Yukinori Okada

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. doi request reprint Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine CGM, RIKEN, Yokohama, Japan
    Nat Genet 44:904-9. 2012
  2. doi request reprint Common genetic factors for hematological traits in humans
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan
    J Hum Genet 57:161-9. 2012
  3. pmc Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 44:302-6. 2012
  4. doi request reprint Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Hum Mol Genet 20:1224-31. 2011
  5. pmc Identification of nine novel loci associated with white blood cell subtypes in a Japanese population
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan
    PLoS Genet 7:e1002067. 2011
  6. doi request reprint Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine, Institute of Physical and Chemical Research RIKEN, Kanagawa, Japan
    Hum Mol Genet 19:2079-85. 2010
  7. doi request reprint A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci
    Yukinori Okada
    Center for Genomic Medicine, Institute of Physical and Chemical Research, RIKEN, Kanagawa, Japan
    Hum Mol Genet 19:2303-12. 2010
  8. doi request reprint An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes
    Kenichi Shimane
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Rheumatology (Oxford) 52:1172-82. 2013
  9. doi request reprint The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population
    Chikashi Terao
    Center for Genomic Medicine, Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hum Mol Genet 20:2680-5. 2011
  10. doi request reprint Genome-wide association study of hematological and biochemical traits in a Japanese population
    Yoichiro Kamatani
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:210-5. 2010

Detail Information

Publications26

  1. doi request reprint Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine CGM, RIKEN, Yokohama, Japan
    Nat Genet 44:904-9. 2012
    ..We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function...
  2. doi request reprint Common genetic factors for hematological traits in humans
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan
    J Hum Genet 57:161-9. 2012
    ....
  3. pmc Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 44:302-6. 2012
    ..0 × 10(-8)) between a SNP in the KLF9 locus (rs11142387) and one in the MSTN (also known as GDF8) locus at 2q32 (rs13034723). These findings should provide useful insights into the etiology of obesity...
  4. doi request reprint Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Hum Mol Genet 20:1224-31. 2011
    ..0 × 10(-4)), although no pleiotropic association was observed in the CRP or HNF1A locus (α = 0.01). Our study demonstrated the pivotal role of the IL6 locus in the regulation of serum CRP levels and inflammatory pathways...
  5. pmc Identification of nine novel loci associated with white blood cell subtypes in a Japanese population
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan
    PLoS Genet 7:e1002067. 2011
    ..This study should contribute to the understanding of the genetic backgrounds of the WBC subtypes and hematological traits...
  6. doi request reprint Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine, Institute of Physical and Chemical Research RIKEN, Kanagawa, Japan
    Hum Mol Genet 19:2079-85. 2010
    ..In conclusion, our study would demonstrate the significant contribution of PSMD3-CSF3 and PLCB4 loci to the regulation of neutrophil count...
  7. doi request reprint A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci
    Yukinori Okada
    Center for Genomic Medicine, Institute of Physical and Chemical Research, RIKEN, Kanagawa, Japan
    Hum Mol Genet 19:2303-12. 2010
    ..26 cm (95% confidence interval: 1.18-1.34) per 1.0 increase of the normalized Z score for height-increasing alleles, explaining 4.6% of the total variance of adult height...
  8. doi request reprint An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes
    Kenichi Shimane
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Rheumatology (Oxford) 52:1172-82. 2013
    ..Conclusion. We identified HLA-DRB1 alleles associated with SLE and RA in a Japanese population and demonstrated a shared susceptibility of DRB1*09:01 between the diseases as well as its effect on autoantibody production...
  9. doi request reprint The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population
    Chikashi Terao
    Center for Genomic Medicine, Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hum Mol Genet 20:2680-5. 2011
    ....
  10. doi request reprint Genome-wide association study of hematological and biochemical traits in a Japanese population
    Yoichiro Kamatani
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:210-5. 2010
    ..05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated...
  11. doi request reprint Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1
    Yukinori Okada
    Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 60:3582-90. 2009
    ..To examine the risk of anti-cyclic citrullinated peptide (anti-CCP) antibody positivity in rheumatoid arthritis (RA) patients carrying certain haplotypes in the HLA region...
  12. ncbi request reprint SLC22A4 polymorphism and rheumatoid arthritis susceptibility: a replication study in a Japanese population and a metaanalysis
    Yukinori Okada
    Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Rheumatol 35:1723-8. 2008
    ..We assessed the RA susceptibility of slc2F1/F2 polymorphisms...
  13. doi request reprint Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus
    Keiko Myouzen
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Tokyo 113 0033, Japan
    Hum Mol Genet 19:2313-20. 2010
    ..Therefore, EGR2 is a genetic risk factor for SLE, in which increased gene expression may contribute to SLE pathogenesis...
  14. pmc Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese
    Keiko Myouzen
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    PLoS Genet 8:e1002949. 2012
    ..These results suggest that the NF-κB pathway plays a role in pathogenesis and would be a rational target for treatment of rheumatoid arthritis...
  15. pmc A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese
    Yukinori Okada
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    PLoS Genet 8:e1002455. 2012
    ..05). As AFF1 transcripts were prominently expressed in CD4(+) and CD19(+) peripheral blood lymphocytes, up-regulation of AFF1 may cause the abnormality in these lymphocytes, leading to disease onset...
  16. pmc Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population
    Natsuhiko Kumasaka
    Research Group for Medical Informatics, Center for Genomic Medicine, RIKEN, Tokyo, Japan
    PLoS ONE 7:e44507. 2012
    ..5 x 10(-52)). These haplotypes were also associated with smoking-related diseases, including lung cancer, chronic obstructive pulmonary disease and arteriosclerosis obliterans...
  17. doi request reprint PlatinumCNV: a Bayesian Gaussian mixture model for genotyping copy number polymorphisms using SNP array signal intensity data
    Natsuhiko Kumasaka
    Research Group for Medical Informatics, Center for Genomic Medicine, RIKEN, Shirokane dai, Minato ku, Tokyo, Japan
    Genet Epidemiol 35:831-44. 2011
    ..The methods described in this work are implemented in a software package, PlatinumCNV, available on the Internet...
  18. doi request reprint HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Yokohama Institute, Japan
    Gastroenterology 141:864-871.e1-5. 2011
    ..There are many genetic factors that are associated with both ulcerative colitis (UC) and Crohn's disease (CD). However, genetic factors that have distinct effects on UC and CD have not been examined...
  19. pmc Genome wide association study of age at menarche in the Japanese population
    Chizu Tanikawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    PLoS ONE 8:e63821. 2013
    ..In addition, six loci in or near CCDC85A, LOC100421670, CA10, ZNF483, ARNTL, and RXRG exhibited suggestive association with AAM (P<0.05). Our findings elucidated the impact of genetic variations on AAM in the Japanese population...
  20. pmc Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese
    Wael Osman
    Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e32683. 2012
    ..013). Rs10007186 in 4q21.2 was associated with serum levels of IgA (P = 0.036), IgM (P = 0.019), and IgE (P = 4.9 × 10(-4)). Our results should add interesting knowledge about the regulation of major serum components...
  21. doi request reprint A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility
    Yuta Kochi
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 42:515-9. 2010
    ..Moreover, CCR6DNP was associated with susceptibility to Graves' and Crohn's diseases. These results suggest that CCR6 is critically involved in IL-17-driven autoimmunity in human diseases...
  22. doi request reprint Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
    Yukinori Okada
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 44:511-6. 2012
    ..This provided evidence of shared genetic risks of rheumatoid arthritis between the populations...
  23. doi request reprint PADI4 polymorphism predisposes male smokers to rheumatoid arthritis
    Yuta Kochi
    Correspondence to Dr Yuta Kochi, Laboratory for Autoimmune Diseases, CGM, RIKEN, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Ann Rheum Dis 70:512-5. 2011
    ....
  24. pmc A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1
    Yuji Urabe
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS Genet 8:e1002541. 2012
    ..54×10⁻⁸), suggesting a crucial role for this variation in renal function. Our findings elucidated the significance of genetic variations for the pathogenesis of nephrolithiasis...
  25. doi request reprint An optimal dose-effect mode trend test for SNP genotype tables
    Ryo Yamada
    Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Genet Epidemiol 33:114-27. 2009
    ....
  26. doi request reprint Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population
    Akari Suzuki
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Nat Genet 40:1224-9. 2008
    ..CD244 is a genetic risk factor for rheumatoid arthritis and may have a role in the autoimmune process shared by rheumatoid arthritis and systemic lupus erythematosus...