Katsuhiko Mikoshiba

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi request reprint IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor
    Hideaki Ando
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama 351 0198
    Mol Cell 22:795-806. 2006
  2. ncbi request reprint IP3 receptor/Ca2+ channel: from discovery to new signaling concepts
    Katsuhiko Mikoshiba
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute and Calcium Oscillation Project, ICORP SORST, Hirosawa, Wako Shi, Saitama, Japan
    J Neurochem 102:1426-46. 2007
  3. pmc Blockage of spontaneous Ca2+ oscillation causes cell death in intraerythrocitic Plasmodium falciparum
    Masahiro Enomoto
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    PLoS ONE 7:e39499. 2012
  4. doi request reprint The discovery and structural investigation of the IP₃ receptor and the associated IRBIT protein
    Katsuhiko Mikoshiba
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute and Calcium Oscillation Project, ICORP SORST, JST 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Adv Exp Med Biol 740:281-304. 2012
  5. doi request reprint The role of Ca2+ signaling in cell function with special reference to exocrine secretion
    Katsuhiko Mikoshiba
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Saitama, Japan
    Cornea 27:S3-8. 2008
  6. doi request reprint Role of IP₃ receptor in development
    Katsuhiko Mikoshiba
    RIKEN Brain Science Institute, Wako, Saitama, Japan
    Cell Calcium 49:331-40. 2011
  7. ncbi request reprint An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites
    Hiroko Bannai
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 279:53427-34. 2004
  8. doi request reprint Receptor-selective diffusion barrier enhances sensitivity of astrocytic processes to metabotropic glutamate receptor stimulation
    Misa Arizono
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Sci Signal 5:ra27. 2012
  9. ncbi request reprint Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse
    Jun Hoshino
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako, Saitama 351 0918, Japan
    Brain Res Mol Brain Res 120:57-64. 2003
  10. ncbi request reprint Modulation of Reelin signaling by Cyclin-dependent kinase 5
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    Brain Res 1140:84-95. 2007

Detail Information

Publications129 found, 100 shown here

  1. ncbi request reprint IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor
    Hideaki Ando
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama 351 0198
    Mol Cell 22:795-806. 2006
    ..We propose a unique mode of IP3R regulation in which IP3 sensitivity is regulated by IRBIT acting as an endogenous "pseudoligand" whose inhibitory activity can be modulated by its phosphorylation status...
  2. ncbi request reprint IP3 receptor/Ca2+ channel: from discovery to new signaling concepts
    Katsuhiko Mikoshiba
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute and Calcium Oscillation Project, ICORP SORST, Hirosawa, Wako Shi, Saitama, Japan
    J Neurochem 102:1426-46. 2007
    ..The structure of IP(3)R1, as revealed by cryoelectron microscopy, fits closely with these molecules...
  3. pmc Blockage of spontaneous Ca2+ oscillation causes cell death in intraerythrocitic Plasmodium falciparum
    Masahiro Enomoto
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    PLoS ONE 7:e39499. 2012
    ..Our results provide a novel concept that IP(3)/Ca(2+) signaling pathway in the intraerythrocytic malaria parasites is a promising target for antimalarial drug development...
  4. doi request reprint The discovery and structural investigation of the IP₃ receptor and the associated IRBIT protein
    Katsuhiko Mikoshiba
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute and Calcium Oscillation Project, ICORP SORST, JST 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Adv Exp Med Biol 740:281-304. 2012
    ..The unique 3-dimensional structure of the IP₃R is convenient for associating with many IP₃R-associated proteins. Therefore, the IP₃R serves as a signaling hub, which forms macromolecular complex with various molecules...
  5. doi request reprint The role of Ca2+ signaling in cell function with special reference to exocrine secretion
    Katsuhiko Mikoshiba
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Saitama, Japan
    Cornea 27:S3-8. 2008
    ..Type 2 and 3 double-deficient mice show a deficit in saliva and lacrimal and pancreatic juice secretion. Type 1 IP3 receptor influences brain-derived neurotrophic factor production...
  6. doi request reprint Role of IP₃ receptor in development
    Katsuhiko Mikoshiba
    RIKEN Brain Science Institute, Wako, Saitama, Japan
    Cell Calcium 49:331-40. 2011
    ..All the data described here show that IP₃Rs are essential for life and abnormality of IP(3)Rs results in severe abnormality in its structure and function of organism...
  7. ncbi request reprint An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites
    Hiroko Bannai
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 279:53427-34. 2004
    ....
  8. doi request reprint Receptor-selective diffusion barrier enhances sensitivity of astrocytic processes to metabotropic glutamate receptor stimulation
    Misa Arizono
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Sci Signal 5:ra27. 2012
    ....
  9. ncbi request reprint Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse
    Jun Hoshino
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako, Saitama 351 0918, Japan
    Brain Res Mol Brain Res 120:57-64. 2003
    ..In addition, Dorz1 expression was up-regulated in cultured cells overexpressing Zic1. These results suggest that Dorz1 expression is positively regulated by Zic1 during cerebellar development...
  10. ncbi request reprint Modulation of Reelin signaling by Cyclin-dependent kinase 5
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    Brain Res 1140:84-95. 2007
    ..These results indicate that Cdk5 modulates Reelin signaling through the Ser/Thr phosphorylation of Dab1 differently in an isoform-specific manner...
  11. ncbi request reprint Xenopus Zic4: conservation and diversification of expression profiles and protein function among the Xenopus Zic family
    Takahiko J Fujimi
    Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    Dev Dyn 235:3379-86. 2006
    ..These results indicate that the five Xenopus Zic genes cooperatively regulate both neural and neural crest development, despite significantly diverged expression profiles and functions...
  12. ncbi request reprint Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue
    Jun Aruga
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Gene 315:87-94. 2003
    ..These results suggest that the human SLITRK genes are useful molecular indicators of brain tumor properties...
  13. doi request reprint Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly
    Takashi Inoue
    Laboratory for Comparative Neurogenesis Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 28:4712-25. 2008
    ..These findings indicate that the Zic genes play critical roles in cortical development through regulating the proliferation of meningeal cells and the pial BM assembly...
  14. pmc Two novel 2-aminoethyl diphenylborinate (2-APB) analogues differentially activate and inhibit store-operated Ca(2+) entry via STIM proteins
    Jun Ichi Goto
    Brain Science Institute, RIKEN, Wako, Saitama, Japan
    Cell Calcium 47:1-10. 2010
    ....
  15. pmc Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human
    Mitsunori Fukuda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem J 365:173-80. 2002
    ....
  16. doi request reprint Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells
    Akihiro Mizutani
    Laboratory for Developmental Neurobiology and Laboratory for Molecular Neurogenesis, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
    J Neurosci 28:5369-82. 2008
    ....
  17. doi request reprint Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase
    Miyuki Ogawa
    Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Genes Cells 13:397-409. 2008
    ..These results suggest that Rines is a membrane-bound E3 ubiquitin ligase...
  18. ncbi request reprint Pak1 regulates dendritic branching and spine formation
    Kanehiro Hayashi
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Wako Shi, Saitama 351 0198, Japan
    Dev Neurobiol 67:655-69. 2007
    ..Thus, our results provide further evidence of the key role of Pak1 in the regulation of dendritogenesis, dendritic arborization, the spine formation, and maintenance...
  19. ncbi request reprint Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo
    Takashi Inoue
    Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Dev Biol 306:669-84. 2007
    ....
  20. pmc Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium
    Tadashi Shinohara
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 108:15486-91. 2011
    ....
  21. ncbi request reprint Glutamate-induced declustering of post-synaptic adaptor protein Cupidin (Homer 2/vesl-2) in cultured cerebellar granule cells
    Yoko Shiraishi
    Laboratory for Molecular Neurogenesis, RIKEN Brain Science Institute, Wako, Saitama, Japan
    J Neurochem 87:364-76. 2003
    ..We suggest that Cupidin acts as a mobile adaptor protein that changes the distribution states, clustered versus declustered, in response to synaptic activity...
  22. ncbi request reprint Unusual patch-matrix organization in the retrosplenial cortex of the reeler mouse and Shaking rat Kawasaki
    Noritaka Ichinohe
    Laboratory for Cortical Organization and Systematics, RIKEN, Brain Science Institute, Wako, Saitama 351 0198, Japan
    Cereb Cortex 18:1125-38. 2008
    ..We conclude that input-target relationships are largely preserved in the mutant GRS and that dendrite-dendrite interactions involving OCAM influence the formation of the mosaic configuration...
  23. ncbi request reprint Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives
    Takashi Inoue
    Laboratory for Developmental Neurobiology and Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Dev Biol 270:146-62. 2004
    ..Based on both their similar expression pattern in mouse embryos and the malformations observed in Zic5-deficient mutant mice, human ZIC5 might be involved in the deletion syndrome...
  24. ncbi request reprint Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Development 134:2273-82. 2007
    ..In addition, proper radial neuronal migration generates an inside-out pattern of cerebral cortex formation and normal axonal trajectories of cortical pyramidal neurons...
  25. ncbi request reprint Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains
    Taruho S Kuroda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 293:899-906. 2002
    ..The results suggest that Slp5 might be involved in Rab27A-dependent membrane trafficking in specific tissues...
  26. ncbi request reprint Three-dimensional rearrangements within inositol 1,4,5-trisphosphate receptor by calcium
    Kozo Hamada
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
    J Biol Chem 278:52881-9. 2003
    ..These data suggest that the Ca2+-specific conformational change structurally regulates the IP3-triggered channel opening within IP3R1...
  27. ncbi request reprint Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport
    Mitsunori Fukuda
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 277:12432-6. 2002
    ..The discovery that myosin Va indirectly recognizes its cargo through Slac2-a, a novel Rab27A/B effector, should shed light on molecular recognition of its specific cargo by class V myosin...
  28. ncbi request reprint Non-polarized distribution of synaptotagmin IV in neurons: evidence that synaptotagmin IV is not a synaptic vesicle protein
    Keiji Ibata
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Neurosci Res 43:401-6. 2002
    ..These results suggest that Syt IV regulates non-polarized membrane trafficking in neurons, which may be involved in synaptic plasticity or neuronal development...
  29. ncbi request reprint Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors
    Takashi Inoue
    Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 27:5461-73. 2007
    ..The functions of these genes may be essential to increasing neural cell numbers regionally in the medial telencephalon and to proper mediolateral patterning of the telencephalon...
  30. doi request reprint An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage
    Hideaki Ando
    International Cooperative Research Project Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, Saitama, Japan
    J Neurochem 109:539-50. 2009
    ..These results suggest that Long-IRBIT has a different function from IRBIT...
  31. pmc Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines
    Yoko Shiraishi-Yamaguchi
    Laboratory for Molecular Neurogenesis, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    BMC Neurosci 10:25. 2009
    ..In this study, we aimed to elucidate the structural and functional properties of the interaction between Cupidin/Homer2 and two actin-cytoskeletal regulators, Cdc42 small GTPase and Drebrin...
  32. ncbi request reprint Synaptotagmin V is targeted to dense-core vesicles that undergo calcium-dependent exocytosis in PC12 cells
    Chika Saegusa
    Fukuda Initiative Research Unit and the Laboratory for Developmental Neurobiology, Brain Science Institute, Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 277:24499-505. 2002
    ..Based on these results, we propose that Syt V is a dense-core vesicle-specific Syt isoform that controls a specific type of Ca2+-regulated secretion...
  33. doi request reprint Ca2+ induces macropinocytosis via F-actin depolymerization during growth cone collapse
    Hiroyuki Kabayama
    Laboratory for Developmental Neurobiology, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Mol Cell Neurosci 40:27-38. 2009
    ..We propose that the coordinated regulation of actin cytoskeletal reorganization and macropinocytosis-mediated retrograde membrane trafficking may contribute to Ca(2+)-induced axon growth inhibition...
  34. doi request reprint Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 in Purkinje cells is regulated by calcium and actin filaments
    Kazumi Fukatsu
    Laboratory for Developmental Neurobiology, Brain Science Institute RIKEN, Wako, Saitama, Japan
    J Neurochem 114:1720-33. 2010
    ..These findings indicate that the neuronal activity-dependent augmentation of actin contributes to the stabilization of IP(3) R1 in spines...
  35. doi request reprint Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum
    Akira Futatsugi
    Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Saitama, Japan
    J Neurochem 105:1153-64. 2008
    ..We conclude that intracellular calcium release via IP(3)R2s and IP(3)R3s promotes the differentiation of GCPs within a specific interval of postnatal development in the cerebellum...
  36. doi request reprint Syntaxin 1B suppresses macropinocytosis and semaphorin 3A-induced growth cone collapse
    Hiroyuki Kabayama
    Laboratory for Developmental Neurobiology, Brain Science Institute, The Institute of Physical and Chemical Research, Wako, Saitama 351 0198, Japan
    J Neurosci 31:7357-64. 2011
    ..These results indicate that Syx1B couples macropinocytosis-mediated massive internalization of the plasma membrane to Sema3A-induced growth cone collapse...
  37. pmc Gephyrin-independent GABA(A)R mobility and clustering during plasticity
    Fumihiro Niwa
    Laboratory for Developmental Neurobiology, Brain Science Institute BSI, RIKEN, Saitama, Japan
    PLoS ONE 7:e36148. 2012
    ..Our results also indicate that GABA(A)R mobility and clustering after sustained excitatory activity is independent of gephyrin...
  38. ncbi request reprint The calcium-binding loops of the tandem C2 domains of synaptotagmin VII cooperatively mediate calcium-dependent oligomerization
    Mitsunori Fukuda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 277:29315-20. 2002
    ..Based on these results, we suggest that the linear Ca2+-dependent oligomer may be aligned at the fusion site between vesicles and plasma membrane and modulate Ca2+-regulated exocytosis by opening or dilating fusion pores...
  39. ncbi request reprint Myogenic repressor I-mfa interferes with the function of Zic family proteins
    Kiyomi Mizugishi
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, Wako Shi, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 320:233-40. 2004
    ..These results suggest that the physical and functional interaction between Zic and I-mfa proteins can play a role in the vertebrate development...
  40. ncbi request reprint The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival
    Tetsushi Sadakata
    Laboratory for Molecular Neurogenesis, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 24:43-52. 2004
    ..Thus, we suggest that CAPS2 mediates the depolarization-dependent release of NT-3 and BDNF from granule cells, leading to regulation in cell differentiation and survival during cerebellar development...
  41. ncbi request reprint Calcium/calmodulin-dependent protein kinase I in Xenopus laevis
    Takeo Saneyoshi
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Saitama, Wako Shi 351 0198, Japan
    Comp Biochem Physiol B Biochem Mol Biol 134:499-507. 2003
    ..laevis embryos and caused a marked change of cell morphology in Hela cells. Taken together, these results suggest that CaM-KI plays a role in cell-structure regulation during early embryonic development...
  42. pmc Highly cooperative dependence of sarco/endoplasmic reticulum calcium ATPase SERCA2a pump activity on cytosolic calcium in living cells
    Kanayo Satoh
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 286:20591-9. 2011
    ..F-L577 will be useful for future studies on Ca(2+) signaling involving SERCA2a activity...
  43. doi request reprint Type 1 inositol trisphosphate receptor regulates cerebellar circuits by maintaining the spine morphology of purkinje cells in adult mice
    Takeyuki Sugawara
    Laboratories for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 33:12186-96. 2013
    ....
  44. pmc ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT
    Peter O Bauer
    Laboratory for Structural Neuropathology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Mol Neurodegener 7:43. 2012
    ..Importantly, chemical and genetic inhibition of inositol 1,4,5-trisphosphate (IP3) receptor type 1 (IP3R1) has been shown to reduce mutant Htt aggregation...
  45. doi request reprint Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo
    Norio Takata
    Laboratory for Neuron Glia Circuit and Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 31:18155-65. 2011
    ..Our data present coherent lines of in vivo evidence for astrocytic involvement in cortical plasticity. These findings suggest an unexpected role of astrocytes as a gate for cholinergic plasticity in the cortex...
  46. ncbi request reprint Amplification of Ca2+ signaling by diacylglycerol-mediated inositol 1,4,5-trisphosphate production
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Biol Chem 280:11723-30. 2005
    ..These results suggest a novel physiological function of DAG, i.e. amplification of Ca2+ signaling by enhancing IP3 production via its positive feedback effect on PLC activity...
  47. pmc Cytosolic inositol 1,4,5-trisphosphate dynamics during intracellular calcium oscillations in living cells
    Toru Matsu-Ura
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama 351 0198, Japan
    J Cell Biol 173:755-65. 2006
    ....
  48. ncbi request reprint Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, Brain Science Institute, Hirosawa, Wako City, Saitama, Japan
    J Neurochem 94:917-25. 2005
    ..These results demonstrate that p35-dependent Cdk5 activity is important to learning and synaptic plasticity. Deletion of p35 may shift the substrate specificity of Cdk5 due to compensatory expression of p39...
  49. ncbi request reprint Inositol 1,4,5-trisphosphate receptor type 1 in granule cells, not in Purkinje cells, regulates the dendritic morphology of Purkinje cells through brain-derived neurotrophic factor production
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako City, Saitama 351 0198, Japan
    J Neurosci 26:10916-24. 2006
    ....
  50. pmc Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening
    Haruka Yamazaki
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Biol Chem 285:36081-91. 2010
    ....
  51. doi request reprint Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation
    Peter O Bauer
    Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 416:13-7. 2011
    ..Our findings suggest that besides functional contribution of the IP3R inhibition on the mutant htt aggregation there are additional mechanisms for the anti-aggregation effect of the 2-APB related compounds...
  52. pmc Cell adhesion molecules regulate Ca2+-mediated steering of growth cones via cyclic AMP and ryanodine receptor type 3
    Noriko Ooashi
    Laboratory for Neuronal Growth Mechanisms, Brain Science Institute, The Institute of Physical and Chemical Research, Saitama 351 0198, Japan
    J Cell Biol 170:1159-67. 2005
    ..In this way, axon-guiding and CAM-derived signals are integrated by RyR3, which serves as a key regulator of growth cone navigation...
  53. pmc Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation
    Hélène Kiefer
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 284:10694-705. 2009
    ....
  54. pmc G-protein-coupled receptor kinase-interacting proteins inhibit apoptosis by inositol 1,4,5-triphosphate receptor-mediated Ca2+ signal regulation
    Songbai Zhang
    Calcium Oscillation Project, International Cooperative Research Project Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Biol Chem 284:29158-69. 2009
    ..Thus, we conclude that GIT inhibits apoptosis by modulating the IP(3)R-mediated Ca(2+) signal through a direct interaction with IP(3)R in a cytosolic Ca(2+)-dependent manner...
  55. ncbi request reprint Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth
    Jun Aruga
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Mol Cell Neurosci 24:117-29. 2003
    ..These results suggest that the Slitrk proteins are the neuronal components that control the neurite outgrowth...
  56. ncbi request reprint Regulation of TRPC6 channel activity by tyrosine phosphorylation
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Biol Chem 279:18887-94. 2004
    ..Thus, our findings demonstrated that tyrosine phosphorylation by Src family PTKs is a novel regulatory mechanism of TRPC6 channel activity...
  57. pmc Role of BMP, FGF, calcium signaling, and Zic proteins in vertebrate neuroectodermal differentiation
    Jun Aruga
    Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, 351 0198, Japan
    Neurochem Res 36:1286-92. 2011
    ..Comprehensive understanding of the Zic family genes is therefore essential for the study of the neuroectodermal differentiation and stem cell biology...
  58. pmc IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Japan
    Front Neural Circuits 7:156. 2013
    ..These findings implicate IP3R1-dependent PC firing patterns in cerebellum in motor coordination and the expression of dystonia through the olivo-cerebellar pathway. ..
  59. pmc Cerebral blood flow modulation by Basal forebrain or whisker stimulation can occur independently of large cytosolic Ca2+ signaling in astrocytes
    Norio Takata
    Laboratory for Neuron Glia Circuit, RIKEN Brain Science Institute, Wako, Saitama, Japan
    PLoS ONE 8:e66525. 2013
    ..Our results show that neural activity-driven CBF modulation could occur without large cytosolic increases of Ca2+ in astrocytes...
  60. ncbi request reprint Novel compartment implicated in calcium signaling--is it an "induced coupling domain"?
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Sci STKE 2005:pe53. 2005
    ....
  61. pmc Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses
    Mika Tanaka
    RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, 351 0198, Japan
    Mol Brain 6:6. 2013
    ..To examine this issue further, we generated an inducible transgenic mouse model in which the expression of an inositol 1,4,5-trisphosphate absorbent, "IP3 sponge", attenuates astrocytic Ca2+ signaling...
  62. ncbi request reprint Two-state conformational changes in inositol 1,4,5-trisphosphate receptor regulated by calcium
    Kozo Hamada
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
    J Biol Chem 277:21115-8. 2002
    ..Ca2+-dependent susceptibilities to limited digestion strongly support the notion that these alterations exist. Thus, Ca2+ appeared to regulate IP3 gating activity through the rearrangement of functional domains...
  63. ncbi request reprint Inhibition of ubiquitin ligase Siah-1A by disabled-1
    Tae Ju Park
    Lab for Neurodegeneration Signal, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 302:671-8. 2003
    ..Our results suggest that Dab1 inhibits the activity of Siah...
  64. ncbi request reprint A wide-range phylogenetic analysis of Zic proteins: implications for correlations between protein structure conservation and body plan complexity
    Jun Aruga
    Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako 351 0198, Japan
    Genomics 87:783-92. 2006
    ..The result indicates that the ancestral bilateralian Zic protein had already acquired an entire set of conserved domains, but that this was lost and diverged in the platyhelminthes, nematodes, and urochordates...
  65. doi request reprint Potent transglutaminase inhibitors, dithio β-aminoethyl ketones
    Shoichiro Ozaki
    Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Bioorg Med Chem Lett 21:377-9. 2011
    ..The disulfide bond and thiophene ring play an important role in inhibitory activity of synthesized aryl β-amino ketones...
  66. ncbi request reprint Isolation of inositol 1,4,5-trisphosphate receptor-associating proteins and selective knockdown using RNA interference
    Akihiro Mizutani
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama, Japan
    Methods Mol Biol 645:133-41. 2010
    ..These methods will provide clues to understand the exact nature of how the signaling complex contributes to the generation of spatio-temporal patterns of intracellular Ca(2+) signals...
  67. pmc L1-dependent neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow
    Kazunari Nishimura
    Laboratory for Neuronal Growth Mechanisms, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Cell Biol 163:1077-88. 2003
    ..Our results indicate that ankyrinB promotes neurite initiation by acting as a component of the clutch module that transmits traction force generated by F-actin flow to the extracellular substrate via L1-CAM...
  68. ncbi request reprint Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons
    Yoko Shiraishi
    Laboratory for Molecular Neurogenesis, RIKEN Brain Science Institute, Wako, Japan
    Mol Cell Neurosci 22:188-201. 2003
    ..Our results indicate a coincidence in dendritic clustering in addition to developmental and activity-regulated synaptic targeting between Homer and the NMDA receptor complex...
  69. ncbi request reprint Kinesin dependent, rapid, bi-directional transport of ER sub-compartment in dendrites of hippocampal neurons
    Hiroko Bannai
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama 351 0198, Japan
    J Cell Sci 117:163-75. 2004
    ..Rapid transport of the Ca2+-releasable sub-compartment of ER might contribute to rapid supply of fresh ER proteins to the distal part of the dendrite, or to the spatial regulation of intracellular Ca2+ signaling...
  70. ncbi request reprint Reelin signaling and Cdk5 in the control of neuronal positioning
    Toshio Ohshima
    Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama, Japan
    Mol Neurobiol 26:153-66. 2002
    ..Recent evidence has implicated synergism between Reelin signaling and Cdk5 in contributing to the proper positioning of selective neuronal populations...
  71. ncbi request reprint Differential expression of Homer family proteins in the developing mouse brain
    Yoko Shiraishi
    Laboratory for Molecular Neurogenesis, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Comp Neurol 473:582-99. 2004
    ..These results demonstrate that Homer family members have distinct regional, cellular, and subcellular distributions in time and space during postnatal brain development...
  72. ncbi request reprint Locomotor and oculomotor impairment associated with cerebellar dysgenesis in Zic3-deficient (Bent tail) mutant mice
    Jun Aruga
    Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Eur J Neurosci 20:2159-67. 2004
    ..These findings may have some clinical implications in relation to disorders characterized by cerebellar dysgenesis, such as Joubert syndrome...
  73. ncbi request reprint Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors
    Nanaho Fukuda
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Eur J Neurosci 27:2665-75. 2008
    ..Our findings suggest that IP3R2 and IP3R3 mediate nasal mucus secretion, which is important for the maintenance of nasal tissue as well as the perception of odors...
  74. ncbi request reprint Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation
    Jun Aruga
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Saitama, Wako Shi, 351 0198, Japan
    Dev Biol 244:329-41. 2002
    ..Notch-mediated inhibition of neuronal differentiation is likely to act downstream of Zic genes since Notch1 is upregulated in Zic1-overexpressing spinal cords in both the mouse and the chick...
  75. ncbi request reprint ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase A
    Akira Ishiguro
    Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 282:9983-95. 2007
    ..Phosphorylation-dependent transformation of Zic2-containing molecular complexes may occur in transcriptional regulation...
  76. doi request reprint Potent transglutaminase inhibitors, aryl beta-aminoethyl ketones
    Shoichiro Ozaki
    Laboratory for Developmental Neurobiology, Brain Science Institute, Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Bioorg Med Chem Lett 20:1141-4. 2010
    ..Heteroaryl-like thiophene groups and N-benzyl N-t-butyl aminoethyl group are critical to the strong inhibitory activity of aryl beta-aminoethyl ketones...
  77. ncbi request reprint Neuronal birthdate-specific gene transfer with adenoviral vectors
    Mitsuhiro Hashimoto
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 24:286-96. 2004
    ..This adenovirus-meditated gene transfer technique will enable us to examine the properties of each subset of progenitor cells that share the same neuronal birthdate...
  78. doi request reprint Control of neuronal growth cone navigation by asymmetric inositol 1,4,5-trisphosphate signals
    Hiroki Akiyama
    Laboratory for Neuronal Growth Mechanisms, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
    Sci Signal 2:ra34. 2009
    ..Thus, locally produced IP(3) encodes spatial information that polarizes the growth cone for guided migration...
  79. doi request reprint Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction
    Hong Zhou
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 369:213-9. 2008
    ..Taken together, we concluded that IP(3)R1 plays a predominant role in the function of the vascular smooth muscle in vivo...
  80. doi request reprint Mechanism of ER stress-induced brain damage by IP(3) receptor
    Takayasu Higo
    Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Neuron 68:865-78. 2010
    ..These results suggest that IP(3)R1 senses ER stress through GRP78 to alter the Ca(2+) signal to promote neuronal cell death implicated in neurodegenerative diseases...
  81. ncbi request reprint Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
    J Neurosci 22:4036-44. 2002
    ..These results indicate that Cdk5/p35 and Reelin signaling regulates the selective mode of neuronal migration in the developing mouse hindbrain...
  82. ncbi request reprint Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells
    Chika Saegusa
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Genes Cells 11:623-31. 2006
    ..Based on these results, we propose that Slp2-a is part of the mucin secretory machinery in surface mucous cells of mouse stomach...
  83. ncbi request reprint Dynamics of Ca(2+) and Na(+) in the dendrites of mouse cerebellar Purkinje cells evoked by parallel fibre stimulation
    Akinori Kuruma
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama, 351 0198 Japan
    Eur J Neurosci 18:2677-89. 2003
    ....
  84. ncbi request reprint Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells
    Mitsunori Fukuda
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 277:4601-4. 2002
    ..Our results support the idea that Syt family proteins that co-reside on secretory vesicles may function cooperatively and redundantly as potential Ca(2+) sensors for exocytosis...
  85. ncbi request reprint Molecular characterization of the starfish inositol 1,4,5-trisphosphate receptor and its role during oocyte maturation and fertilization
    Hirohide Iwasaki
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 277:2763-72. 2002
    ..An immunocytochemical study, however, revealed that the distribution of starfish IP(3)R changes during oocyte maturation...
  86. doi request reprint Syntaxin 6 regulates nerve growth factor-dependent neurite outgrowth
    Hiroyuki Kabayama
    Laboratory for Developmental Neurobiology, Brain Science Institute, Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Neurosci Lett 436:340-4. 2008
    ..However, the coiled-coil domain-disrupting mutant had little effect on neurite outgrowth. These results suggest that the first coiled-coil domain of syntaxin 6 plays a crucial role in NGF-dependent neurite outgrowth...
  87. ncbi request reprint IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism
    Akira Futatsugi
    Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108 0071, Japan
    Science 309:2232-4. 2005
    ..Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP3R2 and IP3R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth...
  88. ncbi request reprint Disabled1 regulates the intracellular trafficking of reelin receptors
    Toshifumi Morimura
    Division of Molecular Neurobiology, Department of Basic Medical Science, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku 108 8639, Japan
    J Biol Chem 280:16901-8. 2005
    ..Taken together, these results indicate that Dab1 regulates both cell surface expression and internalization of Reelin receptors, and these regulations may play a role in correct laminar formation in the developing brain...
  89. ncbi request reprint [IP3 receptor, a Ca2+ oscilator--role of IP3 receptor in development and neural plasticity]
    Katsuhiko Mikoshiba
    Lab For Develop Neurobiology, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako 3510198, Saitama, Japan
    Nihon Yakurigaku Zasshi 120:6P-10P. 2002
    ..Recently we found that IP3R is involved in determination of polarity and input specificity of activity-induced synaptic modification...
  90. ncbi request reprint A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications
    Takeharu Nagai
    Laboratory for Cell Function and Dynamics, Advanced Technology Development Center, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako City, Saitama, 351 0198, Japan
    Nat Biotechnol 20:87-90. 2002
    ..With the improved speed and efficiency of maturation and the increased resistance to environment, Venus will enable fluorescent labelings that were not possible before...
  91. doi request reprint Synthesis of bisboron compounds and their strong inhibitory activity on store-operated calcium entry
    Akinobu Z Suzuki
    Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Bioorg Med Chem Lett 20:1395-8. 2010
    ..All the bisboron compounds showed strong inhibitory activity on SOCE, with IC50 values of less than 1 microM, which were 20-45 times lower than observed with 2-APB...
  92. ncbi request reprint Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Biol Chem 282:37225-31. 2007
    ..We conclude that IP3R3 is a principal mediator of sweet, bitter, and umami taste perception and would be a missing molecule linking phospholipase C beta2 to TRPM5 activation...
  93. pmc Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain
    Minoru Hatayama
    Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    Hum Mol Genet 17:3459-73. 2008
    ..These results indicate that ZIC3 is imported into the cell nucleus by the Karyopherin (Importin) system and that the impaired nuclear localization by the ZF1 mutation is not due to a direct influence on the NLS...
  94. ncbi request reprint Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left-right asymmetry
    Tetsuya Kitaguchi
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Dev Growth Differ 44:55-61. 2002
    ..Furthermore, activation of inducible type Xbra (Xbra-GR) induces Zic3 expression within 20 min. These results suggest that a role of Brachyury in L-R specification may be the direct regulation of Zic3 expression...
  95. doi request reprint From Ca2+ in muscle contraction to IP3 receptor/Ca2+ signaling In memory of Setsuro Ebashi
    Katsuhiko Mikoshiba
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 369:57-61. 2008
  96. ncbi request reprint Zic2 controls cerebellar development in cooperation with Zic1
    Jun Aruga
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 22:218-25. 2002
    ..These results indicate that Zic1 and Zic2 may have very similar functions in the regulation of cerebellar development...
  97. ncbi request reprint Mediolateral compartmentalization of the cerebellum is determined on the "birth date" of Purkinje cells
    Mitsuhiro Hashimoto
    Laboratory for Developmental Neurobiology, RIKEN BSI, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 23:11342-51. 2003
    ..Moreover, we also show that there is a correlation between the M-L clusters established by the birth date-related Purkinje cells and the domains of engrailed-2, Wnt-7B, L7/pcp2, and EphA4 receptor tyrosine kinase expression...
  98. ncbi request reprint Ectopic corticospinal tract and corticothalamic tract neurons in the cerebral cortex of yotari and reeler mice
    Tatsuro Yamamoto
    Division of Anatomy and Developmental Neurobiology, Department of Neuroscience, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    J Comp Neurol 461:61-75. 2003
    ....
  99. pmc Phospholipase Cdelta4 is required for Ca2+ mobilization essential for acrosome reaction in sperm
    Kiyoko Fukami
    Division of Biochemistry, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    J Cell Biol 161:79-88. 2003
    ..These results indicate that PLCdelta4 is an important enzyme for intracellular [Ca2+]i mobilization in the ZP-induced acrosome reaction and for sustained [Ca2+]i increases through SOC induced by ZP and progesterone in sperm...
  100. ncbi request reprint Inositol 1,4,5-trisphosphate IP(3) receptors and their role in neuronal cell function
    Katsuhiko Mikoshiba
    The Institute of Medical Science, The University of Tokyo, RIKEN, Brain Science Institute, Calcium Oscillation Project, SORST, JST, Tokyo, Japan
    J Neurochem 97:1627-33. 2006
    ..IP(3)R associates with ERp44, a redox sensor, Homer, other proteins and is transported as vesicular ER on microtubules. All these data suggests IP(3) receptor/CA(2+) channel works as a signaling center inside cells...