Research Topics
Genomes and Genes | K IzuharaSummaryAffiliation: Saga Medical School Country: Japan Publications
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Publications
The role of interleukin-4 and interleukin-13 in the non-immunologic aspects of asthma pathogenesisKenji Izuhara
Division of Medical Biochemistry, Department of Biomolecular Sciences, Center for Comprehensive Community Medicine, Saga Medical School, Saga, Japan
Clin Chem Lab Med 41:860-4. 2003..Taken together, it was supposed that SCCA may play some role in the pathogenesis of bronchial asthma, and measuring its serum level may be relevant for diagnosing or monitoring the status of bronchial asthma...- IL-4 and IL-13: their pathological roles in allergic diseases and their potential in developing new therapiesK Izuhara
Department of Biochemistry, Saga Medical School, 5 1 1, Nabeshima, Saga, 849 8501, Japan
Curr Drug Targets Inflamm Allergy 1:263-9. 2002..It is expected that in the near future, several drugs will emerge based on these strategies, which will give us wider choice in treating patients, depending on the pathogenesis of the diseases... - Signal transduction of IL-13 and its role in the pathogenesis of bronchial asthmaK Izuhara
Department of Biomolecular Sciences, Saga Medical School, Nabeshima, Saga, Japan
Drug News Perspect 17:91-8. 2004..In this article, we summarize the signal transduction pathway of IL-13, the pathological roles of IL-13 in bronchial asthma and the reagents to inhibit IL-13 signals that are now under development... - Recent advances in understanding how interleukin 13 signals are involved in the pathogenesis of bronchial asthmaK Izuhara
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Arch Immunol Ther Exp (Warsz) 48:505-12. 2000..We describe potential strategies for targeting IL-13 signals to improve allergic states... - [Involvement of IL-4 and IL-13 signals in the pathogenesis of bronchial asthma]Kenji Izuhara
Department of Biomolecular Sciences, Saga Medical School
Arerugi 54:7-11. 2005 - Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activationR Umeshita-Suyama
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Int Immunol 12:1499-509. 2000..These results suggest that STAT3 activation is involved with IL-4 and IL-13 signals in human B cells along with the activation of STAT6, and that there is a unique sequence in IL-13R alpha 1 to activate STAT3... - Localization of human interleukin 13 receptor in non-haematopoietic cellsM Akaiwa
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Cytokine 13:75-84. 2001..Fibroblasts and endothelial cells were stained in some tissues. These results provide clues to elucidate the known pathological roles of IL-13 in atopic dermatitis and allergic rhinitis, as well as its unknown physiological roles... - Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cellsY Arinobu
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Fukuoka, 812 8582, Japan
Biochem Biophys Res Commun 277:317-24. 2000..Augmentation of STAT6 and STAT3 would be a mechanism of the amplification of the IL-4 and IL-13 signals in stimulated B and T cells... - Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bileM Akaiwa
Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
J Histochem Cytochem 47:777-86. 1999.... - [Involvement of interleukin-4, and -13 in the pathogenesis of allergic diseases]K Izuhara
Department of Biochemistry, Saga Medical School, Saga 849-8501
Rinsho Byori 49:360-4. 2001..These analyses provide new information for developing better methods of diagnosing and treating bronchial asthma... - The mechanism of mucus production in bronchial asthmaK Izuhara
Department of Biomolecular Sciences, Saga Medical School, Japan
Curr Med Chem 16:2867-75. 2009..It is hoped that if we can clarify how mucus is produced, this will lead to development of novel therapeutic reagents to suppress mucus production in bronchial asthma... - Microarray-based identification of novel biomarkers in asthmaKenji Izuhara
Division of Medical Biochemistry, Department of Biomolecular Sciences, Center for Comprehensive Community Medicine, Saga Medical School, Japan
Allergol Int 55:361-7. 2006..In this article, we review the outcomes of these analyses by the microarray approach as applied to this disease by focusing on the identification of novel biomarkers... 
Recent progress in understanding the diversity of the human ov-serpin/clade B serpin familyK Izuhara
Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
Cell Mol Life Sci 65:2541-53. 2008..In this article, we describe recent progress in our understanding of how the human ov-serpin/clade B serpin family demonstrates diversity...- Association of the interleukin-4 receptor alpha chain with p47phox, an activator of the phagocyte NADPH oxidase in B cellsK Izuhara
Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Mol Immunol 36:45-52. 1999.... - Squamous cell carcinoma-related antigen in children with acute asthmaNatsuko Nishi
Department of Pediatrics, Faculty of Medicine, Saga University, Saga City, Japan
Ann Allergy Asthma Immunol 94:391-7. 2005..T(H)2 cytokines, which are known to be involved in the pathogenesis of allergic disorders, stimulate new synthesis of SCCA in cultured human airway epithelial cells... - Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumoniasM Okamoto
Dept of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
Eur Respir J 37:1119-27. 2011..Thus, we have found that periostin is a novel component of fibrosis in IIP. Periostin may be a potential biomarker to distinguish IIP with fibrosis... - IL-13: a promising therapeutic target for bronchial asthmaK Izuhara
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Japan
Curr Med Chem 13:2291-8. 2006..In this article, we describe how IL-13 is involved in the pathogenesis of bronchial asthma and then how therapeutic agents to block IL-13 signals are developed for bronchial asthma... - Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary diseaseIsao Nakao
Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
J Immunol 180:6262-9. 2008..These findings collectively suggest that pendrin can induce mucus production in airway epithelial cells and may be a therapeutic target candidate for bronchial asthma and COPD... - The negative-feedback regulation of the IL-13 signal by the IL-13 receptor alpha2 chain in bronchial epithelial cellsNoriko Yuyama
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5-1-1, Nabeshima, Saga 849-8501, Japan
Cytokine 24:293-303. 2003.... - Characterization of the interaction between interleukin-13 and interleukin-13 receptorsKazuhiko Arima
Division of Medical Biochemistry, Department of Biomolecular Sciences, Center for Comprehensive Community Medicine, Saga Medical School, Saga 849 8501, Japan
J Biol Chem 280:24915-22. 2005..These results provide the basis for a precise understanding of the interaction between IL-13 and its receptors... - Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signalsGo Takayama
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan
J Allergy Clin Immunol 118:98-104. 2006..Periostin may contribute to this process by binding to other extracellular matrix proteins. CLINICAL IMPLICATIONS: Periostin induced by IL-4/IL-13 shows promise in inhibiting subepithelial fibrosis in bronchial asthma... - [Clarification of the pathogenesis and development of clinical examination for allergic diseases]Kenji Izuhara
Department of Biomolecular Sciences, Saga Medical School, Saga 849 8501
Rinsho Byori 55:369-74. 2007..In this article, we show how we are addressing this issue... - Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthmaKazuhiko Arima
Department of Biochemistry, Saga Medical School, Saga, Japan
J Allergy Clin Immunol 109:980-7. 2002..We recently found that a variant of the IL13 gene (Arg110Gln) is genetically associated with bronchial asthma, which is concordant with animal experiments using IL-13 in the development of asthma... - [Establishment of a diagnostic system for allergic diseases aiming at personalized medicine--establishment of a novel ELISA system for SCCA]Shoichiro Ohta
Department of Laboratory Medicine, Saga Medical School, Saga 849 8501, Japan
Rinsho Byori 56:980-5. 2008.... - [Search of a novel diagnostic marker for allergic diseases by the microarray approach]Kenji Izuhara
Department of Biomolecular Science, Saga Medical School, Saga
Rinsho Byori 54:738-43. 2006..It is hoped that the measurement of squamous cell carcinoma antigens will be useful to diagnose allergic patients to apply agents targeting interleukin-4 or interleukin-13 in the future... - Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin familyR Sugimoto
Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Kyushu University 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Biol Chem 273:20721-7. 1998..These results suggest that the Hakata antigen, a new member of the ficolin/opsonin P35 family, plays a role in the serum exerting lectin activity under physiological conditions... - Characterization of novel squamous cell carcinoma antigen-related molecules in miceY Sakata
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga 849 8501, Japan
Biochem Biophys Res Commun 324:1340-5. 2004..These results indicate that Serpinb3a and Serpinb3b may play different roles by inhibiting intrinsic or extrinsic proteinases with different expression distributions and different inhibitory profiles... 
Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsivenessTakachika Ito
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
J Biol Chem 284:24289-96. 2009..These results demonstrate that the D1 domain of IL-13Ralpha1 acts as an affinity converter, through direct cytokine interactions, that allows the shared receptor to respond differentially to IL-4 and IL-13...- Involvement of cysteine protease inhibitors in the defense mechanism against parasitesKenji Izuhara
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
Med Chem 4:322-7. 2008.... - Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteasesSachiko Kanaji
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
FEBS Lett 581:4260-4. 2007..The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development... - Analysis of internal motions of interleukin-13 variant associated with severe bronchial asthma using (15)N NMR relaxation measurementsYuichiro Yoshida
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Biochem Biophys Res Commun 358:292-7. 2007..It therefore appears that the difference in the internal motions on helix D between the wild-type IL-13 and IL-13-R110Q may be involved in their affinity differences with IL-13Ralpha2... - Relationship between squamous cell carcinoma antigen and the clinical severity of allergic rhinitis caused by Dermatophagoides farinae and Japanese cedar pollenKumiko Suzuki
Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Saga University, Saga, Japan
Ann Otol Rhinol Laryngol 119:22-6. 2010..We have demonstrated that SCCA is related to allergic diseases such as asthma. The purpose of the present study was to clarify the relationship between allergic rhinitis and SCCA, which had not yet been investigated... - Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cellsGo Tanaka
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan
Int Immunol 17:797-805. 2005..These results indicate that the metabolism of xenobiotics would be a novel biological function of IL-4 and IL-13 in B cells, whereas TCDD is not involved in IgE synthesis in B cells... - The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1Yasuhisa Sakata
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Japan
J Biol Chem 279:5081-7. 2004..These results suggest that SCCA2 acts as a cross-class serpin targeting an extrinsic cysteine proteinase derived from house dust mites and that it may have a protective role against biological reactions caused by mites... - Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1Kiyonari Masumoto
Division of Medical Biochemistry, Department of Biomolecular Sciences, Center for Comprehensive Community Medicine, Saga Medical School, 5 1 1, Nabeshima, Saga, 849 8501, Japan
J Biol Chem 278:45296-304. 2003.... - Analysis of novel disease-related genes in bronchial asthmaNoriko Yuyama
Genox Research, Inc. Kawasaki, Japan
Cytokine 19:287-96. 2002..In a complex disorder such as asthma, this combination of in vitro and in vivo genomic approaches is a powerful discriminatory method enabling identification of novel disease-related genes and their mechanisms of regulation... - Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitisJongkonnee Wongpiyabovorn
Department of Dermatology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
J Dermatol Sci 33:31-40. 2003..The receptor subunits of IL-13 consist of IL-4Ralpha, IL-13Ralpha1 and IL-13Ralpha2. The regulatory mechanisms of the IL-13Ralpha expression in the keratinocytes of certain skin disease have not been known... - IL-4-induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiationNoriyasu Seki
Research Institute for Biological Sciences, Tokyo University of Science, Yamazaki, Noda City, Chiba, Japan
J Immunol 172:6158-66. 2004..In late stages of initial T cell activation, the chromatin structure of the IL-4 locus retains condensation state. These results demonstrate that IL-4-induced GATA-3 expression is time-restriction switch for Th2 differentiation... - Identification of an alternative splicing variant of cathepsin C/dipeptidyl-peptidase IKeiko Matsui
Genox Research, Inc, Kawasaki, Japan
Gene 293:1-7. 2002..These results indicate that the variant may play a role in regulating the biological activities of cathepsin C, involved in the pathogenesis of bronchial asthma... - Coding SNP in tenascin-C Fn-III-D domain associates with adult asthmaAkira Matsuda
Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN, Yokohama, Japan
Hum Mol Genet 14:2779-86. 2005..In addition, TNC expression in lung fibroblasts increases with Th2 immune cytokine stimulation. Thus, Leu1677Ile may be valuable marker for evaluating the risk for developing asthma and plays a role in its pathogenesis... - T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 productionNobuki Hayashi
Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
Proc Natl Acad Sci U S A 104:14765-70. 2007..Thus, IL-18 becomes a key target molecule for the development of a therapeutic regimen for the treatment of Th1-cell-induced bronchial asthma... - Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiationSachiko Kanaji
Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Blood 105:3888-92. 2005..In every case, demethylation of the GP6 promoter correlated with an increase in mRNA level. Thus, megakaryocyte-specific expression of the GP6 gene is regulated, in part, by CpG demethylation, which can be directly initiated by TPO... - Effect of IL-13 receptor alpha2 levels on the biological activity of IL-13 variant R110QAllison Lynn Andrews
Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
J Allergy Clin Immunol 120:91-7. 2007..Recently a polymorphic variant of IL-13 (R110Q) has been shown to be associated with atopy...