Affiliation: RIKEN Brain Science Institute
Yamada T, Habara O, Yoshii Y, Matsushita R, Kubo H, Nojima Y, et al
. The role of glycogen in development and adult fitness in Drosophila. Development. 2019;146: pubmed publisher
..This study provides a fundamental understanding of the stage-specific requirements for glycogen metabolism in the fruit fly. ..
Yamada T, Habara O, Kubo H, Nishimura T. Fat body glycogen serves as a metabolic safeguard for the maintenance of sugar levels in Drosophila. Development. 2018;145: pubmed publisher
..Fat body glycogen plays a crucial role in the maintenance of circulating sugars, including trehalose, under fasting conditions. These results demonstrate the importance of fat body glycogen as a metabolic safeguard in Drosophila. ..
Matsuda H, Yamada T, Yoshida M, Nishimura T. Flies without trehalose. J Biol Chem. 2015;290:1244-55 pubmed publisher
..These diet-dependent phenotypes of Tps1 mutants demonstrate the critical role of trehalose during development in Drosophila and reveal how animals adapt to changes in nutrient availability. ..
Okamoto N, Nishimura T. Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth. Dev Cell. 2015;35:295-310 pubmed publisher
..These results provide a molecular framework that explains how the production of an endocrine hormone in a specific tissue is coordinated with environmental conditions. ..
Yasugi T, Yamada T, Nishimura T. Adaptation to dietary conditions by trehalose metabolism in Drosophila. Sci Rep. 2017;7:1619 pubmed publisher
..These results demonstrate that proper trehalose metabolism plays a critical role in adaptation under various environmental conditions. ..