitis B virus-related hepatocellular carcinoma
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
    World J Gastroenterol 16:2463-7. 2010
    ..Prevention of HBV-related HCC is a key issue in current hepatology. This paper describes the prevention and clinical features of HBV-related HCC, along with a short review of the disease...
  12. pmc Usefulness of Y-shaped sheaths in CT angiography for examination of liver tumors
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Niigata 950 1104, Japan
    World J Gastroenterol 16:4704-8. 2010
    ..To conduct a single-stage, combined computed tomography (CT) arterial portography (CTAP) and CT arteriography (CTA) imaging operation, we used Y-shaped sheaths with 2 valves, which allowed the insertion of 2 catheters simultaneously...
  13. ncbi request reprint Gemcitabine in arterial injection chemotherapy for pancreatic cancer does not cause catheter obstruction or any other complication
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
    Hepatogastroenterology 57:945-8. 2010
    ..Therefore, the purpose of this study was to verify the resistance of catheters to gemcitabine...
  14. doi request reprint Prevention of intrahepatic distant recurrence by transcatheter arterial infusion chemotherapy with platinum agents for stage I/II hepatocellular carcinoma
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan
    Cancer 117:4018-25. 2011
    ..The authors compared the efficacy of 2 platinum-based chemotherapeutic agents in combination with radical local treatment for preventing intrahepatic distant recurrence (IDR)...
  15. doi request reprint Complete early virological response was highly achieved by double filtration plasmapheresis plus IFN-beta induction therapy for HCV-1b patients with relapse or no response after previous IFN therapy
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan
    Ther Apher Dial 15:400-5. 2011
    ..This combination may contribute to sustained virological response (SVR). The effects of DFPP on SVR and its significance remain to be clarified...
  16. pmc Secondary prevention of recurrence by interferon therapy after ablation therapy for hepatocellular carcinoma in chronic hepatitis C patients
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
    World J Gastroenterol 14:6140-4. 2008
    ..We believe that there is a survival benefit in secondary prevention using IFN therapy. However, a controlled study is essential to obtain conclusive evidence of the efficacy of this strategy...
  17. pmc Chemotherapy with enteric-coated tegafur/uracil for advanced hepatocellular carcinoma
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
    World J Gastroenterol 14:2797-801. 2008
    ..In this article, we review the clinical efficacy and toxicity of enteric-coated tegafur/uracil in the treatment of patients with advanced non-resectable HCC...
  18. ncbi request reprint Oral branched-chain amino acids administration improves impaired liver dysfunction after radiofrequency ablation therapy for hepatocellular carcinoma
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Niigata, Japan
    Hepatogastroenterology 56:1491-5. 2009
    ..However, the effects of RFA on hepatic reserve have not yet been thoroughly studied. In the present study, it was evaluated the effect of branched chain amino acid (BCAA) administration after RFA...
  19. ncbi request reprint Clinical efficacy of intra-arterial pharmacokinetic chemotherapy with 5-fluorouracil, CDDP, gemcitabine, and angiotensin-II in patients with advanced pancreatic cancer
    Toru Ishikawa
    Department of Gastroenterology, Saiseikai Niigata Second Hospital, Niigata, Japan
    Hepatogastroenterology 54:2378-82. 2007
    ..To deliver anticancer drugs more selectively into cancer tissues and to improve survival time, we have developed a new method of intra-arterial chemotherapy for unresectable pancreatic cancer...
  20. ncbi request reprint Improved survival for hepatocellular carcinoma with portal vein tumor thrombosis treated by intra-arterial chemotherapy combining etoposide, carboplatin, epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and enteric-coated tegafur/uracil: a p
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
    World J Gastroenterol 13:5465-70. 2007
    ..To investigate the poor prognosis of HCC with PVTT, we evaluated the efficacy by a new combination chemotherapy for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT)...
  21. ncbi request reprint Is it relevant that intra-arterial chemotherapy may be effective for advanced pancreatic cancer?
    Toru Ishikawa
    Department of Gastroenterology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
    World J Gastroenterol 13:4306-9. 2007
    ..Further clinical trials of this method should be subjected to a prospective randomized controlled study for advanced pancreatic cancer...
  22. ncbi request reprint Angiotensin-II administration is useful for the detection of liver metastasis from pancreatic cancer during pharmacoangiographic computed tomography
    Toru Ishikawa
    Department of Gastroenterology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
    World J Gastroenterol 13:3080-3. 2007
    ..To improve the preoperative diagnosis of liver metastasis from pancreatic cancer, we estimated computed tomography during arterial angiography (CTA) with/without administration of angiotensin-II (AT- II)...
  23. ncbi request reprint CT-maximum intensity projection is a clinically useful modality for the detection of gastric varices
    Toru Ishikawa
    Department of Gastroenterology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
    World J Gastroenterol 11:7515-9. 2005
    ....
  24. ncbi request reprint Comparison of a new aspiration needle device and the Quick-Core biopsy needle for transjugular liver biopsy
    Toru Ishikawa
    Department of Gastroenterology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
    World J Gastroenterol 12:6339-42. 2006
    ..To evaluate sample adequacy, safety, and needle passes of a new biopsy needle device compared to the Quick-Core biopsy needle for transjugular liver biopsy in patients affected by liver disease...
  25. pmc Successful treatment of multiple lung metastases of hepatocellular carcinoma by combined chemotherapy with docetaxel, cisplatin and tegafur/uracil
    Atsunori Tsuchiya
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1 757 Asahimachi dori, Chuo Ku, Niigata, Japan
    World J Gastroenterol 15:1779-81. 2009
    ..In the absence of a standardized highly effective therapy, this combined chemotherapy with docetaxel, CDDP and UFT-E may be an attractive option for multiple lung metastases of HCC...
  26. ncbi request reprint [A resected case of fibrolamellar hepatocellular carcinoma with chronic hepatitis (type B)]
    Toru Ishikawa
    Department of Gastroenterology, Saiseikai Niigata Second Hospital
    Nihon Shokakibyo Gakkai Zasshi 104:1076-81. 2007
    ..Partial resection of the liver was performed, and the histological diagnosis was fibrolamellar hepatocellular carcinoma. The patient is now tumor free and doing well 20 months after the operation...
  27. doi request reprint Efficacy of the regimen using twice-daily β-interferon followed by the standard of care for chronic hepatitis C genotype 1b with high viral load
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan
    Hepatol Res 42:864-9. 2012
    ..252), whereas no significant factors were found in the multivariate analysis due to small samples. Conclusion:  IFN-β induction therapy with higher EVR might be beneficial for protease inhibitor-refractory chronic hepatitis C patients...
  28. ncbi request reprint [A case of splenic inflammatory pseudotumor]
    Toru Ishikawa
    Department of Gastroenterology, Saiseikai Niigata Second Hospital
    Nihon Shokakibyo Gakkai Zasshi 104:407-12. 2007
    ..The pathological diagnosis of the tumor was inflammatory pseudotumor. Splenectomy is considered to be significant from the standpoints of both diagnosis and therapy in cases in which diagnostic imaging is difficult to interpret...
  29. ncbi request reprint Serum alpha-fetoprotein levels during and after interferon therapy and the development of hepatocellular carcinoma in patients with chronic hepatitis C
    Yasushi Tamura
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Dig Dis Sci 54:2530-7. 2009
    ..057), and a significantly higher cumulative incidence of HCC was seen in patients with increased serum AFP levels at EOT (P = 0.021). Serum AFP level at EOT is a possible predictor of HCC in CHC patients after IFN therapy...
  30. pmc Anti-viral therapy to reduce recurrence and improve survival in hepatitis B virus-related hepatocellular carcinoma
    Toru Ishikawa
    Toru Ishikawa, Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950 1104, Japan
    World J Gastroenterol 19:8861-6. 2013
    ..Therefore, these drugs may decrease recurrence. In this article, treatment strategies for HBV-related HCC are described in order to reduce recurrence and improve survival. ..
  31. ncbi request reprint Predictive Factor of Local Recurrence after Balloon-Occluded TACE with Miriplatin (MPT) in Hepatocellular Carcinoma
    Toru Ishikawa
    Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan
    PLoS ONE 9:e103009. 2014
    ..Therefore, various methods of administration with MPT have been attempted to increase its therapeutic efficacy. One hopeful method is balloon-occluded TACE (B-TACE), but the therapeutic efficacy of B-TACE with MPT has not been evaluated...
  32. pmc Strategy for improving survival and reducing recurrence of HCV-related hepatocellular carcinoma
    Toru Ishikawa
    Toru Ishikawa, Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950 1104, Japan
    World J Gastroenterol 19:6127-30. 2013
    ..e., intrahepatic distant recurrence vs multicentric recurrence. In this article, we review recurrent HCC and the therapeutic strategies for reducing recurrent HCC, especially HCV-related HCC...
  33. doi request reprint Formula to predict platelet count after partial splenic arterial embolization in patients with hypersplenism
    Akihiko Osaki
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1 757 Asahimachi dori, Chuo Ku, Niigata, Niigata 951 8122, Japan
    J Vasc Interv Radiol 23:900-7. 2012
    ..To establish a formula to guide appropriate embolization volume for postprocedural platelet gain following partial splenic arterial embolization (PSE) for hypersplenism...
  34. doi request reprint Characterization of elevated alanine aminotransferase levels during pegylated-interferon α-2b plus ribavirin treatment for chronic hepatitis C
    Yo Hei Aoki
    Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences Niigata University Niigata Municipal Hospital Tachikawa General Hospital Nagaoka Red Cross Hospital Sai sei kai Second Hospital Takeda General Hospital Watanabe Clinic, Niigata, Japan
    Hepatol Res 41:118-25. 2011
    ..Conclusion:  Abnormal ALT values during peg-IFN plus ribavirin treatment are observed relatively frequently, even in patients without detectable HCV RNA. Direct or indirect involvement of drugs is considered as one possible cause...
  35. ncbi request reprint Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells
    Satoshi Yamagiwa
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatol Res 38:664-72. 2008
    ..041). Conclusion: These findings demonstrate that sustained response to IFN/RBV treatment for patients with CHC is closely associated with increased dynamism of NK and NKT cells in the liver...
  36. ncbi request reprint Complete disappearance of pulmonary metastases in a case of hepatocellular carcinoma treated with docetaxel-based systemic chemotherapy
    Toru Ishikawa
    Department of Internal Medicine III, Niigata University School of Medicine, Niigata, Japan
    J Gastroenterol Hepatol 19:1423-6. 2004
    ..No recurrence of pulmonary metastasis was seen for 10 months. This combination therapy was well-tolerated for lung cancer and could represent an effective treatment for pulmonary metastases from HCC...
  37. ncbi request reprint [Modified pharmacokinetic modulating chemotherapy for progressive gastric cancer accompanied by peritoneal dissemination]
    Toru Ishikawa
    Dept of Gastroenterology, Saiseikai Niigata Second Hospital
    Gan To Kagaku Ryoho 32:469-72. 2005
    ..Objective improvement of ascites was seen in all patients, and all patients could be treated at outpatient clinics. This regimen may be well-tolerated and of clinical benefit for patients with peritoneal dissemination of gastric cancer...
  38. ncbi request reprint [A case of successful management of nonresectable pancreas cancer with liver metastasis by intra-arterial infusion chemotherapy with gemcitabine hydrochloride, 5-FU, CDDP and administration of tegafur/uracil]
    Toru Ishikawa
    Dept of Gastroenterology, Saiseikai Niigata Second Hospital
    Gan To Kagaku Ryoho 31:1555-8. 2004
    ..Furthermore, the patient can take sufficient meals without any adverse effects. His quality of life has been preserved. This regimen could well be effective for advanced pancreatic cancer...
  39. ncbi request reprint [A case of advanced gastric cancer with liver and intra-abdominal lymph node metastasis treated by hypertensive selective chemotherapy with pharmacokinetic modulating chemotherapy]
    Toru Ishikawa
    Dept of Gastroenterology, Saiseikai Niigata Daini Hospital
    Gan To Kagaku Ryoho 30:1151-5. 2003
    ..We conclude that this chemotherapy is effective in cases of advanced gastric cancer with liver and lymph node metastasis from the viewpoints of toxicities, antitumor effect and QOL of the patient...
  40. ncbi request reprint [A case of advanced gastric cancer with bone metastasis and severe DIC responding to hypertensive subselective chemotherapy with pharmacokinetic modulating chemotherapy]
    Toru Ishikawa
    Dept of Gastroenterology, Saiseikai Niigata Second Hospital
    Gan To Kagaku Ryoho 32:523-7. 2005
    ..We concluded that this chemotherapy is effective for advanced gastric cancer complicated with bone metastasis and DIC from the standpoint of toxicities, antitumor effect and QOL of the patient...
  41. ncbi request reprint Systemic administration of liposome-encapsulated OK-432 prolongs the survival of rats with hepatocellular carcinoma through the induction of IFN-gamma-producing hepatic lymphocytes
    Kazuhiro Uehara
    Department of Internal Medicine III, Niigata University School of Medicine, Japan
    J Gastroenterol Hepatol 17:81-90. 2002
    ..Here we aimed to investigate the antitumor effect of OK-Lipo on hepatocellular carcinomas (HCC) in experimental rats...