Keita Kai

Summary

Affiliation: Saga University
Country: Japan

Publications

  1. doi request reprint Actual status of clinical diagnosis in patients with primary gallbladder cancer associated with adenomyomatosis
    Keita Kai
    Department of Pathology and Microbiology, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga City, Saga, 849 8501, Japan
    Indian J Gastroenterol 32:386-91. 2013
  2. doi request reprint Hepatoid carcinoma of the pancreas penetrating into the gastric cavity: a case report and literature review
    Keita Kai
    Department of Pathology and Microbiology, Saga University Faculty of Medicine, Saga, Japan
    Pathol Int 62:485-90. 2012
  3. doi request reprint A case of unclassified multicystic biliary tumor with biliary adenofibroma features
    Keita Kai
    Department of Pathology and Microbiology, Saga University Faculty of Medicine, Saga, Japan
    Pathol Int 62:506-10. 2012
  4. doi request reprint Clinicopathologic features of advanced gallbladder cancer associated with adenomyomatosis
    Keita Kai
    Department of Pathology and Microbiology, Faculty of Medicine, Saga University, Nabesima 5 1 1, Saga City, Saga 849 8501, Japan
    Virchows Arch 459:573-80. 2011
  5. doi request reprint Active neovascularization and possible vascular-centric development of gastric and periscapular elastofibromas
    Keita Kai
    Department of Pathology and Biodefense, Saga University Faculty of Medicine, Nabesima 5 1 1, Saga City, Saga, 849 8501, Japan
    Virchows Arch 454:181-8. 2009
  6. doi request reprint Tumor budding and dedifferentiation in gallbladder carcinoma: potential for the prognostic factors in T2 lesions
    Keita Kai
    Department of Pathology and Microbiology, Faculty of Medicine, Saga University, Nabesima 5 1 1, Saga City, Saga, 849 8501, Japan
    Virchows Arch 459:449-56. 2011
  7. doi request reprint HIF-1alpha is an unfavorable determinant of relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-FU chemotherapy
    Jun Nakamura
    Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Int J Cancer 127:1158-71. 2010
  8. ncbi request reprint A quantitative evaluation of the determinant proteins for S-1 responsiveness in a biopsy specimen assists in patient selection to neoadjuvant therapy in cases of advanced gastric cancer
    Kazuyoshi Hashiguchi
    Department of Surgery, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Int J Oncol 37:257-64. 2010
  9. ncbi request reprint Ribonucleotide reductase subunit M1 assessed by quantitative double-fluorescence immunohistochemistry predicts the efficacy of gemcitabine in biliary tract carcinoma
    Jun Nakamura
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 37:845-52. 2010
  10. doi request reprint Loss of trefoil factor 1 is regulated by DNA methylation and is an independent predictive factor for poor survival in advanced gastric cancer
    Tomokazu Tanaka
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 42:894-902. 2013

Collaborators

Detail Information

Publications27

  1. doi request reprint Actual status of clinical diagnosis in patients with primary gallbladder cancer associated with adenomyomatosis
    Keita Kai
    Department of Pathology and Microbiology, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga City, Saga, 849 8501, Japan
    Indian J Gastroenterol 32:386-91. 2013
    ..The purpose of this study was to reveal differences in clinical diagnosis of gallbladder cancer among patients with or without adenomyomatosis (ADM) by analyzing demonstrated tumor patterns on imaging and diagnostic opportunities...
  2. doi request reprint Hepatoid carcinoma of the pancreas penetrating into the gastric cavity: a case report and literature review
    Keita Kai
    Department of Pathology and Microbiology, Saga University Faculty of Medicine, Saga, Japan
    Pathol Int 62:485-90. 2012
    ..Given these findings and considerations, the tumor was finally diagnosed as poorly differentiated hepatoid carcinoma of the pancreas...
  3. doi request reprint A case of unclassified multicystic biliary tumor with biliary adenofibroma features
    Keita Kai
    Department of Pathology and Microbiology, Saga University Faculty of Medicine, Saga, Japan
    Pathol Int 62:506-10. 2012
    ..The tumor was finally diagnosed as unclassified multicystic biliary tumor with adenofibroma features...
  4. doi request reprint Clinicopathologic features of advanced gallbladder cancer associated with adenomyomatosis
    Keita Kai
    Department of Pathology and Microbiology, Faculty of Medicine, Saga University, Nabesima 5 1 1, Saga City, Saga 849 8501, Japan
    Virchows Arch 459:573-80. 2011
    ..Since preceding adenomyomatosis may prevent the early detection of gallbladder cancer, the usefulness of preventive cholecystectomy in cases of asymptomatic adenomyomatosis should be considered...
  5. doi request reprint Active neovascularization and possible vascular-centric development of gastric and periscapular elastofibromas
    Keita Kai
    Department of Pathology and Biodefense, Saga University Faculty of Medicine, Nabesima 5 1 1, Saga City, Saga, 849 8501, Japan
    Virchows Arch 454:181-8. 2009
    ..The percentage of the CD105-positive vessels in elastofibroma group was significantly higher than in the control group. This result indicates active neovascularization in elastofibromas...
  6. doi request reprint Tumor budding and dedifferentiation in gallbladder carcinoma: potential for the prognostic factors in T2 lesions
    Keita Kai
    Department of Pathology and Microbiology, Faculty of Medicine, Saga University, Nabesima 5 1 1, Saga City, Saga, 849 8501, Japan
    Virchows Arch 459:449-56. 2011
    ..Both DD and BD are frequently observed in GBC and reflect prognosis, particularly for T2 lesions. Therefore, the status of BD and DD should be taken into consideration in pathological reports on GBC...
  7. doi request reprint HIF-1alpha is an unfavorable determinant of relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-FU chemotherapy
    Jun Nakamura
    Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Int J Cancer 127:1158-71. 2010
    ....
  8. ncbi request reprint A quantitative evaluation of the determinant proteins for S-1 responsiveness in a biopsy specimen assists in patient selection to neoadjuvant therapy in cases of advanced gastric cancer
    Kazuyoshi Hashiguchi
    Department of Surgery, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Int J Oncol 37:257-64. 2010
    ..Effective therapy using tailored S-1 NAC according to the OPRT/TS ratio is therefore expected in advanced gastric cancer patients...
  9. ncbi request reprint Ribonucleotide reductase subunit M1 assessed by quantitative double-fluorescence immunohistochemistry predicts the efficacy of gemcitabine in biliary tract carcinoma
    Jun Nakamura
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 37:845-52. 2010
    ..Furthermore, qDFIHC is a useful method for the assessment of RRM1 protein, in order to design a tailor-made chemotherapeutic regimen for BTC patients...
  10. doi request reprint Loss of trefoil factor 1 is regulated by DNA methylation and is an independent predictive factor for poor survival in advanced gastric cancer
    Tomokazu Tanaka
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 42:894-902. 2013
    ..The expression and̸or methylation status of TFF1 may, therefore, serve as a useful biomarker for predicting survival in patients with advanced gastric cancer...
  11. ncbi request reprint Tranilast strongly sensitizes pancreatic cancer cells to gemcitabine via decreasing protein expression of ribonucleotide reductase 1
    Mayumi Mitsuno
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 36:341-9. 2010
    ..In a future, a novel chemotherapeutic strategy by Gem along with tranilast might improve Gem efficacy against pancreatic cancer...
  12. doi request reprint A complete response in small cell carcinoma of the esophagus treated by s-1/cisplatin combined chemotherapy and radiotherapy
    Masatsugu Hiraki
    Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    J Gastrointest Cancer 41:275-80. 2010
    ..We judged the effect to be a complete response. This combination chemo-radiotherapy with S-1 and cisplatin may therefore be one of the effective treatments against SmCCE...
  13. ncbi request reprint Hypoxia-inducible factor-1alpha expression predicts the response to 5-fluorouracil-based adjuvant chemotherapy in advanced gastric cancer
    Jun Nakamura
    Department of Surgery, Saga University Faculty of Medicine, Nabeshima, Saga 849 8501, Japan
    Oncol Rep 22:693-9. 2009
    ..In conclusion, the assessment of the HIF-1alpha expression in the resected tissues might predict the drug response to adjuvant 5-FU chemotherapy in advanced gastric cancer patients...
  14. doi request reprint HIF-1α is a crucial factor in the development of peritoneal dissemination via natural metastatic routes in scirrhous gastric cancer
    Shuusuke Miyake
    Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    Int J Oncol 43:1431-40. 2013
    ..i. mice were formed via extravasation of cancer cells. We provide a possible mechanism in which peritoneal dissemination of gastric cancer develops via a vascular network whereby HIF-1α activates tumor angiogenesis...
  15. pmc Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status
    Keita Kai
    Departments of Pathology and Microbiology, Faculty of Medicine, Saga University, Nabesima 5 1 1, Saga City 849 8501, Saga, Japan
    Int J Hepatol 2012:495950. 2012
    ....
  16. doi request reprint Metachronous aortic aneurysms due to sarcoidosis
    Li Hou
    Department of Pathology and Microbiology, Faculty of Medicine, Saga University, Saga, Japan
    Pathol Int 62:335-8. 2012
    ..He died of cardiac tamponade four years after the first operation for an aortic aneurysm...
  17. pmc Immunohistochemical and molecular genetic analyses of multiple sporadic gastrointestinal stromal tumors
    Masatsugu Hiraki
    Masatsugu Hiraki, Yoshihiko Kitajima, Takao Ohtsuka, Shuusuke Miyake, Yasuo Koga, Hirokazu Noshiro, Kohji Miyazaki, Department of Surgery, Saga University Faculty of Medicine, Saga 849 8501, Japan
    World J Gastrointest Oncol 2:364-8. 2010
    ..Although the patient did not receive any adjuvant chemotherapy, there has been no sign of recurrence over the 3 years since the surgery...
  18. pmc Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer
    Jun Nakamura
    Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
    Am J Pathol 178:515-24. 2011
    ..Furthermore, epigenetic alterations in CA9 differ between the intestinal and diffuse types of gastric cancer...
  19. pmc Spindle and giant cell type undifferentiated carcinoma of the proximal bile duct
    Takao Ide
    Department of Surgery, Saga University Faculty of Medicine, Saga, Japan
    Case Rep Gastroenterol 6:33-9. 2012
    ..Adjuvant chemotherapy was administered following extrahepatic bile duct resection, and he has been doing well for 16 months since the surgical treatment. The literature on this rare malignancy is also reviewed and discussed...
  20. doi request reprint Pathological features of classical polyarteritis nodosa: analysis of 19 autopsy cases
    Masanori Masuda
    Department of Pathology and Microbiology, Saga University, Faculty of Medicine, Saga, Japan
    Pathol Res Pract 209:161-6. 2013
    ..When uncertain or atypical autopsy cases of cPN are examined, these findings can help to make the pathological diagnosis of cPN...
  21. ncbi request reprint Quantitative double-fluorescence immunohistochemistry (qDFIHC), a novel technology to assess protein expression: a pilot study analyzing 5-FU sensitive markers thymidylate synthase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferases i
    Keita Kai
    Department of Surgery, Saga University, Faculty of Medicine, 5 1 1, Nabeshima, Saga City, Saga, Japan
    Cancer Lett 258:45-54. 2007
    ..Therefore, the ratios assessed by qDFIHC may be a potentially effective predictor of the S-1 efficacy. Furthermore, qDFIHC may also be a useful method for assessing various protein levels in cancer tissues...
  22. doi request reprint Fibroadenoma of the gallbladder with borderline malignancy: a poorly recognized gallbladder tumor
    Shinichiro Magata
    Department of Surgery, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga, Saga, 849 8501, Japan
    J Hepatobiliary Pancreat Surg 16:874-7. 2009
    ..We present the details of this extremely rare case and discuss the pathological findings, comparing them to those in the two previously reported cases and to carcinosarcoma of gallbladder...
  23. doi request reprint Fumagillin inhibits colorectal cancer growth and metastasis in mice: in vivo and in vitro study of anti-angiogenesis
    Li Hou
    Department of Pathology and Biodefense, Faculty of Medicine, Saga University, Saga, Japan
    Pathol Int 59:448-61. 2009
    ..This downregulation by Fumagillin may be involved in the anti-angiogenesis by Fumagillin. In conclusion, Fumagillin was found to suppress colorectal cancer growth and metastasis by suppressing angiogenesis...
  24. doi request reprint Endoglin (CD105) expression and angiogenesis status in small cell lung cancer
    Yukari Takase
    Department of Pathology and Biodefense, Saga University, Faculty of Medicine, Nabeshima 5 1 1, Saga City, Saga 849 8501, Japan
    Pathol Res Pract 206:725-30. 2010
    ..These findings suggest that anti-angiogenic therapy, especially CD105-targeting, may prove an effective form of SCLC treatment...
  25. ncbi request reprint Multiple inflammatory pseudotumor of the liver, mimicking cholangiocarcinoma with tumor embolus in the hepatic vein: report of a case
    Keita Kai
    Department of Surgery, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga City, Saga, 849 8501, Japan
    Surg Today 37:530-3. 2007
    ..We herein report this case and discuss the diagnosis and treatment regarding hepatic IPT with massive venous invasion...
  26. ncbi request reprint Intrahepatic multicystic biliary hamartoma: report of a case
    Keita Kai
    Department of Surgery and Department of Pathology and Biodefense, Saga University Faculty of Medicine, Saga, Japan
    Hepatol Res 38:629-34. 2008
    ..These histopathological features were consistent with multicystic biliary hamartoma, and we discuss this rare case in detail in this report...
  27. ncbi request reprint An autopsy case of obstructive jaundice due to hepatic multiple peribiliary cysts accompanying hepatolithiasis
    Keita Kai
    Departments of Pathology and Biodefense, and Surgery, Saga University Faculty of Medicine, Saga, Japan
    Hepatol Res 38:211-6. 2008
    ..Generally, multiple peribiliary cysts are considered to be clinically harmless, but once they cause obstructive jaundice, their presence suggests the occurrence of end-stage cirrhosis and a poor prognosis...