Eiichi Ishii

Summary

Affiliation: Saga University
Country: Japan

Publications

  1. ncbi request reprint Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group
    Eiichi Ishii
    Department of Pediatrics, Saga University, Nabeshima, Saga, Japan
    Pediatr Blood Cancer 47:268-72. 2006
  2. ncbi request reprint Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions
    Eiichi Ishii
    Department of Pediatrics, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Blood 105:3442-8. 2005
  3. ncbi request reprint Review of hemophagocytic lymphohistiocytosis (HLH) in children with focus on Japanese experiences
    Eiichi Ishii
    Department of Pediatrics, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Crit Rev Oncol Hematol 53:209-23. 2005
  4. ncbi request reprint Correlation between phenotypic heterogeneity and gene mutational characteristics in familial hemophagocytic lymphohistiocytosis (FHL)
    Ikuyo Ueda
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Pediatr Blood Cancer 46:482-8. 2006
  5. ncbi request reprint Expression of CD180, a toll-like receptor homologue, is up-regulated in children with Kawasaki disease
    Miyoko Imayoshi
    Department of Pediatrics, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga, 849 8501, Japan
    J Mol Med (Berl) 84:168-74. 2006
  6. ncbi request reprint Interleukin-18 primes human basophilic KU812 cells for higher leukotriene synthesis
    Masafumi Zaitsu
    Department of Pediatrics, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga City 849 8501, Japan
    Prostaglandins Leukot Essent Fatty Acids 74:61-6. 2006
  7. ncbi request reprint Engraftment and dissemination of T lymphocytes from primary haemophagocytic lymphohistiocytosis in scid mice
    Nobuyuki Yoshida
    Department of Paediatrics, Saga Medical School, Saga, Japan
    Br J Haematol 121:349-58. 2003
  8. doi request reprint Hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children: a nationwide survey in Japan
    Takeshi Asano
    Department of Pediatrics, Nippon Medical School, Chiba Hokusoh Hospital, Inzai City, Chiba, Japan
    Pediatr Blood Cancer 59:110-4. 2012
  9. ncbi request reprint Macrolide antibiotics inhibit prostaglandin E2 synthesis and mRNA expression of prostaglandin synthetic enzymes in human leukocytes
    Michiko Miyazaki
    Department of Pediatrics, Faculty of Medicine, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Prostaglandins Leukot Essent Fatty Acids 69:229-35. 2003
  10. doi request reprint Characteristics of hemophagocytic lymphohistiocytosis in neonates: a nationwide survey in Japan
    Nobuhiro Suzuki
    Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Pediatr 155:235-8.e1. 2009

Detail Information

Publications74

  1. ncbi request reprint Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group
    Eiichi Ishii
    Department of Pediatrics, Saga University, Nabeshima, Saga, Japan
    Pediatr Blood Cancer 47:268-72. 2006
    ..We analyzed the features and outcome of neonatal leukemia in Japan to establish an appropriate treatment strategy for this rare disorder...
  2. ncbi request reprint Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions
    Eiichi Ishii
    Department of Pediatrics, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Blood 105:3442-8. 2005
    ..These results suggest an association between the type of genetic mutation in FHL cases and the magnitude of CTL cytolytic activity and age at onset...
  3. ncbi request reprint Review of hemophagocytic lymphohistiocytosis (HLH) in children with focus on Japanese experiences
    Eiichi Ishii
    Department of Pediatrics, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Crit Rev Oncol Hematol 53:209-23. 2005
    ..In the near future, an entire pathogenesis should be clarified in order to establish appropriate therapies including immunotherapy, HSCT and gene therapy...
  4. ncbi request reprint Correlation between phenotypic heterogeneity and gene mutational characteristics in familial hemophagocytic lymphohistiocytosis (FHL)
    Ikuyo Ueda
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Pediatr Blood Cancer 46:482-8. 2006
    ..Classification of familial hemophagocytic lymphohistiocytosis (FHL) into FHL2, FHL3, and other subtypes based on genetic abnormalities has recently become possible. We studied the phenotypic differences among these subtypes in Japan...
  5. ncbi request reprint Expression of CD180, a toll-like receptor homologue, is up-regulated in children with Kawasaki disease
    Miyoko Imayoshi
    Department of Pediatrics, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga, 849 8501, Japan
    J Mol Med (Berl) 84:168-74. 2006
    ..These results suggest that similar mechanisms may be involved in the up-regulation of B cell CD180 expression in patients with either KD or viral infections...
  6. ncbi request reprint Interleukin-18 primes human basophilic KU812 cells for higher leukotriene synthesis
    Masafumi Zaitsu
    Department of Pediatrics, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga City 849 8501, Japan
    Prostaglandins Leukot Essent Fatty Acids 74:61-6. 2006
    ..These results indicated that IL-3 and IL-18 primed human basophils for higher LT-synthesis. Thus, both IL-3 and IL-18 might be important factors for regulating LT-synthesis during the differentiation of human basophils...
  7. ncbi request reprint Engraftment and dissemination of T lymphocytes from primary haemophagocytic lymphohistiocytosis in scid mice
    Nobuyuki Yoshida
    Department of Paediatrics, Saga Medical School, Saga, Japan
    Br J Haematol 121:349-58. 2003
    ..These findings suggest that our murine model implementing HVS-immortalized human T lymphocytes is suitable to clarify the pathogenesis of primary HLH...
  8. doi request reprint Hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children: a nationwide survey in Japan
    Takeshi Asano
    Department of Pediatrics, Nippon Medical School, Chiba Hokusoh Hospital, Inzai City, Chiba, Japan
    Pediatr Blood Cancer 59:110-4. 2012
    ..Although HLH can be also observed after hematopoietic stem cell transplantation (HSCT), the incidence and clinical features of HLH after HSCT remain obscure...
  9. ncbi request reprint Macrolide antibiotics inhibit prostaglandin E2 synthesis and mRNA expression of prostaglandin synthetic enzymes in human leukocytes
    Michiko Miyazaki
    Department of Pediatrics, Faculty of Medicine, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Prostaglandins Leukot Essent Fatty Acids 69:229-35. 2003
    ..Macrolide antibiotics inhibited PGE2 synthesis in human leukocytes by suppressing cPLA2, COX-1, and COX-2 mRNA expression. These data indicate one mechanism of macrolide anti-inflammatory activity...
  10. doi request reprint Characteristics of hemophagocytic lymphohistiocytosis in neonates: a nationwide survey in Japan
    Nobuhiro Suzuki
    Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Pediatr 155:235-8.e1. 2009
    ..To assess the etiology, prognosis, and appropriate treatment of hemophagocytic lymphohistiocytosis (HLH) in neonates...
  11. ncbi request reprint Successful outcome of mismatched hematopoietic stem cell transplantation from a related donor in an infant with acute lymphoblastic leukemia and 9;11 translocation: case report and review of the literature
    Junichi Kitazawa
    Department of Pediatrics, Kuroishi General Hospital, 1 70 Kitami cho, Kuroishi shi, Aomori ken 036 0541, Japan
    Int J Hematol 81:428-32. 2005
    ....
  12. ncbi request reprint Late-onset cases of familial hemophagocytic lymphohistiocytosis with missense perforin gene mutations
    Ikuyo Ueda
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Hematol 82:427-32. 2007
    ..None had homozygous nonsense mutations. Our data suggest that nonsense perforin gene mutations yield early onset and missense mutations late onset in FHL2 cases...
  13. ncbi request reprint Partial tandem duplication of MLL gene in acute myeloid leukemia with translocation (11;17)(q23;q12-21)
    Shuichi Yamamoto
    Department of Pediatrics, Faculty of Medicine, Saga University, Japan
    Am J Hematol 80:46-9. 2005
    ..The patient has been in remission for more than 2 years without hematopoietic stem cell transplantation...
  14. doi request reprint Adenosine A1 receptor blockage mediates theophylline-associated seizures
    Mitsumasa Fukuda
    Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Epilepsia 51:483-7. 2010
    ..Moreover, a selective A(1) antagonist caused a significantly longer seizure duration compared with the control. These findings suggest that blockage of the adenosine A(1) receptor is the main cause of TAS...
  15. ncbi request reprint A novel perforin gene mutation in a Japanese family with hemophagocytic lymphohistiocytosis
    Ikuyo Ueda
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hematol 83:51-4. 2006
    ....
  16. doi request reprint Nationwide survey of single-system single site Langerhans cell histiocytosis in Japan
    Akira Morimoto
    Department of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Japan
    Pediatr Blood Cancer 54:98-102. 2010
    ....
  17. doi request reprint Clinical features and outcome of X-linked lymphoproliferative syndrome type 1 (SAP deficiency) in Japan identified by the combination of flow cytometric assay and genetic analysis
    Hirokazu Kanegane
    Department of Pediatrics, Graduate School of Medicine, University of Toyama, Toyama, Japan
    Pediatr Allergy Immunol 23:488-93. 2012
    ..The prognosis of XLP is very poor, and hematopoietic stem cell transplantation (HSCT) is the only curative therapy. We characterized the clinical features and outcome of Japanese patients with XLP-1...
  18. doi request reprint Reduced-intensity conditioning in unrelated donor cord blood transplantation for familial hemophagocytic lymphohistiocytosis
    Masanori Nishi
    Department of Pediatrics, Saga University Hospital, Saga, Japan
    Am J Hematol 87:637-9. 2012
    ..25%, p = 0.036). The FLU+MEL-based non-myeloablative regimen was acceptable for FHL infants undergoing UCBT, although further studies will be needed for confirmation...
  19. ncbi request reprint Nationwide survey of hemophagocytic lymphohistiocytosis in Japan
    Eiichi Ishii
    Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan
    Int J Hematol 86:58-65. 2007
    ..Although this nationwide survey establishes the heterogeneous characteristics of HLH, the results should be useful in planning prospective studies to identify the most effective therapy for each HLH subtype...
  20. ncbi request reprint Association of transforming growth factor-beta1 gene polymorphism in the development of Epstein-Barr virus-related hematologic diseases
    Kanako Hatta
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamigyo ku, Kyoto, Japan
    Haematologica 92:1470-4. 2007
    ..In this study, the pattern of cytokine gene polymorphisms was comparatively analyzed in EBV-related diseases...
  21. doi request reprint Hematopoietic stem cell transplantation for familial hemophagocytic lymphohistiocytosis and Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in Japan
    Shouichi Ohga
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pediatr Blood Cancer 54:299-306. 2010
    ..Post-transplant outcomes of hemophagocytic lymphohistiocytosis (HLH) patients were analyzed in Japan where Epstein-Barr virus (EBV)-associated severe forms are problematic...
  22. doi request reprint Clinical characteristics and outcomes of ch├ędiak-Higashi syndrome: a nationwide survey of Japan
    Kozo Nagai
    Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Japan
    Pediatr Blood Cancer 60:1582-6. 2013
    ..Recently, several clinical CHS phenotypes have been reported. Here, we report results of a nationwide survey performed to clarify clinical characteristics and outcomes of CHS patients in Japan...
  23. ncbi request reprint Disodium cromoglycate suppresses the induction of cysteinyl leukotriene synthesis during granulocytic differentiation in HL-60 cells
    Masafumi Zaitsu
    Department of Pediatrics, Faculty of Medicine, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Respir Med 98:235-41. 2004
    ..We examined whether DSCG affects the induction of cysteinyl Leukotriene (cysLT) synthesis during dimethyl sulfoxide (DMSO)-induced granulocytic differentiation in HL-60 cells...
  24. ncbi request reprint Improved outcome in the treatment of pediatric multifocal Langerhans cell histiocytosis: Results from the Japan Langerhans Cell Histiocytosis Study Group-96 protocol study
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Cancer 107:613-9. 2006
    ..To overcome these issues, the Japan LCH Study Group-96 (JLSG-96) protocol was conducted prospectively from 1996 to 2001 in Japan...
  25. ncbi request reprint Leukotriene synthesis is increased by transcriptional up-regulation of 5-lipoxygenase, leukotriene A4 hydrolase, and leukotriene C4 synthase in asthmatic children
    Masafumi Zaitsu
    Department of Pediatrics, Saga Medical School, Nabeshima, Saga, Japan
    J Asthma 40:147-54. 2003
    ..The mRNA expression of LT-synthesizing enzymes was up-regulated, resulting in increased LT synthesis, which may play an important role in the pathogenesis of childhood asthma...
  26. doi request reprint Atypical childhood absence epilepsy with preceding or simultaneous generalized tonic clonic seizures
    Hiroyuki Wakamoto
    Department of Pediatrics, Ehime Rehabilitation Center for Children, Ehime, Japan
    Brain Dev 33:589-92. 2011
    ..The aim of this study was to compare the clinical features between children with typical CAE and those with atypical CAE with preceding or simultaneous episodes of GTCS (atypical CAE-GTCS)...
  27. ncbi request reprint Successful bone marrow transplantation in a patient with c-mpl-mutated congenital amegakaryocytic thrombocytopenia from a carrier donor
    Kenji Muraoka
    Department of Pediatrics, Faculty of Medicine, Saga University, Saga, Japan
    Pediatr Transplant 9:101-3. 2005
    ..Engraftment and reconstitution of hematopoietic cells was rapid and without complications. These findings suggest that the carrier donor displaying the c-mpl mutation can serve as a donor source for SCT...
  28. pmc Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children
    Hitomi Hino
    Department of Pediatrics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    PLoS ONE 7:e42920. 2012
    ..Thus, it could be a possible candidate for the treatment of FS in children...
  29. ncbi request reprint Carbamazepine-induced drug-induced hypersensitivity syndrome in a 14-year-old Japanese boy
    Yuka Suzuki
    Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Epilepsia 49:2118-21. 2008
    ..Establishing a treatment strategy for DIHS is warranted to improve its outcome. Therefore, it is important to raise awareness of DIHS among epileptologists...
  30. ncbi request reprint Interleukin-1beta enhances susceptibility to hyperthermia-induced seizures in developing rats
    Mitsumasa Fukuda
    Department of Pediatrics, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, Ehime 791 0295, Japan
    Seizure 18:211-4. 2009
    ..035). These results demonstrate that IL-1beta promotes hyperthermia-induced seizures in developing rats...
  31. doi request reprint Activation of central adenosine A(2A) receptors lowers the seizure threshold of hyperthermia-induced seizure in childhood rats
    Mitsumasa Fukuda
    Department of Pediatrics, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, Ehime 791 0295, Japan
    Seizure 20:156-9. 2011
    ....
  32. ncbi request reprint Clinical features and outcome of MLL gene rearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11q23 translocation
    Hisamichi Tauchi
    Department of Pediatrics, Ehime University, Toon, Ehime, Japan
    Leuk Res 32:1523-9. 2008
    ..Genetic alterations induced by additional chromosomal changes may be associated with disease progression and poorer overall survival rates in infants with MLL-rearranged ALL...
  33. ncbi request reprint Essential roles of perforin in antigen-specific cytotoxicity mediated by human CD4+ T lymphocytes: analysis using the combination of hereditary perforin-deficient effector cells and Fas-deficient target cells
    Fumio Yanai
    Department of Pediatrics, Fukuoka University School of Medicine, Fukuoka, Japan
    J Immunol 170:2205-13. 2003
    ..The present data demonstrate that perforin-negative CD4+ CTLs can exert cytotoxicity against Fas-sensitive target cells; however, perforin plays essential roles in Ag-specific cytotoxicity mediated by human CD4+ as well as CD8+ CTLs...
  34. ncbi request reprint A polymorphism in the promoter of the CD14 gene (CD14/-159) is associated with the development of coronary artery lesions in patients with Kawasaki disease
    Shinji Nishimura
    Department of Pediatrics, Faculty of Medicine, Saga Medical School, and the Division of Pediatrics, Saga Prefectural Hospital Koseikan, Saga, Japan
    J Pediatr 143:357-62. 2003
    ..To investigate whether a polymorphism in the CD14 gene is associated with Kawasaki disease (KD)...
  35. ncbi request reprint Familial hemophagocytic lymphohistiocytosis with the MUNC13-4 mutation: a case report
    Hiroshi Mizumoto
    Department of Pediatrics, Kitano Hospital, The Tazuke Kofukai Medical Institute, 2 4 20 Ohgimachi, Kita ku, Osaka, 530 8480, Japan
    Eur J Pediatr 165:384-8. 2006
    ..FHL may have a broad clinical spectrum, and further analysis on its phenotype-genotype association is required to establish an appropriate treatment strategy, including immunochemotherapy and stem cell transplantation in the future...
  36. doi request reprint ETV6-ARNT fusion in a patient with childhood T lymphoblastic leukemia
    Keisuke Otsubo
    Department of Pediatrics, University of Toyama, Japan
    Cancer Genet Cytogenet 202:22-6. 2010
    ..To our knowledge, the current report is novel in its report of the ETV6-ARNT fusion in childhood T-ALL. The ETV6-ARNT fusion is associated not only with AML but also with T-ALL...
  37. doi request reprint L-arginine is effective in stroke-like episodes of MELAS associated with the G13513A mutation
    Ritsuko Shigemi
    Department of Pediatrics, Matsuyama Shimin Hospital, Ohtemachi 2 6 5, Matsuyama, Ehime 791 0067, Japan
    Brain Dev 33:518-20. 2011
    ..This is the first report on effective l-arginine therapy in MELAS associated with the G13513A mutation...
  38. ncbi request reprint Recent advances in the treatment of infant acute myeloid leukemia
    Eiichi Ishii
    Department of Pediatrics, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Leuk Lymphoma 44:741-8. 2003
    ..A need remains for future development by exploiting the unusual biologic properties of leukemic progenitor cells expressing the abnormal MLL gene product...
  39. ncbi request reprint Autoimmune neutropenia of infancy with multiple brain abscesses during the course of human herpesvirus-6 infection
    Miyoko Tokushima-Imayoshi
    Department of Pediatrics, Saga University, Saga, Japan
    Int J Hematol 84:151-3. 2006
    ..Although autoimmune neutropenia of infancy is benign and self limiting, it must be emphasized that severe bacterial infection will be induced by concurrent viral infection in this specific disorder...
  40. doi request reprint CLTC-ALK fusion as a primary event in congenital blastic plasmacytoid dendritic cell neoplasm
    Kiriko Tokuda
    Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Genes Chromosomes Cancer 53:78-89. 2014
    ..This is the first report of the CLTC-ALK fusion gene being associated with a myeloid malignancy, which may give us an important clue to the origin of this rare neoplasm...
  41. ncbi request reprint Rapid diagnosis of FHL3 by flow cytometric detection of intraplatelet Munc13-4 protein
    Yuuki Murata
    Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Blood 118:1225-30. 2011
    ..These findings indicate that flow cytometric detection of intraplatelet Munc13-4 protein is a sensitive and reliable method to rapidly screen for FHL3 with a very small amount of whole blood, even in the acute phase of the disease...
  42. doi request reprint Association of IRF5 polymorphisms with susceptibility to hemophagocytic lymphohistiocytosis in children
    Masakatsu Yanagimachi
    Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    J Clin Immunol 31:946-51. 2011
    ..IRF5 acts as a master transcription factor in the activation of pro-inflammatory cytokines. We assessed associations of IRF5 gene polymorphisms with susceptibility to secondary HLH...
  43. ncbi request reprint Perforin defects of primary haemophagocytic lymphohistiocytosis in Japan
    Naohiro Suga
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Haematol 116:346-9. 2002
    ..The frequency of mutation was at least 20% of FHL in Japan. Flow cytometry for intracellular perforin may be useful for the screening of FHL2...
  44. doi request reprint Idiopathic childhood occipital epilepsy of Gastaut: report of 12 patients
    Hiroyuki Wakamoto
    Department of Pediatrics, Ehime Rehabilitation Center for Children, Toon shi, Ehime Prefecture 791 0212, Japan
    Pediatr Neurol 44:183-6. 2011
    ....
  45. ncbi request reprint Expression of matrix metalloproteinase (MMP) and tissue inhibitor of MMP (TIMP) genes in blasts of infant acute lymphoblastic leukemia with organ involvement
    Aiko Suminoe
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Leuk Res 31:1437-40. 2007
    ..005 and 0.009) and between CNS involvement and the MMP-2/TIMP-2 ratio (p=0.012). The results suggest that MMP/TIMP balance is closely related to the infiltration of leukemia cells into extramedullary organs...
  46. ncbi request reprint Expression of the Ikaros gene family in childhood acute lymphoblastic leukaemia
    Mami Takanashi
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kajiicho 465 Hirokoji, Kamigyoku, Kyoto 602 8566, Japan
    Br J Haematol 117:525-30. 2002
    ..Only one case of T lineage ALL expressed a small-sized isoform of Helios (designated as He6). It was also found that the expression of Ai1 and He1 was low in Ik6-positive patients (Fisher's exact test; Ai1 P = 0.005, Hel P = 0.035)...
  47. ncbi request reprint In vitro cleavage of the MLL gene by topoisomerase II inhibitor (etoposide) in normal cord and peripheral blood mononuclear cells
    Eiichi Ishii
    Department of Pediatrics, Saga Medical School, Japan
    Int J Hematol 76:74-9. 2002
    ..Instability of the partner gene during the fetal period could be associated with the pathogenesis of infant leukemia...
  48. ncbi request reprint Thromboxane synthesis is increased by upregulation of cytosolic phospholipase A2 and cyclooxygenase-2 in peripheral polymorphonuclear leukocytes during bacterial infection in childhood
    Masafumi Zaitsu
    Department of Pediatrics, Faculty of Medicine, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Am J Hematol 72:115-20. 2003
    ..The upregulation of TXA(2) synthesis may contribute to the process of acute inflammatory reaction caused by bacterial infection...
  49. ncbi request reprint An immunologic case study of acute encephalitis with refractory, repetitive partial seizures
    Hiroyuki Wakamoto
    Department of Pediatrics, Ehime Prefectural Central Hospital, Ehime, Japan
    Brain Dev 34:763-7. 2012
    ..NK cell dysfunction may be the underlying abnormality in this AERRPS case, which might have contributed to the production of GluR autoantibodies...
  50. doi request reprint Beta-hydroxybutyrate alters GABA-transaminase activity in cultured astrocytes
    Yuka Suzuki
    Department of Pediatrics, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    Brain Res 1268:17-23. 2009
    ..These results suggest that beta-hydroxybutyrate induced by ketogenic diet may increase GABA concentration in the epileptic brain by suppressing astrocytic GABA degradation, leading to antiepileptic effects...
  51. ncbi request reprint Protein-losing gastroenteropathy and retinitis associated with cytomegalovirus infection in an immunocompetent infant: a case report
    Manabu Iwanaga
    Department of Paediatrics, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, 849 8501 Saga, Japan
    Eur J Pediatr 163:81-4. 2004
    ..CONCLUSION: breast-feeding by a cytomegalovirus-positive mother can be a primary cause of early onset cytomegalovirus infection in infants...
  52. doi request reprint A nationwide survey of newly diagnosed childhood idiopathic thrombocytopenic purpura in Japan
    Akira Shirahata
    Department of Pediatrics, University of Occupational and Environmental Health, Japan
    J Pediatr Hematol Oncol 31:27-32. 2009
    ..We evaluated the clinical pictures, outcome for childhood idiopathic thrombocytopenic purpura (ITP) and the trends of the choice of management for childhood ITP in Japan...
  53. ncbi request reprint Long-term follow-up of children with refractory immune thrombocytopenia treated with rituximab
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe, 651 2273, Japan
    Int J Hematol 99:429-36. 2014
    ..Furthermore, repeated rituximab administration may be a promising therapy for those who relapse after an initial response...
  54. doi request reprint Clinical and genetic characteristics of XIAP deficiency in Japan
    Xi Yang
    Department of Pediatrics, Graduate School of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
    J Clin Immunol 32:411-20. 2012
    ..These results in our Japanese cohort are compatible with previous studies, confirming the clinical characteristics of XIAP deficiency...
  55. ncbi request reprint Risk-directed treatment of infant acute lymphoblastic leukaemia based on early assessment of MLL gene status: results of the Japan Infant Leukaemia Study (MLL96)
    Keiichi Isoyama
    Department of Paediatrics, Showa University Fujigaoka Hospital, Yokohama, Japan
    Br J Haematol 118:999-1010. 2002
    ..Novel therapeutic initiatives are warranted for infants with MLL+ disease, particularly those with initial CNS leukaemic involvement or age less than 6 months, or both...
  56. ncbi request reprint Low natural killer activity and central nervous system disease as a high-risk prognostic indicator in young patients with hemophagocytic lymphohistiocytosis
    Shinsaku Imashuku
    Kyoto City Institute of Health and Environmental Sciences, Kyoto, Japan
    Cancer 94:3023-31. 2002
    ..To the authors' knowledge, it remains to be determined whether persistently low natural killer cell (NK) activity and a high incidence of central nervous system (CNS) disease increase the probability of FHL...
  57. ncbi request reprint Treatment of a child with myeloid/NK cell precursor acute leukemia with L-asparaginase and unrelated cord blood transplantation
    Kayo Tezuka
    Division of Pediatrics, Hamanomachi Hospital, School of Medicine, Fukuoka University, Japan
    Int J Hematol 75:201-6. 2002
    ..Our findings indicate that combination therapy with L-asparaginase and allogeneic stem cell transplantation may be useful for the treatment of myeloid/NK cell precursor acute leukemia...
  58. ncbi request reprint Characteristic perforin gene mutations of haemophagocytic lymphohistiocytosis patients in Japan
    Ikuyo Ueda
    Department of Paediatrics, and Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Br J Haematol 121:503-10. 2003
    ..Examination of the geographical origins of the ancestors in the perforin-mutant HLH patients revealed that they mostly came from the Western part of Japan, suggesting that the present-day cases may largely derive from a common ancestor...
  59. ncbi request reprint Common gene expression signatures in t(8;21)- and inv(16)-acute myeloid leukaemia
    Hitoshi Ichikawa
    Cancer Transcriptome Project, National Cancer Centre Research Institute, Chuo Ku, Tokyo, Japan
    Br J Haematol 135:336-47. 2006
    ..These distinct features of t(8;21)- and inv(16)-associated genes correlate with the bimodular structures of the chimaeric proteins (CBF-related AML1 and CBFbeta portions, and CBF-unrelated MTG8 and MYH11 portions)...
  60. ncbi request reprint Infants with acute lymphoblastic leukemia and a germline MLL gene are highly curable with use of chemotherapy alone: results from the Japan Infant Leukemia Study Group
    Jun Nagayama
    Section of Pediatrics, National Kyushu Cancer Center, Fukuoka, Japan
    Blood 107:4663-5. 2006
    ..These results indicate that chemotherapy of the type described here is both safe and highly effective against infant precursor B-cell ALL with MLL in the germline configuration...
  61. ncbi request reprint Occurrence of haemophagocytic lymphohistiocytosis at less than 1 year of age: analysis of 96 patients
    Shinsaku Imashuku
    Division of Paediatrics, Takasago seibu Hospital, 1 10 41 Nakasuji, Takasago City, Hyogo Prefecture, Japan
    Eur J Pediatr 164:315-9. 2005
    ..Future novel diagnostic measures are required to define the precise nature of HLH in group 5...
  62. ncbi request reprint Identification of a gene expression signature associated with pediatric AML prognosis
    Tomohito Yagi
    Cancer Transcriptome Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Blood 102:1849-56. 2003
    ....
  63. ncbi request reprint [Genetic defects and pathogenesis of hemophagocytic syndrome]
    Eiichi Ishii
    Rinsho Ketsueki 47:1340-52. 2006
  64. ncbi request reprint Clinical characteristics and outcome of Wilms tumors with a favorable histology in Japan: a report from the Study Group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan
    Sachiyo Suita
    Department of Pediatric Surgery, Kyushu University, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    J Pediatr Surg 41:1501-5. 2006
    ....
  65. ncbi request reprint Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis
    Koji Nagafuji
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka Japan
    Haematologica 92:978-81. 2007
    ..Although primary HLH has been detected in infants and children, genetic mutation of PRF1 or other genes should be considered a differential diagnosis of HLH even in the elderly...
  66. ncbi request reprint The association of a distinctive allele of NAD(P)H:quinone oxidoreductase with pediatric acute lymphoblastic leukemias with MLL fusion genes in Japan
    Minenori Eguchi-Ishimae
    Section of Haemato oncology, Institute of Cancer Research, London, UK
    Haematologica 90:1511-5. 2005
    ..Previous studies in Caucasian populations have provided evidence that a loss of function allele at nt 609 (C609T, Pro187Ser) is associated with increased risk of infant acute lymphoblastic leukemia (ALL) with MLL-AF4 fusion genes...
  67. ncbi request reprint [Defect of secretory granules and hematologic disorders]
    Eiichi Ishii
    Rinsho Ketsueki 49:225-33. 2008
  68. ncbi request reprint Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people
    Ken Yamamoto
    Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Hum Genet 50:600-3. 2005
    ..The patients had no mutations and 10% had one polymorphism (146G>A) of syntaxin 11, while no mutation of SNAP23 was observed. Our results indicate that aberrations in the SNARE system may not cause FHL in Japanese families...
  69. ncbi request reprint Infant acute lymphoblastic leukemia with MLL gene rearrangements: outcome following intensive chemotherapy and hematopoietic stem cell transplantation
    Yoshiyuki Kosaka
    Department of Hematology and Oncology, Hyogo Children s Hospital, Kobe, Japan
    Blood 104:3527-34. 2004
    ..Identification of subgroups or patients who respond well to intensified chemotherapy alone should have a high priority in future investigations...
  70. ncbi request reprint Frequent co-expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement
    Toshihiko Imamura
    Department of Paediatrics, Kyoto Prefectural University of Medicine, Japan
    Br J Haematol 119:119-21. 2002
    ..001). These findings indicate that the HoxA9 and Meis1 genes are closely associated with MLL gene rearrangement in the development of infant ALL, which represents a distinct entity of childhood ALL...
  71. ncbi request reprint FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy
    Takeshi Taketani
    Gunma Children s Medical Center, 779 Shimohadoka, Kitatachibana, Gunma 377 8577, Japan
    Blood 103:1085-8. 2004
    ..These results suggested that FLT3-D835/I836 mutations are one of the second genetic events in infant ALL with MLL rearrangements or pediatric ALL with hyperdiploidy...
  72. ncbi request reprint Identification of simultaneous mutation of fibrinogen alpha chain and protein C genes in a Japanese kindred
    Kumiko Watanabe
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka, Japan
    Br J Haematol 120:101-8. 2003
    ....
  73. ncbi request reprint Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement
    Kaoru Oguchi
    Department of Pediatrics and Developmental Biology, Postgraduate Medical School, Tokyo Medical and Dental University, Tokyo, Japan
    Blood 101:3622-7. 2003
    ..Our finding in this patient suggests that altered function of ATM plays some pathogenic roles in the development of MLL(+) leukemia...
  74. ncbi request reprint Two distinct gene expression signatures in pediatric acute lymphoblastic leukemia with MLL rearrangements
    Shuichi Tsutsumi
    Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Meguro ku, Tokyo 153 8904, Japan
    Cancer Res 63:4882-7. 2003
    ..In addition, their downstream target genes were differentially expressed. These findings provide new insights into the biological mechanisms of leukemogenesis and prognosis for pediatric ALL with MLL rearrangements...