Research Topics
Genomes and Genes
| Hiroki YoshidaSummaryAffiliation: Saga University Country: Japan Publications
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Detail Information
Publications
Incudomalleal joint formation: the roles of apoptosis, migration and downregulationSusan Amin
Department of Craniofacial Development and Orthodontics, King s College London, London, UK
BMC Dev Biol 7:134. 2007..Understanding how this joint forms during normal development is thus an important step in furthering our understanding of such defects...
Interleukin 27 signaling pathways in regulation of immune and autoimmune responsesHiroki Yoshida
Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
Int J Biochem Cell Biol 40:2379-83. 2008..Interleukin 27 suppresses some diseases of autoimmune or allergic origin, demonstrating its promising potential in therapy of diseases mediated by inflammatory cytokines...- Regulation of immune responses by interleukin-27Hiroki Yoshida
Department of Biomolecular Sciences, Division of Molecular and Cellular Immunoscience, Faculty of Medicine, Saga University, Saga, Japan
Immunol Rev 226:234-47. 2008..In this review, we discuss recent studies on the role of IL-27 in immunity to parasitic and bacterial infections as well as in allergy and autoimmunity in view of its pro- and anti-inflammatory properties... - Interleukin 27: a double-edged sword for offense and defenseHiroki Yoshida
Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Nabeshima, Saga, Japan
J Leukoc Biol 86:1295-303. 2009..In this review, we discuss recent studies about the role of IL-27 in immune regulation in view of its pro- and anti-inflammatory properties and possible therapeutic application... - IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infectionYoshiyuki Miyazaki
Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Saga University, Saga, Japan
J Immunol 185:1150-7. 2010..cruzi was impaired in the absence of IL-17A, resulting in the greater susceptibility of those mice to T. cruzi infection. From these results, we conclude that IL-17A is important for the resolution of T. cruzi infection... - Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunityYukari Shinozaki
Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
Int J Cancer 124:1372-8. 2009..It was thus revealed that IL-27 promotes CTL generation while suppressing DC function during generation of tumor immunity. The combination of WT T cells and IL-27 signal-defective DCs may have therapeutic potential against tumors... - Amelioration of experimental allergic rhinitis with suppression of topical immune responses by lack of IL-27/WSX-1 signalingYohei Shimanoe
Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
Ann Allergy Asthma Immunol 102:223-32. 2009..Interleukin (IL) 27 is an immunosuppressive cytokine, and lack of the IL-27 receptor (WSX-1) resulted in exacerbation of allergic airway hyperresponsiveness... - IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in miceHirokazu Fujimoto
Department of Cardiovascular Medicine, Saga University Faculty of Medicine, Saga, Japan
Am J Pathol 179:2327-36. 2011..Thus, IL-27 inhibits STZ-induced hyperglycemia and pancreatic islet inflammation in mice and represents a potential novel therapeutic approach for β-cell protection in diabetes... 
[Immune regulation by IL-27 for therapeutic usage]Hiroki Yoshida
Department of Biomolecular Sciences, Faculty of Medicine, Saga University
Nihon Rinsho Meneki Gakkai Kaishi 32:202-13. 2009....- Amelioration of delayed-type hypersensitivity responses by IL-27 administrationYoshiyuki Miyazaki
Department of Biomolecular Sciences, Division of Molecular and Cellular Immunoscience, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
Biochem Biophys Res Commun 373:397-402. 2008..These results collectively indicate that IL-27 has a suppressive effect on activated T cells in the experimental model and also has a therapeutic potential for some diseases caused by immune disorder... - SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitisMako Nakaya
Department of Biomolecular Sciences, Saga University, 5 1 1 Nabeshima, Saga, Japan
J Immunol 183:7047-53. 2009..These data indicate that SOCS3 plays a negative regulatory role in NKT cell activation and that forced expression of SOCS3 in NKT cells is effective in preventing hepatitis... - The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptorsHiromitsu Hara
Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
Nat Immunol 8:619-29. 2007..Thus, the activation of lymphoid and myeloid cells through ITAM-associated receptors or Toll-like receptors is regulated by CARMA1-Bcl-10 and CARD9-Bcl-10, respectively... - Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9Hiromitsu Hara
Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama City, Kanagawa, Japan
J Immunol 181:918-30. 2008..Thus, NF-kappaB activation signaling through ITAM receptors is regulated by a cell type-specific mechanism depending on the usage of adaptors CARMA1 and CARD9, which determines the PKC dependence of the signaling... - The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivoAkiko Kukita
Department of Microbiology, Faculty of Medicine, Saga University, Saga, Japan
Arthritis Rheum 63:2744-54. 2011.... - L-CBM signaling in lymphocyte development and functionHiromitsu Hara
Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
J Blood Med 1:93-104. 2010.... - Alternative cell death of Apaf1-deficient neural progenitor cells induced by withdrawal of EGF or insulinHiroshi Shiraishi
Division of Medical Biochemistry, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501, Japan
Biochim Biophys Acta 1800:405-15. 2010..A small percentage of the mutant mice, however, are viable and grow to maturity. The occurrence of such normal mutants implicates alternative cell death pathways during neurogenesis... - Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1(IL-27R) deficiencySen Wang
Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
J Immunol 179:6421-8. 2007..Thus, our study demonstrated that IL-27/WSX-1 signaling potently down-regulates APC function and Th1-promoting function of DCs to modulate overall immune responses... - Advantage of ischemic preconditioning for hepatic resection in pigsJun Kadono
Second Department of Surgery, Faculty of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan
J Surg Res 134:173-81. 2006..However, comparison of these two procedures against warm hepatic ischemia-reperfusion injury has not been studied enough... - [Machinery of programmed cell death]Hiroki Yoshida
Department of Biomolecular Sciences, Faculty of Medicine, Saga University
Nippon Rinsho 63:401-6. 2005 - Overexpression of cyclinD1 predicts for poor prognosis in estrogen receptor-negative breast cancer patientsYoshihisa Umekita
Department of Pathology, Faculty of Medicine, Kagoshima University, Sakuragaoka, Japan
Int J Cancer 98:415-8. 2002..02) and relapse-free survival (p = 0.0058), followed by nodal status and histologic grade. These findings suggest that overexpression of cyclinD1 is an independent prognostic indicator in ER-negative breast cancer patients... - Expression of maspin predicts poor prognosis in breast-cancer patientsYoshihisa Umekita
Department of Pathology, Faculty of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan
Int J Cancer 100:452-5. 2002.... - Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitisTakeru Yoshimura
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka
Int Immunol 20:209-14. 2008..Taken together, our data demonstrated that IL-17/T(h)17 participates in the late phases of EAU and also that T(h)1 and T(h)17 responses are differentially required for EAU... - Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanismTakeru Yoshimura
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation and Department of Opthalmology, Graduate School of Medical Sciences Kyushu University, Fukuoka, Japan
J Immunol 177:5377-85. 2006..These data indicated that the preferential activation of STAT3 in fully activated CD4+ T cells plays an important role in the cytokine suppression by IL-27/WSX-1... - Generation and characterization of B7-H4/B7S1/B7x-deficient miceWoong Kyung Suh
Campbell Family Institute for Breast Cancer Research, 620 University Ave, Suite 706, Toronto, Ontario, Canada
Mol Cell Biol 26:6403-11. 2006..These results suggest that B7-H4 is one of multiple negative cosignaling molecules that collectively provide a fine-tuning mechanism for T-cell-mediated immune responses... - The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infectionAlejandro Villarino
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St, Philadelphia, PA 19104, USA
Immunity 19:645-55. 2003.... - WSX-1 plays a significant role for the initiation of experimental autoimmune uveitisKoh Hei Sonoda
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Int Immunol 19:93-8. 2007..Thus, IL-27/WSX-1 affects the early development of EAU, and might be a target for therapy during the onset of autoimmune uveitis in humans... - The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytesHiromitsu Hara
Department of Immunology and Technical Support Laboratory, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Immunol 168:2288-95. 2002..We assume that mechanisms for the negative selection are composed of several cell death pathways to avoid failure of elimination of autoreactive clones... - SOCS1/JAB is a negative regulator of LPS-induced macrophage activationIchiko Kinjyo
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Immunity 17:583-91. 2002..Thus, SOCS1 directly suppresses TLR4 signaling and modulates innate immunity... - Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsHiroshi Takayanagi
Department of Immunology, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Japan
Dev Cell 3:889-901. 2002..Thus, NFATc1 may represent a master switch for regulating terminal differentiation of osteoclasts, functioning downstream of RANKL... - Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitmentAtsunobu Takeda
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, and Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Immunol 170:4886-90. 2003..Thus, during the initiation of Th1 differentiation, the IL-27/WSX-1 signaling system plays a pivotal role by STAT1-mediated T-bet induction before the IL-12R system... - Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunityToshikatsu Hanada
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Immunity 19:437-50. 2003..SOCS1-deficient DCs efficiently stimulated B cell proliferation in vitro and autoantibody production in vivo. These results indicate that SOCS1 plays an essential role in the normal DC functions and suppression of systemic autoimmunity... - Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitisAtsushi Yamanaka
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
J Immunol 172:3590-6. 2004..These data revealed a novel role for WSX-1 as an inhibitory regulator of cytokine production and inflammation in Con A-induced hepatitis... - The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunityDavid Artis
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 173:5626-34. 2004..In addition, IL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites... - The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosisChristoph Holscher
Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
J Immunol 174:3534-44. 2005..In conclusion, IL-27 both prevents optimal antimycobacterial protection and limits the pathological sequelae of chronic inflammation... - Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient miceYoshiyuki Miyazaki
PRESTO, Japan Science and Technology Agency, Saitama, Japan
J Immunol 175:2401-7. 2005.... - WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulationAtsunobu Takeda
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
Int Immunol 17:889-97. 2005.... - A gene-targeted mouse model for chorea-acanthocytosisYuko Tomemori
Department of Psychiatry, Kagoshima University Graduate School of Medical and Ental Sciences, Kagoshima, Japan
J Neurochem 92:759-66. 2005..The CHAC model mouse therefore provides a good model system to study the human disease... - Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in miceMisako Haraguchi
Department of Cancer Chemotherapy, Institute for Cancer Research, Third Department of Internal Medicin, Kagoshima University, 8 35 1 Sakura gaoka, Kagoshima 890 8520, Japan
Mol Cell Biol 22:5212-21. 2002..Since lesions in the brain do not appear to be due to mitochondrial alterations and pathological changes in the muscle were not found, this model will provide further insights into the causes of MNGIE... - T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitisKuniomi Honda
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Inflamm Bowel Dis 11:1044-52. 2005..As a result, IL-27/WSX-1 signal pathway may thus be a promising candidate for the therapeutic intervention of human inflammatory bowel diseases such as Crohn's disease and ulcerative colitis... - The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7Hiroki Yoshida
Gonda Department of Cell and Molecular Biology, House Ear Institute, University of Southern California, Los Angeles, California 90057, USA
J Biol Chem 280:41111-21. 2005..These findings provide novel insights into autoregulation and negative regulation of TLR signaling... - Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFkappaB-mediated cell survival pathwaySandra Ferry
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University, Fukuoka 812-8582, Japan
Carcinogenesis 23:2031-41. 2002..These results revealed that extracellularly applied InsP(6) directly activates the apoptotic machinery as well as inhibits the cell survival signaling, probably by the intracellular delivery followed by a dephosphorylation... - Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cellsHiroyuki Kishimoto
Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Biol Chem 278:16595-601. 2003..These results indicate that the Tyr and Thr residues of SAPK/JNK are sequentially phosphorylated by SEK1 and MKK7, respectively, in the stress-stimulated ES cells... - Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cellsGen Nishitai
Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
J Biol Chem 279:1621-6. 2004.... - Radiation-induced crypt intestinal epithelial cell apoptosis in vivo involves both caspase-3-dependent and -independent pathwaysKyoko Inagaki-Ohara
Section of Gastroenterology, Department of Medicine, Northwestern University Medical School, 10-541 Searle Building, 303 E. Chicago, Chicago, Illinois 60611, USA
Dig Dis Sci 47:2823-30. 2002..Overall, these results demonstrate that radiation-induced crypt IEC apoptosis has both caspase-3-independent and -dependent components... - WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine productionShinjiro Hamano
The Department of Parasitology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
Immunity 19:657-67. 2003.... - Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia proteinMary Ann Suico
Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
J Biol Chem 279:19091-8. 2004..Thus, the recruitment of MEF to PML nuclear bodies may partly regulate lysozyme transcription in epithelial cells... - Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathwaysTsukasa Shibue
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
EMBO J 25:4952-62. 2006..These findings offer a new insight into differential cellular responses induced by p53, and may have therapeutic implications in cancer... - Different initial steps of apoptosis induced by two types of antineoplastic drugsYasumitsu Takagi
Frontier Research Center, Fukuoka Dental College, 2 15 1, Tamura, Sawara ku, Fukuoka, 814 0193, Japan
Biochem Pharmacol 76:303-11. 2008.... - WSX-1: a key role in induction of chronic intestinal nematode infectionAllison J Bancroft
School of Biological Sciences, 3 239 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
J Immunol 172:7635-41. 2004..These studies demonstrate an important role for WSX-1 signaling in the promotion of type 1 responses and chronic gastrointestinal nematode infection... - The regulation of human beta-defensin 2 by the ETS transcription factor MEF (myeloid Elf-1-like factor) is enhanced by promyelocytic leukemia proteinMary Ann Suico
Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan
J Pharmacol Sci 95:466-70. 2004..Here, we show that PML stimulated MEF transcriptional activity, resulting in the up-regulation of endogenous HBD 2 expression... - Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1)Sakiko Shimizu
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
J Immunol 175:7185-92. 2005..Loss of WSX-1 thus favors Th2-type autoimmune responses, suggesting that the Th1/Th2 balance may be a pivotal determinant of human lupus nephritis development... - Autoamplification of NFATc1 expression determines its essential role in bone homeostasisMasataka Asagiri
Department of Cell Signaling, Tokyo Medical and Dental University, Japan
J Exp Med 202:1261-9. 2005..Thus, this study establishes that NFATc1 represents a potential therapeutic target for bone disease and reveals a mechanism that underlies the essential role of NFATc1 in bone homeostasis...