Hiroki Yoshida

Summary

Affiliation: Saga University
Country: Japan

Publications

  1. pmc Incudomalleal joint formation: the roles of apoptosis, migration and downregulation
    Susan Amin
    Department of Craniofacial Development and Orthodontics, King s College London, London, UK
    BMC Dev Biol 7:134. 2007
  2. doi request reprint Regulation of immune responses by interleukin-27
    Hiroki Yoshida
    Department of Biomolecular Sciences, Division of Molecular and Cellular Immunoscience, Faculty of Medicine, Saga University, Saga, Japan
    Immunol Rev 226:234-47. 2008
  3. doi request reprint Interleukin 27 signaling pathways in regulation of immune and autoimmune responses
    Hiroki Yoshida
    Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Int J Biochem Cell Biol 40:2379-83. 2008
  4. doi request reprint Interleukin 27: a double-edged sword for offense and defense
    Hiroki Yoshida
    Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Nabeshima, Saga, Japan
    J Leukoc Biol 86:1295-303. 2009
  5. doi request reprint IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection
    Yoshiyuki Miyazaki
    Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Saga University, Saga, Japan
    J Immunol 185:1150-7. 2010
  6. doi request reprint Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity
    Yukari Shinozaki
    Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
    Int J Cancer 124:1372-8. 2009
  7. doi request reprint Amelioration of experimental allergic rhinitis with suppression of topical immune responses by lack of IL-27/WSX-1 signaling
    Yohei Shimanoe
    Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
    Ann Allergy Asthma Immunol 102:223-32. 2009
  8. doi request reprint Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice
    Tetsuaki Hirase
    Department of Cardiovascular Medicine, Saga University, Saga, Japan
    Am J Physiol Heart Circ Physiol 305:H420-9. 2013
  9. pmc IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice
    Hirokazu Fujimoto
    Department of Cardiovascular Medicine, Saga University Faculty of Medicine, Saga, Japan
    Am J Pathol 179:2327-36. 2011
  10. doi request reprint Amelioration of delayed-type hypersensitivity responses by IL-27 administration
    Yoshiyuki Miyazaki
    Department of Biomolecular Sciences, Division of Molecular and Cellular Immunoscience, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Biochem Biophys Res Commun 373:397-402. 2008

Collaborators

Detail Information

Publications55

  1. pmc Incudomalleal joint formation: the roles of apoptosis, migration and downregulation
    Susan Amin
    Department of Craniofacial Development and Orthodontics, King s College London, London, UK
    BMC Dev Biol 7:134. 2007
    ..Understanding how this joint forms during normal development is thus an important step in furthering our understanding of such defects...
  2. doi request reprint Regulation of immune responses by interleukin-27
    Hiroki Yoshida
    Department of Biomolecular Sciences, Division of Molecular and Cellular Immunoscience, Faculty of Medicine, Saga University, Saga, Japan
    Immunol Rev 226:234-47. 2008
    ..In this review, we discuss recent studies on the role of IL-27 in immunity to parasitic and bacterial infections as well as in allergy and autoimmunity in view of its pro- and anti-inflammatory properties...
  3. doi request reprint Interleukin 27 signaling pathways in regulation of immune and autoimmune responses
    Hiroki Yoshida
    Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Int J Biochem Cell Biol 40:2379-83. 2008
    ..Interleukin 27 suppresses some diseases of autoimmune or allergic origin, demonstrating its promising potential in therapy of diseases mediated by inflammatory cytokines...
  4. doi request reprint Interleukin 27: a double-edged sword for offense and defense
    Hiroki Yoshida
    Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Nabeshima, Saga, Japan
    J Leukoc Biol 86:1295-303. 2009
    ..In this review, we discuss recent studies about the role of IL-27 in immune regulation in view of its pro- and anti-inflammatory properties and possible therapeutic application...
  5. doi request reprint IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection
    Yoshiyuki Miyazaki
    Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Saga University, Saga, Japan
    J Immunol 185:1150-7. 2010
    ..cruzi was impaired in the absence of IL-17A, resulting in the greater susceptibility of those mice to T. cruzi infection. From these results, we conclude that IL-17A is important for the resolution of T. cruzi infection...
  6. doi request reprint Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity
    Yukari Shinozaki
    Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
    Int J Cancer 124:1372-8. 2009
    ..It was thus revealed that IL-27 promotes CTL generation while suppressing DC function during generation of tumor immunity. The combination of WT T cells and IL-27 signal-defective DCs may have therapeutic potential against tumors...
  7. doi request reprint Amelioration of experimental allergic rhinitis with suppression of topical immune responses by lack of IL-27/WSX-1 signaling
    Yohei Shimanoe
    Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
    Ann Allergy Asthma Immunol 102:223-32. 2009
    ..Interleukin (IL) 27 is an immunosuppressive cytokine, and lack of the IL-27 receptor (WSX-1) resulted in exacerbation of allergic airway hyperresponsiveness...
  8. doi request reprint Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice
    Tetsuaki Hirase
    Department of Cardiovascular Medicine, Saga University, Saga, Japan
    Am J Physiol Heart Circ Physiol 305:H420-9. 2013
    ..These findings define a novel inhibitory role for IL-27 in atherosclerosis that regulates macrophage activation in mice. ..
  9. pmc IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice
    Hirokazu Fujimoto
    Department of Cardiovascular Medicine, Saga University Faculty of Medicine, Saga, Japan
    Am J Pathol 179:2327-36. 2011
    ..Thus, IL-27 inhibits STZ-induced hyperglycemia and pancreatic islet inflammation in mice and represents a potential novel therapeutic approach for β-cell protection in diabetes...
  10. doi request reprint Amelioration of delayed-type hypersensitivity responses by IL-27 administration
    Yoshiyuki Miyazaki
    Department of Biomolecular Sciences, Division of Molecular and Cellular Immunoscience, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Biochem Biophys Res Commun 373:397-402. 2008
    ..These results collectively indicate that IL-27 has a suppressive effect on activated T cells in the experimental model and also has a therapeutic potential for some diseases caused by immune disorder...
  11. ncbi request reprint [Immune regulation by IL-27 for therapeutic usage]
    Hiroki Yoshida
    Department of Biomolecular Sciences, Faculty of Medicine, Saga University
    Nihon Rinsho Meneki Gakkai Kaishi 32:202-13. 2009
    ....
  12. doi request reprint SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitis
    Mako Nakaya
    Department of Biomolecular Sciences, Saga University, 5 1 1 Nabeshima, Saga, Japan
    J Immunol 183:7047-53. 2009
    ..These data indicate that SOCS3 plays a negative regulatory role in NKT cell activation and that forced expression of SOCS3 in NKT cells is effective in preventing hepatitis...
  13. ncbi request reprint Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9
    Hiromitsu Hara
    Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama City, Kanagawa, Japan
    J Immunol 181:918-30. 2008
    ..Thus, NF-kappaB activation signaling through ITAM receptors is regulated by a cell type-specific mechanism depending on the usage of adaptors CARMA1 and CARD9, which determines the PKC dependence of the signaling...
  14. ncbi request reprint The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
    Hiromitsu Hara
    Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Nat Immunol 8:619-29. 2007
    ..Thus, the activation of lymphoid and myeloid cells through ITAM-associated receptors or Toll-like receptors is regulated by CARMA1-Bcl-10 and CARD9-Bcl-10, respectively...
  15. doi request reprint The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo
    Akiko Kukita
    Department of Microbiology, Faculty of Medicine, Saga University, Saga, Japan
    Arthritis Rheum 63:2744-54. 2011
    ....
  16. pmc L-CBM signaling in lymphocyte development and function
    Hiromitsu Hara
    Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
    J Blood Med 1:93-104. 2010
    ....
  17. doi request reprint Alternative cell death of Apaf1-deficient neural progenitor cells induced by withdrawal of EGF or insulin
    Hiroshi Shiraishi
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Biochim Biophys Acta 1800:405-15. 2010
    ..A small percentage of the mutant mice, however, are viable and grow to maturity. The occurrence of such normal mutants implicates alternative cell death pathways during neurogenesis...
  18. ncbi request reprint Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1(IL-27R) deficiency
    Sen Wang
    Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
    J Immunol 179:6421-8. 2007
    ..Thus, our study demonstrated that IL-27/WSX-1 signaling potently down-regulates APC function and Th1-promoting function of DCs to modulate overall immune responses...
  19. ncbi request reprint Advantage of ischemic preconditioning for hepatic resection in pigs
    Jun Kadono
    Second Department of Surgery, Faculty of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    J Surg Res 134:173-81. 2006
    ..However, comparison of these two procedures against warm hepatic ischemia-reperfusion injury has not been studied enough...
  20. ncbi request reprint An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells
    Shinsuke Yasukawa
    1 Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima Saga, Saga 849 8501, Japan 2 Department of Dermatology, Graduate School of Medical Sciences, Kyushu University School of Medicine, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nat Commun 5:3755. 2014
    ..These data unveil an innate immune mechanism crucial for allergic contact sensitization to chemical compounds. ..
  21. ncbi request reprint [Machinery of programmed cell death]
    Hiroki Yoshida
    Department of Biomolecular Sciences, Faculty of Medicine, Saga University
    Nihon Rinsho 63:401-6. 2005
  22. ncbi request reprint Overexpression of cyclinD1 predicts for poor prognosis in estrogen receptor-negative breast cancer patients
    Yoshihisa Umekita
    Department of Pathology, Faculty of Medicine, Kagoshima University, Sakuragaoka, Japan
    Int J Cancer 98:415-8. 2002
    ..02) and relapse-free survival (p = 0.0058), followed by nodal status and histologic grade. These findings suggest that overexpression of cyclinD1 is an independent prognostic indicator in ER-negative breast cancer patients...
  23. ncbi request reprint Expression of maspin predicts poor prognosis in breast-cancer patients
    Yoshihisa Umekita
    Department of Pathology, Faculty of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    Int J Cancer 100:452-5. 2002
    ....
  24. ncbi request reprint WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation
    Atsunobu Takeda
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Int Immunol 17:889-97. 2005
    ....
  25. ncbi request reprint Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitis
    Takeru Yoshimura
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Int Immunol 20:209-14. 2008
    ..Taken together, our data demonstrated that IL-17/T(h)17 participates in the late phases of EAU and also that T(h)1 and T(h)17 responses are differentially required for EAU...
  26. ncbi request reprint Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis
    Atsushi Yamanaka
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 172:3590-6. 2004
    ..These data revealed a novel role for WSX-1 as an inhibitory regulator of cytokine production and inflammation in Con A-induced hepatitis...
  27. ncbi request reprint Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity
    Toshikatsu Hanada
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Immunity 19:437-50. 2003
    ..SOCS1-deficient DCs efficiently stimulated B cell proliferation in vitro and autoantibody production in vivo. These results indicate that SOCS1 plays an essential role in the normal DC functions and suppression of systemic autoimmunity...
  28. ncbi request reprint Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
    Atsunobu Takeda
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, and Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 170:4886-90. 2003
    ..Thus, during the initiation of Th1 differentiation, the IL-27/WSX-1 signaling system plays a pivotal role by STAT1-mediated T-bet induction before the IL-12R system...
  29. ncbi request reprint The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection
    Alejandro Villarino
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St, Philadelphia, PA 19104, USA
    Immunity 19:645-55. 2003
    ....
  30. ncbi request reprint Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
    Hiroshi Takayanagi
    Department of Immunology, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Japan
    Dev Cell 3:889-901. 2002
    ..Thus, NFATc1 may represent a master switch for regulating terminal differentiation of osteoclasts, functioning downstream of RANKL...
  31. ncbi request reprint SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
    Ichiko Kinjyo
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Immunity 17:583-91. 2002
    ..Thus, SOCS1 directly suppresses TLR4 signaling and modulates innate immunity...
  32. ncbi request reprint The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity
    David Artis
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:5626-34. 2004
    ..In addition, IL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites...
  33. ncbi request reprint The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes
    Hiromitsu Hara
    Department of Immunology and Technical Support Laboratory, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 168:2288-95. 2002
    ..We assume that mechanisms for the negative selection are composed of several cell death pathways to avoid failure of elimination of autoreactive clones...
  34. ncbi request reprint Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice
    Yoshiyuki Miyazaki
    PRESTO, Japan Science and Technology Agency, Saitama, Japan
    J Immunol 175:2401-7. 2005
    ....
  35. ncbi request reprint The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 174:3534-44. 2005
    ..In conclusion, IL-27 both prevents optimal antimycobacterial protection and limits the pathological sequelae of chronic inflammation...
  36. pmc Generation and characterization of B7-H4/B7S1/B7x-deficient mice
    Woong Kyung Suh
    Campbell Family Institute for Breast Cancer Research, 620 University Ave, Suite 706, Toronto, Ontario, Canada
    Mol Cell Biol 26:6403-11. 2006
    ..These results suggest that B7-H4 is one of multiple negative cosignaling molecules that collectively provide a fine-tuning mechanism for T-cell-mediated immune responses...
  37. ncbi request reprint Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism
    Takeru Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation and Department of Opthalmology, Graduate School of Medical Sciences Kyushu University, Fukuoka, Japan
    J Immunol 177:5377-85. 2006
    ..These data indicated that the preferential activation of STAT3 in fully activated CD4+ T cells plays an important role in the cytokine suppression by IL-27/WSX-1...
  38. ncbi request reprint WSX-1 plays a significant role for the initiation of experimental autoimmune uveitis
    Koh Hei Sonoda
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Int Immunol 19:93-8. 2007
    ..Thus, IL-27/WSX-1 affects the early development of EAU, and might be a target for therapy during the onset of autoimmune uveitis in humans...
  39. pmc Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways
    Tsukasa Shibue
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    EMBO J 25:4952-62. 2006
    ..These findings offer a new insight into differential cellular responses induced by p53, and may have therapeutic implications in cancer...
  40. pmc Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice
    Misako Haraguchi
    Department of Cancer Chemotherapy, Institute for Cancer Research, Third Department of Internal Medicin, Kagoshima University, 8 35 1 Sakura gaoka, Kagoshima 890 8520, Japan
    Mol Cell Biol 22:5212-21. 2002
    ..Since lesions in the brain do not appear to be due to mitochondrial alterations and pathological changes in the muscle were not found, this model will provide further insights into the causes of MNGIE...
  41. ncbi request reprint The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7
    Hiroki Yoshida
    Gonda Department of Cell and Molecular Biology, House Ear Institute, University of Southern California, Los Angeles, California 90057, USA
    J Biol Chem 280:41111-21. 2005
    ..These findings provide novel insights into autoregulation and negative regulation of TLR signaling...
  42. pmc Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
    Masataka Asagiri
    Department of Cell Signaling, Tokyo Medical and Dental University, Japan
    J Exp Med 202:1261-9. 2005
    ..Thus, this study establishes that NFATc1 represents a potential therapeutic target for bone disease and reveals a mechanism that underlies the essential role of NFATc1 in bone homeostasis...
  43. ncbi request reprint Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1)
    Sakiko Shimizu
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    J Immunol 175:7185-92. 2005
    ..Loss of WSX-1 thus favors Th2-type autoimmune responses, suggesting that the Th1/Th2 balance may be a pivotal determinant of human lupus nephritis development...
  44. ncbi request reprint The regulation of human beta-defensin 2 by the ETS transcription factor MEF (myeloid Elf-1-like factor) is enhanced by promyelocytic leukemia protein
    Mary Ann Suico
    Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Pharmacol Sci 95:466-70. 2004
    ..Here, we show that PML stimulated MEF transcriptional activity, resulting in the up-regulation of endogenous HBD 2 expression...
  45. ncbi request reprint Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFkappaB-mediated cell survival pathway
    Sandra Ferry
    Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University, Fukuoka 812 8582, Japan
    Carcinogenesis 23:2031-41. 2002
    ..These results revealed that extracellularly applied InsP(6) directly activates the apoptotic machinery as well as inhibits the cell survival signaling, probably by the intracellular delivery followed by a dephosphorylation...
  46. ncbi request reprint Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells
    Hiroyuki Kishimoto
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 278:16595-601. 2003
    ..These results indicate that the Tyr and Thr residues of SAPK/JNK are sequentially phosphorylated by SEK1 and MKK7, respectively, in the stress-stimulated ES cells...
  47. ncbi request reprint A gene-targeted mouse model for chorea-acanthocytosis
    Yuko Tomemori
    Department of Psychiatry, Kagoshima University Graduate School of Medical and Ental Sciences, Kagoshima, Japan
    J Neurochem 92:759-66. 2005
    ..The CHAC model mouse therefore provides a good model system to study the human disease...
  48. ncbi request reprint WSX-1: a key role in induction of chronic intestinal nematode infection
    Allison J Bancroft
    School of Biological Sciences, 3 239 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    J Immunol 172:7635-41. 2004
    ..These studies demonstrate an important role for WSX-1 signaling in the promotion of type 1 responses and chronic gastrointestinal nematode infection...
  49. ncbi request reprint Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells
    Gen Nishitai
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 279:1621-6. 2004
    ....
  50. ncbi request reprint Radiation-induced crypt intestinal epithelial cell apoptosis in vivo involves both caspase-3-dependent and -independent pathways
    Kyoko Inagaki-Ohara
    Section of Gastroenterology, Department of Medicine, Northwestern University Medical School, 10 541 Searle Building, 303 E Chicago, Chicago, Illinois 60611, USA
    Dig Dis Sci 47:2823-30. 2002
    ..Overall, these results demonstrate that radiation-induced crypt IEC apoptosis has both caspase-3-independent and -dependent components...
  51. ncbi request reprint WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production
    Shinjiro Hamano
    The Department of Parasitology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Immunity 19:657-67. 2003
    ....
  52. ncbi request reprint Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein
    Mary Ann Suico
    Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Biol Chem 279:19091-8. 2004
    ..Thus, the recruitment of MEF to PML nuclear bodies may partly regulate lysozyme transcription in epithelial cells...
  53. doi request reprint Different initial steps of apoptosis induced by two types of antineoplastic drugs
    Yasumitsu Takagi
    Frontier Research Center, Fukuoka Dental College, 2 15 1, Tamura, Sawara ku, Fukuoka, 814 0193, Japan
    Biochem Pharmacol 76:303-11. 2008
    ....
  54. ncbi request reprint T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis
    Kuniomi Honda
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Inflamm Bowel Dis 11:1044-52. 2005
    ..In the present study, we investigated the role of IL-27/WSX-1 signaling in a murine colitis model, dextran sulfate sodium (DSS) colitis, by using WSX-1 knockout (KO) mice...