Y Sadzuka

Summary

Country: Japan

Publications

  1. ncbi request reprint Improvement of idarubicin induced antitumor activity and bone marrow suppression by theanine, a component of tea
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Cancer Lett 158:119-24. 2000
  2. ncbi request reprint Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, Japan
    Toxicol Lett 114:155-62. 2000
  3. ncbi request reprint Enhanced efficacy of 1-methyl-3-propyl-7-butylxanthine on the antitumor activity of doxorubicin against doxorubicin-resistant P388 leukemia
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Cancer Lett 138:5-11. 1999
  4. ncbi request reprint Effects of 1-methyl-3-propyl-7-butylxanthine (MPBX) on idarubicin-induced antitumor activity and bone marrow suppression
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Jpn J Cancer Res 91:651-7. 2000
  5. ncbi request reprint Enhancement of the activity of doxorubicin by inhibition of glutamate transporter
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Toxicol Lett 123:159-67. 2001
  6. ncbi request reprint Effective irinotecan (CPT-11)-containing liposomes: intraliposomal conversion to the active metabolite SN-38
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka
    Jpn J Cancer Res 90:226-32. 1999
  7. ncbi request reprint Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian sarcoma
    T Sugiyama
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Cancer Lett 133:19-26. 1998
  8. ncbi request reprint Intraperitoneal administration of doxorubicin encapsulating liposomes against peritoneal dissemination
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Toxicol Lett 116:51-9. 2000
  9. ncbi request reprint Applicability of anti-neovascular therapy to drug-resistant tumor: suppression of drug-resistant P388 tumor growth with neovessel-targeted liposomal adriamycin
    K Shimizu
    Department of Medical Biochemistry and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka 422 8526, Japan
    Int J Pharm 296:133-41. 2005
  10. ncbi request reprint Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin
    T Sugiyama
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Toxicol Lett 121:89-96. 2001

Detail Information

Publications11

  1. ncbi request reprint Improvement of idarubicin induced antitumor activity and bone marrow suppression by theanine, a component of tea
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Cancer Lett 158:119-24. 2000
    ..Until recently, the antitumor activity and related toxicities of this chemotherapeutic agent in leukemia could not be distinguished. Theanine increases the IDA-induced antitumor activity and ameliorates the toxicities...
  2. ncbi request reprint Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, Japan
    Toxicol Lett 114:155-62. 2000
    ..Theanine attacked the same transport process for DOX in both types of cells, elevated the DOX concentration and increased the DOX induced antitumor activity...
  3. ncbi request reprint Enhanced efficacy of 1-methyl-3-propyl-7-butylxanthine on the antitumor activity of doxorubicin against doxorubicin-resistant P388 leukemia
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Cancer Lett 138:5-11. 1999
    ..e. the inhibitory order of DOX efflux caused by the inhibitor of P-glycoprotein was P388 < P388/DOX. However, the effect of MPBX was P388 > P388/DOX. Therefore, we expect that the site of attack by MPBX is not P-glycoprotein...
  4. ncbi request reprint Effects of 1-methyl-3-propyl-7-butylxanthine (MPBX) on idarubicin-induced antitumor activity and bone marrow suppression
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Jpn J Cancer Res 91:651-7. 2000
    ..In conclusion, the combination of MPBX with IDA increased the antitumor activity and decreased the bone marrow suppression. Therefore, we expect that the combination of MPBX with IDA will be useful for leukemia chemotherapy...
  5. ncbi request reprint Enhancement of the activity of doxorubicin by inhibition of glutamate transporter
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Toxicol Lett 123:159-67. 2001
    ..Namely, theanine increases the concentration of DOX in a tumor in vivo through inhibition of the glutamate transporter via the GS-X pump...
  6. ncbi request reprint Effective irinotecan (CPT-11)-containing liposomes: intraliposomal conversion to the active metabolite SN-38
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka
    Jpn J Cancer Res 90:226-32. 1999
    ..It is therefore considered that a part of CPT-11 is converted to SN-38 in the intact liposomes...
  7. ncbi request reprint Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian sarcoma
    T Sugiyama
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Cancer Lett 133:19-26. 1998
    ..We have found that the modulating action of theanine is useful in clinical cancer chemotherapy...
  8. ncbi request reprint Intraperitoneal administration of doxorubicin encapsulating liposomes against peritoneal dissemination
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Toxicol Lett 116:51-9. 2000
    ..Liposomes, both small and large in size appear to be effective against solid tumors except in the abdominal cavity, and against peritoneal dissemination in the abdominal cavity, respectively...
  9. ncbi request reprint Applicability of anti-neovascular therapy to drug-resistant tumor: suppression of drug-resistant P388 tumor growth with neovessel-targeted liposomal adriamycin
    K Shimizu
    Department of Medical Biochemistry and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka 422 8526, Japan
    Int J Pharm 296:133-41. 2005
    ..These data suggest that APRPG-LipADM is applicable to various kinds of tumor including drug-resistant tumor since it targets angiogenic endothelial cells instead of tumor cells, and eradicates tumor cells through damaging the neovessels...
  10. ncbi request reprint Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin
    T Sugiyama
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Toxicol Lett 121:89-96. 2001
    ..We revealed the novel mechanism of enhancement of the antitumor efficacy of DOX via the inhibition of glutamate transporters by theanine...
  11. ncbi request reprint Effective prodrug liposome and conversion to active metabolite
    Y Sadzuka
    University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Curr Drug Metab 1:31-48. 2000
    ..Although the liposomes induce the improved tissue distribution of the prodrug, the tissue distribution of active metabolites do not always improve. However, CPT-11 entrapped liposome was useful...