Keinosuke Ryu

Summary

Country: Japan

Publications

  1. ncbi request reprint Osteosynthesis for nonunion of the medial humeral condyle in an adolescent: a case report
    Keinosuke Ryu
    Department of Orthopaedic Surgery, Nihon University School of Medicine, 30 1 Ooyaguchikamimachi, Itabasi ku, Tokyo 173 8610, Japan
    J Shoulder Elbow Surg 16:e8-12. 2007
  2. pmc Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway
    Keinosuke Ryu
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Cancer 10:187. 2010
  3. pmc Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS ONE 5:e10764. 2010
  4. pmc Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines
    Zhenfeng Duan
    Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Jackson Building, Boston, Massachusetts 02114, USA
    Mol Cancer Ther 8:2122-30. 2009
  5. ncbi request reprint Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis
    Keinosuke Ryu
    Department of Orthopedic Surgery, Massachusetts General Hospital, Center for Sarcoma and Connective Tissue Oncology, 55 Fruit St Jackson 1115, Boston, Massachusetts 02114, USA
    J Orthop Res 28:971-8. 2010
  6. pmc Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Cancer 9:399. 2009
  7. pmc ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines
    Zhenfeng Duan
    Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 4:e6967. 2009
  8. doi request reprint Safety of fondaparinux versus enoxaparin after TKA in Japanese patients
    Kunihiro Hosaka
    Department of Orthopedic Surgery, Nihon University School of Medicine, Tokyo, Japan
    Orthopedics 36:e428-33. 2013
  9. ncbi request reprint Osteoarthritis of the patella, lateral femoral condyle and posterior medial femoral condyle correlate with range of motion
    Takashi Suzuki
    Department of Orthopaedic Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashiku, Tokyo, 173 8610, Japan
    Knee Surg Sports Traumatol Arthrosc 21:2584-9. 2013
  10. doi request reprint Bilateral fatigue fracture of the femoral components in a cruciate-retaining cementless total knee prosthesis
    Shu Saito
    Department of Orthopedic Surgery, Nihon University School of Medicine, Tokyo, Japan
    Orthopedics 34:e688-91. 2011

Detail Information

Publications10

  1. ncbi request reprint Osteosynthesis for nonunion of the medial humeral condyle in an adolescent: a case report
    Keinosuke Ryu
    Department of Orthopaedic Surgery, Nihon University School of Medicine, 30 1 Ooyaguchikamimachi, Itabasi ku, Tokyo 173 8610, Japan
    J Shoulder Elbow Surg 16:e8-12. 2007
  2. pmc Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway
    Keinosuke Ryu
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Cancer 10:187. 2010
    ....
  3. pmc Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS ONE 5:e10764. 2010
    ..However, for patients who progress after chemotherapy, its effectiveness diminishes due to the emergence of multi-drug resistance (MDR) after prolonged therapy...
  4. pmc Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines
    Zhenfeng Duan
    Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Jackson Building, Boston, Massachusetts 02114, USA
    Mol Cancer Ther 8:2122-30. 2009
    ..Our data suggest that inhibition of IGF-IR with PPP offers a novel and selective therapeutic strategy for ostosarcoma, and at the same time, PPP is effective at reversing the drug-resistant phenotype in osteosarcoma cell lines...
  5. ncbi request reprint Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis
    Keinosuke Ryu
    Department of Orthopedic Surgery, Massachusetts General Hospital, Center for Sarcoma and Connective Tissue Oncology, 55 Fruit St Jackson 1115, Boston, Massachusetts 02114, USA
    J Orthop Res 28:971-8. 2010
    ..Our results suggest that Stat3 may be a prognostic indicator and potential therapeutic target for osteosarcoma. Blocking the pathway of Stat3 may lead to develop new therapeutic strategies against osteosarcoma...
  6. pmc Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Cancer 9:399. 2009
    ....
  7. pmc ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines
    Zhenfeng Duan
    Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 4:e6967. 2009
    ..ET-743 and PM00104 exposure over sustained periods of treatment will result in the development of drug resistance, but the mechanisms which lead to resistance are not yet understood...
  8. doi request reprint Safety of fondaparinux versus enoxaparin after TKA in Japanese patients
    Kunihiro Hosaka
    Department of Orthopedic Surgery, Nihon University School of Medicine, Tokyo, Japan
    Orthopedics 36:e428-33. 2013
    ..However, both drugs had some adverse effects. It is important to be aware of these potential risks when prescribing these drugs...
  9. ncbi request reprint Osteoarthritis of the patella, lateral femoral condyle and posterior medial femoral condyle correlate with range of motion
    Takashi Suzuki
    Department of Orthopaedic Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashiku, Tokyo, 173 8610, Japan
    Knee Surg Sports Traumatol Arthrosc 21:2584-9. 2013
    ..The objective of this study was to analyse the location and the degree of cartilage degeneration that affect knee range of motion and the connection, if any, between femorotibial angle (FTA) and knee ROM restriction...
  10. doi request reprint Bilateral fatigue fracture of the femoral components in a cruciate-retaining cementless total knee prosthesis
    Shu Saito
    Department of Orthopedic Surgery, Nihon University School of Medicine, Tokyo, Japan
    Orthopedics 34:e688-91. 2011
    ..In this case, failure of bone ingrowth in uncemented components, higher body mass index, and a higher athletic activity led to fatigue fracture of the femoral components...