Keiji Tanaka

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi request reprint Columns for complex visual object features in the inferotemporal cortex: clustering of cells with similar but slightly different stimulus selectivities
    Keiji Tanaka
    RIKEN Brain Research Institute, Wako Shi, Saitama 351 0198, Japan
    Cereb Cortex 13:90-9. 2003
  2. ncbi request reprint Late responses and perceptual awareness
    K Tanaka
    RIKEN Brain Science Institute, Laboratory for Cognitive Brain Mapping, Wako, Saitama, 351 0198, Japan
    Nat Neurosci 4:225-6. 2001
  3. ncbi request reprint Medial prefrontal cell activity signaling prediction errors of action values
    Madoka Matsumoto
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Nat Neurosci 10:647-56. 2007
  4. ncbi request reprint Mnemonic function of the dorsolateral prefrontal cortex in conflict-induced behavioral adjustment
    Farshad A Mansouri
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Science 318:987-90. 2007
  5. pmc Demonstration of tuning to stimulus orientation in the human visual cortex: a high-resolution fMRI study with a novel continuous and periodic stimulation paradigm
    Pei Sun
    RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Cereb Cortex 23:1618-29. 2013
  6. doi request reprint Developing intuition: neural correlates of cognitive-skill learning in caudate nucleus
    Xiaohong Wan
    Cognitive Brain Mapping Laboratory and Support Unit for Functional Magnetic Resonance Imaging, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 32:17492-501. 2012
  7. ncbi request reprint A temporal frequency-dependent functional architecture in human V1 revealed by high-resolution fMRI
    Pei Sun
    Laboratory for Cognitive Brain Mapping, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Nat Neurosci 10:1404-6. 2007
  8. ncbi request reprint Reward association affects neuronal responses to visual stimuli in macaque te and perirhinal cortices
    Tsuguo Mogami
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 26:6761-70. 2006
  9. doi request reprint Statistics of visual responses in primate inferotemporal cortex to object stimuli
    Sidney R Lehky
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Inst, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    J Neurophysiol 106:1097-117. 2011
  10. doi request reprint Functional signalers of changes in visual stimuli: cortical responses to increments and decrements in motion coherence
    Mauro Costagli
    Laboratory for Cognitive Brain Mapping, RIKEN Brain Science Institute, Japan
    Cereb Cortex 24:110-8. 2014

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Columns for complex visual object features in the inferotemporal cortex: clustering of cells with similar but slightly different stimulus selectivities
    Keiji Tanaka
    RIKEN Brain Research Institute, Wako Shi, Saitama 351 0198, Japan
    Cereb Cortex 13:90-9. 2003
    ..The two modes may work in parallel, with a graded balance changing according to the behavioral context. Determining whether or not these hypotheses are valid will require further studies...
  2. ncbi request reprint Late responses and perceptual awareness
    K Tanaka
    RIKEN Brain Science Institute, Laboratory for Cognitive Brain Mapping, Wako, Saitama, 351 0198, Japan
    Nat Neurosci 4:225-6. 2001
    ..An electrophysiological study in monkey primary visual cortex reveals that a late component of neural activity is correlated with perceptual awareness of an object...
  3. ncbi request reprint Medial prefrontal cell activity signaling prediction errors of action values
    Madoka Matsumoto
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Nat Neurosci 10:647-56. 2007
    ..Therefore, these responses in medial prefrontal cells may signal the direction and amount of error in prediction of values of executed actions to specify the adjustment in subsequent action selections...
  4. ncbi request reprint Mnemonic function of the dorsolateral prefrontal cortex in conflict-induced behavioral adjustment
    Farshad A Mansouri
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Science 318:987-90. 2007
    ..These results show that the DLPFC, but not the ACC, is essential for the conflict-induced behavioral adjustment and suggest that encoding and maintenance of information about experienced conflict is mediated by the DLPFC...
  5. pmc Demonstration of tuning to stimulus orientation in the human visual cortex: a high-resolution fMRI study with a novel continuous and periodic stimulation paradigm
    Pei Sun
    RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Cereb Cortex 23:1618-29. 2013
    ..Our results, thus, refined the neural mechanisms of these 2 global biases in orientation perception...
  6. doi request reprint Developing intuition: neural correlates of cognitive-skill learning in caudate nucleus
    Xiaohong Wan
    Cognitive Brain Mapping Laboratory and Support Unit for Functional Magnetic Resonance Imaging, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 32:17492-501. 2012
    ....
  7. ncbi request reprint A temporal frequency-dependent functional architecture in human V1 revealed by high-resolution fMRI
    Pei Sun
    Laboratory for Cognitive Brain Mapping, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Nat Neurosci 10:1404-6. 2007
    ..Using high-resolution functional magnetic resonance imaging, we have found such a functional architecture containing domains that respond preferentially to either low or high temporal frequency...
  8. ncbi request reprint Reward association affects neuronal responses to visual stimuli in macaque te and perirhinal cortices
    Tsuguo Mogami
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 26:6761-70. 2006
    ..These results suggest the involvement of PRh and TE in associating visual stimuli with reward outcomes...
  9. doi request reprint Statistics of visual responses in primate inferotemporal cortex to object stimuli
    Sidney R Lehky
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Inst, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    J Neurophysiol 106:1097-117. 2011
    ..These results are inconsistent with some structural models of object recognition that posit that objects are decomposed into a small number of standard features...
  10. doi request reprint Functional signalers of changes in visual stimuli: cortical responses to increments and decrements in motion coherence
    Mauro Costagli
    Laboratory for Cognitive Brain Mapping, RIKEN Brain Science Institute, Japan
    Cereb Cortex 24:110-8. 2014
    ....
  11. doi request reprint The neural basis of intuitive best next-move generation in board game experts
    Xiaohong Wan
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Science 331:341-6. 2011
    ..These results suggest that the precuneus-caudate circuit implements the automatic, yet complicated, processes of board-pattern perception and next-move generation in board game experts...
  12. pmc Development of monotonic neuronal tuning in the monkey inferotemporal cortex through long-term learning of fine shape discrimination
    Wataru Suzuki
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Eur J Neurosci 33:748-57. 2011
    ..These results suggest that visual expertise could be based on the development, in the inferotemporal cortex, of neuronal selectivity monotonically tuned over the parameter space of the object images...
  13. ncbi request reprint Neuronal responses to object images in the macaque inferotemporal cortex at different stimulus discrimination levels
    Wataru Suzuki
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 26:10524-35. 2006
    ..Neuronal adaptations to behavioral context may occur downstream of the inferotemporal cortex...
  14. ncbi request reprint The role of the medial prefrontal cortex in achieving goals
    Kenji Matsumoto
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Curr Opin Neurobiol 14:178-85. 2004
    ..Medial prefrontal cells were also active when the subjects extracted the rules of a task in a novel environment. The processes described above might play important roles in rule learning...
  15. ncbi request reprint Effects of novelty on activity of lateral and medial prefrontal neurons
    Madoka Matsumoto
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama, Japan
    Neurosci Res 57:268-76. 2007
    ..These results suggest that the lateral and medial divisions of the prefrontal cortex are differentially involved in the control of attention triggered by novel sensory events...
  16. doi request reprint Conflict-induced behavioural adjustment: a clue to the executive functions of the prefrontal cortex
    Farshad A Mansouri
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Nat Rev Neurosci 10:141-52. 2009
    ....
  17. ncbi request reprint Correction of 3D rigid body motion in fMRI time series by independent estimation of rotational and translational effects in k-space
    Mauro Costagli
    Laboratory for Cognitive Brain Mapping, RIKEN Brain Science Institute, Wakoshi, Saitama, Japan
    Neuroimage 45:749-57. 2009
    ..Our data show that the algorithm proposed here successfully corrects for rigid-body motion, and its employment in future fMRI studies is feasible and promising...
  18. doi request reprint Processing of infant-directed speech by adults
    Yoshi Taka Matsuda
    Laboratory for Language Development, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    Neuroimage 54:611-21. 2011
    ..Increased cortical activation levels were not found for fathers, non-parents, or mothers with older children...
  19. ncbi request reprint Neuroscience. Conflict and cognitive control
    Kenji Matsumoto
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Science 303:969-70. 2004
  20. ncbi request reprint Behavioral evidence for working memory of sensory dimension in macaque monkeys
    Farshad A Mansouri
    Laboratory for Cognitive Brain Mapping, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Behav Brain Res 136:415-26. 2002
    ....
  21. ncbi request reprint Neuronal correlates of goal-based motor selection in the prefrontal cortex
    Kenji Matsumoto
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Science 301:229-32. 2003
    ..This prefrontal activity is likely to underlie goal-based action selection...
  22. ncbi request reprint Divergent backward projections from the anterior part of the inferotemporal cortex (area TE) in the macaque
    W Suzuki
    Graduate School of Engineering Sciences, Osaka University, Toyonaka shi, Osaka 560 0043, Japan
    J Comp Neurol 422:206-28. 2000
    ..However, single axons have more variable laminar patterns of terminal distribution than those in the other backward systems...
  23. ncbi request reprint Human ocular dominance columns as revealed by high-field functional magnetic resonance imaging
    K Cheng
    Laboratory for Cognitive Brain Mapping, RIKEN Brain Science Institute and CREST, Japan Science and Technology Corporation, 2 1 Hirosawa, 351 0198, Wako, Saitama, Japan
    Neuron 32:359-74. 2001
    ..Our results demonstrate that high-field fMRI can be used for studying the functions of human brains at columnar spatial resolution...
  24. ncbi request reprint Memory-related acetylcholine efflux from rat prefrontal cortex and hippocampus: a microdialysis study
    N Hironaka
    Department of Physiology, Saitama Medical School, Saitama, Japan
    Brain Res 901:143-50. 2001
    ..These results suggest that the prefrontal ACh is mainly related to working memory, whereas the hippocampal ACh is mainly related to reference memory...
  25. ncbi request reprint Diversification of the microtubule system in the early stage of eukaryote evolution: elongation factor 1 alpha and alpha-tubulin protein phylogeny of termite symbiotic oxymonad and hypermastigote protists
    S Moriya
    Laboratory of Microbiology, The Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Mol Evol 52:6-16. 2001
    ..Our findings suggest that these protists have a cellular microtubule system that has diverged considerably, and it seems that such divergence of the microtubule system occurred in the earliest stage of eukaryotic evolution...
  26. ncbi request reprint Connections between anterior inferotemporal cortex and superior temporal sulcus regions in the macaque monkey
    K S Saleem
    RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 20:5083-101. 2000
    ..It is also suggested that the information processing in the ventral bank of the rostral STS is distinct from that in TEad, and the former more directly interacts with TEav than TEad...
  27. ncbi request reprint Representation of objective similarity among three-dimensional shapes in the monkey
    T Sugihara
    Department of Biochemical Engineering and Science, Kyushu Institute Technology, Fukuoka, Japan
    Biol Cybern 78:1-7. 1998
    ..A simulation study showed that the resemblance could not be due to chance. These results demonstrate the possibility of veridical representation of parametric similarity among complex objects in the monkey...
  28. ncbi request reprint Prefrontal cell activities related to monkeys' success and failure in adapting to rule changes in a Wisconsin Card Sorting Test analog
    Farshad A Mansouri
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 26:2745-56. 2006
    ....
  29. pmc Contrast adaptation and representation in human early visual cortex
    Justin L Gardner
    Laboratory for Cognitive Brain Mapping, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Neuron 47:607-20. 2005
    ..These findings suggest that the visual system discounts slow uninformative changes in contrast with adaptation, yet remains exquisitely sensitive to changes that may signal important events in the environment...
  30. ncbi request reprint Visual response properties of cells in the ventral and dorsal parts of the macaque inferotemporal cortex
    H Tamura
    RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan
    Cereb Cortex 11:384-99. 2001
    ..These results support an earlier anatomical finding that TEav and TEad are located at the same hierarchical level of separate serial pathways rather than at successive stages of a single pathway...
  31. pmc Cognitive control functions of anterior cingulate cortex in macaque monkeys performing a Wisconsin Card Sorting Test analog
    Masaru Kuwabara
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan, Graduate School of Frontier Biosciences, Osaka University, Toyonaka, Osaka 560 8531, Japan, and
    J Neurosci 34:7531-47. 2014
    ..These results suggest that ACCs represent both context-dependent and internally detected error likelihoods and promote modes of response selections in situations that involve these two types of error likelihood. ..
  32. ncbi request reprint Selective expression of a novel surface molecule by human Th2 cells in vivo
    K Nagata
    R and D Center, BioMedical Laboratories, Kawagoe, Saitama, Japan
    J Immunol 162:1278-86. 1999
    ..Together, these results indicate that CRTH2 is selectively expressed in vivo in an activated state of Th2 cells including allergen-responsive Th2 cells, suggesting its pivotal roles in ongoing Th2-type immune reactions...
  33. ncbi request reprint Cloning and expression of a glutamate transporter from mouse brain
    K Tanaka
    Laboratory for Neural Networks, Institute of Physical and Chemical Research, RIKEN, Saitama, Japan
    Neurosci Lett 159:183-6. 1993
    ..The cDNA sequence predicts a protein of 543 amino acids with 6 potential transmembrane domains. Northern blot analysis indicates the mRNA encoding the glutamate transporter is expressed both in the brain and in peripheral tissues...
  34. ncbi request reprint Expression cloning of a rat glutamate transporter
    K Tanaka
    Laboratory for Neural Network, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    Neurosci Res 16:149-53. 1993
    ..The glutamate transporter mRNA is expressed in both the brain and the peripheral tissues at different levels...
  35. ncbi request reprint Identification and characterization of genes associated with human hepatocellular carcinogenesis
    N Kondoh
    Department of Biochemistry II, National Defense Medical College, Saitama, Japan
    Cancer Res 59:4990-6. 1999
    ..These transcripts are differentially regulated depending on cell-cell contact, serum growth factors, growth and differentiation status, and/or other mechanisms in premalignant and malignant liver cells...
  36. pmc Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23
    C Masutani
    Cellular Physiology Laboratory, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    EMBO J 13:1831-43. 1994
    ..All RAD23 derivatives share a ubiquitin-like N-terminus. The nature of the XP-C defect implies that the complex exerts a unique function in the genome-overall repair pathway which is important for prevention of skin cancer...
  37. ncbi request reprint Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase
    N Matsuda
    Molecular Membrane Biology Laboratory, RIKEN, Wako, Saitama 351 0198, Japan
    J Cell Sci 114:1949-57. 2001
    ..Free MBP in solution is not a substrate of Rma1. These observations indicate that bringing the substrate into its physical vicinity is very important for the action of ubiquitin ligase...
  38. doi request reprint Stochastic resonance in brain activity elicited by auditory stimuli
    K Tanaka
    Division of Science and Engineering, Tokyo Denki University, Saitama, Japan
    Conf Proc IEEE Eng Med Biol Soc 2009:6300-3. 2009
    ..The observed stochastic resonance (SR) most likely occurred within the central nervous system. Our finding may be quite important as mechanisms of SR in biological systems are mostly unknown...
  39. ncbi request reprint A novel serum protein that is selectively produced by cytotoxic lymphocytes
    K Ogawa
    R and D Center and Laboratory Headquarters, BML, Saitama, Japan
    J Immunol 166:6404-12. 2001
    ..These results suggest that Ksp37 may be involved in an essential process of cytotoxic lymphocyte-mediated immunity and that Ksp37 may also have clinical value as a new type of serum indicator for monitoring cytotoxic lymphocytes in vivo...
  40. ncbi request reprint Enhanced expression of S8, L12, L23a, L27 and L30 ribosomal protein mRNAs in human hepatocellular carcinoma
    N Kondoh
    Second Department of Biochemistry, National Defense Medical College, Saitama, Japan
    Anticancer Res 21:2429-33. 2001
    ..The expression of these mRNAs was also high in three human HCC cell lines (HuH-7, HepG2 and HLF), irrespective of the growth state. These results suggest that activation of these genes is an important manifestation of HCC phenotypes...
  41. ncbi request reprint Prior experience of rotation is not required for recognizing objects seen from different angles
    Gang Wang
    Department of Bioengineering, Faculty of Engineering, Kagoshima University, Kagoshima, Kagoshima 890 0065, Japan
    Nat Neurosci 8:1768-75. 2005
    ..Our results suggest that object recognition across small or medium changes in viewing angle depends on features common to similar views of objects...
  42. ncbi request reprint Enhancement of object representations in primate perirhinal cortex during a visual working-memory task
    Sidney R Lehky
    Computational Neuroscience Lab, The Salk Institute, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Neurophysiol 97:1298-310. 2007
    ..The onset of the enhanced signal in PRh during the object-memory task occurred with a latency of 80 ms after the onset of the stimulus response, suggesting that it was the result of top-down feedback...
  43. ncbi request reprint Object category structure in response patterns of neuronal population in monkey inferior temporal cortex
    Roozbeh Kiani
    Research Group for Brain and Cognitive Sciences, School of Medicine, Shaheed Beheshti University, P O Box 19835 181, Tehran, Iran
    J Neurophysiol 97:4296-309. 2007
    ..These results advance our understanding of the nature of the IT neural code, suggesting an inherently categorical representation that comprises a range of categories including the amply investigated face category...
  44. ncbi request reprint Differences in onset latency of macaque inferotemporal neural responses to primate and non-primate faces
    Roozbeh Kiani
    Research Group for Brain and Cognitive Sciences, School of Medicine, Shaheed Beheshti University, Tehran, Iran
    J Neurophysiol 94:1587-96. 2005
    ..Differences in onset latency may be used to increase the coding capacity or enhance or suppress information about particular object groups by time-dependent modulation...
  45. ncbi request reprint Loss of autophagy in the central nervous system causes neurodegeneration in mice
    Masaaki Komatsu
    Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    Nature 441:880-4. 2006
    ..Our results indicate that autophagy is essential for the survival of neural cells, and that impairment of autophagy is implicated in the pathogenesis of neurodegenerative disorders involving ubiquitin-containing inclusion bodies...
  46. ncbi request reprint Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity
    Tomonori Fujiwara
    Department of Cell Physiology, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    J Neurosci 26:5767-76. 2006
    ..Interestingly, the KO mice had impaired conditioned fear memory extinction. These observations suggest that HPC-1/syntaxin 1A may be closely related to synaptic plasticity...
  47. ncbi request reprint Autophagy and neurodegeneration
    Masaaki Komatsu
    Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo, Japan
    Autophagy 2:315-7. 2006
    ..Here we discuss the consequences of autophagy deficiency in neurons...
  48. ncbi request reprint Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
    Masaaki Komatsu
    Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    Cell 131:1149-63. 2007
    ....
  49. ncbi request reprint Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders
    Shinsuke Ishigaki
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8500, Japan
    J Biol Chem 279:51376-85. 2004
    ..Our results indicate that VCPs functionally regulate Dorfin through direct interaction and that their functional interplay may be related to the process of UBI formation in neurodegenerative disorders, such as ALS or PD...
  50. ncbi request reprint A palmitoylated RING finger ubiquitin ligase and its homologue in the brain membranes
    Kazuaki Araki
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    J Neurochem 86:749-62. 2003
    ..In agreement, Sakura associating with the membrane was specifically palmitoylated. Although the molecular targets of their Ub ligation remain to be identified, these findings imply a novel function of the palmitoylated E3 Ub ligase(s)...
  51. pmc SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release
    Ikuko Yao
    Mitsubishi Kagaku Institute of Life Sciences MITILS, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    Cell 130:943-57. 2007
    ..Thus, SCRAPPER has an essential function in regulating proteasome-mediated degradation of RIM1 required for synaptic tuning...
  52. ncbi request reprint Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity
    Jun ichi Niwa
    Department of Neurology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 277:36793-8. 2002
    ..Our results indicate that Dorfin protects neurons by recognizing and then ubiquitylating mutant SOD1 proteins followed by targeting them for proteasomal degradation...
  53. ncbi request reprint Selective proteasomal dysfunction in the hippocampal CA1 region after transient forebrain ischemia
    Akio Asai
    Laboratory for Neuroscience and Neurooncology, Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Cereb Blood Flow Metab 22:705-10. 2002
    ..The irreversible loss of proteasome function underlies the delayed neuronal death induced by transient forebrain ischemia in the hippocampal CA1 region...