Yoshihiko Kitajima

Summary

Affiliation: Saga University
Country: Japan

Publications

  1. ncbi request reprint Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancer
    Yoshihiko Kitajima
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Oncol Rep 19:197-202. 2008
  2. ncbi request reprint Ribonucleotide reductase subunit M1 is a possible chemoresistance marker to gemcitabine in biliary tract carcinoma
    Kazuma Ohtaka
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Oncol Rep 20:279-86. 2008
  3. ncbi request reprint Ribonucleotide reductase subunit M1 assessed by quantitative double-fluorescence immunohistochemistry predicts the efficacy of gemcitabine in biliary tract carcinoma
    Jun Nakamura
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 37:845-52. 2010
  4. doi request reprint Aberrant gene methylation in the lymph nodes provides a possible marker for diagnosing micrometastasis in gastric cancer
    Masatsugu Hiraki
    Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga, 849 8501, Japan
    Ann Surg Oncol 17:1177-86. 2010
  5. doi request reprint HIF-1alpha is an unfavorable determinant of relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-FU chemotherapy
    Jun Nakamura
    Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Int J Cancer 127:1158-71. 2010
  6. doi request reprint Aberrant gene methylation is a biomarker for the detection of cancer cells in peritoneal wash samples from advanced gastric cancer patients
    Masatsugu Hiraki
    Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
    Ann Surg Oncol 18:3013-9. 2011
  7. ncbi request reprint A quantitative evaluation of the determinant proteins for S-1 responsiveness in a biopsy specimen assists in patient selection to neoadjuvant therapy in cases of advanced gastric cancer
    Kazuyoshi Hashiguchi
    Department of Surgery, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Int J Oncol 37:257-64. 2010
  8. pmc Aberrant gene methylation in the peritoneal fluid is a risk factor predicting peritoneal recurrence in gastric cancer
    Masatsugu Hiraki
    Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    World J Gastroenterol 16:330-8. 2010
  9. ncbi request reprint Tranilast strongly sensitizes pancreatic cancer cells to gemcitabine via decreasing protein expression of ribonucleotide reductase 1
    Mayumi Mitsuno
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 36:341-9. 2010
  10. ncbi request reprint Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer
    Takao Ide
    Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
    Oncol Rep 19:1571-6. 2008

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancer
    Yoshihiko Kitajima
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Oncol Rep 19:197-202. 2008
    ..When a persistent infection by H. pylori continues in the middle/lower stomach for a long period, Runx3 methylation may be induced and the subsequent loss of Runx3 expression may therefore affect gastric carcinogenesis...
  2. ncbi request reprint Ribonucleotide reductase subunit M1 is a possible chemoresistance marker to gemcitabine in biliary tract carcinoma
    Kazuma Ohtaka
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Oncol Rep 20:279-86. 2008
    ..In conclusion, RRM1 may be one of the key marker molecules for GEM chemotherapy that overcomes advanced and recurrent biliary tract carcinoma...
  3. ncbi request reprint Ribonucleotide reductase subunit M1 assessed by quantitative double-fluorescence immunohistochemistry predicts the efficacy of gemcitabine in biliary tract carcinoma
    Jun Nakamura
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 37:845-52. 2010
    ..Furthermore, qDFIHC is a useful method for the assessment of RRM1 protein, in order to design a tailor-made chemotherapeutic regimen for BTC patients...
  4. doi request reprint Aberrant gene methylation in the lymph nodes provides a possible marker for diagnosing micrometastasis in gastric cancer
    Masatsugu Hiraki
    Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga, 849 8501, Japan
    Ann Surg Oncol 17:1177-86. 2010
    ..This study was designed to determine whether gene methylation is a novel diagnostic marker for micrometastasis to the lymph nodes (LNs) in gastric cancer...
  5. doi request reprint HIF-1alpha is an unfavorable determinant of relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-FU chemotherapy
    Jun Nakamura
    Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Int J Cancer 127:1158-71. 2010
    ....
  6. doi request reprint Aberrant gene methylation is a biomarker for the detection of cancer cells in peritoneal wash samples from advanced gastric cancer patients
    Masatsugu Hiraki
    Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
    Ann Surg Oncol 18:3013-9. 2011
    ..To assess whether gene methylation in peritoneal fluid (PF) is clinically feasible for determining micrometastasis to the peritoneum in gastric cancer...
  7. ncbi request reprint A quantitative evaluation of the determinant proteins for S-1 responsiveness in a biopsy specimen assists in patient selection to neoadjuvant therapy in cases of advanced gastric cancer
    Kazuyoshi Hashiguchi
    Department of Surgery, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Int J Oncol 37:257-64. 2010
    ..Effective therapy using tailored S-1 NAC according to the OPRT/TS ratio is therefore expected in advanced gastric cancer patients...
  8. pmc Aberrant gene methylation in the peritoneal fluid is a risk factor predicting peritoneal recurrence in gastric cancer
    Masatsugu Hiraki
    Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    World J Gastroenterol 16:330-8. 2010
    ..To investigate whether gene methylation in the peritoneal fluid (PF) predicts peritoneal recurrence in gastric cancer patients...
  9. ncbi request reprint Tranilast strongly sensitizes pancreatic cancer cells to gemcitabine via decreasing protein expression of ribonucleotide reductase 1
    Mayumi Mitsuno
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 36:341-9. 2010
    ..In a future, a novel chemotherapeutic strategy by Gem along with tranilast might improve Gem efficacy against pancreatic cancer...
  10. ncbi request reprint Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer
    Takao Ide
    Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
    Oncol Rep 19:1571-6. 2008
    ..These data suggest that the hMLH1 mRNA quantitation in colorectal cancer cells may be helpful for evaluating the prognosis of CRC patients receiving 5-FU-based adjuvant chemotherapy after a surgical resection...
  11. ncbi request reprint CpG island methylation of BNIP3 predicts resistance against S-1/CPT-11 combined therapy in colorectal cancer patients
    Masatsugu Hiraki
    Department of Surgery, Saga University Faculty of Medicine, Nabeshima, Saga, Japan
    Oncol Rep 23:191-7. 2010
    ..466, P=0.021). In conclusion, BNIP3 gene methylation is a possible marker predicting a poor response to the S-1/CPT-11 combined therapy in colorectal cancer...
  12. ncbi request reprint Aberrant methylation of p16 predicts candidates for 5-fluorouracil-based adjuvant therapy in gastric cancer patients
    Mayumi Mitsuno
    Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    J Gastroenterol 42:866-73. 2007
    ..The present study was designed to determine whether DNA methylation in six cancer-related genes affects recurrence of gastric cancer in patients who received 5-fluorouracil-based adjuvant chemotherapy...
  13. doi request reprint Loss of trefoil factor 1 is regulated by DNA methylation and is an independent predictive factor for poor survival in advanced gastric cancer
    Tomokazu Tanaka
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 42:894-902. 2013
    ..The expression and̸or methylation status of TFF1 may, therefore, serve as a useful biomarker for predicting survival in patients with advanced gastric cancer...
  14. ncbi request reprint Hypoxia-inducible factor-1alpha expression predicts the response to 5-fluorouracil-based adjuvant chemotherapy in advanced gastric cancer
    Jun Nakamura
    Department of Surgery, Saga University Faculty of Medicine, Nabeshima, Saga 849 8501, Japan
    Oncol Rep 22:693-9. 2009
    ..In conclusion, the assessment of the HIF-1alpha expression in the resected tissues might predict the drug response to adjuvant 5-FU chemotherapy in advanced gastric cancer patients...
  15. ncbi request reprint The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling
    Takao Ide
    Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
    Ann Surg Oncol 14:2600-7. 2007
    ..We previously demonstrated that tumor-stromal interaction under hypoxia enhances the invasiveness of pancreatic cancer cells through hepatocyte growth factor (HGF)/c-Met signaling...
  16. ncbi request reprint HIF-1α is a crucial factor in the development of peritoneal dissemination via natural metastatic routes in scirrhous gastric cancer
    Shuusuke Miyake
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 43:1431-40. 2013
    ..i. mice were formed via extravasation of cancer cells. We provide a possible mechanism in which peritoneal dissemination of gastric cancer develops via a vascular network whereby HIF-1α activates tumor angiogenesis...
  17. doi request reprint Clinical significance of CEA and CA19-9 in postoperative follow-up of colorectal cancer
    Tomomi Yakabe
    Faculty of Medicine, Department of Surgery, Saga University, Saga, Japan
    Ann Surg Oncol 17:2349-56. 2010
    ..We evaluated the efficiency of CEA and CA19-9 as tools for diagnosing recurrence in the postoperative surveillance of colorectal cancer...
  18. ncbi request reprint CPT-11 (SN-38) chemotherapy may be selectively applicable to biliary tract cancer with low hMLH1 expression
    Ken Sato
    Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
    Anticancer Res 27:865-72. 2007
    ..In conclusion, a low expression of hMLH1 in biliary tract cancer may aid in predicting its responsiveness to CPT-11 (SN38)...
  19. ncbi request reprint The effect of o6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair gene (hMLH1) status on the sensitivity to alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea(ACNU) in gallbladder carcinoma cells
    Ken Sato
    Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
    Anticancer Res 25:4021-8. 2005
    ..ACNU might be a useful chemotherapeutic agent for MGMT- gallbladder carcinoma, which is associated with poor patient outcome...
  20. ncbi request reprint Different roles of tumor marker monitoring after curative resections of gastric and colorectal cancers
    Takao Ohtsuka
    Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Dig Dis Sci 53:1537-43. 2008
    ..Surgeons and oncologists should thus be aware that the role of the tumor marker monitoring after a curative operation differs between patients with gastric and colorectal cancers...
  21. ncbi request reprint Aberrant promoter hypermethylation in biliary tract carcinoma
    Naohiko Kohya
    Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga, 849 8501, Japan
    J Hepatobiliary Pancreat Surg 13:296-305. 2006
    ..In this review, we summarize recent data on gene silencing by promoter hypermethylation, and we discuss the implications for biliary tract carcinomas...
  22. ncbi request reprint Deficient MGMT and proficient hMLH1 expression renders gallbladder carcinoma cells sensitive to alkylating agents through G2-M cell cycle arrest
    Ken Sato
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 26:1653-61. 2005
    ..These results indicated that expression of MGMT and hMLH1 could be used to select candidates for alkylating agent chemotherapy against gallbladder carcinoma...
  23. ncbi request reprint Comparison of multivisceral resection and standard operation for locally advanced colorectal cancer: analysis of prognostic factors for short-term and long-term outcome
    Yuji Nakafusa
    Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
    Dis Colon Rectum 47:2055-63. 2004
    ..The aim of the present study is to clarify the characteristics of multivisceral resection and to discuss strategies for improving the overall outcome of multivisceral resection for locally advanced colorectal cancer...
  24. ncbi request reprint Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancers
    Yasuo Koga
    Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
    Ann Surg Oncol 12:354-63. 2005
    ..The purpose of this study was to clarify how MGMT deficiency leads to a poor outcome in biliary tract cancer. Thus, we examined epigenetic (promoter methylation) and genetic (gene mutation) alterations in biliary tract cancer...
  25. doi request reprint Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer
    Yoshihiko Kitajima
    Department of Surgery, Saga University Faculty of Medicine, Saga, B49 8501 Japan
    Cancer Sci 99:1341-7. 2008
    ..HGF/HGFA/c-Met recruited between cancer-stromal fibroblasts is activated under hypoxic conditions and therefore might play a central role in the aggressive invasion of pancreatic cancer...
  26. doi request reprint Second-line chemotherapy with paclitaxel and doxifluridine after failure of S-1 in elderly patients with unresectable advanced or recurrent gastric cancer
    Tomomi Yakabe
    Department of Surgery, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga, 849 8501, Japan
    J Cancer Res Clin Oncol 137:1499-504. 2011
    ..The aim of this study was to identify the benefits of the second-line paclitaxel (PTX) plus doxifluridine (5'-DFUR) regimen for URGC in elderly patients in comparison to nonelderly patients...
  27. pmc Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer
    Jun Nakamura
    Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
    Am J Pathol 178:515-24. 2011
    ..Furthermore, epigenetic alterations in CA9 differ between the intestinal and diffuse types of gastric cancer...
  28. ncbi request reprint Loss of estrogen receptor beta expression at cancer front correlates with tumor progression and poor prognosis of gallbladder cancer
    Kenji Sumi
    Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
    Oncol Rep 12:979-84. 2004
    ..In conclusion, evaluation of ERbeta expression at cancer front may be an important factor in identifying a highly malignant group of gallbladder carcinoma...
  29. ncbi request reprint Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway
    Takao Ide
    Department of Surgery, Faculty of Medicine, Saga University, Saga, Japan
    Int J Cancer 119:2750-9. 2006
    ..These results indicate that the hypoxic environment within stromal as well as cancer cells activates the HGF/c-Met system, thereby contributing to the aggressive invasive features of pancreatic cancer...
  30. ncbi request reprint The significance of aberrant CHFR methylation for clinical response to microtubule inhibitors in gastric cancer
    Yasuo Koga
    Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
    J Gastroenterol 41:133-9. 2006
    ..We studied the correlations between CHFR (checkpoint with FHA and RING finger) gene methylation and responses to microtubule inhibitors (MI) in gastric cancer...
  31. ncbi request reprint False-positive findings for tumor markers after curative gastrectomy for gastric cancer
    Takao Ohtsuka
    Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
    Dig Dis Sci 53:73-9. 2008
    ..Surgeons and oncologists should therefore keep in mind the high frequency of false-positive findings for tumor markers after curative gastrectomy for gastric cancer...
  32. ncbi request reprint Quantitative double-fluorescence immunohistochemistry (qDFIHC), a novel technology to assess protein expression: a pilot study analyzing 5-FU sensitive markers thymidylate synthase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferases i
    Keita Kai
    Department of Surgery, Saga University, Faculty of Medicine, 5 1 1, Nabeshima, Saga City, Saga, Japan
    Cancer Lett 258:45-54. 2007
    ..Therefore, the ratios assessed by qDFIHC may be a potentially effective predictor of the S-1 efficacy. Furthermore, qDFIHC may also be a useful method for assessing various protein levels in cancer tissues...
  33. ncbi request reprint Cisplatin represses transcriptional activity from the minimal promoter of the O6-methylguanine methyltransferase gene and increases sensitivity of human gallbladder cancer cells to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-2-chloroethyl)-3-nitrosourea
    Ken Sato
    Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
    Oncol Rep 13:899-906. 2005
    ..The 59 bp region in the MGMT promoter was crucial for repression by cisplatin. These results might form the basis of a chemotherapeutic strategy involving alkylating agents via prior cisplatin-induced biochemical modulation...
  34. pmc Immunohistochemical and molecular genetic analyses of multiple sporadic gastrointestinal stromal tumors
    Masatsugu Hiraki
    Masatsugu Hiraki, Yoshihiko Kitajima, Takao Ohtsuka, Shuusuke Miyake, Yasuo Koga, Hirokazu Noshiro, Kohji Miyazaki, Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    World J Gastrointest Oncol 2:364-8. 2010
    ..Although the patient did not receive any adjuvant chemotherapy, there has been no sign of recurrence over the 3 years since the surgery...
  35. doi request reprint Phase I/II study of combination therapy with S-1 and CPT-11 for metastatic colorectal cancer
    Yuji Nakafusa
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Mol Med Report 1:925-30. 2008
    ..These data suggest that assessing this combination therapy in a Phase III study would be worthwhile...
  36. ncbi request reprint Deficient expression of the DPD gene is caused by epigenetic modification in biliary tract cancer cells, and induces high sensitivity to 5-FU treatment
    Ken Sato
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 29:429-35. 2006
    ..Furthermore, epigenetic gene silencing appears to be an important mechanism of DPD suppression in biliary tract cancer...
  37. ncbi request reprint Infectious complications after gastric cancer surgery accelerate a rapid hepatic recurrence
    Takao Ohtsuka
    Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
    Hepatogastroenterology 56:1277-80. 2009
    ..Rapid hepatic recurrence is sometimes experienced after gastric or pancreatobiliary cancer surgery. The aim of this study was to investigate the risk factors for the timing of hepatic recurrence...
  38. ncbi request reprint Loss of expression of DNA repair enzymes MGMT, hMLH1, and hMSH2 during tumor progression in gastric cancer
    Yoshihiko Kitajima
    Department of Surgery, Saga Medical School, 5 1 1 Nabeshima, Saga 849 0937, Japan
    Gastric Cancer 6:86-95. 2003
    ..Disorders of the DNA repair system that protects against alkylating mutagens are known to play an important role in carcinogenesis...
  39. ncbi request reprint Allelic loss of the DNA repair gene OGG1 against oxidative damage in esophageal squamous cell carcinoma
    Atsushi Hagiwara
    Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
    Oncol Rep 13:1009-16. 2005
    ..Thus, OGG1 allelic loss is related to carcinogenesis by oxidative stress rather than cancer progression in esophageal cancer...
  40. ncbi request reprint Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer
    Tetsuji Nakagawachi
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Oncogene 22:8835-44. 2003
    ..Furthermore, MeCP2 preferentially bound to the CpG-methylated island in the MGMT negative line. Given these results, we propose a model for gene silencing of MGMT that is dependent on the epigenetic state in cancer...
  41. ncbi request reprint Gallbladder cancers rarely overexpress HER-2/neu, demonstrated by Hercep test
    Satoru Matsuyama
    Department of Surgery, Faculty of Medicine, Saga University, Saga City, Saga 849 8501, Japan
    Oncol Rep 11:815-9. 2004
    ..Our study implied that Trastzumab may not contribute to improvement in treatment of gallbladder cancer. However, there may be a therapeutic possibility for cases with lymph node recurrence overexpressing c-erbB-2...
  42. ncbi request reprint Modification of lymph node dissection for colon cancer by clinical diagnosis
    Yuji Nakafusa
    Department of Surgery, Saga Medical School, Saga, Japan
    Hepatogastroenterology 51:722-6. 2004
    ..The aim of the present study is to establish oncologically safe criteria for modifying lymph node dissection for colon cancer by clinical diagnosis...
  43. doi request reprint Role of ASC in hypoxia-mediated cell death in pancreatic cancer
    Takao Ohtsuka
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Mol Med Report 1:827-31. 2008
    ..Our data demonstrate the possible mechanism of chemoresistance under hypoxia in pancreatic cancer cells, thereby suggesting the potential use of ASC as a new treatment strategy for pancreatic cancer...
  44. doi request reprint Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers
    Takashi Kakimoto
    Department of Internal Medicine, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Oncol Rep 26:1385-92. 2011
    ..PDCD4 expression was correlated with β-catenin expression in gastric carcinoma cell lines, but not with E-cadherin, as the binding partner in the cell membrane...
  45. ncbi request reprint Effects of E-cadherin transfection on gene expression of a gallbladder carcinoma cell line: repression of MTS1/S100A4 gene expression
    Naohiko Kohya
    Department of Surgery, Saga Medical School, Saga, Japan
    Int J Cancer 104:44-53. 2003
    ..Loss of E-cadherin expression followed by expression of the mts1 gene may be an important event for increasing cell proliferation, motility and invasion activity in the progression of GB cancer...
  46. ncbi request reprint Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma
    Naohiko Kohya
    Department of Surgery, Saga Medical School, Saga, Japan
    Ann Surg Oncol 9:371-9. 2002
    ..The O(6)-methyl G:T mismatch is recognized by the mismatch-repair (MMR) pathway. The biliary duct is highly exposed to alkylating agents because of its anatomical location...
  47. ncbi request reprint Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer
    Hidenobu Soejima
    Department of Biomolecular Sciences, Division of Molecular Biology and Genetics, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501 Japan
    Oncogene 23:4380-8. 2004
    ....