Kazuo Yamada

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. pmc Brain region-specific altered expression and association of mitochondria-related genes in autism
    Ayyappan Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192, Japan
    Mol Autism 3:12. 2012
  2. pmc Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Hum Genet 131:443-51. 2012
  3. ncbi request reprint A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia
    Mika Aoki-Suzuki
    Laboratories for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
    Biol Psychiatry 57:382-93. 2005
  4. ncbi request reprint Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts
    Kazuo Yamada
    RIKEN Brain Science Institute, Laboratory for Molecular Psychiatry, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biol Psychiatry 56:683-90. 2004
  5. ncbi request reprint A family-based and case-control association study of SOX10 in schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 141:477-81. 2006
  6. ncbi request reprint Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Kawaguchi, Saitama, Japan
    Biol Psychiatry 60:192-201. 2006
  7. ncbi request reprint Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neurosci Lett 417:316-21. 2007
  8. pmc Population-specific haplotype association of the postsynaptic density gene DLG4 with schizophrenia, in family-based association studies
    Shabeesh Balan
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS ONE 8:e70302. 2013
  9. ncbi request reprint Case-control association study of human netrin G1 gene in Japanese schizophrenia
    Masayuki Fukasawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    J Med Dent Sci 51:121-8. 2004
  10. ncbi request reprint Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia
    Mizuho Takeshita
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Schizophr Res 99:359-64. 2008

Collaborators

Detail Information

Publications50

  1. pmc Brain region-specific altered expression and association of mitochondria-related genes in autism
    Ayyappan Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192, Japan
    Mol Autism 3:12. 2012
    ..abstract:..
  2. pmc Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Hum Genet 131:443-51. 2012
    ..These data suggest that the KCNJ3 gene is genetically associated with schizophrenia in Asian populations and add further evidence to the "channelopathy theory of psychiatric illnesses"...
  3. ncbi request reprint A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia
    Mika Aoki-Suzuki
    Laboratories for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
    Biol Psychiatry 57:382-93. 2005
    ..We therefore set out to examine the genetic contribution of human NTNG1 and NTNG2 to schizophrenia...
  4. ncbi request reprint Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts
    Kazuo Yamada
    RIKEN Brain Science Institute, Laboratory for Molecular Psychiatry, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biol Psychiatry 56:683-90. 2004
    ..We recently identified FEZ1 as an interacting partner for DISC1. To investigate the role of FEZ1 in schizophrenia and bipolar disorder, case-control association analyses were conducted in Japanese cohorts...
  5. ncbi request reprint A family-based and case-control association study of SOX10 in schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 141:477-81. 2006
    ..Haplotype analysis did not reveal significant associations between the two groups. We concluded that genetic variations in the SOX10 gene do not contribute to susceptibility to Japanese schizophrenia...
  6. ncbi request reprint Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Kawaguchi, Saitama, Japan
    Biol Psychiatry 60:192-201. 2006
    ..But the polymorphisms highlighted in these reports map to different locations in the two genes, therefore it is unclear which gene exerts a stronger effect on susceptibility...
  7. ncbi request reprint Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neurosci Lett 417:316-21. 2007
    ..Contribution of common variations of ATF4 and ATF5 to the pathophysiology of bipolar disorder may be minimal if any...
  8. pmc Population-specific haplotype association of the postsynaptic density gene DLG4 with schizophrenia, in family-based association studies
    Shabeesh Balan
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS ONE 8:e70302. 2013
    ..The current study highlights a putative role for DLG4 in schizophrenia pathogenesis, evidenced by haplotype association, and warrants further dense screening for variants within these haplotypes...
  9. ncbi request reprint Case-control association study of human netrin G1 gene in Japanese schizophrenia
    Masayuki Fukasawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    J Med Dent Sci 51:121-8. 2004
    ..017). These findings suggest that netrin G1 or a nearby gene may contribute to the overall genetic risk for schizophrenia...
  10. ncbi request reprint Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia
    Mizuho Takeshita
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Schizophr Res 99:359-64. 2008
    ..These findings suggest that PLXNA2 confers a varying genetic risk for schizophrenia among different populations...
  11. doi request reprint Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder
    Kenji Amano
    Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako Shi, Japan
    Psychiatr Genet 18:1-10. 2008
    ....
  12. doi request reprint Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:508-14. 2009
    ..108) in our sample sets. These results suggest that the genetic contribution of CHI3L1 to schizophrenia is variable, even though it is mechanistically involved in the disease process...
  13. ncbi request reprint Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia
    Hiromitsu Shimizu
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Schizophr Res 84:244-52. 2006
    ..These data suggest that the contribution of MAP6 to the processes that lead to schizophrenia should be further investigated...
  14. ncbi request reprint A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Neuropsychopharmacology 32:1727-37. 2007
    ..In conclusion, the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations...
  15. ncbi request reprint Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Biol Psychiatry 57:1493-503. 2005
    ....
  16. doi request reprint Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder
    Yoshimi Iwayama
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:484-93. 2010
    ..Therefore, future identification of unknown regulatory elements will be necessary to make a more detailed analysis of their genetic contribution to mental illnesses...
  17. ncbi request reprint Mitochondrial DNA haplogroup analysis in patients with bipolar disorder
    An a Kazuno
    RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:243-7. 2009
    ..However, this association was not replicated in an independent sample set. Possible significances of these findings are discussed...
  18. ncbi request reprint Extended analyses support the association of a functional (GT)n polymorphism in the GRIN2A promoter with Japanese schizophrenia
    Yoshimi Iwayama-Shigeno
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Neurosci Lett 378:102-5. 2005
    ..These results suggest a probable genetic effect for the GRIN2A promoter (GT)n variation on the predisposition to schizophrenia in Japanese cohorts...
  19. pmc Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia
    Kazuo Yamada
    Laboratories for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 104:2815-20. 2007
    ..These findings support the previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis and identify EGR3 as a compelling susceptibility gene...
  20. ncbi request reprint Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders: evidence for association of ASCL1 with Parkinson's disease
    Masayuki Ide
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Hum Genet 117:520-7. 2005
    ..The present genetic data may thus suggest that polyglutamine length polymorphisms in ASCL1 could influence predispositions to PD through the fine-tuning of LC integrity...
  21. ncbi request reprint Analysis of correlation between serum D-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes
    Yoshimi Iwayama
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Neurosci Lett 394:101-4. 2006
    ....
  22. pmc Variable number of tandem repeat polymorphisms of DRD4: re-evaluation of selection hypothesis and analysis of association with schizophrenia
    Eiji Hattori
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Eur J Hum Genet 17:793-801. 2009
    ..Collectively, this study suggests that the VNTR variation does not have an effect large enough to cause either selection or a detectable association with schizophrenia in a study of samples of moderate size...
  23. doi request reprint Lack of association of EGR2 variants with bipolar disorder in Japanese population
    Shabeesh Balan
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Gene 526:246-50. 2013
    ....
  24. ncbi request reprint Association analysis of HSP90B1 with bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Hum Genet 52:794-803. 2007
    ..HSP90B1 may have a pathophysiological role in bipolar disorder in the Japanese population, though further study will be needed to understand the underlying functional mechanisms...
  25. pmc Genome-wide association study of schizophrenia in Japanese population
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS ONE 6:e20468. 2011
    ..026). The current data in Asian population would be helpful for deciphering ethnic diversity of schizophrenia etiology...
  26. ncbi request reprint A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Neurosci Lett 462:267-71. 2009
    ..Our findings suggest the necessity of further studies on the causal relationship between PAX6 and autism...
  27. doi request reprint Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain
    Miki Bundo
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Psychiatry Clin Neurosci 64:57-61. 2010
    ..Here we examined the relationship between genetic variations and expression level or RNA editing level of HTR2C in the human brain...
  28. ncbi request reprint Association between schizophrenia with ocular misalignment and polyalanine length variation in PMX2B
    Tomoko Toyota
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Hum Mol Genet 13:551-61. 2004
    ....
  29. pmc Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype
    Akiko Watanabe
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS Biol 5:e297. 2007
    ..We also discuss the results from the perspective of fetal programming...
  30. ncbi request reprint Transcriptional activities of cholecystokinin promoter haplotypes and their relevance to panic disorder susceptibility
    Mitsuru Ebihara
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Am J Med Genet B Neuropsychiatr Genet 118:32-5. 2003
    ..0032; odds ratio, 95% confidence interval = 0.06, 0.01-0.69). These results suggest that the L-(-188G) haplotype may act as a protective factor against panic by reducing the expression of anxiogenic CCK...
  31. ncbi request reprint Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects
    Joanne Meerabux
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Biol Psychiatry 58:401-7. 2005
    ..Both angiotensin-converting enzyme (ACE) and orexin (hypocretin) signaling can modulate drinking behavior through interactions with the dopaminergic system...
  32. ncbi request reprint Evidence of association between gamma-aminobutyric acid type A receptor genes located on 5q34 and female patients with mood disorders
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Neurosci Lett 349:9-12. 2003
    ..Polymorphisms on GABRA1 and GABRA6 genes displayed significant associations with mood disorders in female patients. These data offer genetic support for a role of GABA(A) receptor genes in susceptibility to mood disorders...
  33. doi request reprint Association study of Nogo-related genes with schizophrenia in a Japanese case-control sample
    Daisuke Jitoku
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 156:581-92. 2011
    ....
  34. doi request reprint Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    J Neurochem 115:1374-85. 2010
    ..We detected a nominal association between SHMT1 and schizophrenia. These results suggest that Shmt1 (SHMT1), but not Srr, is likely to be one of the genetic components regulating PPI in mice and possibly relevant to schizophrenia...
  35. pmc Association and synergistic interaction between promoter variants of the DRD4 gene in Japanese schizophrenics
    Mizuho Nakajima
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama, 351 0198, Japan
    J Hum Genet 52:86-91. 2007
    ..These results suggest that the upstream variants have a primary functional effect in the etiology of schizophrenia in the Japanese population...
  36. ncbi request reprint C18orf1 located on chromosome 18p11.2 may confer susceptibility to schizophrenia
    Mika Kikuchi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    J Med Dent Sci 50:225-9. 2003
    ..021). These findings suggest that C18orf1 or a gene nearby may contribute to the overall genetic risk for schizophrenia...
  37. ncbi request reprint Genetic and expression analyses of FZD3 in schizophrenia
    Masayuki Ide
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Biol Psychiatry 56:462-5. 2004
    ..Our study attempted to confirm associations between FZD3 and schizophrenia in Japanese family and case-control samples...
  38. doi request reprint Preliminary genome-wide association study of bipolar disorder in the Japanese population
    Eiji Hattori
    RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:1110-7. 2009
    ..Sample stratification was virtually negligible. Collectively, this is the first GWAS of BD in the Japanese population. But given the small sample size and the limited genomic coverage, these results should be taken as preliminary...
  39. doi request reprint A population-specific uncommon variant in GRIN3A associated with schizophrenia
    Atsushi Takata
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Biol Psychiatry 73:532-9. 2013
    ..However, individually, these variants only produce a weak effect. To identify genetic variants with larger effect sizes, increasing attention is now being paid to uncommon and rare variants...
  40. pmc Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
    PLoS ONE 6:e29499. 2011
    ..These results prompt further examination of the gene, including its putative contribution to hyper-γ-glutamyl transpeptidasemia and schizophrenia...
  41. ncbi request reprint Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees
    Shinsuke Washizuka
    Laboratories for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    Biol Psychiatry 56:483-9. 2004
    ..We previously reported that a polymorphism in the upstream region of NDUFV2, -602G> A, was associated with bipolar disorder in Japanese subjects; however, functional significance of -602G> A was not known...
  42. ncbi request reprint A novel scale including strabismus and 'cuspidal ear' for distinguishing schizophrenia patients from controls using minor physical anomalies
    Kiyoshi Yoshitsugu
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Psychiatry Res 145:249-58. 2006
    ..The scale may also facilitate the identification of schizophrenia susceptibility genetic/environmental factors by stratifying etiologically heterogeneous patients according to physical abnormalities...
  43. ncbi request reprint Mitochondrial DNA 3644T-->C mutation associated with bipolar disorder
    Kae Munakata
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Genomics 84:1041-50. 2004
    ..The result of modest functional impairment caused by 3644T-->C suggests that this mutation could increase the risk for bipolar disorder...
  44. ncbi request reprint Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia
    Masayuki Ide
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    J Neurochem 99:277-87. 2006
    ..Collectively, this study failed to support reduced signaling of the AKT-GSK3beta molecular cascade in schizophrenia...
  45. ncbi request reprint DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Neurosci 25:5376-81. 2005
    ..Therefore, DNA methylation status of the SOX10 CpG island could be an epigenetic sign of oligodendrocyte dysfunction in schizophrenia...
  46. ncbi request reprint A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia
    Masanari Itokawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Pharmacogenetics 13:271-8. 2003
    ..These results illustrate a genotype-phenotype correlation in schizophrenia and suggest that the longer (GT)(n) stretch may act as a risk-conferring factor that worsens chronic outcome by reducing GRIN2A levels in the brain...
  47. ncbi request reprint Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophrenia
    Yoshimi Iwayama-Shigeno
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Am J Med Genet B Neuropsychiatr Genet 118:20-4. 2003
    ..Haplotypes derived from all three polymorphisms generated similar results. These data do not support the notion that the NR4A2 gene plays a major role in risk for schizophrenia among Japanese individuals...
  48. ncbi request reprint Association study of the short tandem repeat in the 5' upstream region of the cholecystokinin gene with mood disorders in the Japanese population
    Eiji Hattori
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute BSI, Wako, Saitama, Japan
    Am J Med Genet 114:523-6. 2002
    ..885), the unipolar group (P = 0.296), or the bipolar group (P = 0.605). These data suggest that the CCK promoter STR is unlikely to have a major genetic effect on the development of mood disorders in the Japanese population...
  49. ncbi request reprint Analysis of a cluster of polymorphisms in AKT1 gene in bipolar pedigrees: a family-based association study
    Tomoko Toyota
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, 351 0198, Saitama, Japan
    Neurosci Lett 339:5-8. 2003
    ..Seven polymorphic sites were clustered in a small segment spanning exon 14 and downstream intron. Transmission of haplotypes constructed from this cluster showed a weak evidence of association between the AKT1 and bipolar disorder...
  50. ncbi request reprint Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders
    Tomoko Toyota
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet 114:84-92. 2002
    ..The DNA polymorphisms detected in this study can be tested in other ethnic samples and/or other psychiatric diseases...