Research Topics
Genomes and Genes
Species | Yoshihiko KitajimaSummaryAffiliation: Saga University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancerYoshihiko Kitajima
Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
Oncol Rep 19:197-202. 2008..When a persistent infection by H. pylori continues in the middle/lower stomach for a long period, Runx3 methylation may be induced and the subsequent loss of Runx3 expression may therefore affect gastric carcinogenesis...- Ribonucleotide reductase subunit M1 is a possible chemoresistance marker to gemcitabine in biliary tract carcinomaKazuma Ohtaka
Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
Oncol Rep 20:279-86. 2008..In conclusion, RRM1 may be one of the key marker molecules for GEM chemotherapy that overcomes advanced and recurrent biliary tract carcinoma... - Ribonucleotide reductase subunit M1 assessed by quantitative double-fluorescence immunohistochemistry predicts the efficacy of gemcitabine in biliary tract carcinomaJun Nakamura
Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
Int J Oncol 37:845-52. 2010..Furthermore, qDFIHC is a useful method for the assessment of RRM1 protein, in order to design a tailor-made chemotherapeutic regimen for BTC patients... 
HIF-1alpha is an unfavorable determinant of relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-FU chemotherapyJun Nakamura
Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
Int J Cancer 127:1158-71. 2010....- Aberrant gene methylation in the lymph nodes provides a possible marker for diagnosing micrometastasis in gastric cancerMasatsugu Hiraki
Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga, 849 8501, Japan
Ann Surg Oncol 17:1177-86. 2010..This study was designed to determine whether gene methylation is a novel diagnostic marker for micrometastasis to the lymph nodes (LNs) in gastric cancer... - Aberrant gene methylation is a biomarker for the detection of cancer cells in peritoneal wash samples from advanced gastric cancer patientsMasatsugu Hiraki
Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
Ann Surg Oncol 18:3013-9. 2011..To assess whether gene methylation in peritoneal fluid (PF) is clinically feasible for determining micrometastasis to the peritoneum in gastric cancer... - A quantitative evaluation of the determinant proteins for S-1 responsiveness in a biopsy specimen assists in patient selection to neoadjuvant therapy in cases of advanced gastric cancerKazuyoshi Hashiguchi
Department of Surgery, Faculty of Medicine, Saga University, Saga 849 8501, Japan
Int J Oncol 37:257-64. 2010..Effective therapy using tailored S-1 NAC according to the OPRT/TS ratio is therefore expected in advanced gastric cancer patients... 
Aberrant gene methylation in the peritoneal fluid is a risk factor predicting peritoneal recurrence in gastric cancerMasatsugu Hiraki
Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
World J Gastroenterol 16:330-8. 2010..To investigate whether gene methylation in the peritoneal fluid (PF) predicts peritoneal recurrence in gastric cancer patients...- Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancerTakao Ide
Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
Oncol Rep 19:1571-6. 2008..These data suggest that the hMLH1 mRNA quantitation in colorectal cancer cells may be helpful for evaluating the prognosis of CRC patients receiving 5-FU-based adjuvant chemotherapy after a surgical resection... - Tranilast strongly sensitizes pancreatic cancer cells to gemcitabine via decreasing protein expression of ribonucleotide reductase 1Mayumi Mitsuno
Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
Int J Oncol 36:341-9. 2010..In a future, a novel chemotherapeutic strategy by Gem along with tranilast might improve Gem efficacy against pancreatic cancer... - CpG island methylation of BNIP3 predicts resistance against S-1/CPT-11 combined therapy in colorectal cancer patientsMasatsugu Hiraki
Department of Surgery, Saga University Faculty of Medicine, Nabeshima, Saga, Japan
Oncol Rep 23:191-7. 2010..466, P=0.021). In conclusion, BNIP3 gene methylation is a possible marker predicting a poor response to the S-1/CPT-11 combined therapy in colorectal cancer... - Aberrant methylation of p16 predicts candidates for 5-fluorouracil-based adjuvant therapy in gastric cancer patientsMayumi Mitsuno
Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
J Gastroenterol 42:866-73. 2007..The present study was designed to determine whether DNA methylation in six cancer-related genes affects recurrence of gastric cancer in patients who received 5-fluorouracil-based adjuvant chemotherapy... - Hypoxia-inducible factor-1alpha expression predicts the response to 5-fluorouracil-based adjuvant chemotherapy in advanced gastric cancerJun Nakamura
Department of Surgery, Saga University Faculty of Medicine, Nabeshima, Saga 849 8501, Japan
Oncol Rep 22:693-9. 2009..In conclusion, the assessment of the HIF-1alpha expression in the resected tissues might predict the drug response to adjuvant 5-FU chemotherapy in advanced gastric cancer patients... - The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signalingTakao Ide
Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
Ann Surg Oncol 14:2600-7. 2007..We previously demonstrated that tumor-stromal interaction under hypoxia enhances the invasiveness of pancreatic cancer cells through hepatocyte growth factor (HGF)/c-Met signaling... - Clinical significance of CEA and CA19-9 in postoperative follow-up of colorectal cancerTomomi Yakabe
Faculty of Medicine, Department of Surgery, Saga University, Saga, Japan
Ann Surg Oncol 17:2349-56. 2010..We evaluated the efficiency of CEA and CA19-9 as tools for diagnosing recurrence in the postoperative surveillance of colorectal cancer... - Different roles of tumor marker monitoring after curative resections of gastric and colorectal cancersTakao Ohtsuka
Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
Dig Dis Sci 53:1537-43. 2008..Surgeons and oncologists should thus be aware that the role of the tumor marker monitoring after a curative operation differs between patients with gastric and colorectal cancers... - The effect of o6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair gene (hMLH1) status on the sensitivity to alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea(ACNU) in gallbladder carcinoma cellsKen Sato
Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
Anticancer Res 25:4021-8. 2005..ACNU might be a useful chemotherapeutic agent for MGMT- gallbladder carcinoma, which is associated with poor patient outcome... - CPT-11 (SN-38) chemotherapy may be selectively applicable to biliary tract cancer with low hMLH1 expressionKen Sato
Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
Anticancer Res 27:865-72. 2007..In conclusion, a low expression of hMLH1 in biliary tract cancer may aid in predicting its responsiveness to CPT-11 (SN38)... - Comparison of multivisceral resection and standard operation for locally advanced colorectal cancer: analysis of prognostic factors for short-term and long-term outcomeYuji Nakafusa
Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
Dis Colon Rectum 47:2055-63. 2004..The aim of the present study is to clarify the characteristics of multivisceral resection and to discuss strategies for improving the overall outcome of multivisceral resection for locally advanced colorectal cancer... - Deficient MGMT and proficient hMLH1 expression renders gallbladder carcinoma cells sensitive to alkylating agents through G2-M cell cycle arrestKen Sato
Department of Surgery, Saga University Faculty of Medicine, Saga 849-8501, Japan
Int J Oncol 26:1653-61. 2005..These results indicated that expression of MGMT and hMLH1 could be used to select candidates for alkylating agent chemotherapy against gallbladder carcinoma... - Second-line chemotherapy with paclitaxel and doxifluridine after failure of S-1 in elderly patients with unresectable advanced or recurrent gastric cancerTomomi Yakabe
Department of Surgery, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga, 849 8501, Japan
J Cancer Res Clin Oncol 137:1499-504. 2011..The aim of this study was to identify the benefits of the second-line paclitaxel (PTX) plus doxifluridine (5'-DFUR) regimen for URGC in elderly patients in comparison to nonelderly patients... - Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancerYoshihiko Kitajima
Department of Surgery, Saga University Faculty of Medicine, Saga, B49 8501 Japan
Cancer Sci 99:1341-7. 2008..HGF/HGFA/c-Met recruited between cancer-stromal fibroblasts is activated under hypoxic conditions and therefore might play a central role in the aggressive invasion of pancreatic cancer... - Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancerJun Nakamura
Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
Am J Pathol 178:515-24. 2011..Furthermore, epigenetic alterations in CA9 differ between the intestinal and diffuse types of gastric cancer... - Loss of estrogen receptor beta expression at cancer front correlates with tumor progression and poor prognosis of gallbladder cancerKenji Sumi
Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
Oncol Rep 12:979-84. 2004..In conclusion, evaluation of ERbeta expression at cancer front may be an important factor in identifying a highly malignant group of gallbladder carcinoma... - Aberrant promoter hypermethylation in biliary tract carcinomaNaohiko Kohya
Department of Surgery, Saga University Faculty of Medicine, 5-1-1 Nabeshima, Saga, 849-8501, Japan
J Hepatobiliary Pancreat Surg 13:296-305. 2006..In this review, we summarize recent data on gene silencing by promoter hypermethylation, and we discuss the implications for biliary tract carcinomas... - Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancersYasuo Koga
Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
Ann Surg Oncol 12:354-63. 2005..The purpose of this study was to clarify how MGMT deficiency leads to a poor outcome in biliary tract cancer. Thus, we examined epigenetic (promoter methylation) and genetic (gene mutation) alterations in biliary tract cancer... - False-positive findings for tumor markers after curative gastrectomy for gastric cancerTakao Ohtsuka
Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
Dig Dis Sci 53:73-9. 2008..Surgeons and oncologists should therefore keep in mind the high frequency of false-positive findings for tumor markers after curative gastrectomy for gastric cancer... - Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathwayTakao Ide
Department of Surgery, Faculty of Medicine, Saga University, Saga, Japan
Int J Cancer 119:2750-9. 2006..These results indicate that the hypoxic environment within stromal as well as cancer cells activates the HGF/c-Met system, thereby contributing to the aggressive invasive features of pancreatic cancer... - The significance of aberrant CHFR methylation for clinical response to microtubule inhibitors in gastric cancerYasuo Koga
Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5-1-1, Saga 849-8501, Japan
J Gastroenterol 41:133-9. 2006..CONCLUSIONS: These observations indicated that CHFR methylation may be a clinically useful approach to predict the responsiveness of gastric cancers to treatment with MI... - Immunohistochemical and molecular genetic analyses of multiple sporadic gastrointestinal stromal tumorsMasatsugu Hiraki
Masatsugu Hiraki, Yoshihiko Kitajima, Takao Ohtsuka, Shuusuke Miyake, Yasuo Koga, Hirokazu Noshiro, Kohji Miyazaki, Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
World J Gastrointest Oncol 2:364-8. 2010..Although the patient did not receive any adjuvant chemotherapy, there has been no sign of recurrence over the 3 years since the surgery... - Quantitative double-fluorescence immunohistochemistry (qDFIHC), a novel technology to assess protein expression: a pilot study analyzing 5-FU sensitive markers thymidylate synthase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferases iKeita Kai
Department of Surgery, Saga University, Faculty of Medicine, 5 1 1, Nabeshima, Saga City, Saga, Japan
Cancer Lett 258:45-54. 2007..Therefore, the ratios assessed by qDFIHC may be a potentially effective predictor of the S-1 efficacy. Furthermore, qDFIHC may also be a useful method for assessing various protein levels in cancer tissues... - Cisplatin represses transcriptional activity from the minimal promoter of the O6-methylguanine methyltransferase gene and increases sensitivity of human gallbladder cancer cells to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-2-chloroethyl)-3-nitrosoureaKen Sato
Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
Oncol Rep 13:899-906. 2005..The 59 bp region in the MGMT promoter was crucial for repression by cisplatin. These results might form the basis of a chemotherapeutic strategy involving alkylating agents via prior cisplatin-induced biochemical modulation... - Deficient expression of the DPD gene is caused by epigenetic modification in biliary tract cancer cells, and induces high sensitivity to 5-FU treatmentKen Sato
Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
Int J Oncol 29:429-35. 2006..Furthermore, epigenetic gene silencing appears to be an important mechanism of DPD suppression in biliary tract cancer... - Infectious complications after gastric cancer surgery accelerate a rapid hepatic recurrenceTakao Ohtsuka
Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
Hepatogastroenterology 56:1277-80. 2009..Rapid hepatic recurrence is sometimes experienced after gastric or pancreatobiliary cancer surgery. The aim of this study was to investigate the risk factors for the timing of hepatic recurrence... - Phase I/II study of combination therapy with S-1 and CPT-11 for metastatic colorectal cancerYuji Nakafusa
Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
Mol Med Report 1:925-30. 2008..These data suggest that assessing this combination therapy in a Phase III study would be worthwhile... - Allelic loss of the DNA repair gene OGG1 against oxidative damage in esophageal squamous cell carcinomaAtsushi Hagiwara
Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
Oncol Rep 13:1009-16. 2005..Thus, OGG1 allelic loss is related to carcinogenesis by oxidative stress rather than cancer progression in esophageal cancer... - Loss of expression of DNA repair enzymes MGMT, hMLH1, and hMSH2 during tumor progression in gastric cancerYoshihiko Kitajima
Department of Surgery, Saga Medical School, 5-1-1 Nabeshima, Saga 849-0937, Japan
Gastric Cancer 6:86-95. 2003..On the other hand, in undifferentiated-type cancer, loss of MGMT and the MMR proteins appears to be an important event at carcinogenesis or at an earlier step of tumor progression... - Modification of lymph node dissection for colon cancer by clinical diagnosisYuji Nakafusa
Department of Surgery, Saga Medical School, Saga, Japan
Hepatogastroenterology 51:722-6. 2004..The aim of the present study is to establish oncologically safe criteria for modifying lymph node dissection for colon cancer by clinical diagnosis... - Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancerTetsuji Nakagawachi
Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
Oncogene 22:8835-44. 2003..Furthermore, MeCP2 preferentially bound to the CpG-methylated island in the MGMT negative line. Given these results, we propose a model for gene silencing of MGMT that is dependent on the epigenetic state in cancer... - Role of ASC in hypoxia-mediated cell death in pancreatic cancerTakao Ohtsuka
Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
Mol Med Report 1:827-31. 2008..Our data demonstrate the possible mechanism of chemoresistance under hypoxia in pancreatic cancer cells, thereby suggesting the potential use of ASC as a new treatment strategy for pancreatic cancer... - Gallbladder cancers rarely overexpress HER-2/neu, demonstrated by Hercep testSatoru Matsuyama
Department of Surgery, Faculty of Medicine, Saga University, Saga City, Saga 849 8501, Japan
Oncol Rep 11:815-9. 2004..Our study implied that Trastzumab may not contribute to improvement in treatment of gallbladder cancer. However, there may be a therapeutic possibility for cases with lymph node recurrence overexpressing c-erbB-2... - Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancersTakashi Kakimoto
Department of Internal Medicine, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
Oncol Rep 26:1385-92. 2011..PDCD4 expression was correlated with β-catenin expression in gastric carcinoma cell lines, but not with E-cadherin, as the binding partner in the cell membrane... - Effects of E-cadherin transfection on gene expression of a gallbladder carcinoma cell line: repression of MTS1/S100A4 gene expressionNaohiko Kohya
Department of Surgery, Saga Medical School, Saga, Japan
Int J Cancer 104:44-53. 2003..Loss of E-cadherin expression followed by expression of the mts1 gene may be an important event for increasing cell proliferation, motility and invasion activity in the progression of GB cancer... - Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinomaNaohiko Kohya
Department of Surgery, Saga Medical School, Saga, Japan
Ann Surg Oncol 9:371-9. 2002..The O(6)-methyl G:T mismatch is recognized by the mismatch-repair (MMR) pathway. The biliary duct is highly exposed to alkylating agents because of its anatomical location... - Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancerHidenobu Soejima
Department of Biomolecular Sciences, Division of Molecular Biology and Genetics, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501 Japan
Oncogene 23:4380-8. 2004....