Sunao Sugita

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. doi request reprint Use of a comprehensive polymerase chain reaction system for diagnosis of ocular infectious diseases
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    Ophthalmology 120:1761-8. 2013
  2. pmc Role of IL-22- and TNF-α-producing Th22 cells in uveitis patients with Behcet's disease
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Tokyo 113 8519, Japan
    J Immunol 190:5799-808. 2013
  3. doi request reprint Mature dendritic cell suppression by IL-1 receptor antagonist on retinal pigment epithelium cells
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Tokyo, Japan
    Invest Ophthalmol Vis Sci 54:3240-9. 2013
  4. doi request reprint Virological analysis in patients with human herpes virus 6-associated ocular inflammatory disorders
    Sunao Sugita
    Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Chuo Ku, Kobe, Japan
    Invest Ophthalmol Vis Sci 53:4692-8. 2012
  5. pmc Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arthritis Res Ther 14:R99. 2012
  6. doi request reprint Suppression of bystander T helper 1 cells by iris pigment epithelium-inducing regulatory T cells via negative costimulatory signals
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:2529-36. 2010
  7. doi request reprint Human retinal pigment epithelium-induced CD4+CD25+ regulatory T cells suppress activation of intraocular effector T cells
    Shintaro Horie
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo, Japan
    Clin Immunol 136:83-95. 2010
  8. ncbi request reprint Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    J Immunol 181:7525-36. 2008
  9. doi request reprint Retinoic acid from retinal pigment epithelium induces T regulatory cells
    Yuko Kawazoe
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Exp Eye Res 94:32-40. 2012
  10. doi request reprint Suppression of interleukin-17-producing T-helper 17 cells by retinal pigment epithelial cells
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Jpn J Ophthalmol 55:565-75. 2011

Collaborators

Detail Information

Publications59

  1. doi request reprint Use of a comprehensive polymerase chain reaction system for diagnosis of ocular infectious diseases
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    Ophthalmology 120:1761-8. 2013
    ..To measure the genomic DNA of ocular infectious pathogens in ocular fluids and to analyze the clinical relevance of these pathogens in uveitis and endophthalmitis...
  2. pmc Role of IL-22- and TNF-α-producing Th22 cells in uveitis patients with Behcet's disease
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Tokyo 113 8519, Japan
    J Immunol 190:5799-808. 2013
    ..Our results suggest that inflammatory cytokines IL-22 and TNF-α may play a key role in the ocular immune response in Behçet's disease...
  3. doi request reprint Mature dendritic cell suppression by IL-1 receptor antagonist on retinal pigment epithelium cells
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Tokyo, Japan
    Invest Ophthalmol Vis Sci 54:3240-9. 2013
    ..To determine whether retinal pigment epithelial (RPE) cells can inhibit mature dendritic cells (mDCs)...
  4. doi request reprint Virological analysis in patients with human herpes virus 6-associated ocular inflammatory disorders
    Sunao Sugita
    Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Chuo Ku, Kobe, Japan
    Invest Ophthalmol Vis Sci 53:4692-8. 2012
    ..To determine whether human herpes virus 6 (HHV-6) genomic DNA and mRNA can be detected in ocular samples from patients with inflammatory disorders, and whether viral replication is involved in the development of inflammation in the eye...
  5. pmc Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arthritis Res Ther 14:R99. 2012
    ..The purpose of this study was to determine whether anti-tumour necrosis factor alpha (anti-TNF-α) antibody, infliximab, can inhibit T helper 17 (Th17) differentiation in uveitis patients who have Behçet's disease (BD)...
  6. doi request reprint Suppression of bystander T helper 1 cells by iris pigment epithelium-inducing regulatory T cells via negative costimulatory signals
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:2529-36. 2010
    ..To determine whether iris pigment epithelium (IPE)-induced T regulatory (Treg) cells can suppress the activation of bystander T cells with cell contact via costimulatory interactions...
  7. doi request reprint Human retinal pigment epithelium-induced CD4+CD25+ regulatory T cells suppress activation of intraocular effector T cells
    Shintaro Horie
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo, Japan
    Clin Immunol 136:83-95. 2010
    ..Thus, in vitro manipulated Treg cells acquire functions that participate in the establishment of immune tolerance in the eye...
  8. ncbi request reprint Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    J Immunol 181:7525-36. 2008
    ..The results are compatible with the hypothesis that the eye-derived Treg cells acquire functions that participate in the establishment of immune tolerance in the posterior segment of the eye...
  9. doi request reprint Retinoic acid from retinal pigment epithelium induces T regulatory cells
    Yuko Kawazoe
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Exp Eye Res 94:32-40. 2012
    ..Our data support the hypothesis that RPE cells produce RA, thereby enabling bystander T cells to be converted into Tregs through TGFβ promotion, which can then participate in the establishment of immune tolerance in the eye...
  10. doi request reprint Suppression of interleukin-17-producing T-helper 17 cells by retinal pigment epithelial cells
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Jpn J Ophthalmol 55:565-75. 2011
    ..To determine whether retinal pigment epithelial (RPE) cells can inhibit cytokine production by activated T helper (Th) cells...
  11. doi request reprint T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:2862-70. 2009
    ..To determine whether retinal pigment epithelial (RPE) cells can inhibit in vitro T-cell activation during inflammatory conditions...
  12. ncbi request reprint [Effects and safety of infliximab administration in refractory uveoretinitis with Behçet's disease]
    Hiroyuki Tanaka
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Nihon Ganka Gakkai Zasshi 114:87-95. 2010
    ..To evaluate the efficacy and safety of infliximab administration in refractory uveoretinitis in Behçet's disease (BD)...
  13. doi request reprint Inhibitory effect of corneal endothelial cells on IL-17-producing Th17 cells
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Br J Ophthalmol 96:293-9. 2012
    ..To determine whether cultured corneal endothelial (CE) cells suppress interleukin 17 (IL-17)-producing effector T cells in vitro...
  14. ncbi request reprint Ocular infiltrating CD4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:2547-54. 2006
    ..To determine whether patients with Vogt-Koyanagi-Harada (VKH) disease have immune responses specific to the melanocyte antigens tyrosinase and gp100...
  15. doi request reprint Mechanisms of immune suppression for CD8+ T cells by human corneal endothelial cells via membrane-bound TGFbeta
    Yukiko Yamada
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:2548-57. 2010
    ..To determine whether CD8(+) T cells in vitro are suppressed or converted into regulators (Treg cells) by human corneal endothelial (HCE) cells...
  16. doi request reprint Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Tokyo, Japan
    J Immunol 183:5013-22. 2009
    ..In both EAU models, there was significant suppression of the ocular inflammation. These results indicate that RPE secretes CTLA-2alpha, thereby enabling the bystander T cells to be converted into Treg cells via TGF-beta promotion...
  17. doi request reprint Human corneal endothelial cells expressing programmed death-ligand 1 (PD-L1) suppress PD-1+ T helper 1 cells by a contact-dependent mechanism
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:263-72. 2009
    ..This study was designed to determine whether human corneal endothelial (HCE) cells could regulate the activation of bystander T cells in vitro...
  18. ncbi request reprint Quantitative PCR for the detection of genomic DNA of Epstein-Barr virus in ocular fluids of patients with uveitis
    Sayaka Yamamoto
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    Jpn J Ophthalmol 52:463-7. 2008
    ..To measure the genomic DNA from Epstein-Barr virus (EBV) in ocular fluids and to analyze the clinical relevance of EBV in uveitis...
  19. doi request reprint Induction of T regulatory cells by cytotoxic T-lymphocyte antigen-2α on corneal endothelial cells
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:2598-605. 2011
    ..To determine whether murine corneal endothelial (CE) cells can promote the generation of T regulatory (Treg) cells in vitro...
  20. ncbi request reprint Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Int Ophthalmol 27:87-95. 2007
    ..To determine whether T lymphocytes of patients with Vogt-Koyanagi-Harada (VKH) disease cross-react with peptides of melanocytes and with exogenous antigens...
  21. ncbi request reprint Identification of human herpesvirus 6 in a patient with severe unilateral panuveitis
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arch Ophthalmol 125:1426-7. 2007
  22. doi request reprint Diagnosis of intraocular lymphoma by polymerase chain reaction analysis and cytokine profiling of the vitreous fluid
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    Jpn J Ophthalmol 53:209-14. 2009
    ..To determine whether a diagnosis of intraocular lymphoma (IOL) can be made using a combination of polymerase chain reaction (PCR) analysis to detect gene rearrangement of immunoglobulin and cytokine concentrations in the vitreous fluid...
  23. ncbi request reprint Transforming growth factor beta-producing Foxp3(+)CD8(+)CD25(+) T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Exp Eye Res 85:626-36. 2007
    ..In conclusion, ocular pigment epithelial cells convert CD8(+) T cells into CD25(+) Tregs by inducing the transcription factor Foxp3. Thus, T cells that encounter ocular parenchymal cells participate in the T-cell suppression...
  24. doi request reprint Human iris pigment epithelium suppresses activation of bystander T cells via TGFbeta-TGFbeta receptor interaction
    Shintaro Horie
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Exp Eye Res 88:1033-42. 2009
    ..In conclusion, cultured human iris pigment epithelium fully inhibits T cell activation in vitro. Our data support the hypothesis that the ocular resident cells play a critical role in immunosuppression in the eye...
  25. doi request reprint A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis
    Masaru Miyanaga
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan
    Br J Ophthalmol 94:336-40. 2010
    ..The aim of the study was to investigate the correlation between the clinical manifestation and the cytomegalovirus (CMV) viral load in the aqueous humour of patients with CMV anterior uveitis...
  26. doi request reprint Inhibition of B-cell activation by retinal pigment epithelium
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:5783-8. 2010
    ..To determine whether retinal pigment epithelial (RPE) cells can inhibit B-cell activation in vitro...
  27. doi request reprint Diagnosis of bacterial endophthalmitis by broad-range quantitative PCR
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Br J Ophthalmol 95:345-9. 2011
    ..To measure the bacterial genome in ocular fluids and to analyse the clinical relevance of infectious endophthalmitis...
  28. ncbi request reprint [Detection of herpesvirus genome by multiplex polymerase chain reaction (PCR) and real-time PCR in ocular fluids of patients with acute retinal necrosis]
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Japan
    Nihon Ganka Gakkai Zasshi 112:30-8. 2008
    ....
  29. ncbi request reprint The role of soluble TNF receptors for TNF-alpha in uveitis
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Yushima, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:3246-52. 2007
    ..To investigate the presence of soluble tumor necrosis factor receptors (sTNF-Rs) and TNF-alpha in the ocular fluids of patients with uveitis and the capacity of sTNF-Rs to affect TNF-alpha production by intraocular T cells...
  30. doi request reprint Immunosuppressive properties of regulatory T cells generated by incubation of peripheral blood mononuclear cells with supernatants of human RPE cells
    Ayano Imai
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Tokyo, Japan
    Invest Ophthalmol Vis Sci 53:7299-309. 2012
    ..To determine whether supernatants of human retinal pigment epithelium (RPE) cells can convert CD4⁺ T cells into regulatory T cells (Tregs) under Treg-induction conditions in vitro and in vivo...
  31. ncbi request reprint Role of thrombospondin-1 in T cell response to ocular pigment epithelial cells
    Yuri Futagami
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    J Immunol 178:6994-7005. 2007
    ..Thus, intraocular TSP-1 produced by both ocular parenchymal cells and regulatory T cells is essential for immune regulation in the eye...
  32. doi request reprint Suppression of IL-22-producing T helper 22 cells by RPE cells via PD-L1/PD-1 interactions
    Sunao Sugita
    Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Kobe, Japan
    Invest Ophthalmol Vis Sci 54:6926-33. 2013
    ..To determine whether RPE cells can suppress a novel T helper subset, the Th22 cells, via costimulatory interactions...
  33. ncbi request reprint Cytokine profile in aqueous humor and sera of patients with infectious or noninfectious uveitis
    Hiroshi Takase
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Yushima, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:1557-61. 2006
    ..To determine the cytokine expression profile at the protein level in aqueous humor (AqH) and sera of patients with uveitis...
  34. ncbi request reprint [Murine ciliary body pigment epithelial cells inhibit activation of T cells]
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    Nihon Ganka Gakkai Zasshi 111:598-605. 2007
    ..Although cultured iris PE (IPE) and retinal PE (RPE) achieve suppression, the function of ciliary body PE (CBPE) is still unknown. We investigated whether CBPE can suppress the activation of T cells in vitro...
  35. doi request reprint Timing of recurrent uveitis in patients with Behcet's disease receiving infliximab treatment
    Yukiko Yamada
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo, Japan
    Br J Ophthalmol 95:205-8. 2011
    ..To investigate the relationship between recurrence of uveitis and timing of infliximab in patients with Behçet's disease...
  36. ncbi request reprint Evaluation of characteristic ocular signs and systemic investigations in ocular sarcoidosis patients
    Tatsushi Kawaguchi
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 51:121-6. 2007
    ..To evaluate the diagnostic values of ocular signs and systemic investigations in ocular sarcoidosis, in a retrospective case-control study...
  37. ncbi request reprint Kinetics of aqueous flare, intraocular pressure and virus-DNA copies in a patient with cytomegalovirus iridocyclitis without retinitis
    Tatsushi Kawaguchi
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Bunkyo ku, Tokyo, Japan
    Int Ophthalmol 27:383-6. 2007
    ..A case report of recurrent unilateral granulomatous iridocyclitis with ocular hypertension without retinitis caused by cytomegalovirus (CMV) in an immunocompetent patient...
  38. doi request reprint Detection of Candida and Aspergillus species DNA using broad-range real-time PCR for fungal endophthalmitis
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Graefes Arch Clin Exp Ophthalmol 250:391-8. 2012
    ....
  39. doi request reprint Induction of regulatory T cells by infliximab in Behcet's disease
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:476-84. 2011
    ..To determine whether infliximab induces the development of Foxp3+ T regulatory (Treg) cells in patients with Behçet's disease...
  40. ncbi request reprint High-resolution genomic copy number profiling of primary intraocular lymphoma by single nucleotide polymorphism microarrays
    Ludan Wang
    Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 105:592-9. 2014
    ..The results suggest that IOCNSL is a highly malignant form of PIOL that infiltrates into the CNS at an early stage. They also indicate that genetic differences between PIOL and primary CNS lymphoma need to be clarified. ..
  41. doi request reprint Diagnosis of ocular toxoplasmosis by two polymerase chain reaction (PCR) examinations: qualitative multiplex and quantitative real-time
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Jpn J Ophthalmol 55:495-501. 2011
    ..To establish a two-step polymerase chain reaction (PCR) diagnostic system for ocular toxoplasmosis...
  42. doi request reprint Comparison of infliximab versus ciclosporin during the initial 6-month treatment period in Behçet disease
    Yukiko Yamada
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    Br J Ophthalmol 94:284-8. 2010
    ..To compare the efficacy and safety of infliximab versus ciclosporin A (CsA) in refractory uveoretinitis in Behçet disease...
  43. doi request reprint Novel diagnosis of fungal endophthalmitis by broad-range real-time PCR detection of fungal 28S ribosomal DNA
    Manabu Ogawa
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Graefes Arch Clin Exp Ophthalmol 250:1877-83. 2012
    ..To detect the fungal genome in the ocular fluids of patients with fungal endophthalmitis by using a novel broad-range polymerase chain reaction (PCR) system...
  44. doi request reprint Regression of optic disc neovascularization in patients with Behçet's uveoretinitis after infliximab therapy
    Tatsushi Kawaguchi
    Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    J Ocul Pharmacol Ther 26:627-30. 2010
    ..We report 2 cases of Behçet's uveoretinitis that achieved partial regression of NVD after infliximab therapy...
  45. doi request reprint Clinical course of patients with Behçet's uveitis following discontinuation of infliximab therapy
    Tatsushi Kawaguchi
    Department of Ophthalmology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, 3 18 22 Honkomagome, Bunkyo, Tokyo, 113 8677, Japan
    Jpn J Ophthalmol 58:75-80. 2014
    ..To investigate the clinical course of Behçet's uveitis patients following discontinuation of infliximab therapy...
  46. doi request reprint Role of ocular pigment epithelial cells in immune privilege
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arch Immunol Ther Exp (Warsz) 57:263-8. 2009
    ..This review focuses on the immunosuppressive property and role of ocular PE cells in immune privileged sites...
  47. doi request reprint Bilateral anterior granulomatous keratouveitis with sunset glow fundus in a patient with autoimmune polyglandular syndrome
    Yuri Futagami
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    Ocul Immunol Inflamm 17:88-90. 2009
    ..To report the case of a patient with bilateral anterior granulomatous keratouveitis and sunset glow fundus...
  48. doi request reprint Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement
    Yusuke Nakauchi
    Department of Hematology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo, Japan
    Int J Hematol 92:179-85. 2010
    ..Grade 3 adverse event, leukocytopenia, was observed in only 1 patient. No grade 4 event was observed. Although further evaluation is required, concurrent sMTX and vMTX may be effective for IOL with CNS involvement...
  49. ncbi request reprint Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Tokyo, Japan
    Exp Eye Res 83:1459-71. 2006
    ..We propose that this mechanism of suppression via TGFbeta ensures that soluble active TGFbeta is released into the ocular microenvironment in order to create the immune privilege of the posterior segment of the eye...
  50. doi request reprint Broad-range real-time PCR assay for detection of bacterial DNA in ocular samples from infectious endophthalmitis
    Manabu Ogawa
    Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Jpn J Ophthalmol 56:529-35. 2012
    ..To evaluate a broad-range real-time polymerase chain reaction (PCR) targeting the bacterial 16S rRNA gene for detection of bacterial DNA in infectious endophthalmitis...
  51. ncbi request reprint [A case of intraocular malignant lymphoma diagnosed by immunoglobulin gene rearrangement and translocation, and IL-10/IL-6 ratio in the vitreous fluid]
    Mako Yokota
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 0034, Japan
    Nihon Ganka Gakkai Zasshi 107:287-91. 2003
    ..We report here a case where we used the new diagnostic tests and the results aided us to make a diagnosis of intraocular lymphoma...
  52. doi request reprint Psoriasis triggered by infliximab in a patient with Behçet's disease
    Yuko Kawazoe
    Department of Ophthalmology, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Tokyo, Japan
    Jpn J Ophthalmol 57:95-7. 2013
    ..To report a case of psoriasis triggered by anti-tumor necrosis factor-alpha (TNF-α) therapy in a uveitis patient with Behçet's disease...
  53. doi request reprint Prophylactic vitrectomy for acute retinal necrosis
    Tomoka Ishida
    Department of Ophthalmology, Tokyo Metropolitan Cancer and Infectious Disease Center, Komagome Hospital, Tokyo, Japan
    Jpn J Ophthalmol 53:486-9. 2009
    ..To evaluate the efficacy of prophylactic vitrectomy for acute retinal necrosis...
  54. ncbi request reprint [Ocular infiltrating CD 4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens]
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Nihon Ganka Gakkai Zasshi 112:953-64. 2008
    ..These results indicate that CMV infection may stimulate the production of T cells that crossreact with tyrosinase by molecular mimicry. These events may be responsible for the onset of VKH disease...
  55. ncbi request reprint The presence of macrophage migration inhibitory factor in human trabecular meshwork and its upregulatory effects on the T helper 1 cytokine
    Hiroshi Takase
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Invest Ophthalmol Vis Sci 43:2691-6. 2002
    ..To investigate the expression and secretion of macrophage migration inhibitory factor (MIF) in human trabecular meshwork (HTM) and evaluate its role in ocular inflammation...
  56. doi request reprint Immunological homeostasis of the eye
    Manabu Mochizuki
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    Prog Retin Eye Res 33:10-27. 2013
    ....
  57. ncbi request reprint [Disc neovascularization in a patient with Vogt-Koyanagi-Harada disease and efficacy of steroid pulse therapy]
    Tatsushi Kawaguchi
    Department of Ophthalmology and Visual Science, Graduate School, Tokyo Medical and Dental University, Japan
    Nihon Ganka Gakkai Zasshi 110:58-60. 2006
    ..To report a patient with Vogt-Koyanagi-Harada disease who developed neovascularization at the optic disc...
  58. ncbi request reprint Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci
    Nobuhisa Mizuki
    Department of Ophthalmology and Visual Science, Yokohama City University, Yokohama, Kanagawa, Japan
    Nat Genet 42:703-6. 2010
    ..9 x 10(-11), odds ratio = 1.35; rs1800871 in IL10, P = 1.0 x 10(-14), odds ratio = 1.45)...
  59. doi request reprint Relationship between serum infliximab levels and acute uveitis attacks in patients with Behcet disease
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    Br J Ophthalmol 95:549-52. 2011
    ..To investigate the relationship between the serum concentration of infliximab, a chimeric monoclonal antibody to tumour necrosis factor-α (TNF-α), and its effectiveness in treating uveitis in Behçet disease...