Shigenobu Yonemura

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi request reprint [Overview of plasma membrane/cytoskeleton interaction]
    Shigenobu Yonemura
    Tanpakushitsu Kakusan Koso 51:666-71. 2006
  2. doi request reprint Cadherin-actin interactions at adherens junctions
    Shigenobu Yonemura
    Electron Microscope Laboratory, RIKEN Center for Developmental Biology, Kobe, 650 0047, Japan
    Curr Opin Cell Biol 23:515-22. 2011
  3. ncbi request reprint alpha-Catenin as a tension transducer that induces adherens junction development
    Shigenobu Yonemura
    Electron Microscope Laboratory, RIKEN Center for Developmental Biology, Kobe, Hyogo 650 0047, Japan
    Nat Cell Biol 12:533-42. 2010
  4. pmc Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice
    Toshihiro Uesaka
    Laboratory for Neuronal Differentiation and Regeneration and Laboratory for Cellular Morphogenesis, RIKEN Center for Developmental Biology, Kobe, Japan
    J Clin Invest 118:1890-8. 2008
  5. doi request reprint Syntabulin, a motor protein linker, controls dorsal determination
    Hideaki Nojima
    Laboratory for Vertebrate Axis Formation, RIKEN Center for Developmental Biology, Hyogo 650 0047, Japan
    Development 137:923-33. 2010
  6. pmc Joint morphology in the insect leg: evolutionary history inferred from Notch loss-of-function phenotypes in Drosophila
    Reiko Tajiri
    Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Development 138:4621-6. 2011
  7. pmc Apical accumulation of Rho in the neural plate is important for neural plate cell shape change and neural tube formation
    Nagatoki Kinoshita
    Electron Microscope Laboratory and Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Mol Biol Cell 19:2289-99. 2008
  8. doi request reprint Self-formation of optic cups and storable stratified neural retina from human ESCs
    Tokushige Nakano
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cell Stem Cell 10:771-85. 2012
  9. pmc Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex
    Takashi Ishiuchi
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 185:959-67. 2009
  10. doi request reprint IKKε regulates cell elongation through recycling endosome shuttling
    Tetsuhisa Otani
    Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, Kobe, Hyogo 650 0047, Japan
    Dev Cell 20:219-32. 2011

Collaborators

Detail Information

Publications41

  1. ncbi request reprint [Overview of plasma membrane/cytoskeleton interaction]
    Shigenobu Yonemura
    Tanpakushitsu Kakusan Koso 51:666-71. 2006
  2. doi request reprint Cadherin-actin interactions at adherens junctions
    Shigenobu Yonemura
    Electron Microscope Laboratory, RIKEN Center for Developmental Biology, Kobe, 650 0047, Japan
    Curr Opin Cell Biol 23:515-22. 2011
    ..Here, I provide an overview of cadherin-actin interaction from morphological aspects and of possible molecular mechanisms revealed by recent studies...
  3. ncbi request reprint alpha-Catenin as a tension transducer that induces adherens junction development
    Shigenobu Yonemura
    Electron Microscope Laboratory, RIKEN Center for Developmental Biology, Kobe, Hyogo 650 0047, Japan
    Nat Cell Biol 12:533-42. 2010
    ....
  4. pmc Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice
    Toshihiro Uesaka
    Laboratory for Neuronal Differentiation and Regeneration and Laboratory for Cellular Morphogenesis, RIKEN Center for Developmental Biology, Kobe, Japan
    J Clin Invest 118:1890-8. 2008
    ..Thus, enteric neuron survival is sensitive to RET dosage, and cell death is potentially involved in the etiology of HSCR...
  5. doi request reprint Syntabulin, a motor protein linker, controls dorsal determination
    Hideaki Nojima
    Laboratory for Vertebrate Axis Formation, RIKEN Center for Developmental Biology, Hyogo 650 0047, Japan
    Development 137:923-33. 2010
    ..Our findings suggest that Syntabulin regulates the microtubule-dependent transport of the DDs, and provide evidence for the link between AV and dorsoventral axis formation...
  6. pmc Joint morphology in the insect leg: evolutionary history inferred from Notch loss-of-function phenotypes in Drosophila
    Reiko Tajiri
    Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Development 138:4621-6. 2011
    ....
  7. pmc Apical accumulation of Rho in the neural plate is important for neural plate cell shape change and neural tube formation
    Nagatoki Kinoshita
    Electron Microscope Laboratory and Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Mol Biol Cell 19:2289-99. 2008
    ....
  8. doi request reprint Self-formation of optic cups and storable stratified neural retina from human ESCs
    Tokushige Nakano
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cell Stem Cell 10:771-85. 2012
    ..This storage method at an intermediate step during the time-consuming differentiation process provides a versatile solution for quality control in large-scale preparation of clinical-grade retinal tissues...
  9. pmc Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex
    Takashi Ishiuchi
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 185:959-67. 2009
    ..Depletion of Fat4 or Pals1 abolished this membrane apposition. These results highlight the importance of the Fat4-Dachsous1-Pals1 complex in organizing the apical membrane architecture of neural progenitor cells...
  10. doi request reprint IKKε regulates cell elongation through recycling endosome shuttling
    Tetsuhisa Otani
    Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, Kobe, Hyogo 650 0047, Japan
    Dev Cell 20:219-32. 2011
    ..Our results establish an evolutionarily conserved function of IKK-related kinases in regulating recycling endosome dynamics and point to a key role of endosome dynamics in cell morphogenesis...
  11. ncbi request reprint Actomyosin tension is required for correct recruitment of adherens junction components and zonula occludens formation
    Yuka Miyake
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Exp Cell Res 312:1637-50. 2006
    ..These findings suggest that tension generated by actomyosin is essential for correct AJ assembly...
  12. pmc Talin couples the actomyosin cortex to the plasma membrane during rear retraction and cytokinesis
    Masatsune Tsujioka
    Electron Microscope Laboratory, Center for Developmental Biology, RIKEN, Chuo Ku, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 109:12992-7. 2012
    ....
  13. doi request reprint The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes
    Thomas W Gould
    Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    J Neurosci 28:2131-46. 2008
    ..Therefore, although GDNF influences several aspects of MN development, the survival-promoting effects of GDNF during programmed cell death are mostly confined to spindle-innervating MNs...
  14. doi request reprint Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals
    Mototsugu Eiraku
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cell Stem Cell 3:519-32. 2008
    ..Thus, spatial and temporal aspects of early corticogenesis are recapitulated and can be manipulated in this ESC culture...
  15. doi request reprint Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors
    Makoto Ikeya
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo, Kobe 650 0047, Japan
    Dev Biol 337:405-14. 2010
    ..These findings revealed the molecular hierarchy between extracellular modifiers that orchestrate local BMP signal peaks in the organogenetic microenvironment...
  16. ncbi request reprint Bidirectional developmental potential in reprogrammed cells with acquired pluripotency
    Haruko Obokata
    1 Laboratory for Cellular Reprogramming, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan 2 Laboratory for Genomic Reprogramming, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan 3 Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 505:676-80. 2014
    ..Taken together, the developmental potential of STAP cells, shown by chimaera formation and in vitro cell conversion, indicates that they represent a unique state of pluripotency. ..
  17. ncbi request reprint Dynamic shape changes of ECM-producing cells drive morphogenesis of ball-and-socket joints in the fly leg
    Reiko Tajiri
    Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Development 137:2055-63. 2010
    ..Our results highlight the importance of dynamic cell behaviors in precise shaping of skeletal ECM architecture...
  18. doi request reprint Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex
    Shinji Yamamoto
    Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Dev Cell 15:23-36. 2008
    ..These results suggest that Cthrc1 is a Wnt cofactor protein that selectively activates the Wnt/PCP pathway by stabilizing ligand-receptor interaction...
  19. ncbi request reprint Specialized extraembryonic cells connect embryonic and extraembryonic epidermis in response to Dpp during dorsal closure in Drosophila
    Atsushi Wada
    Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Dev Biol 301:340-9. 2007
    ....
  20. ncbi request reprint Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype
    Toshihiro Uesaka
    Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Development 134:2171-81. 2007
    ..This study reveals an essential role for GFRalpha1 in the survival of enteric neurons and suggests that caspase-independent death can be triggered by abolition of neurotrophic signals...
  21. ncbi request reprint GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration
    Hideki Enomoto
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 44:623-36. 2004
    ..Thus RET-independent GFRalpha1 is dispensable for organogenesis and nerve regeneration in vivo, indicating that trans-signaling and GFRalpha-dependent NCAM signaling play a minor role physiologically...
  22. pmc Overlapping functions of the two talin homologues in Dictyostelium
    Masatsune Tsujioka
    National Institute of Advanced Industrial Science and Technology AIST, Tsukuba Central 4, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8562, Japan
    Eukaryot Cell 7:906-16. 2008
    ..This is the first study demonstrating overlapping functions of two talin homologues, and our data further indicate the importance of talin...
  23. ncbi request reprint E-cadherin is required for gastrulation cell movements in zebrafish
    Takashi Shimizu
    Laboratory for Vertebrate Axis Formation, Center for Developmental Biology, RIKEN, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Mech Dev 122:747-63. 2005
    ..These data suggest that E-cadherin-mediated cell adhesion between the DC and EVL plays a role in the epiboly movement in zebrafish...
  24. doi request reprint Loss of N-cadherin from the endothelium causes stromal edema and epithelial dysgenesis in the mouse cornea
    Vassil S Vassilev
    Cell Adhesion and Tissue Patterning Laboratory, RIKEN Center for Developmental Biology, Kobe, Japan
    Invest Ophthalmol Vis Sci 53:7183-93. 2012
    ..We analyzed the role of N-cadherin in maintaining proper architecture and function of corneal endothelium...
  25. ncbi request reprint Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm
    Chiharu Kimura-Yoshida
    Vertebrate Body Plan Group, RIKEN Center for Developmental Biology CDB, 2 2 3 Minatojima minami cho, Chuou ku Kobe, Hyogo 650 0047, Japan
    Dev Cell 9:639-50. 2005
    ..We propose that Wnt/beta-catenin signaling mediates A-P axis polarization by guiding cell migration toward the prospective anterior in the pregastrula mouse embryo...
  26. doi request reprint Self-formation of functional adenohypophysis in three-dimensional culture
    Hidetaka Suga
    Neurogenesis and Organogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Nature 480:57-62. 2011
    ..Thus, functional anterior pituitary tissue self-forms in ES cell culture, recapitulating local tissue interactions...
  27. ncbi request reprint Rho localization in cells and tissues
    Shigenobu Yonemura
    Laboratory for Cellular Morphogenesis, RIKEN Center for Developmental Biology, Chuo, Kobe, Hyogo 650 0047, Japan
    Exp Cell Res 295:300-14. 2004
    ..In mouse tissues, Rho localization differed depending on cell type, probably reflecting the functional differences of each cell type...
  28. ncbi request reprint Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis
    Yukako Nishimura
    Laboratory for Cellular Morphogenesis, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    J Cell Sci 119:104-14. 2006
    ..Positional information for division plane determination from microtubules is transmitted to the cell cortex to organize actin cytoskeleton through a mechanism involving these proteins...
  29. pmc Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex
    Keisuke Hamada
    Structural Biology Laboratory, Nara Institute of Science and Technology and CREST, Japan Science and Technology Corporation, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    EMBO J 22:502-14. 2003
    ..Mutation analyses based on the crystal structure reveal the determinant elements of recognition and provide the first insights into the physical link between adhesion molecules and ERM proteins...
  30. ncbi request reprint Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes
    Shojiro Kikuchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nat Genet 31:320-5. 2002
    ..These findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs...
  31. ncbi request reprint Cdc42 and mDia3 regulate microtubule attachment to kinetochores
    Shingo Yasuda
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Nature 428:767-71. 2004
    ..We now show that one member of this family, Cdc42, and its effector, mDia3, regulate MT attachment to kinetochores...
  32. ncbi request reprint Apical membrane and junctional complex formation during simple epithelial cell differentiation of F9 cells
    Satoshi Komiya
    Division of Cellular Interactions, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Genes Cells 10:1065-80. 2005
    ..These results showed that a monolayer culture of F9 cells represents a viable in vitro model that can be employed to elucidate mechanisms pertaining to epithelium formation...
  33. ncbi request reprint Rho-dependent and -independent activation mechanisms of ezrin/radixin/moesin proteins: an essential role for polyphosphoinositides in vivo
    Shigenobu Yonemura
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Japan
    J Cell Sci 115:2569-80. 2002
    ....
  34. ncbi request reprint Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium
    Yuko Shimada
    Laboratory of Cell Recognition and Pattern Formation, Graduate School of Biostudies, South Campus Research Building Building G, Room 118, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Dev Cell 10:209-22. 2006
    ..Furthermore, there appeared to be a bias in the P-D MTs, with slightly more plus ends oriented distally. The hypothesis of polarized vesicular trafficking of Fz is discussed...
  35. pmc EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition
    Mariko Hirano
    Laboratory for Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 182:1217-30. 2008
    ..At the same time, EPB41L5 binds to paxillin through its C terminus, enhancing integrin/paxillin association, thereby stimulating focal adhesion formation...
  36. pmc HSF4 is required for normal cell growth and differentiation during mouse lens development
    Mitsuaki Fujimoto
    Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube 755 8505, Japan
    EMBO J 23:4297-306. 2004
    ....
  37. ncbi request reprint Maintenance of olfactory neurogenesis requires HSF1, a major heat shock transcription factor in mice
    Eiichi Takaki
    Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Ube 755 8505, Japan
    J Biol Chem 281:4931-7. 2006
    ....
  38. ncbi request reprint Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse
    Yoshifumi Yamaguchi
    Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Myodaiji, Okazaki, 444 8787, Japan
    Development 133:4737-48. 2006
    ..Furthermore, the composition of saliva and urine was abnormal in these mice. These results indicate that Cp2l1 expression is required for normal duct development in both the salivary gland and kidney...
  39. pmc Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit
    Hiroyuki Nakajima
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Cell Biol 181:89-103. 2008
    ....
  40. pmc Regulation of myosin II dynamics by phosphorylation and dephosphorylation of its light chain in epithelial cells
    Toshiyuki Watanabe
    RIKEN, Center for Developmental Biology, Kobe 650 0047, Japan
    Mol Biol Cell 18:605-16. 2007
    ..We further found that myosin phosphatase or Zipper-interacting protein kinase localizes to stress fibers depending on the activity of myosin II ATPase...
  41. pmc A B-Myb complex containing clathrin and filamin is required for mitotic spindle function
    Tomohiro Yamauchi
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Tsukuba, Japan
    EMBO J 27:1852-62. 2008
    ..Thus, identification of the Myb-Clafi complex reveals a previously unrecognized function of B-Myb that may contribute to its role in chromosome stability, possibly, tumour suppression...