Hiroaki Okamoto

Summary

Affiliation: Saga Medical School
Country: Japan

Publications

  1. ncbi request reprint Proteins and protein pattern differences between glioma cell lines and glioblastoma multiforme
    Timothy W Vogel
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA
    Clin Cancer Res 11:3624-32. 2005
  2. ncbi request reprint Analysis of the full-length genome of a subgenotype IIIB hepatitis A virus isolate: primers for broadly reactive PCR and genotypic analysis
    Kazunori Endo
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi ken, Japan
    J Med Virol 79:8-17. 2007
  3. ncbi request reprint Detection of JC virus DNA sequences in brain tumors in pediatric patients
    Hiroaki Okamoto
    Department of Neurosurgery, Faculty of Medicine, Saga University, Saga, Japan
    J Neurosurg 102:294-8. 2005
  4. ncbi request reprint Molecular analysis of astrocytoma associated with Turcot syndrome type 1--case report
    Hiroaki Okamoto
    Department of Neurosurgery, Saga Medical School, Saga, Japan
    Neurol Med Chir (Tokyo) 44:124-8. 2004
  5. pmc Detrended fluctuation analysis of genome-wide copy number profiles of glioblastomas using array-based comparative genomic hybridization
    Yukiko Nakahara
    Department of Neurosurgery, Faculty of Medicine, Saga University, Saga 849 850, Japan
    Neuro Oncol 6:281-9. 2004
  6. ncbi request reprint Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas
    Shigeo Ueda
    Department of Neurosurgery, Faculty of Medicine, Saga University, Saga, Japan
    J Neurosurg 101:659-63. 2004
  7. ncbi request reprint Combined proteomic approach with SELDI-TOF-MS and peptide mass fingerprinting identified the rapid increase of monomeric transthyretin in rat cerebrospinal fluid after transient focal cerebral ischemia
    Kenji Suzuyama
    Department of Neurosurgery, Faculty of Medicine, Saga University, Japan
    Brain Res Mol Brain Res 129:44-53. 2004
  8. ncbi request reprint Expression of the Wilms' tumor gene product WT1 in glioblastomas and medulloblastomas
    Yukiko Nakahara
    Department of Neurosurgery, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Brain Tumor Pathol 21:113-6. 2004
  9. ncbi request reprint [Blood blister-like aneurysm on the posterior wall of the internal carotid artery causing subarachnoid hemorrhage: a case report]
    Motofumi Koguchi
    Department of Neurosurgery, Karatsu Red Cross Hospital, Japan
    No Shinkei Geka 41:229-34. 2013
  10. ncbi request reprint Identification of pleiotrophin in conditioned medium secreted from neural stem cells by SELDI-TOF and SELDI-tandem mass spectrometry
    Makoto Furuta
    Department of Neurosurgery, Faculty of Medicine, Saga University, Japan
    Brain Res Dev Brain Res 152:189-97. 2004

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Proteins and protein pattern differences between glioma cell lines and glioblastoma multiforme
    Timothy W Vogel
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA
    Clin Cancer Res 11:3624-32. 2005
    ..We compared protein expression patterns between solid primary GBMs and GBM cell lines to identify proteins whose expression may be altered in cell culture...
  2. ncbi request reprint Analysis of the full-length genome of a subgenotype IIIB hepatitis A virus isolate: primers for broadly reactive PCR and genotypic analysis
    Kazunori Endo
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi ken, Japan
    J Med Virol 79:8-17. 2007
    ..These results suggest that two broadly reactive PCRs using primers derived from the VP1-2B and 3C/3D regions, respectively, may be applicable to universal detection and phylogenetic analysis of various HAV strains...
  3. ncbi request reprint Detection of JC virus DNA sequences in brain tumors in pediatric patients
    Hiroaki Okamoto
    Department of Neurosurgery, Faculty of Medicine, Saga University, Saga, Japan
    J Neurosurg 102:294-8. 2005
    ....
  4. ncbi request reprint Molecular analysis of astrocytoma associated with Turcot syndrome type 1--case report
    Hiroaki Okamoto
    Department of Neurosurgery, Saga Medical School, Saga, Japan
    Neurol Med Chir (Tokyo) 44:124-8. 2004
    ..These results suggest that inactivation of mismatch repair system and p53 is closely associated with the tumorigenesis of this neoplasm. The final diagnosis was Turcot syndrome type 1...
  5. pmc Detrended fluctuation analysis of genome-wide copy number profiles of glioblastomas using array-based comparative genomic hybridization
    Yukiko Nakahara
    Department of Neurosurgery, Faculty of Medicine, Saga University, Saga 849 850, Japan
    Neuro Oncol 6:281-9. 2004
    ..Furthermore, we show that nonlinear analysis methods of whole genome copy number profiles may provide prognostic information about glioblastoma patients...
  6. ncbi request reprint Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas
    Shigeo Ueda
    Department of Neurosurgery, Faculty of Medicine, Saga University, Saga, Japan
    J Neurosurg 101:659-63. 2004
    ..This study was performed to elucidate whether dexamethasone affects the expression of MGMT in glioblastoma multiforme (GBM) cells, thereby limiting the benefit of chemotherapeutic alkylating agents...
  7. ncbi request reprint Combined proteomic approach with SELDI-TOF-MS and peptide mass fingerprinting identified the rapid increase of monomeric transthyretin in rat cerebrospinal fluid after transient focal cerebral ischemia
    Kenji Suzuyama
    Department of Neurosurgery, Faculty of Medicine, Saga University, Japan
    Brain Res Mol Brain Res 129:44-53. 2004
    ..The monomeric transthyretin may represent an ischemia-specific CSF marker to indicate the sequential changes according to ischemic insults of the brain...
  8. ncbi request reprint Expression of the Wilms' tumor gene product WT1 in glioblastomas and medulloblastomas
    Yukiko Nakahara
    Department of Neurosurgery, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Brain Tumor Pathol 21:113-6. 2004
    ....
  9. ncbi request reprint [Blood blister-like aneurysm on the posterior wall of the internal carotid artery causing subarachnoid hemorrhage: a case report]
    Motofumi Koguchi
    Department of Neurosurgery, Karatsu Red Cross Hospital, Japan
    No Shinkei Geka 41:229-34. 2013
    ..To our knowledge, BBA on the posterior wall of the ICA is rare. Radical surgery with bypass should be performed as soon as possible when the BBA is found to regrow. We discuss the clinical characteristics with a review of the literature...
  10. ncbi request reprint Identification of pleiotrophin in conditioned medium secreted from neural stem cells by SELDI-TOF and SELDI-tandem mass spectrometry
    Makoto Furuta
    Department of Neurosurgery, Faculty of Medicine, Saga University, Japan
    Brain Res Dev Brain Res 152:189-97. 2004
    ....
  11. ncbi request reprint Increased cytotoxicity of soluble Fas ligand by fusing isoleucine zipper motif
    Tetsuya Shiraishi
    Department of Neurosurgery, Faculty of Medicine, Saga University, Japan
    Biochem Biophys Res Commun 322:197-202. 2004
    ..The upper limit of FIZ-shFasL for safe systemic administration to rat is estimated as below 2 microg/ml in plasma concentration. FIZ-shFasL could be applicable as a therapeutic agent for cancer...
  12. ncbi request reprint [A case of cervicothoracic subpial lipoma]
    Taku Uchiyama
    Department of Neurosurgery, Saga Prefectural Hospital Koseikan, Japan
    No Shinkei Geka 40:359-63. 2012
    ..Therefore, early surgical decompression and debulking of the subpial lipoma in patients with neurological abnormalities is recommended because most symptomatic patients do not improve after surgery...
  13. ncbi request reprint Treatment of dural arteriovenous fistula presenting as typical symptoms of hydrocephalus caused by venous congestion: case report
    Yukiko Nakahara
    Department of Neurosurgery, Saga Prefectural Hospital Koseikan, Saga, Japan
    Neurol Med Chir (Tokyo) 51:229-32. 2011
    ..Venous hypertension associated with the DAVF in the transverse-sigmoid sinuses may have been caused by normal pressure hydrocephalus...
  14. ncbi request reprint N-CoR pathway targeting induces glioblastoma derived cancer stem cell differentiation
    Deric M Park
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Cycle 6:467-70. 2007
    ..The identification of N-CoR in GBM provides insights into the tumorigenesis process and supports the development of differentiation-based therapeutic strategies...
  15. ncbi request reprint Full-length sequences of subgenotype IIIA and IIIB hepatitis A virus isolates: characterization of genotype III HAV genomes
    Kazunori Endo
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke shi, Tochigi Ken 329 0498, Japan
    Virus Res 126:116-27. 2007
    ..Conserved and divergent amino acid sequences as well as amino acids unique to genotype III, IIIA or IIIB were recognized...
  16. ncbi request reprint Comparative proteomic profiles of meningioma subtypes
    Hiroaki Okamoto
    Surgical Neurology Branch and Protein Peptide Sequencing Facility, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:10199-204. 2006
    ..The proteins and proteomic profiles enhance understanding of the pathogenesis of meningiomas and have implications for diagnosis, prognosis, and treatment...
  17. ncbi request reprint Development and validation of an improved RT-PCR assay with nested universal primers for detection of hepatitis E virus strains with significant sequence divergence
    Jun Inoue
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi Ken 329 0498, Japan
    J Virol Methods 137:325-33. 2006
    ..Since the amplicons of ORF2/3-137 PCR contain variable sequences, a phylogenetic tree of the ORF2/3-137 products could clearly distinguish the different HEV genotypes...
  18. ncbi request reprint Proteomic analysis of inclusion body myositis
    Jie Li
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland, USA
    J Neuropathol Exp Neurol 65:826-33. 2006
    ..We further applied Western blot and immunohistochemistry to verify the proteomic findings. This study validates proteomics as a powerful tool in the study of muscle disease and indicates a unique pattern of protein expression in IBM...
  19. ncbi request reprint Analysis of human and swine hepatitis E virus (HEV) isolates of genotype 3 in Japan that are only 81-83 % similar to reported HEV isolates of the same genotype over the entire genome
    Jun Inoue
    Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi Ken 329 0498, Japan
    J Gen Virol 87:2363-9. 2006
    ..8-100 % and 87.9-92.4 %, respectively. Genotype 3 HEV isolates were found to be markedly heterogeneous. The UK-isolate-like HEV strains in Japan may have originated from the UK via the importation of pigs since 1900...
  20. ncbi request reprint A combination chemotherapy of carboplatin and irinotecan with granulocyte colony-stimulating factor (G-CSF) support in elderly patients with small cell lung cancer
    Hiroaki Okamoto
    Department of Respiratory Medicine, Yokohama Municipal Citizen s Hospital, Yokohama, Kanagawa, Japan
    Lung Cancer 53:197-203. 2006
    ....
  21. ncbi request reprint Possible association of vigorous hepatitis B virus replication with the development of fulminant hepatitis
    Kazuaki Inoue
    Division of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama 227 8501, Japan
    J Gastroenterol 41:383-7. 2006
    ..The present case report provides clinical evidence of a possible association between the rapid spread of highly replicative HBV before host immunological recognition and the development of fulminant hepatitis...
  22. ncbi request reprint Proteomic analysis of hemangioblastoma cyst fluid
    Sven Glasker
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Biol Ther 5:549-53. 2006
    ..Hemangioblastoma cyst formation is a major cause of morbidity and mortality with these tumors. While peritumoral cysts have been suggested to result from vascular leakage, the mechanism of intratumoral cyst formation is not understood...
  23. ncbi request reprint Phase II trial of amrubicin for treatment of refractory or relapsed small-cell lung cancer: Thoracic Oncology Research Group Study 0301
    Sayaka Onoda
    Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    J Clin Oncol 24:5448-53. 2006
    ..This multicenter, phase II study was conducted to evaluate the activity of amrubicin, a topoisomerase II inhibitor, against refractory or relapsed small-cell lung cancer (SCLC)...
  24. ncbi request reprint Proteomic comparison of oligodendrogliomas with and without 1pLOH
    Hiroaki Okamoto
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland 20892 1414, USA
    Cancer Biol Ther 6:391-6. 2007
    ..Despite a high morphological similarity, tumors with allelic loss on the short arm of chromosome 1 (1pLOH) are more chemosensitive than those without 1pLOH...
  25. ncbi request reprint Identification and genomic characterization of a novel human torque teno virus of 3.2 kb
    Masashi Ninomiya
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi Ken 329 0498, Japan
    J Gen Virol 88:1939-44. 2007
    ..These results suggest that SAVs are deletion mutants of the novel virus with intermediate genomic length between those of TTV and TTMV and that the novel virus can be classified into a third group of the genus Anellovirus...
  26. ncbi request reprint Analysis of the full-length genome of hepatitis E virus isolates obtained from farm pigs in Mongolia
    Felipe R Lorenzo
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi ken, Japan
    J Med Virol 79:1128-37. 2007
    ..These results indicate that farm pigs in Mongolia are frequently infected with presumably indigenous HEV strains of genotype 3 and could be a source of HEV infections in humans in Mongolia...
  27. ncbi request reprint Proteomic profiling: a novel method for differential diagnosis?
    Sven Glasker
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Biol Ther 6:343-5. 2007
    ..Proteomics may complement pathological evaluation and characterization of tumors in the future. Furthermore, these results show that metastasis of malignant RCC is not necessarily equivalent to aggressive growth patterns...
  28. ncbi request reprint Ongoing subclinical infection of hepatitis E virus among blood donors with an elevated alanine aminotransferase level in Japan
    Yuhko Gotanda
    Japanese Red Cross Saitama Blood Center, Saitama Ken, Japan
    J Med Virol 79:734-42. 2007
    ..This study suggests that approximately 3% of Japanese individuals with ALT > or = 201 IU/l have ongoing subclinical infection with various HEV strains...
  29. ncbi request reprint Complete genomes of hepatitis C virus (HCV) subtypes 6c, 6l, 6o, 6p and 6q: completion of a full panel of genomes for HCV genotype 6
    Ling Lu
    Division of Gastroenterology Hepatology, Department of Medicine, University of Kansas Medical Center, 4035 Delp, MS 1023, Kansas City, KS 66160, USA, and The First People s Hospital of Yunnan Province, Kunming, China
    J Gen Virol 88:1519-25. 2007
    ..The utility of this panel of complete sequences for accurate detection and classification of infection, and for estimating the origin of this genotype of HCV, is discussed...
  30. ncbi request reprint Complete genomes for hepatitis C virus subtypes 6f, 6i, 6j and 6m: viral genetic diversity among Thai blood donors and infected spouses
    Ling Lu
    Division of Gastroenterology Hepatology, Department of Medicine, University of Kansas Medical Center, 4035 Delp, MS 1023, Kansas City, KS 66160, USA
    J Gen Virol 88:1505-18. 2007
    ..3 to 100%. The similarities of the complete genome sequences from the two couples in the current study are consistent with HCV transmission between spouses...
  31. pmc Development of PCR assays with nested primers specific for differential detection of three human anelloviruses and early acquisition of dual or triple infection during infancy
    Masashi Ninomiya
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi Ken 329 0498, Japan
    J Clin Microbiol 46:507-14. 2008
    ..9%]), comparable with the 93.1% (243/261) prevalence among subjects 1 to 81 years of age, indicating early acquisition of dual or triple anellovirus infection during infancy...
  32. ncbi request reprint Initial load of hepatitis B virus (HBV), its changing profile, and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection
    Shigehiko Sainokami
    First Department of Internal Medicine, Iwate Medical University, Iwate, Japan
    J Gastroenterol 42:241-9. 2007
    ..We aimed to define possible viral factors implicated in the severe form of acute HBV infection...
  33. pmc Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas
    Jie Li
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1414, USA
    Neuro Oncol 10:45-51. 2008
    ..RNA interference could suppress glioma cell growth by blocking WHSC1 expression. Our novel findings encourage the application of proteomic techniques in cancer research...
  34. doi request reprint Analysis of the full-length genome of hepatitis B virus in the serum and cerebrospinal fluid of a patient with acute hepatitis B and transverse myelitis
    Jun Inoue
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    J Clin Virol 41:301-4. 2008
    ..One clone of the 6 CSF clones had an additional substitution at nt 2119. These substitutions were not found in 16 serum clones. The presence of HBV clones unique to CSF suggests that HBV was a possible causative agent of the myelitis...
  35. doi request reprint Torque teno virus DNA titre elevated in idiopathic pulmonary fibrosis with primary lung cancer
    Masashi Bando
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Tochigi, Japan
    Respirology 13:263-9. 2008
    ..This study aimed to investigate the prevalence and titre of TTV DNA among patients with IPF and lung cancer...
  36. ncbi request reprint Hemangioblastomas share protein expression with embryonal hemangioblast progenitor cell
    Sven Glasker
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:4167-72. 2006
    ..Finally, the consistent identification of Scl in the stromal cells may help explain the unique and characteristic topographical distribution of hemangioblastomas within the CNS...
  37. ncbi request reprint Analysis of the full-length genome of genotype 4 hepatitis E virus isolates from patients with fulminant or acute self-limited hepatitis E
    Jun Inoue
    Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi ken, Japan
    J Med Virol 78:476-84. 2006
    ..A silent substitution of U3148 in HEV may be associated with the development of fulminant hepatitis. Further studies are needed to clarify the underlying mechanism...
  38. pmc Infection of a Japanese patient by genotype 4 hepatitis e virus while traveling in Vietnam
    Yuko Koizumi
    Department of Gastroenterology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi Machi, Tochigi Ken 329 0498, Japan
    J Clin Microbiol 42:3883-5. 2004
    ..We report a 56-year-old Japanese man who acquired infection with a genotype 4 HEV with 98.8% identity to a Vietnamese isolate after ingestion of uncooked shellfish while traveling in Vietnam...
  39. ncbi request reprint Epidemiological and clinical study of sporadic acute hepatitis E caused by indigenous strains of hepatitis E virus in Japan compared with acute hepatitis A
    Shigehiko Sainokami
    First Department of Internal Medicine, Iwate Medical University, Morioka, Japan
    J Gastroenterol 39:640-8. 2004
    ..We compared acute hepatitis E (AH-E) and acute hepatitis A (AH-A) to investigate the epidemiology, clinical features, and prognosis of AH-E caused by an indigenous hepatitis E virus (HEV) in Japan...
  40. ncbi request reprint Prevalence of antibodies to hepatitis E virus among Japanese blood donors: identification of three blood donors infected with a genotype 3 hepatitis E virus
    Satoko Fukuda
    Japanese Red Cross Tochigi Blood Center, Tochigi ken, Japan
    J Med Virol 73:554-61. 2004
    ..This study suggests that a small but significant proportion of blood donors in Japan with or without elevated ALT are viremic and are potentially able to cause transfusion-associated hepatitis E...
  41. ncbi request reprint Helicobacter pylori and TT virus prevalence in Japanese children
    Seiichi Kato
    Department of Pediatrics, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, 980 8574 Sendai, Japan
    J Gastroenterol 38:1126-30. 2003
    ..The purpose of this study was to test the hypothesis that these two microorganisms have a common mode of transmission...
  42. ncbi request reprint [Management of adverse reactions caused by cancer chemotherapy in elderly patients]
    Hiroaki Okamoto
    Yokohama Municipal Citizen s Hospital
    Nihon Rinsho 61:1025-9. 2003
    ..New therapeutic strategies are clearly needed to prolong survival, and to improve quality of life in elderly patients with cancer...
  43. ncbi request reprint [An acute hepatitis case domestically infected with a hepatitis E virus whose nucleotide sequence showed a high similarity to that from a domestic swine in Japan]
    Yoshiaki Yajima
    Department of Gastroenterology, Sendai City Hospital
    Nihon Shokakibyo Gakkai Zasshi 100:454-8. 2003
  44. ncbi request reprint Characterization of Japanese swine and human hepatitis E virus isolates of genotype IV with 99 % identity over the entire genome
    Tsutomu Nishizawa
    Immunology Division and Division of Molecular Virology, Jichi Medical School, Tochigi Ken 329 0498, Japan
    J Gen Virol 84:1245-51. 2003
    ..8, 100 and 100 %, respectively. The high degree of genomic similarity observed between swine and human HEV isolates in a restricted area of Japan further supports the finding that sporadic hepatitis E in Japan is a zoonosis...
  45. ncbi request reprint Molecular investigation of hepatitis E virus infection in patients with acute hepatitis in Kathmandu, Nepal
    Santosh Man Shrestha
    Liver Foundation Nepal, Tripureswor, Kathmandu, Nepal
    J Med Virol 69:207-14. 2003
    ..These results suggest that a particular HEV 1c strain spread widely during the rainy season and was implicated in a small epidemic in the Kathmandu valley in August 1997...
  46. ncbi request reprint TT virus infection during childhood
    Hitoshi Ohto
    Division of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima City, Japan
    Transfusion 42:892-8. 2002
    ..TT virus (TTV) is widespread in the general population, however, the mode of its transmission and the mechanism of maintaining it in the general population are unclear...
  47. pmc Polyphyletic strains of hepatitis E virus are responsible for sporadic cases of acute hepatitis in Japan
    Hitoshi Mizuo
    Department of Internal Medicine, Kin ikyo chuo Hospital, Hokkaido 007 0870, Japan
    J Clin Microbiol 40:3209-18. 2002
    ..These results indicate that multiple genotypes of HEV cocirculate in Japan and contribute to the development of sporadic acute hepatitis, with the prevalence differing by age, sex, and geographic region...
  48. ncbi request reprint Identification of two distinct genotypes of hepatitis E virus in a Japanese patient with acute hepatitis who had not travelled abroad
    Masaharu Takahashi
    Immunology Division and Division of Molecular Virology, Jichi Medical School, Tochigi Ken 329 0498, Japan
    J Gen Virol 83:1931-40. 2002
    ..1% nucleotide identity. These results indicate that multiple genotypes of HEV co-circulate in Japan, and that genotype IV comprises a remarkably heterogeneous group of HEVs...
  49. ncbi request reprint TT virus is distributed in various leukocyte subpopulations at distinct levels, with the highest viral load in granulocytes
    Masaharu Takahashi
    Immunology Division and Division of Molecular Virology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi Machi, Tochigi Ken 329 0498, Japan
    Biochem Biophys Res Commun 290:242-8. 2002
    ....
  50. ncbi request reprint [Genotyping of hepatitis C virus based on the full genome sequence]
    Hajime Tokita
    Department of Gastroenterology, National Tokyo Hospital
    Nihon Rinsho 62:70-5. 2004
  51. ncbi request reprint [Molecular biology of TTV]
    Hiroaki Okamoto
    Division of Virology, Department of Infection and Immunity, Jichi Medical School
    Nihon Rinsho 62:557-65. 2004
  52. ncbi request reprint Identification of tumor precursor cells in the brains of primates with radiation-induced de novo glioblastoma multiforme
    Irina A Lubensky
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Cycle 5:452-6. 2006
    ..The findings provide insight into the tumorigenesis of de novo GBMs and suggest a new strategy for treatment of these lethal tumors by targeting both inactivation of N-CoR and inhibition of EGFR...
  53. ncbi request reprint Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan
    Tsutomu Nishizawa
    Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi Ken 329 0498, Japan
    J Gen Virol 86:3321-6. 2005
    ..2+/-2.6 vs 85.9+/-2.2 %; P<0.0001). A proportion of wild boars in Japan are infected with markedly heterogeneous HEV strains that are indigenous to Japan and may serve as reservoirs of HEV...
  54. ncbi request reprint Individual adult human neurons display aneuploidy: detection by fluorescence in situ hybridization and single neuron PCR
    Svetlana D Pack
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Cell Cycle 4:1758-60. 2005
    ..The fact that neuronal stem cells can be identified in adult humans and that somatic mosaicism may be found in neuronal precursor cells deserves further investigation before using adult neural stem cells to treat human disease...
  55. ncbi request reprint Serological and molecular studies on subclinical hepatitis E virus infection using periodic serum samples obtained from healthy individuals
    Takehiro Mitsui
    Masuko Memorial Hospital and Masuko Institute for Medical Research, Aichi Ken, Japan
    J Med Virol 76:526-33. 2005
    ....
  56. ncbi request reprint Evolution in the hypervariable region of the hepatitis C virus in two infants infected by mother-to-infant transmission
    Tsutomu Ishii
    Department of Pediatrics, Fukushima Medical School of Medicine, Fukushima, Japan
    Pediatr Int 47:278-85. 2005
    ..The hypervariable region 1 (HVR1) of the HCV genome was investigated in two mother-infant pairs from birth to 7.6 and 10.2 years, respectively...
  57. ncbi request reprint Possible risk factors for the transmission of hepatitis E virus and for the severe form of hepatitis E acquired locally in Hokkaido, Japan
    Hitoshi Mizuo
    Department of Internal Medicine, Kin ikyo chuo Hospital, Sapporo, Hokkaido, Japan
    J Med Virol 76:341-9. 2005
    ....
  58. ncbi request reprint High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia
    Jun Inoue
    Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi ken, Japan
    J Med Virol 76:333-40. 2005
    ..The anti-HDV assay may be useful for further epidemiological studies on HDV infection in larger cohorts in urban and rural areas of Mongolia, where elucidation of the transmission route of HDV is required urgently...
  59. ncbi request reprint Risk factors for the development of hepatocellular carcinoma among patients with chronic hepatitis C who achieved a sustained virological response to interferon therapy
    Hajime Tokita
    Department of Gastroenterology, National Tokyo Hospital, Tokyo, Japan
    J Gastroenterol Hepatol 20:752-8. 2005
    ..The aim of the present study was to elucidate the risk factors for liver carcinogenesis among such patients...
  60. ncbi request reprint Characterization of seven genotypes (A to E, G and H) of hepatitis B virus recovered from Japanese patients infected with human immunodeficiency virus type 1
    Takao Shibayama
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    J Med Virol 76:24-32. 2005
    ..3%, 99.9%, and 98.5%, respectively, with reported HBV isolates of the same genotype. Most Japanese patients coinfected with HIV and HBV had HBV genotypes that are found rarely or had not been reported in Japan...
  61. ncbi request reprint Characterization of genotype H hepatitis B virus strain identified for the first time from a Japanese blood donor by nucleic acid amplification test
    Hitoshi Ohnuma
    Saitama Red Cross Blood Center, 1370 12, Takahagi, Hidaka, Saitama ken 350 1213, Japan
    J Gen Virol 86:595-9. 2005
    ..3 % homology with the strain from Los Angeles, USA (LSA2523). Here, a leucine zipper motif was found in the region of the HBV surface antigen conserved through genotypes A-H...
  62. ncbi request reprint Molecular investigation of interspousal transmission of hepatitis C virus in two Japanese patients who acquired acute hepatitis C after 40 or 42 years of marriage
    Haruo Nakayama
    Department of Internal Medicine, Iwaki Kyoritsu General Hospital, Fukushima Ken, Japan
    J Med Virol 75:258-66. 2005
    ..This study indicates that two Japanese patients with acute hepatitis C had acquired HCV infection most probably by interspousal sexual transmission during a long-lasting marriage...
  63. ncbi request reprint High TT virus load as an independent factor associated with the occurrence of hepatocellular carcinoma among patients with hepatitis C virus-related chronic liver disease
    Hajime Tokita
    Department of Gastroenterology, National Tokyo Hospital, Japan
    J Med Virol 67:501-9. 2002
    ....