Research Topics
Genomes and GenesSpecies | Toru IshikawaSummaryAffiliation: Saiseikai Kumamoto Hospital Country: Japan Publications
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Publications
Radiofrequency ablation during continuous saline infusion can extend ablation marginsToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950 1104, Japan
World J Gastroenterol 19:1278-82. 2013..To determine whether fluid injection during radiofrequency ablation (RFA) can increase the coagulation area...
Surfactant protein-D is more useful than Krebs von den Lungen 6 as a marker for the early diagnosis of interstitial pneumonitis during pegylated interferon treatment for chronic hepatitis CToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan
Hepatogastroenterology 59:2260-3. 2012..Hence, the predictors of interstitial pneumonitis have not been elucidated...- Combination PEG-IFN a-2b/ribavirin therapy following treatment of hepatitis C virus-associated hepatocellular carcinoma is capable of improving hepatic functional reserve and survivalToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Nigata Second Hospital, Niigata, Japan
Hepatogastroenterology 59:529-32. 2012..We investigated therapeutic response and hepatic functional reserve improvement in patients receiving PEG-IFN a-2b/RBV after curative HCC treatment... 
Histopathology of the tissue adhering to the multiple tine expandable electrodes used for radiofrequency ablation of hepatocellular carcinoma predicts local recurrenceToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Japan
Intern Med 51:2683-8. 2012..To assess the ability to predict the local recurrence of hepatocellular carcinoma by analyzing tissues adhering to the radiofrequency ablation probe after complete ablation...- Early administration of branched-chain amino acid granulesToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950 1104, Japan
World J Gastroenterol 18:4486-90. 2012..This review discusses data regarding the effect of early administration of BCAA granules based on the ratio of BCAA to BTR on prognosis in patients with cirrhosis... - Can zinc enhance response interferon therapy for patients with HCV-related liver disease?Toru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950 1104, Japan
World J Gastroenterol 18:3196-200. 2012..Treatment options for patients who have relapsed or are refractory to treatment with PEG-IFN and RBV therefore need to be critically assessed. This paper overviews the relationship between chronic liver disease and zinc metabolism... - Branched-chain amino acids to tyrosine ratio value as a potential prognostic factor for hepatocellular carcinomaToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, 280 7 Teraji, Niigata 950 1104, Japan
World J Gastroenterol 18:2005-8. 2012..This manuscript examines the literature to clarify whether BTR can serve as a prognostic factor for treatment of HCC... - Chemotherapy with enteric-coated tegafur/uracil for advanced hepatocellular carcinomaToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
World J Gastroenterol 14:2797-801. 2008..In this article, we review the clinical efficacy and toxicity of enteric-coated tegafur/uracil in the treatment of patients with advanced non-resectable HCC... - Secondary prevention of recurrence by interferon therapy after ablation therapy for hepatocellular carcinoma in chronic hepatitis C patientsToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
World J Gastroenterol 14:6140-4. 2008..We believe that there is a survival benefit in secondary prevention using IFN therapy. However, a controlled study is essential to obtain conclusive evidence of the efficacy of this strategy... - Gemcitabine in arterial injection chemotherapy for pancreatic cancer does not cause catheter obstruction or any other complicationToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
Hepatogastroenterology 57:945-8. 2010..Therefore, the purpose of this study was to verify the resistance of catheters to gemcitabine... - Usefulness of Y-shaped sheaths in CT angiography for examination of liver tumorsToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Niigata 950 1104, Japan
World J Gastroenterol 16:4704-8. 2010..To conduct a single-stage, combined computed tomography (CT) arterial portography (CTAP) and CT arteriography (CTA) imaging operation, we used Y-shaped sheaths with 2 valves, which allowed the insertion of 2 catheters simultaneously... - Therapeutic efficacy of continuous arterial infusion of the protease inhibitor and the antibiotics and via celiac and superior mesenteric artery for severe acute pancreatitis--pilot studyToru Ishikawa
Department of Gastroenterology, Saiseikai Niigata Second Hospital, Niigata, Japan
Hepatogastroenterology 56:524-8. 2009..Continuous regional arterial infusion of protease inhibitors and antibiotics were developed in Japan. We evaluated whether arterial infusion both celiac artery and superior mesenteric artery for this disease would reduce mortality... - Oral branched-chain amino acids administration improves impaired liver dysfunction after radiofrequency ablation therapy for hepatocellular carcinomaToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Niigata, Japan
Hepatogastroenterology 56:1491-5. 2009..However, the effects of RFA on hepatic reserve have not yet been thoroughly studied. In the present study, it was evaluated the effect of branched chain amino acid (BCAA) administration after RFA... - Prevention of intrahepatic distant recurrence by transcatheter arterial infusion chemotherapy with platinum agents for stage I/II hepatocellular carcinomaToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan
Cancer 117:4018-25. 2011..The authors compared the efficacy of 2 platinum-based chemotherapeutic agents in combination with radical local treatment for preventing intrahepatic distant recurrence (IDR)... - Clinical efficacy of intra-arterial pharmacokinetic chemotherapy with 5-fluorouracil, CDDP, gemcitabine, and angiotensin-II in patients with advanced pancreatic cancerToru Ishikawa
Department of Gastroenterology, Saiseikai Niigata Second Hospital, Niigata, Japan
Hepatogastroenterology 54:2378-82. 2007..To deliver anticancer drugs more selectively into cancer tissues and to improve survival time, we have developed a new method of intra-arterial chemotherapy for unresectable pancreatic cancer... - Improved survival for hepatocellular carcinoma with portal vein tumor thrombosis treated by intra-arterial chemotherapy combining etoposide, carboplatin, epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and enteric-coated tegafur/uracil: a pToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
World J Gastroenterol 13:5465-70. 2007..To investigate the poor prognosis of HCC with PVTT, we evaluated the efficacy by a new combination chemotherapy for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT)... - Is it relevant that intra-arterial chemotherapy may be effective for advanced pancreatic cancer?Toru Ishikawa
Department of Gastroenterology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
World J Gastroenterol 13:4306-9. 2007..Further clinical trials of this method should be subjected to a prospective randomized controlled study for advanced pancreatic cancer... - Complete early virological response was highly achieved by double filtration plasmapheresis plus IFN-beta induction therapy for HCV-1b patients with relapse or no response after previous IFN therapyToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan
Ther Apher Dial 15:400-5. 2011..This combination may contribute to sustained virological response (SVR). The effects of DFPP on SVR and its significance remain to be clarified... - Angiotensin-II administration is useful for the detection of liver metastasis from pancreatic cancer during pharmacoangiographic computed tomographyToru Ishikawa
Department of Gastroenterology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
World J Gastroenterol 13:3080-3. 2007..To improve the preoperative diagnosis of liver metastasis from pancreatic cancer, we estimated computed tomography during arterial angiography (CTA) with/without administration of angiotensin-II (AT- II)... - Comparison of a new aspiration needle device and the Quick-Core biopsy needle for transjugular liver biopsyToru Ishikawa
Department of Gastroenterology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
World J Gastroenterol 12:6339-42. 2006..To evaluate sample adequacy, safety, and needle passes of a new biopsy needle device compared to the Quick-Core biopsy needle for transjugular liver biopsy in patients affected by liver disease... - CT-maximum intensity projection is a clinically useful modality for the detection of gastric varicesToru Ishikawa
Department of Gastroenterology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
World J Gastroenterol 11:7515-9. 2005.... - Clinical features of hepatitis B virus-related hepatocellular carcinomaToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Second Hospital, Teraji 280 7, Niigata 950 1104, Japan
World J Gastroenterol 16:2463-7. 2010..Prevention of HBV-related HCC is a key issue in current hepatology. This paper describes the prevention and clinical features of HBV-related HCC, along with a short review of the disease... - Successful treatment of multiple lung metastases of hepatocellular carcinoma by combined chemotherapy with docetaxel, cisplatin and tegafur/uracilAtsunori Tsuchiya
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1 757 Asahimachi dori, Chuo Ku, Niigata, Japan
World J Gastroenterol 15:1779-81. 2009..In the absence of a standardized highly effective therapy, this combined chemotherapy with docetaxel, CDDP and UFT-E may be an attractive option for multiple lung metastases of HCC... - [A resected case of fibrolamellar hepatocellular carcinoma with chronic hepatitis (type B)]Toru Ishikawa
Department of Gastroenterology, Saiseikai Niigata Second Hospital
Nihon Shokakibyo Gakkai Zasshi 104:1076-81. 2007..Partial resection of the liver was performed, and the histological diagnosis was fibrolamellar hepatocellular carcinoma. The patient is now tumor free and doing well 20 months after the operation... - Efficacy of the regimen using twice-daily β-interferon followed by the standard of care for chronic hepatitis C genotype 1b with high viral loadToru Ishikawa
Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan
Hepatol Res 42:864-9. 2012..252), whereas no significant factors were found in the multivariate analysis due to small samples. Conclusion: IFN-β induction therapy with higher EVR might be beneficial for protease inhibitor-refractory chronic hepatitis C patients... - Serum alpha-fetoprotein levels during and after interferon therapy and the development of hepatocellular carcinoma in patients with chronic hepatitis CYasushi Tamura
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Dig Dis Sci 54:2530-7. 2009..057), and a significantly higher cumulative incidence of HCC was seen in patients with increased serum AFP levels at EOT (P = 0.021). Serum AFP level at EOT is a possible predictor of HCC in CHC patients after IFN therapy... - [A case of splenic inflammatory pseudotumor]Toru Ishikawa
Department of Gastroenterology, Saiseikai Niigata Second Hospital
Nihon Shokakibyo Gakkai Zasshi 104:407-12. 2007..The pathological diagnosis of the tumor was inflammatory pseudotumor. Splenectomy is considered to be significant from the standpoints of both diagnosis and therapy in cases in which diagnostic imaging is difficult to interpret... - Formula to predict platelet count after partial splenic arterial embolization in patients with hypersplenismAkihiko Osaki
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1 757 Asahimachi dori, Chuo Ku, Niigata, Niigata 951 8122, Japan
J Vasc Interv Radiol 23:900-7. 2012..To establish a formula to guide appropriate embolization volume for postprocedural platelet gain following partial splenic arterial embolization (PSE) for hypersplenism... - Characterization of elevated alanine aminotransferase levels during pegylated-interferon α-2b plus ribavirin treatment for chronic hepatitis CYo Hei Aoki
Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences Niigata University Niigata Municipal Hospital Tachikawa General Hospital Nagaoka Red Cross Hospital Sai sei kai Second Hospital Takeda General Hospital Watanabe Clinic, Niigata, Japan
Hepatol Res 41:118-25. 2011..Conclusion: Abnormal ALT values during peg-IFN plus ribavirin treatment are observed relatively frequently, even in patients without detectable HCV RNA. Direct or indirect involvement of drugs is considered as one possible cause... - Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cellsSatoshi Yamagiwa
Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Hepatol Res 38:664-72. 2008..041). Conclusion: These findings demonstrate that sustained response to IFN/RBV treatment for patients with CHC is closely associated with increased dynamism of NK and NKT cells in the liver... - Complete disappearance of pulmonary metastases in a case of hepatocellular carcinoma treated with docetaxel-based systemic chemotherapyToru Ishikawa
Department of Internal Medicine III, Niigata University School of Medicine, Niigata, Japan
J Gastroenterol Hepatol 19:1423-6. 2004..No recurrence of pulmonary metastasis was seen for 10 months. This combination therapy was well-tolerated for lung cancer and could represent an effective treatment for pulmonary metastases from HCC... - [A case of advanced gastric cancer with liver and intra-abdominal lymph node metastasis treated by hypertensive selective chemotherapy with pharmacokinetic modulating chemotherapy]Toru Ishikawa
Dept. of Gastroenterology, Saiseikai Niigata Daini Hospital
Gan To Kagaku Ryoho 30:1151-5. 2003..We conclude that this chemotherapy is effective in cases of advanced gastric cancer with liver and lymph node metastasis from the viewpoints of toxicities, antitumor effect and QOL of the patient... - [A case of successful management of nonresectable pancreas cancer with liver metastasis by intra-arterial infusion chemotherapy with gemcitabine hydrochloride, 5-FU, CDDP and administration of tegafur/uracil]Toru Ishikawa
Dept. of Gastroenterology, Saiseikai Niigata Second Hospital
Gan To Kagaku Ryoho 31:1555-8. 2004..Furthermore, the patient can take sufficient meals without any adverse effects. His quality of life has been preserved. This regimen could well be effective for advanced pancreatic cancer... - [Modified pharmacokinetic modulating chemotherapy for progressive gastric cancer accompanied by peritoneal dissemination]Toru Ishikawa
Dept of Gastroenterology, Saiseikai Niigata Second Hospital
Gan To Kagaku Ryoho 32:469-72. 2005..Objective improvement of ascites was seen in all patients, and all patients could be treated at outpatient clinics. This regimen may be well-tolerated and of clinical benefit for patients with peritoneal dissemination of gastric cancer... - [A case of advanced gastric cancer with bone metastasis and severe DIC responding to hypertensive subselective chemotherapy with pharmacokinetic modulating chemotherapy]Toru Ishikawa
Dept of Gastroenterology, Saiseikai Niigata Second Hospital
Gan To Kagaku Ryoho 32:523-7. 2005..We concluded that this chemotherapy is effective for advanced gastric cancer complicated with bone metastasis and DIC from the standpoint of toxicities, antitumor effect and QOL of the patient... - Systemic administration of liposome-encapsulated OK-432 prolongs the survival of rats with hepatocellular carcinoma through the induction of IFN-gamma-producing hepatic lymphocytesKazuhiro Uehara
Department of Internal Medicine III, Niigata University School of Medicine, Japan
J Gastroenterol Hepatol 17:81-90. 2002..OK-Lipo induced NK cells and IFN-gamma-producing cells specifically in the liver and these cells seemed to reduce hepatocarcinogenesis and tumor growth...