T Ohshima

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi request reprint Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Development 134:2273-82. 2007
  2. pmc Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain
    T Ohshima
    Laboratory for Developmental Neurobiology, Cell Culture Development, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 98:2764-9. 2001
  3. ncbi request reprint Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, Brain Science Institute, Hirosawa, Wako City, Saitama, Japan
    J Neurochem 94:917-25. 2005
  4. ncbi request reprint Modulation of Reelin signaling by Cyclin-dependent kinase 5
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    Brain Res 1140:84-95. 2007
  5. ncbi request reprint Reelin signaling and Cdk5 in the control of neuronal positioning
    Toshio Ohshima
    Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama, Japan
    Mol Neurobiol 26:153-66. 2002
  6. ncbi request reprint Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
    J Neurosci 22:4036-44. 2002
  7. ncbi request reprint Unusual patch-matrix organization in the retrosplenial cortex of the reeler mouse and Shaking rat Kawasaki
    Noritaka Ichinohe
    Laboratory for Cortical Organization and Systematics, RIKEN, Brain Science Institute, Wako, Saitama 351 0198, Japan
    Cereb Cortex 18:1125-38. 2008
  8. ncbi request reprint Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons
    Kanehiro Hayashi
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Wako Shi, Saitama 351 0198, Japan
    Mol Cell Neurosci 20:579-94. 2002
  9. ncbi request reprint Pak1 regulates dendritic branching and spine formation
    Kanehiro Hayashi
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Wako Shi, Saitama 351 0198, Japan
    Dev Neurobiol 67:655-69. 2007
  10. ncbi request reprint Inhibition of ubiquitin ligase Siah-1A by disabled-1
    Tae Ju Park
    Lab for Neurodegeneration Signal, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 302:671-8. 2003

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Development 134:2273-82. 2007
    ..In addition, proper radial neuronal migration generates an inside-out pattern of cerebral cortex formation and normal axonal trajectories of cortical pyramidal neurons...
  2. pmc Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain
    T Ohshima
    Laboratory for Developmental Neurobiology, Cell Culture Development, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 98:2764-9. 2001
    ..These additional defects in neuronal migration in mice lacking both Cdk5/p35 and Reelin/Dab1 indicate that Cdk5/p35 may contribute synergistically to the positioning of the cortical neurons in the developing mouse brain...
  3. ncbi request reprint Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, Brain Science Institute, Hirosawa, Wako City, Saitama, Japan
    J Neurochem 94:917-25. 2005
    ..These results demonstrate that p35-dependent Cdk5 activity is important to learning and synaptic plasticity. Deletion of p35 may shift the substrate specificity of Cdk5 due to compensatory expression of p39...
  4. ncbi request reprint Modulation of Reelin signaling by Cyclin-dependent kinase 5
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    Brain Res 1140:84-95. 2007
    ..These results indicate that Cdk5 modulates Reelin signaling through the Ser/Thr phosphorylation of Dab1 differently in an isoform-specific manner...
  5. ncbi request reprint Reelin signaling and Cdk5 in the control of neuronal positioning
    Toshio Ohshima
    Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama, Japan
    Mol Neurobiol 26:153-66. 2002
    ..Recent evidence has implicated synergism between Reelin signaling and Cdk5 in contributing to the proper positioning of selective neuronal populations...
  6. ncbi request reprint Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
    J Neurosci 22:4036-44. 2002
    ..These results indicate that Cdk5/p35 and Reelin signaling regulates the selective mode of neuronal migration in the developing mouse hindbrain...
  7. ncbi request reprint Unusual patch-matrix organization in the retrosplenial cortex of the reeler mouse and Shaking rat Kawasaki
    Noritaka Ichinohe
    Laboratory for Cortical Organization and Systematics, RIKEN, Brain Science Institute, Wako, Saitama 351 0198, Japan
    Cereb Cortex 18:1125-38. 2008
    ..We conclude that input-target relationships are largely preserved in the mutant GRS and that dendrite-dendrite interactions involving OCAM influence the formation of the mosaic configuration...
  8. ncbi request reprint Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons
    Kanehiro Hayashi
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Wako Shi, Saitama 351 0198, Japan
    Mol Cell Neurosci 20:579-94. 2002
    ..These results suggest that Pak1 regulates dendrite initiation as a downstream effector of Rac1...
  9. ncbi request reprint Pak1 regulates dendritic branching and spine formation
    Kanehiro Hayashi
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Wako Shi, Saitama 351 0198, Japan
    Dev Neurobiol 67:655-69. 2007
    ..Thus, our results provide further evidence of the key role of Pak1 in the regulation of dendritogenesis, dendritic arborization, the spine formation, and maintenance...
  10. ncbi request reprint Inhibition of ubiquitin ligase Siah-1A by disabled-1
    Tae Ju Park
    Lab for Neurodegeneration Signal, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 302:671-8. 2003
    ..Our results suggest that Dab1 inhibits the activity of Siah...
  11. ncbi request reprint A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex
    Ryan Remedios
    Department of Biological Sciences, B 304, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, India
    Nat Neurosci 10:1141-50. 2007
    ..This is first evidence of a dorsal pallial contribution to the amygdala, demonstrating a developmental and mechanistic link between the amygdala and the neocortex...
  12. ncbi request reprint Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone
    Yuki Hirota
    Department of Developmental and Regenerative Biology, Institute of Molecular Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Neurosci 27:12829-38. 2007
    ..These findings suggest that Cdk5 plays an important role in neuroblast migration in the postnatal subventricular zone...
  13. ncbi request reprint Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration
    Naoya Yamashita
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 26:13357-62. 2006
    ..Loss of crmp1 in a dab1 heterozygous background led to the disruption of hippocampal lamination, a Reeler-like phenotype. In addition to axon guidance, CRMP1 regulates neuronal migration by mediating Reln signaling...
  14. ncbi request reprint Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1
    Naoya Yamashita
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 27:12546-54. 2007
    ..These findings suggest that Sema3A-induced spine development is regulated by phosphorylation of CRMP1 by Cdk5...
  15. ncbi request reprint Enhanced activation of Ca2+/calmodulin-dependent protein kinase II upon downregulation of cyclin-dependent kinase 5-p35
    Tomohisa Hosokawa
    Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Hachiohji, Tokyo, Japan
    J Neurosci Res 84:747-54. 2006
    ..These results suggest that Cdk5 activity suppresses CaMKII activation, and that the downregulation of Cdk5 activity after treatment withNMDA facilitates CaMKII activation, leading to the easier induction of long-term potentiation...
  16. pmc Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling
    Satoru Takahashi
    Functional Genomics Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:1737-42. 2005
    ..These results support the idea that Cdk5 activity is involved in altered gene expression after chronic exposure to cocaine and hence impacts the long-lasting changes in neuronal function underlying cocaine addiction...
  17. doi request reprint Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability
    Sayuko Kaminosono
    Department of Biological Sciences, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
    J Neurosci 28:8747-55. 2008
    ..This Cdk5 inhibition of htt aggregates is a novel mechanism different from htt phosphorylation and interaction with Cdk5 reported previously (Luo et al., 2005; Anne et al., 2007)...
  18. ncbi request reprint Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex
    Yukio Sasaki
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University School of Medicine, Yokohama, Japan
    Neuron 35:907-20. 2002
    ..The sema3A gene shows strong interaction with fyn for apical dendrite guidance in the cerebral cortex. We propose a signal transduction pathway in which Fyn and Cdk5 mediate neuronal guidance regulated by Sema3A...
  19. ncbi request reprint Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability
    Fan Yan Wei
    Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Minami Osawa, Hachiohji, Tokyo, Japan
    J Neurochem 93:502-12. 2005
    ..p35(-/-) mice exhibited a lower threshold for induction of long-term potentiation. Thus excitatory glutamatergic neurotransmission regulates Cdk5 activity through p35 degradation, and this pathway may contribute to plasticity...
  20. ncbi request reprint Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease
    Yutaka Uchida
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Genes Cells 10:165-79. 2005
    ..These results suggest that the sequential phosphorylation of CRMP is an important process of Sema3A signalling and the same mechanism may have some relevance to the pathological aggregation of the microtubule-associated proteins...
  21. pmc Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles
    Kazuhito Tomizawa
    Department of Physiology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    J Cell Biol 163:813-24. 2003
    ..Moreover, the phosphorylation of both proteins completely disrupted the copolymerization into a ring formation. Finally, phosphorylation of both proteins was undetectable in p35-deficient mice...
  22. ncbi request reprint Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E
    Chanxia Li
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 24:6161-70. 2004
    ..These results provide evidence for a mutual regulatory mechanism between local protein synthesis and axonal transport...
  23. pmc Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects
    Motoyuki Hirasawa
    Functional Genomics Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:6249-54. 2004
    ..These results indicate that abrogation of Cdk5 expression in mature neurons results in a viable mouse model that offers further opportunities to investigate the molecular roles of Cdk5 in the adult CNS...
  24. ncbi request reprint Comparison of the effects of agalsidase alfa and agalsidase beta on cultured human Fabry fibroblasts and Fabry mice
    Hitoshi Sakuraba
    Department of Clinical Genetics, The Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3 18 22 Honkomagome, Tokyo, 113 8613, Japan
    J Hum Genet 51:180-8. 2006
    ..Repeated administration of agalsidase beta apparently decreased the number of accumulated lamellar inclusion bodies in renal tubular cells of Fabry mice...
  25. ncbi request reprint Phosphorylation of the tubulin-binding protein, stathmin, by Cdk5 and MAP kinases in the brain
    Kanehiro Hayashi
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurochem 99:237-50. 2006
    ..Thus, microtubule regulatory mechanisms involving the phosphorylation of stathmin may contribute to developmental synaptic pruning and structural plasticity, and may be involved in neuropsychiatric and neurodegenerative disorders...
  26. ncbi request reprint Cdk5-dependent regulation of glucose-stimulated insulin secretion
    Fan Yan Wei
    Department of Physiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Nat Med 11:1104-8. 2005
    ..These results suggest that Cdk5/p35 may be a drug target for the regulation of glucose-stimulated insulin secretion...