Yoshihiro Onouchi

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. doi request reprint Molecular genetics of Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Pediatr Res 65:46R-54R. 2009
  2. doi request reprint ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease
    Y Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine RIKEN, Yokohama, Kanagawa, Japan
    Pharmacogenomics J 13:52-9. 2013
  3. ncbi request reprint Genetics of Kawasaki disease: what we know and don't know
    Yoshihiro Onouchi
    Department of Public Health, Chiba University Graduate School of Medicine, Chiba and Laboratory for Cardiovascular Disease, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Circ J 76:1581-6. 2012
  4. doi request reprint A genome-wide association study identifies three new risk loci for Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 44:517-21. 2012
  5. pmc Common variants in CASP3 confer susceptibility to Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine RIKEN, Yokohama 230 0045, Japan
    Hum Mol Genet 19:2898-906. 2010
  6. pmc ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms
    Yoshihiro Onouchi
    Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, Yokohama, Kanagawa, 230 0045, Japan
    Nat Genet 40:35-42. 2008
  7. ncbi request reprint CD40 ligand gene and Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, 1 7 22 Suehiro, Tsurumi, Yokohama, Japan
    Eur J Hum Genet 12:1062-8. 2004
  8. ncbi request reprint A genomewide linkage analysis of Kawasaki disease: evidence for linkage to chromosome 12
    Yoshihiro Onouchi
    Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Hum Genet 52:179-90. 2007
  9. doi request reprint SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population
    Asako Aoki
    Laboratory for Cardiovascular disease, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    J Hum Genet 56:47-51. 2011
  10. doi request reprint SNPs in BRAP associated with risk of myocardial infarction in Asian populations
    Kouichi Ozaki
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama 230 0045, Japan
    Nat Genet 41:329-33. 2009

Detail Information

Publications16

  1. doi request reprint Molecular genetics of Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Pediatr Res 65:46R-54R. 2009
    ..I also introduce our recent findings in genome-wide approach, which revealed the importance of Ca2+/nuclear factor of activated T-cells pathway in the pathogenesis of KD...
  2. doi request reprint ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease
    Y Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine RIKEN, Yokohama, Kanagawa, Japan
    Pharmacogenomics J 13:52-9. 2013
    ..0031). Our findings strongly suggest the existence of genetic factors affecting patients' responses to treatment and the risk for cardiac complications, and provide clues toward understanding the pathophysiology of KD inflammation...
  3. ncbi request reprint Genetics of Kawasaki disease: what we know and don't know
    Yoshihiro Onouchi
    Department of Public Health, Chiba University Graduate School of Medicine, Chiba and Laboratory for Cardiovascular Disease, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Circ J 76:1581-6. 2012
    ..Recently, susceptibility genes for KD have been identified in succession by studies with a genome-wide approach. Recent advances in genetic studies for KD will be presented...
  4. doi request reprint A genome-wide association study identifies three new risk loci for Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 44:517-21. 2012
    ..6 × 10(-6)) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease...
  5. pmc Common variants in CASP3 confer susceptibility to Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine RIKEN, Yokohama 230 0045, Japan
    Hum Mol Genet 19:2898-906. 2010
    ..Our findings suggest that altered CASP3 expression in immune effecter cells influences susceptibility to KD...
  6. pmc ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms
    Yoshihiro Onouchi
    Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, Yokohama, Kanagawa, 230 0045, Japan
    Nat Genet 40:35-42. 2008
    ..This finding provides new insights into the mechanisms of immune activation in Kawasaki disease and emphasizes the importance of activated T cells in the pathogenesis of this vasculitis...
  7. ncbi request reprint CD40 ligand gene and Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, 1 7 22 Suehiro, Tsurumi, Yokohama, Japan
    Eur J Hum Genet 12:1062-8. 2004
    ..07-3.66; P=0.030). Interestingly, this variation was extremely rare in a control Caucasian population (1/145, 0.7%). Our results suggest a role of CD40L in the pathogenesis of CAL and might explain the excess of males affected with KD...
  8. ncbi request reprint A genomewide linkage analysis of Kawasaki disease: evidence for linkage to chromosome 12
    Yoshihiro Onouchi
    Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Hum Genet 52:179-90. 2007
    ..This is the first large-scale study of the genetic susceptibility to KD, and our results, combined with the accumulated knowledge of the human genome, could greatly promote research on identification of the molecular pathogenesis of KD...
  9. doi request reprint SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population
    Asako Aoki
    Laboratory for Cardiovascular disease, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    J Hum Genet 56:47-51. 2011
    ..These findings indicate that the SNPs on chromosome 5p15.3 are novel protective genetic factors against MI...
  10. doi request reprint SNPs in BRAP associated with risk of myocardial infarction in Asian populations
    Kouichi Ozaki
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama 230 0045, Japan
    Nat Genet 41:329-33. 2009
    ..BRAP knockdown by siRNA using cultured coronary endothelial cells suppressed activation of NF-kappaB, a central mediator of inflammation...
  11. ncbi request reprint Identification of susceptibility genes for Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Cardiovascular disease, Center for Genomic Medicine, RIKEN
    Nihon Rinsho Meneki Gakkai Kaishi 33:73-80. 2010
    ..Our findings highlighted the importance of Ca(2+)/NFAT pathway in the pathogenesis of KD and shed light on the possibility of immuno-suppressants targeting the pathway as a therapeutic strategy for KD...
  12. doi request reprint Susceptibility genes for Kawasaki disease: toward implementation of personalized medicine
    Akira Hata
    Department of Public Health, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hum Genet 54:67-73. 2009
    ..In this review, we summarize the cumulative knowledge regarding KD, and then outline our hypothesis of the role ITPKC plays in KD susceptibility and our trial that aims toward the implementation of personalized medicine for KD...
  13. ncbi request reprint [Susceptibility genes for Kawasaki disease]
    Yoshihiro Onouchi
    Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN
    Nihon Rinsho 66:272-7. 2008
    ..S. population. We hope that our ongoing investigation of the function of the SNP (s) and the gene in which these SNPs locate will lead further understanding of the disease and pave the way to a new therapeutic strategy...
  14. ncbi request reprint Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients
    Keiko Yamazaki
    Laboratory for Gastrointestinal Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Kanagawa, Japan
    J Hum Genet 52:575-83. 2007
    ..Further genetic studies are required to confirm our findings with ethnically divergent populations...
  15. ncbi request reprint Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease
    Keiko Yamazaki
    Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    J Hum Genet 49:664-8. 2004
    ..These findings imply significant differences in genetic background with CD susceptibility among different ethnic groups and further indicate some difficulty of population-based studies...
  16. ncbi request reprint Functional polymorphisms of the FPR1 gene and aggressive periodontitis in Japanese
    Tomohiko Gunji
    Periodontology, Department of Hard Tissue Engineering, Tokyo Medical and Dental University Graduate School, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8549, Japan
    Biochem Biophys Res Commun 364:7-13. 2007
    ..000020). Thus, altered FPR1 function might confer increased risk to AgP...