Hidenobu Soejima

Summary

Affiliation: Saga University
Country: Japan

Publications

  1. pmc Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumours
    Y Satoh
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Br J Cancer 95:541-7. 2006
  2. ncbi request reprint Epigenetic silencing of the MGMT gene in cancer
    Hidenobu Soejima
    Division of Molecular Biology and Genetics, Department of Molecular Sciences, Saga University, Japan
    Biochem Cell Biol 83:429-37. 2005
  3. ncbi request reprint [Epigenetics-related diseases and analytic methods]
    Hidenobu Soejima
    Division of Molecular Genetics and Epigenetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Rinsho Byori 57:769-78. 2009
  4. ncbi request reprint Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer
    Hidenobu Soejima
    Department of Biomolecular Sciences, Division of Molecular Biology and Genetics, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501 Japan
    Oncogene 23:4380-8. 2004
  5. ncbi request reprint The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island
    Wei Zhao
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501
    J Biochem 137:431-40. 2005
  6. ncbi request reprint Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice
    Zhongming Zhang
    Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Gene 366:77-86. 2006
  7. ncbi request reprint Retinoic acid receptor beta2 is epigenetically silenced either by DNA methylation or repressive histone modifications at the promoter in cervical cancer cells
    Zhongming Zhang
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Cancer Lett 247:318-27. 2007
  8. ncbi request reprint Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer
    Tetsuji Nakagawachi
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Oncogene 22:8835-44. 2003
  9. ncbi request reprint Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse
    Ken Higashimoto
    Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga, 849 8501, Japan
    Genomics 80:575-84. 2002
  10. ncbi request reprint MeCP2 knockdown reveals DNA methylation-independent gene repression of target genes in living cells and a bias in the cellular location of target gene products
    Shinya Yakabe
    Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
    Genes Genet Syst 83:199-208. 2008

Collaborators

Detail Information

Publications39

  1. pmc Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumours
    Y Satoh
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Br J Cancer 95:541-7. 2006
    ..5 and/or 11p13. One-third of the tumours had alterations at multiple loci. Our results suggest that chromosome 11p is not only genetically but also epigenetically critical for the majority of Wilms' tumours...
  2. ncbi request reprint Epigenetic silencing of the MGMT gene in cancer
    Hidenobu Soejima
    Division of Molecular Biology and Genetics, Department of Molecular Sciences, Saga University, Japan
    Biochem Cell Biol 83:429-37. 2005
    ..In this review, we describe recent advances in understanding the silencing of MGMT and its role in carcinogenesis; epigenetic mechanisms; and clinical implications...
  3. ncbi request reprint [Epigenetics-related diseases and analytic methods]
    Hidenobu Soejima
    Division of Molecular Genetics and Epigenetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Rinsho Byori 57:769-78. 2009
    ..The great advance in epigenetic research, from basic to clinical, will bring significant benefits to human health and a broad range of life sciences...
  4. ncbi request reprint Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer
    Hidenobu Soejima
    Department of Biomolecular Sciences, Division of Molecular Biology and Genetics, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501 Japan
    Oncogene 23:4380-8. 2004
    ....
  5. ncbi request reprint The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island
    Wei Zhao
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501
    J Biochem 137:431-40. 2005
    ..The epigenetic mechanism leading to silent heterochromatin at the promoter CpG island may be the same in different types of cancer irrespective of the extent of DNA methylation...
  6. ncbi request reprint Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice
    Zhongming Zhang
    Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Gene 366:77-86. 2006
    ..These results suggest that this region is the imprinting control region of the Murr1/U2af1-rs1 locus in mouse...
  7. ncbi request reprint Retinoic acid receptor beta2 is epigenetically silenced either by DNA methylation or repressive histone modifications at the promoter in cervical cancer cells
    Zhongming Zhang
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Cancer Lett 247:318-27. 2007
    ..Our results suggest that RAR beta2 is silenced by either of the two key epigenetic pathways, DNA methylation or repressive histone modifications, depending on the individual cancer cells...
  8. ncbi request reprint Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer
    Tetsuji Nakagawachi
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Oncogene 22:8835-44. 2003
    ..Furthermore, MeCP2 preferentially bound to the CpG-methylated island in the MGMT negative line. Given these results, we propose a model for gene silencing of MGMT that is dependent on the epigenetic state in cancer...
  9. ncbi request reprint Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse
    Ken Higashimoto
    Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga, 849 8501, Japan
    Genomics 80:575-84. 2002
    ..It remains to be elucidated whether the gene is under the control of the KIP2/LIT1 subdomain or is regulated by a specific mechanism. Analysis of the precise genomic sequence around the region should help resolve this question...
  10. ncbi request reprint MeCP2 knockdown reveals DNA methylation-independent gene repression of target genes in living cells and a bias in the cellular location of target gene products
    Shinya Yakabe
    Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
    Genes Genet Syst 83:199-208. 2008
    ..These results suggest that in addition to the canonical gene repression function, MeCP2 can repress gene expression by binding to unmethylated DNA in particular genes in living cells...
  11. doi request reprint Organotypic culture of human bone marrow adipose tissue
    Kazuyoshi Uchihashi
    Department of Pathology, Faculty of Medicine, Saga University, Saga, Japan
    Pathol Int 60:259-67. 2010
    ..The present novel method proved to be useful for the study of BMAT biology...
  12. ncbi request reprint Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancers
    Yasuo Koga
    Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
    Ann Surg Oncol 12:354-63. 2005
    ..The purpose of this study was to clarify how MGMT deficiency leads to a poor outcome in biliary tract cancer. Thus, we examined epigenetic (promoter methylation) and genetic (gene mutation) alterations in biliary tract cancer...
  13. doi request reprint Antisense transcription occurs at the promoter of a mouse imprinted gene, commd1, on the repressed paternal allele
    Keiichiro Joh
    Division of Molecular Genetics and Epigenetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    J Biochem 146:771-4. 2009
    ..These results strongly suggested that imprinting of Commd1 is generated by interference with paternal Commd1 transcription by the oppositely directed U2af1-rs1 transcription...
  14. pmc Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma
    Janette Mareska Rumbajan
    Department of Biomolecular Sciences, Division of Molecular Genetics and Epigenetics, Faculty of Medicine, Saga University, Nabeshima 5 1 1, Saga 849 8501, Japan
    BMC Cancer 13:608. 2013
    ..5 has been reported in many tumors including hepatoblastoma. However, the methylation status of imprinted DMRs in imprinted loci scattered through the human genome has not been analyzed yet in any tumors...
  15. pmc Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract polycomb silencing
    Hitomi Miyazaki
    Division of Molecular Genetics and Epigenetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga City, Saga, Japan Precursory Research for Embryonic Science and Technology PRESTO, Japan Science and Technology Agency JST, 4 1 8 Honcho, Kawaguchi City, Saitama, Japan
    PLoS Genet 9:e1003897. 2013
    ..Our results uncover a novel regulatory cascade orchestrated by Ash1l with RAR and provide insights into mechanisms underlying the establishment of the transcriptional activation that counteracts Polycomb silencing. ..
  16. ncbi request reprint Japanese and North American/European patients with Beckwith-Wiedemann syndrome have different frequencies of some epigenetic and genetic alterations
    Kensaku Sasaki
    Department of Biomolecular Sciences, Saga University, Saga, Japan
    Eur J Hum Genet 15:1205-10. 2007
    ..These results suggest that susceptibility to epigenetic and genetic alterations differs between the two groups...
  17. pmc Homozygous deletion of DIS3L2 exon 9 due to non-allelic homologous recombination between LINE-1s in a Japanese patient with Perlman syndrome
    Ken Higashimoto
    Division of Molecular Genetics and Epigenetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
    Eur J Hum Genet 21:1316-9. 2013
    ..The data suggest that the region around exon 9 might be a hot spot of L1-mediated NAHR. ..
  18. pmc Loss of CpG methylation is strongly correlated with loss of histone H3 lysine 9 methylation at DMR-LIT1 in patients with Beckwith-Wiedemann syndrome
    Ken Higashimoto
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Saga Medical School, Nabeshima, Saga, Japan
    Am J Hum Genet 73:948-56. 2003
    ....
  19. pmc The mouse Murr1 gene is imprinted in the adult brain, presumably due to transcriptional interference by the antisense-oriented U2af1-rs1 gene
    Youdong Wang
    Department of Biomolecular Sciences, Saga Medical School, Saga 849 8501, Japan
    Mol Cell Biol 24:270-9. 2004
    ....
  20. ncbi request reprint Cisplatin represses transcriptional activity from the minimal promoter of the O6-methylguanine methyltransferase gene and increases sensitivity of human gallbladder cancer cells to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-2-chloroethyl)-3-nitrosourea
    Ken Sato
    Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
    Oncol Rep 13:899-906. 2005
    ..The 59 bp region in the MGMT promoter was crucial for repression by cisplatin. These results might form the basis of a chemotherapeutic strategy involving alkylating agents via prior cisplatin-induced biochemical modulation...
  21. ncbi request reprint Significant reduction of WT1 gene expression, possibly due to epigenetic alteration in Wilms' tumor
    Yuji Satoh
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    J Biochem 133:303-8. 2003
    ..beta-catenin mutated in only one WT without WT1 silencing, suggesting that the beta-catenin mutation was not associated with the reduction of WT1 expression...
  22. doi request reprint Epigenetic and genetic alterations of the imprinting disorder Beckwith-Wiedemann syndrome and related disorders
    Hidenobu Soejima
    Division of Molecular Genetics and Epigenetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
    J Hum Genet 58:402-9. 2013
    ..5, in addition to epigenetic and genetic etiologies of BWS, associated childhood tumors, the effects of ART and multilocus hypomethylation disorders. ..
  23. ncbi request reprint A novel de novo point mutation of the OCT-binding site in the IGF2/H19-imprinting control region in a Beckwith-Wiedemann syndrome patient
    Ken Higashimoto
    Division of Molecular Genetics and Epigenetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga, 849 8501, Japan
    Clin Genet . 2013
    ..These findings indicate that the OCT-binding site is important for maintaining an unmethylated status of maternal ICR1 in early embryogenesis...
  24. doi request reprint Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome
    Ken Higashimoto
    Division of Molecular Genetics and Epigenetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
    Am J Med Genet A 158:1670-5. 2012
    ..In addition, of 16 primary imprinted DMRs analyzed, only H19-DMR was aberrantly methylated, except for NNAT DMR in the placental chorangioma of Patient 2. To our knowledge, these are the first data suggesting when GOM of H19-DMR occurs...
  25. ncbi request reprint Primary palmar hyperhidrosis locus maps to 14q11.2-q13
    Ikuyo Higashimoto
    Department of Anesthesiology, Faculty of Medicine, Saga University, Nabeshima, Saga, Japan
    Am J Med Genet A 140:567-72. 2006
    ..This is the first report of systemic mapping of the PPH locus...
  26. pmc Domain regulation of imprinting cluster in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5: large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control region
    Hitomi Yatsuki
    Department of Biochemistry, Saga Medical School, Saga, Saga 849 8501, Japan
    Genome Res 12:1860-70. 2002
    ..These data indicate that CGI8, called DMR-Lit1, is not only the region for gametic methylation but might also be the imprinting control region (ICR) of the subdomain...
  27. ncbi request reprint Imprinting centers, chromatin structure, and disease
    Hidenobu Soejima
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    J Cell Biochem 95:226-33. 2005
    ..ICs for both regions are subject to parent-specific epigenetic marking by covalent modification of DNA and histones. In this review, we summarize our current understanding of IC function and IC modification in these two regions...
  28. doi request reprint A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells
    Emiko Sonoda
    Department of Pathology and Biodefense, Faculty of Medicine, Saga University, Nabeshima 5 1 1, Saga 849 8501, Japan
    Endocrinology 149:4794-8. 2008
    ..This suggests that our method will open up a new way for studying both multiple cell types within adipose tissue and the cell-based mechanisms of obesity and metabolic syndrome...
  29. doi request reprint Beckwith-Wiedemann syndrome with placental chorangioma due to H19-differentially methylated region hypermethylation: a case report
    Aiko Aoki
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Obstet Gynaecol Res 37:1872-6. 2011
    ..This is the first report of BWS with placental tumor due to H19-differentially methylated region hypermethylation...
  30. ncbi request reprint Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells
    Ayumi Satoh
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Oncogene 23:8876-86. 2004
    ..It thus appears that CIITA methylation is a key mechanism that enables some gastrointestinal cancer cells to escape immune surveillance...
  31. pmc ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome
    Takahiro Arima
    Department of Reproductive Physiology and Endocrinology, Medical Institute of Bioregulation, Kyusyu University 4546, Tsurumihara, Beppu, Oita 874 0838, Japan
    Nucleic Acids Res 33:2650-60. 2005
    ..Mutations in ZAC may, therefore, contribute to Beckwith-Wiedemann syndrome. Furthermore, we find changes in DNA methylation at the LIT1 putative imprinting control region in two patients with TNDB...
  32. ncbi request reprint Neuron-specific relaxation of Igf2r imprinting is associated with neuron-specific histone modifications and lack of its antisense transcript Air
    Yoko Yamasaki
    Department of Human Genetics, Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Hum Mol Genet 14:2511-20. 2005
    ....
  33. pmc A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 21q
    Yoichi Yamada
    Division of Genome Biology, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
    Genome Res 14:247-66. 2004
    ..Thus, the cell seems to have a broader repertoire of methylating CGIs than previously thought, and our approach may contribute to uncover novel modes of allelic methylation...
  34. doi request reprint Duplication of paternal IGF2 or loss of maternal IGF2 imprinting occurs in half of Wilms tumors with various structural WT1 abnormalities
    Masayuki Haruta
    Department of Cancer Diagnosis, Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan
    Genes Chromosomes Cancer 47:712-27. 2008
    ..03) and CTNNB1 mutation (17/23; P = 0.03) more frequently than WTs with the deletion (2/13 and 4/13). Thus, three WT1 subtypes were correlated with certain genetic and clinicopathological characteristics...
  35. doi request reprint MeCP2-dependent repression of an imprinted miR-184 released by depolarization
    Tasuku Nomura
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8512, Japan
    Hum Mol Genet 17:1192-9. 2008
    ..The restricted release of MeCP2 from the paternal allele results in paternal allele-specific expression of miR-184. Our finding provides a clue to the link between the microRNA and DNA methylation pathways...
  36. ncbi request reprint A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q: comparison with chromosome 21q
    Yoichi Yamada
    Department of Information and Systems Engineering, Faculty of Engineering, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    DNA Seq 17:300-6. 2006
    ..Thus, methylation status of CGIs may substantially differ from one chromosome to another...
  37. pmc Role of DNA methylation and histone H3 lysine 27 methylation in tissue-specific imprinting of mouse Grb10
    Yoko Yamasaki-Ishizaki
    Division of Functional Genomics, Center for Frontier Life Sciences, Nagasaki University, Sakamoto 1 12 4, Nagasaki 852 8523, Japan
    Mol Cell Biol 27:732-42. 2007
    ..Here, we propose a molecular model that gametic DNA methylation and chromatin remodeling by PcG proteins during cell differentiation cause tissue-specific imprinting in embryonic tissues...
  38. ncbi request reprint Expression profile of LIT1/KCNQ1OT1 and epigenetic status at the KvDMR1 in colorectal cancers
    Seiji Nakano
    Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishimachi, Yonago, Tottori 683 8503, Japan
    Cancer Sci 97:1147-54. 2006
    ..Therefore, these findings suggest that LOI of LIT1 via epigenetic disruption plays an important role in colorectal carcinogenesis, but it is not necessarily associated with CDKN1C expression...
  39. pmc The human ASCL2 gene escaping genomic imprinting and its expression pattern
    Toshinobu Miyamoto
    Department of Human Genetics, School of Medicine, Nagasaki University, Japan
    J Assist Reprod Genet 19:240-4. 2002
    ..In addition, it has been shown that the human ASCL2 gene escapes genomic imprinting...