K Izuhara

Summary

Affiliation: Saga Medical School
Country: Japan

Publications

  1. ncbi request reprint The role of interleukin-4 and interleukin-13 in the non-immunologic aspects of asthma pathogenesis
    Kenji Izuhara
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Center for Comprehensive Community Medicine, Saga Medical School, Saga, Japan
    Clin Chem Lab Med 41:860-4. 2003
  2. ncbi request reprint IL-4 and IL-13: their pathological roles in allergic diseases and their potential in developing new therapies
    K Izuhara
    Department of Biochemistry, Saga Medical School, 5 1 1, Nabeshima, Saga, 849 8501, Japan
    Curr Drug Targets Inflamm Allergy 1:263-9. 2002
  3. ncbi request reprint Signal transduction of IL-13 and its role in the pathogenesis of bronchial asthma
    K Izuhara
    Department of Biomolecular Sciences, Saga Medical School, Nabeshima, Saga, Japan
    Drug News Perspect 17:91-8. 2004
  4. ncbi request reprint Recent advances in understanding how interleukin 13 signals are involved in the pathogenesis of bronchial asthma
    K Izuhara
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arch Immunol Ther Exp (Warsz) 48:505-12. 2000
  5. ncbi request reprint [Involvement of IL-4 and IL-13 signals in the pathogenesis of bronchial asthma]
    Kenji Izuhara
    Department of Biomolecular Sciences, Saga Medical School
    Arerugi 54:7-11. 2005
  6. ncbi request reprint Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation
    R Umeshita-Suyama
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int Immunol 12:1499-509. 2000
  7. ncbi request reprint Localization of human interleukin 13 receptor in non-haematopoietic cells
    M Akaiwa
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cytokine 13:75-84. 2001
  8. ncbi request reprint Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells
    Y Arinobu
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Fukuoka, 812 8582, Japan
    Biochem Biophys Res Commun 277:317-24. 2000
  9. ncbi request reprint Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile
    M Akaiwa
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Histochem Cytochem 47:777-86. 1999
  10. ncbi request reprint [Involvement of interleukin-4, and -13 in the pathogenesis of allergic diseases]
    K Izuhara
    Department of Biochemistry, Saga Medical School, Saga 849-8501
    Rinsho Byori 49:360-4. 2001

Collaborators

Detail Information

Publications43

  1. ncbi request reprint The role of interleukin-4 and interleukin-13 in the non-immunologic aspects of asthma pathogenesis
    Kenji Izuhara
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Center for Comprehensive Community Medicine, Saga Medical School, Saga, Japan
    Clin Chem Lab Med 41:860-4. 2003
    ..Taken together, it was supposed that SCCA may play some role in the pathogenesis of bronchial asthma, and measuring its serum level may be relevant for diagnosing or monitoring the status of bronchial asthma...
  2. ncbi request reprint IL-4 and IL-13: their pathological roles in allergic diseases and their potential in developing new therapies
    K Izuhara
    Department of Biochemistry, Saga Medical School, 5 1 1, Nabeshima, Saga, 849 8501, Japan
    Curr Drug Targets Inflamm Allergy 1:263-9. 2002
    ..It is expected that in the near future, several drugs will emerge based on these strategies, which will give us wider choice in treating patients, depending on the pathogenesis of the diseases...
  3. ncbi request reprint Signal transduction of IL-13 and its role in the pathogenesis of bronchial asthma
    K Izuhara
    Department of Biomolecular Sciences, Saga Medical School, Nabeshima, Saga, Japan
    Drug News Perspect 17:91-8. 2004
    ..In this article, we summarize the signal transduction pathway of IL-13, the pathological roles of IL-13 in bronchial asthma and the reagents to inhibit IL-13 signals that are now under development...
  4. ncbi request reprint Recent advances in understanding how interleukin 13 signals are involved in the pathogenesis of bronchial asthma
    K Izuhara
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arch Immunol Ther Exp (Warsz) 48:505-12. 2000
    ..We describe potential strategies for targeting IL-13 signals to improve allergic states...
  5. ncbi request reprint [Involvement of IL-4 and IL-13 signals in the pathogenesis of bronchial asthma]
    Kenji Izuhara
    Department of Biomolecular Sciences, Saga Medical School
    Arerugi 54:7-11. 2005
  6. ncbi request reprint Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation
    R Umeshita-Suyama
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int Immunol 12:1499-509. 2000
    ..These results suggest that STAT3 activation is involved with IL-4 and IL-13 signals in human B cells along with the activation of STAT6, and that there is a unique sequence in IL-13R alpha 1 to activate STAT3...
  7. ncbi request reprint Localization of human interleukin 13 receptor in non-haematopoietic cells
    M Akaiwa
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cytokine 13:75-84. 2001
    ..Fibroblasts and endothelial cells were stained in some tissues. These results provide clues to elucidate the known pathological roles of IL-13 in atopic dermatitis and allergic rhinitis, as well as its unknown physiological roles...
  8. ncbi request reprint Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells
    Y Arinobu
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Fukuoka, 812 8582, Japan
    Biochem Biophys Res Commun 277:317-24. 2000
    ..Augmentation of STAT6 and STAT3 would be a mechanism of the amplification of the IL-4 and IL-13 signals in stimulated B and T cells...
  9. ncbi request reprint Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile
    M Akaiwa
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Histochem Cytochem 47:777-86. 1999
    ....
  10. ncbi request reprint [Involvement of interleukin-4, and -13 in the pathogenesis of allergic diseases]
    K Izuhara
    Department of Biochemistry, Saga Medical School, Saga 849-8501
    Rinsho Byori 49:360-4. 2001
    ..These analyses provide new information for developing better methods of diagnosing and treating bronchial asthma...
  11. ncbi request reprint The mechanism of mucus production in bronchial asthma
    K Izuhara
    Department of Biomolecular Sciences, Saga Medical School, Japan
    Curr Med Chem 16:2867-75. 2009
    ..It is hoped that if we can clarify how mucus is produced, this will lead to development of novel therapeutic reagents to suppress mucus production in bronchial asthma...
  12. ncbi request reprint Microarray-based identification of novel biomarkers in asthma
    Kenji Izuhara
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Center for Comprehensive Community Medicine, Saga Medical School, Japan
    Allergol Int 55:361-7. 2006
    ..In this article, we review the outcomes of these analyses by the microarray approach as applied to this disease by focusing on the identification of novel biomarkers...
  13. doi request reprint Recent progress in understanding the diversity of the human ov-serpin/clade B serpin family
    K Izuhara
    Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    Cell Mol Life Sci 65:2541-53. 2008
    ..In this article, we describe recent progress in our understanding of how the human ov-serpin/clade B serpin family demonstrates diversity...
  14. ncbi request reprint Association of the interleukin-4 receptor alpha chain with p47phox, an activator of the phagocyte NADPH oxidase in B cells
    K Izuhara
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Mol Immunol 36:45-52. 1999
    ....
  15. ncbi request reprint Squamous cell carcinoma-related antigen in children with acute asthma
    Natsuko Nishi
    Department of Pediatrics, Faculty of Medicine, Saga University, Saga City, Japan
    Ann Allergy Asthma Immunol 94:391-7. 2005
    ..T(H)2 cytokines, which are known to be involved in the pathogenesis of allergic disorders, stimulate new synthesis of SCCA in cultured human airway epithelial cells...
  16. doi request reprint Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias
    M Okamoto
    Dept of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Eur Respir J 37:1119-27. 2011
    ..Thus, we have found that periostin is a novel component of fibrosis in IIP. Periostin may be a potential biomarker to distinguish IIP with fibrosis...
  17. ncbi request reprint IL-13: a promising therapeutic target for bronchial asthma
    K Izuhara
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Japan
    Curr Med Chem 13:2291-8. 2006
    ..In this article, we describe how IL-13 is involved in the pathogenesis of bronchial asthma and then how therapeutic agents to block IL-13 signals are developed for bronchial asthma...
  18. ncbi request reprint Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease
    Isao Nakao
    Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    J Immunol 180:6262-9. 2008
    ..These findings collectively suggest that pendrin can induce mucus production in airway epithelial cells and may be a therapeutic target candidate for bronchial asthma and COPD...
  19. ncbi request reprint The negative-feedback regulation of the IL-13 signal by the IL-13 receptor alpha2 chain in bronchial epithelial cells
    Shin ichiro Yasunaga
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5 1 1, Nabeshima, Saga 849 8501, Japan
    Cytokine 24:293-303. 2003
    ....
  20. ncbi request reprint Characterization of the interaction between interleukin-13 and interleukin-13 receptors
    Kazuhiko Arima
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Center for Comprehensive Community Medicine, Saga Medical School, Saga 849 8501, Japan
    J Biol Chem 280:24915-22. 2005
    ..These results provide the basis for a precise understanding of the interaction between IL-13 and its receptors...
  21. ncbi request reprint Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals
    Go Takayama
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    J Allergy Clin Immunol 118:98-104. 2006
    ..We have previously identified the POSTN gene encoding periostin as an IL-4/IL-13-inducible gene in bronchial epithelial cells. Periostin is thought to be an adhesion molecule because it possesses 4 fasciclin I domains...
  22. ncbi request reprint [Clarification of the pathogenesis and development of clinical examination for allergic diseases]
    Kenji Izuhara
    Department of Biomolecular Sciences, Saga Medical School, Saga 849 8501
    Rinsho Byori 55:369-74. 2007
    ..In this article, we show how we are addressing this issue...
  23. ncbi request reprint Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma
    Kazuhiko Arima
    Department of Biochemistry, Saga Medical School, Saga, Japan
    J Allergy Clin Immunol 109:980-7. 2002
    ..We recently found that a variant of the IL13 gene (Arg110Gln) is genetically associated with bronchial asthma, which is concordant with animal experiments using IL-13 in the development of asthma...
  24. ncbi request reprint [Establishment of a diagnostic system for allergic diseases aiming at personalized medicine--establishment of a novel ELISA system for SCCA]
    Shoichiro Ohta
    Department of Laboratory Medicine, Saga Medical School, Saga 849 8501, Japan
    Rinsho Byori 56:980-5. 2008
    ....
  25. ncbi request reprint [Search of a novel diagnostic marker for allergic diseases by the microarray approach]
    Kenji Izuhara
    Department of Biomolecular Science, Saga Medical School, Saga
    Rinsho Byori 54:738-43. 2006
    ..It is hoped that the measurement of squamous cell carcinoma antigens will be useful to diagnose allergic patients to apply agents targeting interleukin-4 or interleukin-13 in the future...
  26. ncbi request reprint Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family
    R Sugimoto
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Kyushu University 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 273:20721-7. 1998
    ..These results suggest that the Hakata antigen, a new member of the ficolin/opsonin P35 family, plays a role in the serum exerting lectin activity under physiological conditions...
  27. ncbi request reprint Characterization of novel squamous cell carcinoma antigen-related molecules in mice
    Y Sakata
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga 849 8501, Japan
    Biochem Biophys Res Commun 324:1340-5. 2004
    ..These results indicate that Serpinb3a and Serpinb3b may play different roles by inhibiting intrinsic or extrinsic proteinases with different expression distributions and different inhibitory profiles...
  28. pmc Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness
    Takachika Ito
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    J Biol Chem 284:24289-96. 2009
    ..These results demonstrate that the D1 domain of IL-13Ralpha1 acts as an affinity converter, through direct cytokine interactions, that allows the shared receptor to respond differentially to IL-4 and IL-13...
  29. ncbi request reprint Involvement of cysteine protease inhibitors in the defense mechanism against parasites
    Kenji Izuhara
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    Med Chem 4:322-7. 2008
    ....
  30. ncbi request reprint Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases
    Sachiko Kanaji
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    FEBS Lett 581:4260-4. 2007
    ..The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development...
  31. ncbi request reprint Analysis of internal motions of interleukin-13 variant associated with severe bronchial asthma using (15)N NMR relaxation measurements
    Yuichiro Yoshida
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 358:292-7. 2007
    ..It therefore appears that the difference in the internal motions on helix D between the wild-type IL-13 and IL-13-R110Q may be involved in their affinity differences with IL-13Ralpha2...
  32. ncbi request reprint Relationship between squamous cell carcinoma antigen and the clinical severity of allergic rhinitis caused by Dermatophagoides farinae and Japanese cedar pollen
    Kumiko Suzuki
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Saga University, Saga, Japan
    Ann Otol Rhinol Laryngol 119:22-6. 2010
    ..We have demonstrated that SCCA is related to allergic diseases such as asthma. The purpose of the present study was to clarify the relationship between allergic rhinitis and SCCA, which had not yet been investigated...
  33. ncbi request reprint Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells
    Go Tanaka
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Int Immunol 17:797-805. 2005
    ..These results indicate that the metabolism of xenobiotics would be a novel biological function of IL-4 and IL-13 in B cells, whereas TCDD is not involved in IgE synthesis in B cells...
  34. ncbi request reprint The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1
    Yasuhisa Sakata
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Japan
    J Biol Chem 279:5081-7. 2004
    ..These results suggest that SCCA2 acts as a cross-class serpin targeting an extrinsic cysteine proteinase derived from house dust mites and that it may have a protective role against biological reactions caused by mites...
  35. ncbi request reprint Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1
    Kiyonari Masumoto
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Center for Comprehensive Community Medicine, Saga Medical School, 5 1 1, Nabeshima, Saga, 849 8501, Japan
    J Biol Chem 278:45296-304. 2003
    ....
  36. ncbi request reprint Analysis of novel disease-related genes in bronchial asthma
    Noriko Yuyama
    Genox Research, Inc Kawasaki, Japan
    Cytokine 19:287-96. 2002
    ..In a complex disorder such as asthma, this combination of in vitro and in vivo genomic approaches is a powerful discriminatory method enabling identification of novel disease-related genes and their mechanisms of regulation...
  37. ncbi request reprint Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis
    Jongkonnee Wongpiyabovorn
    Department of Dermatology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Dermatol Sci 33:31-40. 2003
    ..The receptor subunits of IL-13 consist of IL-4Ralpha, IL-13Ralpha1 and IL-13Ralpha2. The regulatory mechanisms of the IL-13Ralpha expression in the keratinocytes of certain skin disease have not been known...
  38. ncbi request reprint IL-4-induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiation
    Noriyasu Seki
    Research Institute for Biological Sciences, Tokyo University of Science, Yamazaki, Noda City, Chiba, Japan
    J Immunol 172:6158-66. 2004
    ..In late stages of initial T cell activation, the chromatin structure of the IL-4 locus retains condensation state. These results demonstrate that IL-4-induced GATA-3 expression is time-restriction switch for Th2 differentiation...
  39. ncbi request reprint Identification of an alternative splicing variant of cathepsin C/dipeptidyl-peptidase I
    Keiko Matsui
    Genox Research, Inc, Kawasaki, Japan
    Gene 293:1-7. 2002
    ..These results indicate that the variant may play a role in regulating the biological activities of cathepsin C, involved in the pathogenesis of bronchial asthma...
  40. ncbi request reprint Coding SNP in tenascin-C Fn-III-D domain associates with adult asthma
    Akira Matsuda
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN, Yokohama, Japan
    Hum Mol Genet 14:2779-86. 2005
    ..In addition, TNC expression in lung fibroblasts increases with Th2 immune cytokine stimulation. Thus, Leu1677Ile may be valuable marker for evaluating the risk for developing asthma and plays a role in its pathogenesis...
  41. pmc T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production
    Nobuki Hayashi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Proc Natl Acad Sci U S A 104:14765-70. 2007
    ..Thus, IL-18 becomes a key target molecule for the development of a therapeutic regimen for the treatment of Th1-cell-induced bronchial asthma...
  42. pmc Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation
    Sachiko Kanaji
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 105:3888-92. 2005
    ..In every case, demethylation of the GP6 promoter correlated with an increase in mRNA level. Thus, megakaryocyte-specific expression of the GP6 gene is regulated, in part, by CpG demethylation, which can be directly initiated by TPO...
  43. ncbi request reprint Effect of IL-13 receptor alpha2 levels on the biological activity of IL-13 variant R110Q
    Allison Lynn Andrews
    Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    J Allergy Clin Immunol 120:91-7. 2007
    ..Recently a polymorphic variant of IL-13 (R110Q) has been shown to be associated with atopy...