Hitoshi Sawa

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi Cortical beta-catenin and APC regulate asymmetric nuclear beta-catenin localization during asymmetric cell division in C. elegans
    Kota Mizumoto
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe 650 0047, Japan
    Dev Cell 12:287-99. 2007
  2. ncbi Two betas or not two betas: regulation of asymmetric division by beta-catenin
    Kota Mizumoto
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe 650 0047, Japan
    Trends Cell Biol 17:465-73. 2007
  3. ncbi Specification of neurons through asymmetric cell divisions
    Hitoshi Sawa
    Laboratory for Cell Fate Decision, RIKEN Center for Developmental Biology, Kobe, Hyogo 650 0047, Japan
    Curr Opin Neurobiol 20:44-9. 2010
  4. ncbi [Wnt as positional information for cell polarization]
    Hitoshi Sawa
    Tanpakushitsu Kakusan Koso 51:2297-305. 2006
  5. ncbi Multiple functions of PBRM-1/Polybromo- and LET-526/Osa-containing chromatin remodeling complexes in C. elegans development
    Yukimasa Shibata
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe 650 0047, Japan
    Dev Biol 361:349-57. 2012
  6. ncbi Wnt regulates spindle asymmetry to generate asymmetric nuclear β-catenin in C. elegans
    Kenji Sugioka
    Laboratory for Cell Fate Decision, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cell 146:942-54. 2011
  7. ncbi Extracellular control of PAR protein localization during asymmetric cell division in the C. elegans embryo
    Yukinobu Arata
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe, Japan
    Development 137:3337-45. 2010
  8. ncbi Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells
    Yuko Yamamoto
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe, Japan
    PLoS Genet 7:e1002308. 2011
  9. ncbi Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans
    Yukimasa Shibata
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe, Hyogo, 650 0047, Japan
    Development 137:1045-53. 2010
  10. ncbi Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans
    Yukinobu Arata
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe 650 0047, Japan
    Dev Cell 11:105-15. 2006

Collaborators

Detail Information

Publications22

  1. ncbi Cortical beta-catenin and APC regulate asymmetric nuclear beta-catenin localization during asymmetric cell division in C. elegans
    Kota Mizumoto
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe 650 0047, Japan
    Dev Cell 12:287-99. 2007
    ..Because beta-catenin and APC are localized to the cortex in many cell types in different species, our results suggest that these cortical proteins may regulate asymmetric divisions or Wnt signaling in other organisms as well...
  2. ncbi Two betas or not two betas: regulation of asymmetric division by beta-catenin
    Kota Mizumoto
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe 650 0047, Japan
    Trends Cell Biol 17:465-73. 2007
    ..The recent discovery of reiterative nuclear asymmetries of a highly conserved beta-catenin in an annelid suggests that similar molecular mechanisms might regulate asymmetric cell divisions in other organisms...
  3. ncbi Specification of neurons through asymmetric cell divisions
    Hitoshi Sawa
    Laboratory for Cell Fate Decision, RIKEN Center for Developmental Biology, Kobe, Hyogo 650 0047, Japan
    Curr Opin Neurobiol 20:44-9. 2010
    ..Recent studies suggest that neurons are specified by the combined effects of asymmetric divisions, which are regulated by common mechanisms, and specific transcription factors expressed in the mother cell...
  4. ncbi [Wnt as positional information for cell polarization]
    Hitoshi Sawa
    Tanpakushitsu Kakusan Koso 51:2297-305. 2006
  5. ncbi Multiple functions of PBRM-1/Polybromo- and LET-526/Osa-containing chromatin remodeling complexes in C. elegans development
    Yukimasa Shibata
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe 650 0047, Japan
    Dev Biol 361:349-57. 2012
    ..Our results show that the target selection by SWI/SNF-like complexes during C. elegans development is intricately regulated by accessory components...
  6. ncbi Wnt regulates spindle asymmetry to generate asymmetric nuclear β-catenin in C. elegans
    Kenji Sugioka
    Laboratory for Cell Fate Decision, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cell 146:942-54. 2011
    ..Moreover, laser manipulation of the spindles rescued defects in nuclear POP-1 asymmetry in wnt mutants. Our results reveal a mechanism in which the nuclear localization of proteins is regulated through the modulation of microtubules...
  7. ncbi Extracellular control of PAR protein localization during asymmetric cell division in the C. elegans embryo
    Yukinobu Arata
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe, Japan
    Development 137:3337-45. 2010
    ..Our findings suggest that Src functions as an evolutionarily conserved molecular link that coordinates extrinsic cues with PAR protein localization...
  8. ncbi Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells
    Yuko Yamamoto
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe, Japan
    PLoS Genet 7:e1002308. 2011
    ..Our results provide a paradigm for understanding how cell polarity is coordinated by extrinsic signals...
  9. ncbi Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans
    Yukimasa Shibata
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe, Hyogo, 650 0047, Japan
    Development 137:1045-53. 2010
    ..Our results therefore indicate that histone acetylation plays a crucial role in cell-fate maintenance...
  10. ncbi Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans
    Yukinobu Arata
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe 650 0047, Japan
    Dev Cell 11:105-15. 2006
    ..These results indicate that cooperation between Wnt signaling and a Hox protein functions to determine the specific fate of a daughter cell...
  11. ncbi Cyclin E and CDK2 repress the terminal differentiation of quiescent cells after asymmetric division in C. elegans
    Masaki Fujita
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe, Japan
    PLoS ONE 2:e407. 2007
    ..Our results suggest that the balance between the levels of CKI and cyclin E determines three distinct cell states: terminally differentiated, quiescent and uncommitted, and proliferating...
  12. ncbi Regulation of asymmetric positioning of nuclei by Wnt and Src signaling and its roles in POP-1/TCF nuclear asymmetry in Caenorhabditis elegans
    Kenji Sugioka
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe 650 0047, Japan
    Genes Cells 15:397-407. 2010
    ..These results suggest that the asymmetric nuclear anchoring functions in asymmetric division by enhancing POP-1 asymmetry...
  13. ncbi RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans
    Kumiko Oishi
    Laboratory for Cell Fate Decision, RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 179:1149-62. 2007
    ..Human homologues of RMD-1 could also bind microtubules, which would suggest a function for these proteins in chromosome segregation during mitosis in other organisms as well...
  14. ncbi Asymmetric cortical and nuclear localizations of WRM-1/beta-catenin during asymmetric cell division in C. elegans
    Hisako Takeshita
    Laboratory for Cell Fate Decision, RIKEN, Center for Developmental Biology, Kobe 650 0047, Japan
    Genes Dev 19:1743-8. 2005
    ..Our results indicate that Wnt signals release cortical WRM-1 from the posterior cortex to generate cortical asymmetry that may control WRM-1 asymmetric nuclear localization by regulating cell polarity...
  15. ncbi Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans
    Akinori Yoda
    Division of Neuroanatomy, Osaka University Graduate School of Medicine, Kobe University, Kobe 650 0017, Japan
    Development 132:1885-93. 2005
    ..These results suggest that LET-19 and DPY-22 in the Mediator complex repress the transcription of Wnt target genes...
  16. ncbi tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C. elegans
    Xiaojun Zhao
    Program in Molecular, Cellular and Developmental Biology, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    Dev Biol 256:276-89. 2003
    ..Our results suggest that tcl-2 functions with Wnt pathways to control T cell fate specification, gonad development, and P12 cell fate specification...
  17. ncbi [The SWI/SNF chromatin-remodeling complex regulates asymmetric cell division in C. elegans]
    Masahiro Uchida
    Tanpakushitsu Kakusan Koso 50:569-74. 2005
  18. ncbi Complex network of Wnt signaling regulates neuronal migrations during Caenorhabditis elegans development
    Anna Y Zinovyeva
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Genetics 179:1357-71. 2008
    ..Finally, we find striking differences between the phenotypes of the Wnt quintuple and Frizzled quadruple mutants...
  19. ncbi Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions
    Takahiro Kanamori
    Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    EMBO J 27:1647-57. 2008
    ..We propose that membrane trafficking regulated by ipla-1 provides a mechanism to control the cortical asymmetry of beta-catenin...
  20. ncbi A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling
    Ambrose R Kidd
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Wisconsin 53706, USA
    Cell 121:761-72. 2005
    ..We discuss the idea that a similar pathway may be employed broadly in animal development...
  21. ncbi The C. elegans RUNX transcription factor RNT-1/MAB-2 is required for asymmetrical cell division of the T blast cell
    Hiroshi Kagoshima
    Genome Biology Laboratory, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Dev Biol 287:262-73. 2005
    ..All our data suggest that RNT-1/MAB-2 functions with POP-1 to control the asymmetry of the T cell division...
  22. ncbi Wnt signals can function as positional cues in establishing cell polarity
    Bob Goldstein
    Biology Department, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Dev Cell 10:391-6. 2006
    ..These results demonstrate that Wnt proteins can function as positional cues in establishing cell polarity...