Ichiro Taniuchi

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi request reprint Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
    Tian H Chi
    Department of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
    Nature 418:195-9. 2002
  2. doi request reprint Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate
    Sawako Muroi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Nat Immunol 9:1113-21. 2008
  3. pmc Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer
    Yoshinori Naoe
    Institute of Physical and Chemical Research, Research Center for Allergy and Immunology, Turumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Exp Med 204:1749-55. 2007
  4. pmc Runx1-Cbfβ facilitates early B lymphocyte development by regulating expression of Ebf1
    Wooseok Seo
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama 230 0045, Japan
    J Exp Med 209:1255-62. 2012
  5. ncbi request reprint Epigenetic gene silencing by Runx proteins
    Ichiro Taniuchi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
    Oncogene 23:4341-5. 2004
  6. doi request reprint Transcriptional regulation in helper versus cytotoxic-lineage decision
    Ichiro Taniuchi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    Curr Opin Immunol 21:127-32. 2009
  7. doi request reprint Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development
    Ruka Setoguchi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    Science 319:822-5. 2008
  8. pmc Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus
    Hirokazu Tanaka
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    EMBO J 32:1183-94. 2013
  9. pmc Cutting edge: fine-tuning of Thpok gene activation by an enhancer in close proximity to its own silencer
    Sawako Muroi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
    J Immunol 190:1397-401. 2013
  10. doi request reprint Transcriptional control of T-cell development
    Taku Naito
    Laboratory of Transcriptional Regulation, RIKEN Research Institute for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, 230 0045, Japan
    Int Immunol 23:661-8. 2011

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
    Tian H Chi
    Department of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
    Nature 418:195-9. 2002
    ..These results indicate that BAF complexes contribute to lineage bifurcation by reciprocally regulating lineage-specific genes, reminiscent of the role of the yeast SWI/SNF complex in mediating mating-type switching...
  2. doi request reprint Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate
    Sawako Muroi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Nat Immunol 9:1113-21. 2008
    ..Our results show how an initial lineage-specification signal can be amplified and stabilized during the lineage-commitment process...
  3. pmc Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer
    Yoshinori Naoe
    Institute of Physical and Chemical Research, Research Center for Allergy and Immunology, Turumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Exp Med 204:1749-55. 2007
    ..These results demonstrate critical roles of Runx complexes in regulating immune responses, at least in part, through the repression of the Il4 gene...
  4. pmc Runx1-Cbfβ facilitates early B lymphocyte development by regulating expression of Ebf1
    Wooseok Seo
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama 230 0045, Japan
    J Exp Med 209:1255-62. 2012
    ..Collectively, these results demonstrate that Runx1-Cbfβ complexes are essential to facilitate B lineage specification, in part via epigenetic activation of the Ebf1 gene...
  5. ncbi request reprint Epigenetic gene silencing by Runx proteins
    Ichiro Taniuchi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
    Oncogene 23:4341-5. 2004
    ..These findings link Runx function to epigenetic gene regulation, and shed new light on the mechanisms by which Runx represses target gene expression...
  6. doi request reprint Transcriptional regulation in helper versus cytotoxic-lineage decision
    Ichiro Taniuchi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    Curr Opin Immunol 21:127-32. 2009
    ..It has now become evident that an antagonistic interplay between ThPOK and Runx transcription factor complexes plays an essential role in thwarting an alternate fate during the commitment process...
  7. doi request reprint Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development
    Ruka Setoguchi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    Science 319:822-5. 2008
    ..Identification of the transcription factors network in CD4 and CD8 lineage choice provides insight into how distinct T cell subsets are developed for regulating the adaptive immune system...
  8. pmc Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus
    Hirokazu Tanaka
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    EMBO J 32:1183-94. 2013
    ....
  9. pmc Cutting edge: fine-tuning of Thpok gene activation by an enhancer in close proximity to its own silencer
    Sawako Muroi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
    J Immunol 190:1397-401. 2013
    ..Thus, regulation of contiguous but separable sequences with opposite function in the DRE plays an important role in precise coupling of TCR signaling with the selection process of two opposite lineages...
  10. doi request reprint Transcriptional control of T-cell development
    Taku Naito
    Laboratory of Transcriptional Regulation, RIKEN Research Institute for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, 230 0045, Japan
    Int Immunol 23:661-8. 2011
    ..In this review, we briefly discuss how T-cell characteristics are acquired and become divergent from the point of view of transcriptional regulation...
  11. doi request reprint Transcriptional and epigenetic regulation of CD4/CD8 lineage choice
    Ichiro Taniuchi
    Laboratory for Transcriptional Regulation, Research Center for Allergy and Immunology, RIKEN, Suehiro cho, Turumi ku, Yokohama, Kanagawa, Japan
    Adv Immunol 110:71-110. 2011
    ....
  12. doi request reprint Roles of VWRPY motif-mediated gene repression by Runx proteins during T-cell development
    Wooseok Seo
    Laboratory for Transcriptional Regulation, Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa, Japan
    Immunol Cell Biol 90:827-30. 2012
    ..These results indicate that Runx proteins utilize different modes to repress expression of different target genes...
  13. doi request reprint Runx1/Cbfβ2 complexes are required for lymphoid tissue inducer cell differentiation at two developmental stages
    Masashi Tachibana
    Laboratory for Transcriptional Regulation, Research Center for Allergy and Immunology, RIKEN, Yokohama 230 0045, Japan
    J Immunol 186:1450-7. 2011
    ....
  14. doi request reprint Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation
    Masashi Tachibana
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    Biochem Biophys Res Commun 368:536-42. 2008
    ....
  15. ncbi request reprint The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development
    Ichiro Taniuchi
    RIKEN Research Center, Yokohama 230 0045, Japan
    Adv Immunol 83:55-89. 2004
  16. ncbi request reprint The CD4/CD8 lineages: central decisions and peripheral modifications for T lymphocytes
    Hirokazu Tanaka
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045, Japan
    Curr Top Microbiol Immunol 373:113-29. 2014
    ..We then discuss a novel aspect of the ThPOK/Runx3 axis in modifying CD4(+) T cell function upon exposure to gut microenvironment. ..
  17. pmc Roles of repressive epigenetic machinery in lineage decision of T cells
    Taku Naito
    Laboratory for Transcriptional Regulation, Research Centre for Allergy and Immunology, RIKEN, Yokohama, Japan
    Immunology 139:151-7. 2013
    ..We also discuss the current challenges faced when analysing the function of the epigenetic machinery and potential directions to overcome the problems...
  18. doi request reprint The network of transcription factors that underlie the CD4 versus CD8 lineage decision
    Taku Naito
    Laboratory of Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cyo, Tsurumi ku, Yokohama 230 0045, Japan
    Int Immunol 22:791-6. 2010
    ....
  19. ncbi request reprint Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells
    Atsushi Hijikata
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, Japan
    Bioinformatics 23:2934-41. 2007
    ..To address this, we constructed an open-access database that enabled us to cross-reference transcriptomic and proteomic data obtained from immune cells...
  20. ncbi request reprint Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 111:621-33. 2002
    ..Runx3-deficient cytotoxic T cells, but not helper cells, have defective responses to antigen, suggesting that Runx proteins have critical functions in lineage specification and homeostasis of CD8-lineage T lymphocytes...
  21. ncbi request reprint Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development
    Yoko Fukushima-Nakase
    Department of Molecular Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Blood 105:4298-307. 2005
    ..Thus, the C-terminal portions of Runx family members have both similar and distinct biologic functions...
  22. ncbi request reprint Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors
    Takeshi Egawa
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Immunity 22:705-16. 2005
    ..Our results indicate that even though CD1d binding DP thymocytes have yet to be observed, Valpha14-Jalpha18 rearrangement in these cells is required for development of iNKT cells...
  23. pmc Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle
    Xiaoxia Wang
    Molecular Neurobiology Program, Molecular Pathogenesis Program and Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, New York 10016, USA
    Genes Dev 19:1715-22. 2005
    ..Moreover, these results suggest that reduced muscle activity could cause or contribute to congenital myopathies if Runx1 or its target genes were compromised...
  24. ncbi request reprint Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells
    Baerbel Grueter
    Institute of Molecular Biology Cancer Research, University of Essen, Medical School, Essen, Germany
    J Immunol 175:1694-705. 2005
    ..Thus, Runx3 is a main regulator of CD4 silencing and CD103 induction and thus contributes to the phenotype of CD8 SP T cells during thymocyte development...
  25. ncbi request reprint Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Mol Cell 10:1083-96. 2002
    ....
  26. ncbi request reprint A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification
    Ina Kramer
    Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Neuron 49:379-93. 2006
    ..Together, our findings suggest that Runx transcription factor signaling plays a key role in sensory neuron diversification...