Affiliation: Saga University
Uchida K, Nomura M, Yamamoto T, Ogawa Y, Teramoto N. Rab8a is involved in membrane trafficking of Kir6.2 in the MIN6 insulinoma cell line. Pflugers Arch. 2019;: pubmed publisher
..These results suggest that Rab8a may be involved in membrane trafficking of KATP channels and the maintenance of normal insulin secretion in the MIN6 pancreatic beta cell line. ..
Teramoto N, Yotsu Yamashita M. Selective blocking effects of 4,9-anhydrotetrodotoxin, purified from a crude mixture of tetrodotoxin analogues, on NaV1.6 channels and its chemical aspects. Mar Drugs. 2015;13:984-95 pubmed publisher
..6 channels. In addition, chemical aspects of 4,9-anhydroTTX are briefly covered. ..
Yamamoto T, Takahara K, Inai T, Node K, Teramoto N. Molecular analysis of ATP-sensitive K(+) channel subunits expressed in mouse portal vein. Vascul Pharmacol. 2015;75:29-39 pubmed publisher
..The results indicate that native KATP channels in mouse portal vein are likely to be composed of a heterocomplex of KIR6.1 and SUR2B subunits. ..
Mori K, Yamashita Y, Teramoto N. Effects of ZD0947, a novel and potent ATP-sensitive K+ channel opener, on smooth muscle-type ATP-sensitive K+ channels. Eur J Pharmacol. 2016;791:773-779 pubmed publisher
..e. SUR2A/Kir6.2). These results suggest that a pharmacological agent can possess either agonist or antagonist actions on the activity of KATP channels, depending on the subtype of SUR.x. ..
Takahara K, Yamamoto T, Uchida K, Zhu H, Shibata A, Inai T, et al
. Effects of 4,9-anhydrotetrodotoxin on voltage-gated Na+ channels of mouse vas deferens myocytes and recombinant NaV1.6 channels. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:489-499 pubmed publisher
Teramoto N, Zhu H, Yotsu Yamashita M, Inai T, Cunnane T. Resurgent-like currents in mouse vas deferens myocytes are mediated by NaV1.6 voltage-gated sodium channels. Pflugers Arch. 2012;464:493-502 pubmed publisher
..6(+/+) but not Na(V)1.6(-/-) murine vas deferens myocytes. These results strongly indicate that, primarily, resurgent-like currents are generated as a result of Na(V)1.6 channel activity...
Nomura M, Morinaga H, Zhu H, Wang L, Hasuzawa N, Takayanagi R, et al
. Activation of activin type IB receptor signals in pancreatic β cells leads to defective insulin secretion through the attenuation of ATP-sensitive K+ channel activity. Biochem Biophys Res Commun. 2014;450:440-6 pubmed publisher
..These results indicate that an appropriate level of activin signaling may be required for GSIS in pancreatic β cells, and that activin signaling involves modulation of KATP channel activity. ..
Yamamoto T, Takahara K, Uchida K, Teramoto N. ZD0947, a sulphonylurea receptor modulator, detects functional sulphonylurea receptor subunits in murine vascular smooth muscle ATP-sensitive K+ channels. Eur J Pharmacol. 2017;800:34-39 pubmed publisher
..x in mouse portal vein KATP channels, based on its pharmacological selectivity. ..